5-amino-4-[(3-chloro-2-methylphenyl)methyl]-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-7-one

4-[(3-chloro-2-methylphenyl)methyl]-5-(hydroxymethyl)-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-7-one

4-[(3-chloro-2-methylphenyl)methyl]-5-methoxy-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-7-one

5-methyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-7-one

5-cyclopropyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-7-one

5-ethyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-7-one

4-[(3-chloro-2-methylphenyl)methyl]-5-methyl-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-7-one

3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-pyridin-4-yl-1H-pyrazolo[1,5-a]pyrimidin-7-one

2-methyl-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-yl-1H-pyrazolo[1,5-a]pyrimidin-7-one

3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-yl-1H-pyrazolo[1,5-a]pyrimidin-7-one

3-[(2,3-dichlorophenyl)methyl]-2-methoxy-5-pyridin-4-yl-1H-pyrazolo[1,5-a]pyrimidin-7-one

2-methyl-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-ylpyrazolo[1,5-a]pyrimidine-7-carboxylic acid

2-methyl-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-ylpyrazolo[1,5-a]pyrimidin-7-amine

2-methyl-5-morpholin-4-yl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one

[2-methyl-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]urea

2-amino-3-[(2,3-dichlorophenyl)methyl]-5-(oxan-4-yl)-1H-pyrazolo[1,5-a]pyrimidin-7-one

2-methyl-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-ylpyrazolo[1,5-a]pyrimidine-7-carboxamide

3-[(2,3-dichlorophenyl)methyl]-5-morpholin-4-yl-2-(trifluoromethyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one

2-methyl-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-(oxan-4-yl)-1H-pyrazolo[1,5-a]pyrimidin-7-one

3-[(2,3-dichlorophenyl)methyl]-2-ethyl-5-pyridin-4-yl-1H-pyrazolo[1,5-a]pyrimidin-7-one

8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-[(2S)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide

8-[(1R)-1-(3-chloro-5-fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

2-methyl-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-one

N-[2-(dimethylamino)ethyl]-9-[1-(3-fluoroanilino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

6-(azetidine-1-carbonyl)-8-[(1R)-1-(3,5-difluoroanilino)ethyl]-2-morpholin-4-ylchromen-4-one

US8673906, 4.02

8-[(3,5-difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide

8-[(8-fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide

9-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N-methyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

8-[(6-fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide

8-[(6,8-difluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide

3-[(2,3-dichlorophenyl)methyl]-2-methyl-5-(2-methylmorpholin-4-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-one

9-[1-(3-chloro-2-fluoroanilino)ethyl]-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

8-[(8-fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-2-[(2R)-2-methylmorpholin-4-yl]-6-(morpholine-4-carbonyl)chromen-4-one

2-cyclopropyl-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-one

8-[[3,5-difluoro-N-(2-methoxyethyl)anilino]methyl]-N,N-dimethyl-2-[(2R)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide

2-methylsulfanyl-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-one

N,N-dimethyl-2-morpholin-4-yl-4-oxo-8-[(1R)-1-(2,3,5-trifluoroanilino)ethyl]chromene-6-carboxamide

8-[(6,8-difluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-2-[(2R)-2-methylmorpholin-4-yl]-6-(morpholine-4-carbonyl)chromen-4-one

9-[1-(2-chloroanilino)ethyl]-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

US8673906, 4.11

9-(1-anilinoethyl)-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

9-[1-(3,5-difluoroanilino)ethyl]-N-(2-hydroxyethyl)-N-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

9-[1-(3,5-difluoroanilino)ethyl]-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one

US8673906, 3.09

8-[(6,8-difluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

9-[1-(3-chloroanilino)ethyl]-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

8-[(1R)-1-(3,5-difluoro-N-methylanilino)ethyl]-N-(2-hydroxyethyl)-N-methyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

N,N-dimethyl-2-morpholin-4-yl-4-oxo-9-[1-(3,4,5-trifluoroanilino)ethyl]pyrido[1,2-a]pyrimidine-7-carboxamide

9-[1-(3-chloro-5-fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

N-[2-(dimethylamino)ethyl]-9-[1-(4-fluoroanilino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

8-[(1S)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-[(2S)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide

8-[(1R)-1-(3,5-difluoro-N-methylanilino)ethyl]-6-(4-hydroxypiperidine-1-carbonyl)-2-morpholin-4-ylchromen-4-one

8-[(8-fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

8-[(6-fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-2-[(2R)-2-methylmorpholin-4-yl]-6-(morpholine-4-carbonyl)chromen-4-one

3-[(2,3-dichlorophenyl)methyl]-2-methylsulfanyl-5-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-one

N,N-dimethyl-2-morpholin-4-yl-4-oxo-8-[(1R)-1-(3,4,5-trifluoroanilino)ethyl]chromene-6-carboxamide

US8673906, 4.1

US8673906, 4.17

US8673906, 4.07

8-[(1R)-1-(3,5-difluoro-N-methylanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

US8673906, 3.3

US8673906, 4.01

US8673906, 3.05

9-[1-(3-chloroanilino)ethyl]-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one

8-[(1R)-1-(3,4-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

US8673906, 3.33

US8673906, 4.09

US8673906, 4.24

8-[[3,5-difluoro-N-(2-methoxyethyl)anilino]methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

2-cyclopropyl-3-[(2,3-dichlorophenyl)methyl]-5-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-one

8-[(1R)-1-(3-chloro-2-fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one

N-[2-(dimethylamino)ethyl]-9-[1-(2-fluoroanilino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

US8673906, 3.1

9-[(1R)-1-(3,5-difluoroanilino)ethyl]-7-(morpholine-4-carbonyl)-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one

N,N-dimethyl-2-morpholin-4-yl-4-oxo-9-[1-(2,3,5-trifluoroanilino)ethyl]pyrido[1,2-a]pyrimidine-7-carboxamide

9-[(1R)-1-(3,5-difluoroanilino)ethyl]-7-(4-methylpiperazine-1-carbonyl)-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one

US8673906, 4.15

US8673906, 3.12

US8673906, 2.07

3-[(2,3-dichlorophenyl)methyl]-2-methyl-5-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-one

9-[1-(3,4-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

8-[(3,5-difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

8-[(3,5-difluoroanilino)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

8-[(6-fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

9-[1-(3-fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

2-[[(1R)-1-(7-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid

8-[1-(6,8-difluoro-2,3-dihydro-1,4-benzoxazin-4-yl)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

US8673906, 3.16

US8673906, 3.15

9-[1-(4-fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

9-[1-(2,3-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxo-9-[1-[3-(trifluoromethyl)anilino]ethyl]pyrido[1,2-a]pyrimidine-7-carboxamide

9-[1-(4-chloroanilino)ethyl]-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-7-morpholin-4-ylimidazo[1,2-a]pyrimidin-5-one

7-methyl-9-[1-(3-methylanilino)ethyl]-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one

2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-7-morpholin-4-yl-[1,2,4]triazolo[1,5-c]pyrimidin-5-one

US8673906, 6

8-[[N-(2-cyanoethyl)-3,5-difluoroanilino]methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

US8673906, 2.01

8-[(1R)-1-(3,5-difluorophenoxy)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

9-(1-anilinoethyl)-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

9-[1-(4-fluoroanilino)ethyl]-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one

8-[[N-(cyanomethyl)-3,5-difluoroanilino]methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide

N-[2-(dimethylamino)ethyl]-9-[1-(4-methylanilino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide

1-[4-[5-[5-amino-6-(benzotriazol-1-yl)pyrazin-2-yl]-1-methylpyrazol-3-yl]piperidin-1-yl]-2-(dimethylamino)ethanone

1-[4-[5-[5-amino-6-(benzotriazol-1-yl)pyrazin-2-yl]-1-methyl-1,2,4-triazol-3-yl]piperidin-1-yl]-2-(dimethylamino)ethanone

1-(4-(4-(5-amino-6-(1H-benzo[d][1,2,3]triazol-1-yl)pyrazin-2-yl)-2H-1,2,3-triazol-2-yl)piperidin-1-yl)-2-(dimethylamino)ethanone

1-[4-[2-[5-amino-6-(benzotriazol-1-yl)pyrazin-2-yl]-1-methylimidazol-4-yl]piperidin-1-yl]-2-(dimethylamino)ethanone

1-(4-(3-(5-amino-6-(1H-benzo[d][1,2,3]triazol-1-yl)pyrazin-2-yl)-1H-pyrazol-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone

1-[4-[5-[5-amino-6-(benzotriazol-1-yl)pyrazin-2-yl]-2-methyl-1,2,4-triazol-3-yl]piperidin-1-yl]-2-(dimethylamino)ethanone

1-[4-[4-[5-amino-6-(benzotriazol-1-yl)pyrazin-2-yl]pyrazol-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone

7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one

9-[(3R,4R)-4-fluoropyrrolidin-3-yl]-7-methyl-2-[(7-methylquinolin-6-yl)amino]purin-8-one

N-[5-[2-[(1S)-1-cyclopropylethyl]-7-methylsulfonyl-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide

N-[5-[2-[(1S)-1-cyclopropylethyl]-7-(methanesulfonamido)-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide

N-[5-[2-[(1S)-1-cyclopropylethyl]-7-(methylsulfamoyl)-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide