General Information of the Compound
Compound ID
CP0146227
Compound Name
(+/-)-4-(5-(1-aminoethyl)-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine
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Structure
Formula
C15H16N4S
Molecular Weight
284.388
Canonical SMILES
CC(N)c1ccc2sc(c(C)c2c1)-c1ccnc(N)n1
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InChI
InChI=1S/C15H16N4S/c1-8-11-7-10(9(2)16)3-4-13(11)20-14(8)12-5-6-18-15(17)19-12/h3-7,9H,16H2,1-2H3,(H2,17,18,19)
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InChIKey
GZRMTEKIJSSDOK-UHFFFAOYSA-N
Physicochemical Property
logP
3.26862
Rotatable Bonds
2
Heavy Atom Count
20
Polar Areas
77.82
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46889388
ChEMBL ID
CHEMBL1083965
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01184, Rho-associated protein kinase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000333 GTM-3 Homo sapiens (Human)  1
1
EC50 = 4200 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 400 nM