Brief Information of the Cell Line and Protein
Cell Line ID: CL000333 , GTM-3
 Cell Line Info 
Synonyms
GTM3
Glaucomatous Trabecular Meshwork-3
HTM-3
Human Trabecular Meshwork-3
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_5G33
Protein ID: PT00890 , Rho-associated protein kinase 2
 Protein Info 
Gene Name ROCK2
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID O75116
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000333
 Cell Line Info 
 Protein ID: PT00890
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0060392
 Compound Info 
(R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide
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C16H16N4O
  1
1
EC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0058927
 Compound Info 
5-[6-(1,4-diazepan-1-yl)pyrazin-2-yl]-1H-indazole
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C16H18N6
  1
1
EC50 = 260 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0225487
 Compound Info 
5-[6-(1,4-diazepan-1-yl)pyrazin-2-yl]-3-methyl-2H-indazole
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C17H20N6
  1
1
EC50 = 380 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0060393
 Compound Info 
5-[6-(1,4-diazepan-1-yl)-5-pyrrolidin-1-ylpyrazin-2-yl]-1H-pyrazolo[3,4-c]pyridine
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C19H24N8
  1
1
EC50 = 416 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0035246
 Compound Info 
2-(4-(6-(pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-2-yl)piperazin-1-yl)ethanol
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C19H26N6O
  1
1
EC50 = 680 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0209095
 Compound Info 
N-[3-[4-(6-pyridin-4-yl-3-pyrrolidin-1-ylpyrazin-2-yl)piperazin-1-yl]propyl]acetamide
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C22H31N7O
  1
1
EC50 = 760 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0225486
 Compound Info 
1-(dimethylamino)-3-[4-(6-pyridin-4-yl-3-pyrrolidin-1-ylpyrazin-2-yl)piperazin-1-yl]propan-2-ol
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C22H33N7O
  1
1
EC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0058928
 Compound Info 
N-[2-hydroxy-3-[4-(6-pyridin-4-yl-3-pyrrolidin-1-ylpyrazin-2-yl)piperazin-1-yl]propyl]acetamide
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C22H31N7O2
  1
1
EC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS