General Information of the Compound
Compound ID
CP0035530
Compound Name
(6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid tetrahydro-pyran-4-yl ester
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Structure
Formula
C25H34N4O6
Molecular Weight
486.569
Canonical SMILES
ONC(=O)[C@H]1CC2(CC2)CN([C@@H]1C(=O)N1CCN(CC1)c1ccccc1)C(=O)OC1CCOCC1
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InChI
InChI=1S/C25H34N4O6/c30-22(26-33)20-16-25(8-9-25)17-29(24(32)35-19-6-14-34-15-7-19)21(20)23(31)28-12-10-27(11-13-28)18-4-2-1-3-5-18/h1-5,19-21,33H,6-17H2,(H,26,30)/t20-,21-/m0/s1
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InChIKey
ZMPZOWIAKRPTEQ-SFTDATJTSA-N
Physicochemical Property
logP
1.6269
Rotatable Bonds
4
Heavy Atom Count
35
Polar Areas
111.65
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44446839
ChEMBL ID
CHEMBL429669
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00847, Disintegrin and metalloproteinase domain-containing protein 10
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000218 BT-474 Homo sapiens (Human)  1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 37 nM