General Information of the Compound
| Compound ID |
CP0015521
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| Compound Name |
5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine
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| Synonyms |
GW-2580
GW2580
GW632580X
PMID28270010-Compound-Figure24-a
cFMS receptor tyrosine kinase inhibitor
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| Structure |
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| Formula |
C20H22N4O3
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| Molecular Weight |
366.421
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| Canonical SMILES |
COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
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| InChI |
InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
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| InChIKey |
MYQAUKPBNJWPIE-UHFFFAOYSA-N
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01008, Macrophage colony-stimulating factor 1 receptor
Protein ID: PT02032, Macrophage colony-stimulating factor 1 receptor
Clinical Information about the Compound