General Information of the Cell Line
Cell Line ID
CL000124
Cell Line Name
NFS-60
Synonyms
M-NFS-60
NFS 60
NFS60
Category
Cancer cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_3543
Disease
Mouse leukemia (NCIt: C21604)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02032, Macrophage colony-stimulating factor 1 receptor
Compound ID Compound Name Compound Formula
CP0258590
(1S,2S)-2-[[4-methoxy-6-[[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C23H27N7O3S
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0768044
(1S,2S)-2-((6-((2-((1H-Pyrazol-4-yl)amino)pyrimidin-4-yl)methoxy)-4-methoxybenzo[d]thiazol-2-yl)amino)cyclohexanol
   Show/Hide
C22H25N7O3S
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0555751
(1S,2S)-2-[[7-chloro-4-methoxy-6-[[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C23H26ClN7O3S
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0133124
5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine
   Show/Hide
C20H15ClF3N5
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0189243
N-[2-methyl-5-[[6-(trifluoromethyl)pyridine-3-carbonyl]amino]phenyl]imidazo[1,2-a]pyridine-3-carboxamide
   Show/Hide
C22H16F3N5O2
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0219505
(1S,2S)-2-[[4-methoxy-6-[[2-(1,2-oxazol-4-ylamino)pyrimidin-4-yl]methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C22H24N6O4S
 1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
CP0329537
N-[2-methyl-5-[[6-(trifluoromethyl)pyridine-3-carbonyl]amino]phenyl]pyrazolo[1,5-a]pyridine-3-carboxamide
   Show/Hide
C22H16F3N5O2
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0518142
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-piperidin-4-yloxypyridine-2-carboxamide
   Show/Hide
C25H30N6O4
 1
1
IC50 = 35.7 nM
   TI
   LI
   LO
   TS
CP0523442
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-(1-ethylpiperidin-4-yl)pyridine-2-carboxamide
   Show/Hide
C27H34N6O3
 1
1
IC50 = 37 nM
   TI
   LI
   LO
   TS
CP0086292
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-(1-ethylpiperidin-4-yl)oxypyridine-2-carboxamide
   Show/Hide
C27H34N6O4
 1
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
CP0120915
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yl)oxypyridine-2-carboxamide
   Show/Hide
C31H42N6O4
 1
1
IC50 = 46.3 nM
   TI
   LI
   LO
   TS
CP0556421
(1S,2S)-2-[[4-methoxy-6-[[2-[(1-methyltriazol-4-yl)amino]pyrimidin-4-yl]methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C22H26N8O3S
 1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0556416
(1S,2S)-2-[[6-[(2-amino-3-chloropyridin-4-yl)methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H21ClN4O2S
 1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CP0086291
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-(1,2,2,6,6-pentamethylpiperidin-4-yl)oxypyridine-2-carboxamide
   Show/Hide
C30H40N6O4
 1
1
IC50 = 50.4 nM
   TI
   LI
   LO
   TS
CP0127888
AB-460
   Show/Hide
C24H23N5O3
 1
1
IC50 = 53 nM
   TI
   LI
   LO
   TS
CP0354626
(1S,2S)-2-[[6-[(2-aminopyrimidin-4-yl)methoxy]-7-chloro-4-methoxy-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H22ClN5O3S
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0458958
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-4-methylpyridine-2-carboxamide
   Show/Hide
C21H23N5O3
 1
1
IC50 = 63.9 nM
   TI
   LI
   LO
   TS
CP0481760
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-(1-tert-butylpiperidin-4-yl)oxypyridine-2-carboxamide
   Show/Hide
C29H38N6O4
 1
1
IC50 = 64.4 nM
   TI
   LI
   LO
   TS
CP0523502
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-[(1-ethylpiperidin-4-yl)methyl]pyridine-2-carboxamide
   Show/Hide
C28H36N6O3
 1
1
IC50 = 67.4 nM
   TI
   LI
   LO
   TS
CP0381932
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-(2,2,6,6-tetramethylpiperidin-4-yl)oxypyridine-2-carboxamide
   Show/Hide
C29H38N6O4
 1
1
IC50 = 74.7 nM
   TI
   LI
   LO
   TS
CP0523443
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-(1-propan-2-ylpiperidin-4-yl)oxypyridine-2-carboxamide
   Show/Hide
C28H36N6O4
 1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
CP0352626
N-[4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-4-methoxy-1,3-benzothiazol-6-yl]oxymethyl]pyridin-2-yl]acetamide
   Show/Hide
C22H26N4O4S
 1
1
IC50 = 82 nM
   TI
   LI
   LO
   TS
CP0350711
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]pyrazolo[1,5-a]pyridine-3-carboxamide
   Show/Hide
C30H31F3N6O2
 1
1
IC50 = 91 nM
   TI
   LI
   LO
   TS
CP0556418
(1R,2S)-2-[[6-[(2-amino-3-chloropyridin-4-yl)methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H21ClN4O2S
 1
1
IC50 = 98 nM
   TI
   LI
   LO
   TS
CP0555750
(1R,2R)-2-[[6-[(2-amino-3-chloropyridin-4-yl)methoxy]-7-chloro-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H20Cl2N4O2S
 1
1
IC50 = 104 nM
   TI
   LI
   LO
   TS
CP0343421
(1S,2S)-2-[[4-methoxy-6-[[2-[(1-methylpyrazol-3-yl)amino]pyrimidin-4-yl]methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C23H27N7O3S
 1
1
IC50 = 105 nM
   TI
   LI
   LO
   TS
CP0381929
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-[(4-methylpiperazin-1-yl)methyl]pyridine-2-carboxamide
   Show/Hide
C26H33N7O3
 1
1
IC50 = 109 nM
   TI
   LI
   LO
   TS
CP0189218
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]carbamoyl]-2-methylphenyl]imidazo[1,2-b]pyridazine-3-carboxamide
   Show/Hide
C29H30F3N7O2
 1
1
IC50 = 122 nM
   TI
   LI
   LO
   TS
CP0258606
(1R,2R)-2-[[6-[(2-amino-3-chloropyridin-4-yl)methoxy]-4-fluoro-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H20ClFN4O2S
 1
1
IC50 = 125 nM
   TI
   LI
   LO
   TS
CP0219508
(1R,2R)-2-[[6-[(2-amino-3-chloropyridin-4-yl)methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H21ClN4O2S
 1
1
IC50 = 133 nM
   TI
   LI
   LO
   TS
CP0458957
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-4-piperidin-4-yloxypyridine-2-carboxamide
   Show/Hide
C25H30N6O4
 1
1
IC50 = 145 nM
   TI
   LI
   LO
   TS
CP0176154
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide
   Show/Hide
C30H31F3N6O2
 1
1
IC50 = 149 nM
   TI
   LI
   LO
   TS
CP0441092
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-(1-cyclopropylpiperidin-4-yl)oxypyridine-2-carboxamide
   Show/Hide
C28H34N6O4
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0441094
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]oxypyridine-2-carboxamide
   Show/Hide
C27H31F3N6O4
 1
1
IC50 = 169 nM
   TI
   LI
   LO
   TS
CP0487630
(1S,2S)-2-[[6-[(2-aminopyrimidin-4-yl)methoxy]-4-methoxy-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H23N5O3S
 1
1
IC50 = 178 nM
   TI
   LI
   LO
   TS
CP0514608
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]imidazo[1,2-b]pyridazine-3-carboxamide
   Show/Hide
C29H30F3N7O2
 1
1
IC50 = 178 nM
   TI
   LI
   LO
   TS
CP0487629
(1S,2R)-2-[[6-[(2-amino-3-chloropyridin-4-yl)methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H21ClN4O2S
 1
1
IC50 = 189 nM
   TI
   LI
   LO
   TS
CP0562700
(1R,2R)-2-[[6-[(2-amino-3-chloropyridin-4-yl)methoxy]-7-fluoro-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H20ClFN4O2S
 1
1
IC50 = 194 nM
   TI
   LI
   LO
   TS
CP0499589
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-5-methylpyridine-2-carboxamide
   Show/Hide
C21H23N5O3
 1
1
IC50 = 223 nM
   TI
   LI
   LO
   TS
CP0219509
6-[(2-amino-3-chloropyridin-4-yl)methoxy]-N-cyclohexyl-1,3-benzothiazol-2-amine
   Show/Hide
C19H21ClN4OS
 1
1
IC50 = 228 nM
   TI
   LI
   LO
   TS
CP0176158
4-[[2-[[(1S,2R)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide
   Show/Hide
C20H22N4O3S
 1
1
IC50 = 245 nM
   TI
   LI
   LO
   TS
CP0567536
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]-2H-pyrazolo[3,4-b]pyridine-3-carboxamide
   Show/Hide
C29H30F3N7O2
 1
1
IC50 = 254 nM
   TI
   LI
   LO
   TS
CP0487631
1-[4-[[2-[[(1S,2S)-2-hydroxycyclohexyl]amino]-4-methoxy-1,3-benzothiazol-6-yl]oxymethyl]pyrimidin-2-yl]-3-methylurea
   Show/Hide
C21H26N6O4S
 1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CP0571978
(1R,2R)-2-[[6-[(2-amino-3-chloropyridin-4-yl)methoxy]-4-chloro-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H20Cl2N4O2S
 1
1
IC50 = 288 nM
   TI
   LI
   LO
   TS
CP0523444
N-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-4-(1-ethylpiperidin-4-yl)oxypyridine-2-carboxamide
   Show/Hide
C27H34N6O4
 1
1
IC50 = 296 nM
   TI
   LI
   LO
   TS
CP0562644
(1R,2R)-2-[[6-[(2-amino-3-chloropyridin-4-yl)methoxy]-4-methoxy-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C20H23ClN4O3S
 1
1
IC50 = 345 nM
   TI
   LI
   LO
   TS
CP0015521
5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine
   Show/Hide
C20H22N4O3
 1
1
IC50 = 392 nM
   TI
   LI
   LO
   TS
CP0176165
4-[(4-ethylpiperazin-1-yl)methyl]-N-[3-[(6-methoxyimidazo[1,2-b]pyridazin-3-yl)methylamino]-4-methylphenyl]-3-(trifluoromethyl)benzamide
   Show/Hide
C30H34F3N7O2
 1
1
IC50 = 406 nM
   TI
   LI
   LO
   TS
CP0129944
N-[2-methyl-5-[[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]carbamoyl]phenyl]imidazo[1,2-a]pyridine-3-carboxamide
   Show/Hide
C27H21F3N6O2
 1
1
IC50 = 486 nM
   TI
   LI
   LO
   TS
CP0343500
(1R,2R)-2-[[6-[(2-aminopyrimidin-4-yl)methoxy]-4-methoxy-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C19H23N5O3S
 1
1
IC50 = 504 nM
   TI
   LI
   LO
   TS
CP0002230
4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
   Show/Hide
C28H22F3N7O
 1
1
IC50 = 534 nM
   TI
   LI
   LO
   TS
CP0129689
4-[(4-ethylpiperazin-1-yl)methyl]-N-[3-(imidazo[1,2-b]pyridazin-3-ylmethylamino)-4-methylphenyl]-3-(trifluoromethyl)benzamide
   Show/Hide
C29H32F3N7O
 1
1
IC50 = 660 nM
   TI
   LI
   LO
   TS
CP0466342
(1R,2R)-2-[[6-[(2-amino-3-chloropyridin-4-yl)methoxy]-4-(trifluoromethoxy)-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C20H20ClF3N4O3S
 1
1
IC50 = 930 nM
   TI
   LI
   LO
   TS
CP0571977
6-[(3-chloropyridin-4-yl)methoxy]-N-cyclohexyl-1,3-benzothiazol-2-amine
   Show/Hide
C19H20ClN3OS
 1
1
IC50 = 1204 nM
   TI
   LI
   LO
   TS
CP0912062
(1S,2S)-2-[[4-methoxy-6-[[2-(1H-pyrazol-3-ylamino)pyrimidin-4-yl]methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexanol
   Show/Hide
C22H25N7O3S
 1
1
IC50 = 1304 nM
   TI
   LI
   LO
   TS
CP0556420
(1R,2R)-2-[[6-[(2-aminopyridin-4-yl)methoxy]-4-methoxy-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C20H24N4O3S
 1
1
IC50 = 1455 nM
   TI
   LI
   LO
   TS
CP0129690
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]-1H-indazole-3-carboxamide
   Show/Hide
C30H31F3N6O2
 1
1
IC50 = 1576 nM
   TI
   LI
   LO
   TS
CP0129687
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]cinnoline-4-carboxamide
   Show/Hide
C31H31F3N6O2
 1
1
IC50 = 1596 nM
   TI
   LI
   LO
   TS
CP0363780
N-[2-methyl-5-[[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]carbamoyl]phenyl]imidazo[1,2-b]pyridazine-3-carboxamide
   Show/Hide
C26H20F3N7O2
 1
1
IC50 = 1815 nM
   TI
   LI
   LO
   TS
CP0562643
6-[(2-aminopyridin-4-yl)methoxy]-N-cyclohexyl-1,3-benzothiazol-2-amine
   Show/Hide
C19H22N4OS
 1
1
IC50 = 2269 nM
   TI
   LI
   LO
   TS
CP0352629
(1S,2S)-2-[[4-methoxy-6-[[2-(pyridin-3-ylamino)pyrimidin-4-yl]methoxy]-1,3-benzothiazol-2-yl]amino]cyclohexan-1-ol
   Show/Hide
C24H26N6O3S
 1
1
IC50 = 2511 nM
   TI
   LI
   LO
   TS
CP0533786
N-[2-methyl-5-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]phenyl]imidazo[1,2-a]pyridine-3-carboxamide
   Show/Hide
C22H18F3N5O
 1
1
IC50 = 3147 nM
   TI
   LI
   LO
   TS
CP0355543
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]imidazo[1,2-a]pyrimidine-3-carboxamide
   Show/Hide
C29H30F3N7O2
 1
1
IC50 = 4174 nM
   TI
   LI
   LO
   TS
CP0129943
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]-1H-pyrazole-5-carboxamide
   Show/Hide
C26H29F3N6O2
 1
1
IC50 = 4725 nM
   TI
   LI
   LO
   TS
CP0176151
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]-1-methylpyrazole-3-carboxamide
   Show/Hide
C27H31F3N6O2
 1
1
IC50 = 5149 nM
   TI
   LI
   LO
   TS
CP0176155
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]-1H-imidazole-5-carboxamide
   Show/Hide
C26H29F3N6O2
 1
1
IC50 = 5432 nM
   TI
   LI
   LO
   TS
CP0129910
N-[2-methyl-5-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]phenyl]pyrazolo[1,5-a]pyridine-3-carboxamide
   Show/Hide
C22H18F3N5O
 1
1
IC50 = 5772 nM
   TI
   LI
   LO
   TS
CP0129912
N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoyl]amino]-2-methylphenyl]-1H-imidazole-2-carboxamide
   Show/Hide
C26H29F3N6O2
 1
1
IC50 = 5779 nM
   TI
   LI
   LO
   TS
CP0129945
N-[2-methyl-5-[[6-(trifluoromethyl)pyridine-3-carbonyl]amino]phenyl]imidazo[1,2-b]pyridazine-3-carboxamide
   Show/Hide
C21H15F3N6O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0551893
N-[2-methyl-5-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]phenyl]imidazo[1,2-b]pyridazine-3-carboxamide
   Show/Hide
C21H17F3N6O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0446674
4-amino-N-[3-bromo-1-(pyridin-4-ylmethyl)indazol-4-yl]thieno[3,2-d]pyrimidine-7-carboxamide
   Show/Hide
C20H14BrN7OS  1
1
GI50 = 135 nM
   TI
   LI
   LO
   TS
CP0476340
4-amino-N-[3-bromo-1-[(6-fluoropyridin-2-yl)methyl]indazol-4-yl]thieno[3,2-d]pyrimidine-7-carboxamide
   Show/Hide
C20H13BrFN7OS  1
1
GI50 = 233 nM
   TI
   LI
   LO
   TS
CP0565352
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[[4-(trifluoromethyl)phenyl]methyl]urea
   Show/Hide
C25H22F3N5O2  1
1
EC50 = 97 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line