Brief Information of the Cell Line and Protein
Cell Line ID: CL000218 , BT-474
Synonyms
Bt-474
BT474
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0179
Protein ID: PT00847 , Disintegrin and metalloproteinase domain-containing protein 10
Gene Name ADAM10
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID O14672
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000218  Protein ID: PT00847
 
Compound ID Compound Name Compound Formula
CP0340923
(2-hydroxycyclopentyl) 4-(hydroxycarbamoyl)-4-[[4-(2-methylphenyl)piperidin-1-yl]sulfonylmethyl]piperidine-1-carboxylate
   Show/Hide
C25H37N3O7S
 1
1
IC50 = 6.2 nM
   TI
   LI
   LO
   TS
CP0195738
(S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylphenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C26H37N5O6S
 1
1
IC50 = 6.5 nM
   TI
   LI
   LO
   TS
CP0202230
(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-phenyl-5,6-dihydropyridin-1(2H)-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C23H31N3O7S
 1
1
IC50 = 7.1 nM
   TI
   LI
   LO
   TS
CP0062381
(6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C19H23N3O3
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0202231
(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-phenylpiperazin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C22H32N4O7S
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0268839
pyrrolidin-3-yl 4-[[4-(4-cyano-2-methylphenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C25H35N5O6S
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0118698
4,4-dimethyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-o-tolylpiperidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C26H39N3O7S
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0202240
(S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylphenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C25H34N4O7S
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0195808
pyrrolidin-3-yl 4-(hydroxycarbamoyl)-4-[[4-(2-methylphenyl)piperidin-1-yl]sulfonylmethyl]piperidine-1-carboxylate
   Show/Hide
C24H36N4O6S
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0051806
(6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C20H25N3O3
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0050580
(R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylphenyl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C26H35N5O6S
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0034647
(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-phenylpiperidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C23H33N3O7S
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0264042
(R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylphenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C26H37N5O6S
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0295723
(S)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-((4-o-tolylpiperidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C25H38N4O6S
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0117600
(6S,7S)-6-[4-(3,5-difluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C20H23F2N3O3
 1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0034644
(S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylphenyl)piperazin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C24H33N5O7S
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0035530
(6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid tetrahydro-pyran-4-yl ester
   Show/Hide
C25H34N4O6
 1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
CP0050581
(S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylphenyl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C26H35N5O6S
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0295722
(R)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-((4-o-tolylpiperidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C25H38N4O6S
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0195062
(6S,7S)-7-hydroxycarbamoyl-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid methyl ester
   Show/Hide
C21H25N3O5
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0264045
3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-o-tolylpiperidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C25H37N3O7S
 1
1
IC50 = 36 nM
   TI
   LI
   LO
   TS
CP0118699
(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-o-tolylpiperidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C24H35N3O7S
 1
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
CP0155578
(6S,7S)-6-(4-m-tolyl-3,6-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C21H27N3O3
 1
1
IC50 = 42 nM
   TI
   LI
   LO
   TS
CP0339389
(6S,7S)-6-[4-(3-chloro-phenyl)-piperazine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C19H25ClN4O3
 1
1
IC50 = 42 nM
   TI
   LI
   LO
   TS
CP0209978
(6S,7S)-5-methanesulfonyl-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C20H28N4O5S
 1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CP0336809
(S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylphenyl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C25H32N4O7S
 1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CP0051802
(6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C19H26N4O3
 1
1
IC50 = 52 nM
   TI
   LI
   LO
   TS
CP0035533
(6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid methyl ester
   Show/Hide
C22H27N3O5
 1
1
IC50 = 68 nM
   TI
   LI
   LO
   TS
CP0156056
(6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C22H27N3O4
 1
1
IC50 = 72 nM
   TI
   LI
   LO
   TS
CP0118702
(S)-tetrahydrofuran-3-yl 4-((4-(2-fluorophenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C23H32FN3O7S
 1
1
IC50 = 76 nM
   TI
   LI
   LO
   TS
CP0050576
(S)-tetrahydrofuran-3-yl 4-((4-(4-cyanophenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C24H32N4O7S
 1
1
IC50 = 77 nM
   TI
   LI
   LO
   TS
CP0295555
(6S,7S)-6-[4-(3,5-dimethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C22H29N3O3
 1
1
IC50 = 86 nM
   TI
   LI
   LO
   TS
CP0035538
(6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C19H25N3O3
 1
1
IC50 = 92 nM
   TI
   LI
   LO
   TS
CP0098800
(6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C21H27N3O5S
 1
1
IC50 = 93 nM
   TI
   LI
   LO
   TS
CP0034646
(S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-3,5-dimethylphenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C26H36N4O7S
 1
1
IC50 = 96 nM
   TI
   LI
   LO
   TS
CP0157727
(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((3-phenyl-2H-pyrrol-1(5H)-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C22H29N3O7S
 1
1
IC50 = 102 nM
   TI
   LI
   LO
   TS
CP0321243
(6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C23H28N4O3
 1
1
IC50 = 129 nM
   TI
   LI
   LO
   TS
CP0354220
(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-o-tolyl-5,6-dihydropyridin-1(2H)-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C24H33N3O7S
 1
1
IC50 = 133 nM
   TI
   LI
   LO
   TS
CP0035541
(6S,7S)-6-(4-phenyl-piperidine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C20H27N3O3
 1
1
IC50 = 137 nM
   TI
   LI
   LO
   TS
CP0035545
(6S,7S)-6-[4-(3-isopropyl-phenyl)-piperidine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C23H33N3O3
 1
1
IC50 = 139 nM
   TI
   LI
   LO
   TS
CP0310404
(S)-tetrahydrofuran-3-yl 4-((4-(4-fluoro-2-methylphenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C24H34FN3O7S
 1
1
IC50 = 141 nM
   TI
   LI
   LO
   TS
CP0035540
(6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid isobutyl ester
   Show/Hide
C25H33N3O5
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0035527
(6S,7S)-6-[4-(3-cyclopropyl-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C23H29N3O3
 1
1
IC50 = 162 nM
   TI
   LI
   LO
   TS
CP0209981
(6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperidine-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid methyl ester
   Show/Hide
C22H29N3O5
 1
1
IC50 = 169 nM
   TI
   LI
   LO
   TS
CP0098801
(6S,7S)-6-(4-m-tolyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C20H28N4O3
 1
1
IC50 = 184 nM
   TI
   LI
   LO
   TS
CP0035537
(6S,7S)-6-[4-(3-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C21H27N3O4
 1
1
IC50 = 194 nM
   TI
   LI
   LO
   TS
CP0195739
(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-o-tolylpiperazin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C23H34N4O7S
 1
1
IC50 = 217 nM
   TI
   LI
   LO
   TS
CP0209976
(6S,7S)-6-[4-(3-isopropyl-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C23H31N3O3
 1
1
IC50 = 229 nM
   TI
   LI
   LO
   TS
CP0209982
(6S,7S)-6-[4-(3-ethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C22H29N3O3
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0098799
(6S,7S)-7-hydroxycarbamoyl-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid methyl ester
   Show/Hide
C21H27N3O5
 1
1
IC50 = 289 nM
   TI
   LI
   LO
   TS
CP0295502
(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((3-phenylpyrrolidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C22H31N3O7S
 1
1
IC50 = 358 nM
   TI
   LI
   LO
   TS
CP0295552
(6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid benzyl ester
   Show/Hide
C28H31N3O5
 1
1
IC50 = 431 nM
   TI
   LI
   LO
   TS
CP0342039
(6S,7S)-6-[4-(4-cyano-3-methyl-phenyl)-piperazine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C21H27N5O3
 1
1
IC50 = 594 nM
   TI
   LI
   LO
   TS
CP0035524
(6S,7S)-6-(4-m-tolyl-piperidine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C21H29N3O3
 1
1
IC50 = 689 nM
   TI
   LI
   LO
   TS
CP0050579
(S)-tetrahydrofuran-3-yl 4-((4-(3,5-dimethylphenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C25H37N3O7S
 1
1
IC50 = 833 nM
   TI
   LI
   LO
   TS
CP0035526
(6S,7S)-6-[4-(4-cyano-3-isopropyl-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide
   Show/Hide
C24H30N4O3
 1
1
IC50 = 902 nM
   TI
   LI
   LO
   TS
CP0034637
(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-(2-(trifluoromethyl)phenyl)piperidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
   Show/Hide
C24H32F3N3O7S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0202237
(S)-tetrahydrofuran-3-yl 4-((4-(2-cyanophenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C24H32N4O7S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0344107
(S)-tetrahydrofuran-3-yl 4-((4-(4-(dimethylcarbamoyl)-2-methylphenyl)piperidin-1-ylsulfonyl)methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate
   Show/Hide
C27H40N4O8S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS