General Information of the Compound
Compound ID
CP0295502
Compound Name
(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((3-phenylpyrrolidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate
    Show/Hide
Structure
Formula
C22H31N3O7S
Molecular Weight
481.571
Canonical SMILES
ONC(=O)C1(CS(=O)(=O)N2CCC(C2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1
    Show/Hide
InChI
InChI=1S/C22H31N3O7S/c26-20(23-28)22(8-11-24(12-9-22)21(27)32-19-7-13-31-15-19)16-33(29,30)25-10-6-18(14-25)17-4-2-1-3-5-17/h1-5,18-19,28H,6-16H2,(H,23,26)/t18?,19-/m0/s1
    Show/Hide
InChIKey
AFJYAUBLMRWZHB-GGYWPGCISA-N
Physicochemical Property
logP
1.3188
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
125.48
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44447348
ChEMBL ID
CHEMBL254715
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00847, Disintegrin and metalloproteinase domain-containing protein 10
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000218 BT-474 Homo sapiens (Human)  1
1
IC50 = 358 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 261 nM