Brief Information of the Compound and Protein
Compound Name
5-methyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-7-one
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PubChem ID
CID: 49778924
SID: 103051360
Canonical SMILES
Cc1nc(=O)c2sc(nc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
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Compound Formula C19H19F3N4O2S
Compound Structure
Protein Name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Protein Classification
Enzyme
>
Transferase
Uniprot ID
P42338
Gene Name
PIK3CB
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000196 MDA-MB-468 Homo sapiens (Human)  3
1
EC50 = 6.31 nM
   TI
   LI
   LO
   TS
2
EC50 = 15.85 nM
   TI
   LI
   LO
   TS
3
EC50 = 24 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.6 nM
2 IC50 = 0.631 nM
3 IC50 = 16 nM