Brief Information of the Compound and Protein
Compound Name
3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-yl-1H-pyrazolo[1,5-a]pyrimidin-7-one
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PubChem ID
SID: 163527577
Canonical SMILES
Cc1c(Cc2cnn3c(O)cc(nc23)N2CCOCC2)cccc1C(F)(F)F
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Compound Formula C19H19F3N4O2
Compound Structure
Protein Name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Protein Classification
Enzyme
>
Transferase
Uniprot ID
P42338
Gene Name
PIK3CB
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000481 HCC1954 Homo sapiens (Human)  2
1
EC50 = 15848.93 nM
   TI
   LI
   LO
   TS
2
EC50 > 31622.78 nM
   TI
   LI
   LO
   TS
CL000196 MDA-MB-468 Homo sapiens (Human)  3
1
EC50 = 63.1 nM
   TI
   LI
   LO
   TS
2
EC50 = 1000 nM
   TI
   LI
   LO
   TS
3
EC50 = 3162.28 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5.012 nM