| Compound ID |
Compound Name |
Compound Formula |
|
CP0545086
|
N-(quinolin-8-ylcarbamothioyl)adamantane-1-carboxamide
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|
C21H23N3OS
|
5
|
| 1 |
EC50 = 2192 nM
|
|
|
| 2 |
EC50 = 6084 nM
|
|
|
| 3 |
EC50 = 6617 nM
|
|
|
| 4 |
IC50 = 68 nM
|
|
|
| 5 |
IC50 = 73 nM
|
|
|
|
CP0550179
|
N-(quinolin-8-ylcarbamothioyl)-1,3-benzodioxole-5-carboxamide
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|
C18H13N3O3S
|
5
|
| 1 |
EC50 = 8310 nM
|
|
|
| 2 |
EC50 = 9140 nM
|
|
|
| 3 |
EC50 = 9440 nM
|
|
|
| 4 |
IC50 = 18 nM
|
|
|
| 5 |
IC50 = 30 nM
|
|
|
|
CP0417275
|
US10047092, 32
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|
C17H13ClF3N5OS
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0375375
|
US10047092, 17
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|
C20H15ClF4N4O
|
2
|
| 1 |
IC50 = 0.2 nM
|
|
|
| 2 |
IC50 < 1 nM
|
|
|
|
CP0385042
|
US10047092, 18
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|
C19H15ClF3N5O
|
2
|
| 1 |
IC50 = 0.5 nM
|
|
|
| 2 |
IC50 < 1 nM
|
|
|
|
CP0385599
|
BDBM160086
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|
C18H14ClF3N6O
|
2
|
| 1 |
IC50 = 0.5 nM
|
|
|
| 2 |
Ki = 2.5 nM
|
|
|
|
CP0846069
|
US9040534, 28
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|
C17H14ClF3N6O
|
2
|
| 1 |
IC50 = 0.6 nM
|
|
|
| 2 |
IC50 = 1 nM
|
|
|
|
CP0056677
|
US10047092, 16
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|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0419739
|
US10047092, 35
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|
C20H17ClF3N5O2
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0381007
|
US10047092, 30
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|
C19H14ClF4N5O
|
2
|
| 1 |
IC50 = 0.7 nM
|
|
|
| 2 |
IC50 = 0.9 nM
|
|
|
|
CP0422528
|
US10047092, 63
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|
C20H16ClF3N6O
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0380496
|
US10047092, 76
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|
C20H16ClF4N5O
|
1
|
| 1 |
IC50 < 1 nM
|
|
|
|
CP0384906
|
US10047092, 34
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|
C18H13ClF4N6O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0385598
|
US10047092, 29
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|
C19H15ClF3N5O
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 1.9 nM
|
|
|
|
CP0391607
|
US10047092, 13
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|
C17H14Cl2N6O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0403649
|
US10047092, 75
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|
C19H15ClF4N6O
|
1
|
| 1 |
IC50 < 1 nM
|
|
|
|
CP0427095
|
US10047092, 66
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|
C20H16ClF3N6O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0484511
|
US10047092, 21
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|
C17H13ClF3N5O2
|
1
|
| 1 |
IC50 < 1 nM
|
|
|
|
CP0515163
|
US10112937, Example 205
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|
C17H13Cl2FN6O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0880953
|
US9040534, 68
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|
C19H16ClF3N6O
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0468095
|
US10053462, 18
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|
C20H15ClF4N6O
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0512291
|
US10112937, Example 222
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|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0508728
|
US10047092, 31
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|
C17H13ClF3N5OS
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0877279
|
US9040534, 26
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|
C18H16ClF3N6O
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0555500
|
US10112937, Example 119
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|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0231820
|
(2,3-dichlorophenyl)-[(8R)-8-methyl-3-pyridin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C18H15Cl2N5O
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0389368
|
US10047092, 64
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|
C20H16ClF3N6O
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0409905
|
US10047092, 73
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|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0860077
|
US9040534, 74
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|
C18H16ClF3N6O
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0385625
|
US10047092, 85
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|
C19H17F3N6O
|
2
|
| 1 |
IC50 = 1.6 nM
|
|
|
| 2 |
IC50 = 3.4 nM
|
|
|
|
CP0462829
|
US10047092, 54
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|
C19H13ClF6N6O
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0895816
|
US9096596, 83
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|
C19H17Cl2N5O
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0470360
|
US10053462, 58
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|
C19H14ClF3N4OS
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0446999
|
US10112937, Example 202
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|
C18H13ClF4N6O
|
2
|
| 1 |
IC50 = 1.7 nM
|
|
|
| 2 |
IC50 = 1.9 nM
|
|
|
|
CP0548852
|
US10112937, Example 118
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|
C19H15ClF3N5O
|
2
|
| 1 |
IC50 = 1.7 nM
|
|
|
| 2 |
IC50 = 1185.8 nM
|
|
|
|
CP0512552
|
US10047092, 11
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|
C17H14Cl2N6O
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0462212
|
US10112937, Example 404
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|
C19H18ClF3N6O
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0206765
|
(2,3-dichlorophenyl)-(3-pyrazin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Show/Hide
|
C16H12Cl2N6O
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0451547
|
US10112937, Example 215
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|
C17H12Cl2F2N6O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0481150
|
US10112937, Example 142
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|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0462214
|
US10112937, Example 420
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|
C18H14ClF3N4OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0154754
|
[2-chloro-3-(trifluoromethyl)phenyl]-(3-pyrazin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Show/Hide
|
C17H12ClF3N6O
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0397177
|
US10047092, 14
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|
C18H14ClF3N6O
|
2
|
| 1 |
IC50 = 2.1 nM
|
|
|
| 2 |
IC50 = 3.4 nM
|
|
|
|
CP0408643
|
US10112937, Example 88
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|
C18H14ClF3N6O
|
3
|
| 1 |
IC50 = 2.188 nM
|
|
|
| 2 |
IC50 = 2.2 nM
|
|
|
| 3 |
Ki = 12.88 nM
|
|
|
|
CP0960333
|
US9464084, 133
Show/Hide
|
C17H14ClF3N6O
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0554085
|
US10112937, Example 166
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|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0408299
|
US10047092, 23
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|
C18H16ClF3N6O
|
2
|
| 1 |
IC50 = 2.5 nM
|
|
|
| 2 |
IC50 = 4.2 nM
|
|
|
|
CP0539932
|
US10112937, Example 96
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|
C19H14ClF3N4O
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0472424
|
US10053462, 61
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|
C19H14ClF3N4OS
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0483499
|
US10112937, Example 188
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|
C19H17F3N6O
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0896590
|
US9096596, 113
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|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0866681
|
US9096596, 71
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|
C19H16Cl2FN5O
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0465863
|
US10112937, Example 91
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|
C17H12ClF3N6O
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0492574
|
US10112937, Example 282
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|
C19H17F3N6O
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0544418
|
US10112937, Example 131
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|
C18H12ClF4N5O
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0027823
|
US10112937, Example 158
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|
C18H13ClF4N6O
|
3
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 3.467 nM
|
|
|
| 3 |
Ki = 5.012 nM
|
|
|
|
CP0402595
|
US10112937, Example 67
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|
C16H12Cl2N6O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0456491
|
US10053462, 53
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|
C19H16F3N5OS
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0515226
|
US10112937, Example 281
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|
C18H15F3N6O
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0101455
|
(2,3-dichlorophenyl)-[(6S)-3-(5-fluoropyridin-2-yl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0407689
|
US10047092, 20
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|
C17H13ClF3N5O2
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0507286
|
US10112937, Example 237
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|
C19H17Cl2N5O
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0564148
|
US10112937, Example 121
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|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0434339
|
US10047092, 46
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|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0445141
|
US10112937, Example 63
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|
C18H13ClF3N5O
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0518505
|
US10112937, Example 271
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|
C18H14F4N6O
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0564149
|
US10112937, Example 174
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|
C17H13Cl2FN6O
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0483500
|
US10112937, Example 195
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|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0544287
|
US10112937, Example 75
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|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0468873
|
US10112937, Example 74
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|
C18H14ClF3N6O
|
2
|
| 1 |
IC50 = 3.467 nM
|
|
|
| 2 |
IC50 = 13366 nM
|
|
|
|
CP0456896
|
US10047092, 88
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|
C18H15F3N6O
|
2
|
| 1 |
IC50 = 3.6 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
|
CP0445020
|
US10112937, Example 130
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|
C17H12Cl2FN5O
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0554747
|
US10112937, Example 168
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|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0375684
|
US10053462, 1
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|
C20H16ClF3N6O
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0385597
|
US10047092, 33
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|
C18H14ClF3N6O
|
2
|
| 1 |
IC50 = 3.8 nM
|
|
|
| 2 |
IC50 = 4.3 nM
|
|
|
|
CP0253004
|
(2,3-dichlorophenyl)-(8-methyl-3-pyridin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Show/Hide
|
C18H15Cl2N5O
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0910267
|
US9464084, 189
Show/Hide
|
C17H14F4N6O
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0389315
|
US10047092, 61
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|
C20H16ClF3N6O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0132094
|
US10112937, Example 1
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|
C19H14ClF3N4O
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 6.1 nM
|
|
|
|
CP0424453
|
US10112937, Example 40
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|
C20H15ClF4N4O
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
Ki = 7 nM
|
|
|
|
CP0419426
|
US10112937, Example 72
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|
C18H12ClF3N6O
|
1
|
| 1 |
IC50 = 4.2 nM
|
|
|
|
CP0546701
|
US10047092, 67
Show/Hide
|
C21H17ClF3N5O
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0407144
|
US10047092, 52
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|
C19H14Cl2F3N5O
|
2
|
| 1 |
IC50 = 4.3 nM
|
|
|
| 2 |
IC50 = 5.2 nM
|
|
|
|
CP0305153
|
US10323032, Example 107
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|
C16H12Cl2N6O
|
2
|
| 1 |
IC50 = 4.5 nM
|
|
|
| 2 |
Ki = 9.5 nM
|
|
|
|
CP0419428
|
US10112937, Example 97
Show/Hide
|
C18H13ClF3N5O
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0451344
|
US10112937, Example 283
Show/Hide
|
C17H14Cl2N6O
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0559161
|
US10112937, Example 61
Show/Hide
|
C19H14ClF3N4O
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0030383
|
US10112937, Example 220
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|
C18H13F5N6O
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0554402
|
US10112937, Example 122
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0397123
|
US10053462, 49
Show/Hide
|
C18H13ClF3N5OS
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0406868
|
US10112937, Example 12
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|
C21H17ClF3N3O
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 6.1 nM
|
|
|
|
CP0462215
|
US10112937, Example 212
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|
C18H14ClF3N6O
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 7.3 nM
|
|
|
|
CP0018791
|
US10112937, Example 228
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|
C17H12F5N7O
|
2
|
| 1 |
IC50 = 5.1 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0406855
|
US10112937, Example 178
Show/Hide
|
C18H13F5N6O
|
1
|
| 1 |
IC50 = 5.1 nM
|
|
|
|
CP0488352
|
US10112937, Example 153
Show/Hide
|
C18H13ClF4N6O
|
1
|
| 1 |
IC50 = 5.1 nM
|
|
|
|
CP0406857
|
US10112937, Example 185
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 5.2 nM
|
|
|
|
CP0228560
|
US10112937, Example 235
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|
C19H16ClF3N6O
|
2
|
| 1 |
IC50 = 5.37 nM
|
|
|
| 2 |
IC50 = 5.4 nM
|
|
|
|
CP0561902
|
US10112937, Example 92
Show/Hide
|
C20H16ClF3N4O
|
1
|
| 1 |
IC50 = 5.4 nM
|
|
|
|
CP0554400
|
US10112937, Example 89
Show/Hide
|
C17H10ClF3N6O
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0850616
|
US9096596, 118
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 5.7 nM
|
|
|
|
CP0492564
|
US10112937, Example 151
Show/Hide
|
C20H17ClF3N5O2
|
1
|
| 1 |
IC50 = 5.7 nM
|
|
|
|
CP0880632
|
US9096596, 122
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 5.8 nM
|
|
|
|
CP0440539
|
US10323032, Example 20
Show/Hide
|
C17H12Cl2FN5O
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0869093
|
US9096596, 116
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0488345
|
US10112937, Example 120
Show/Hide
|
C18H15Cl2N5O
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0451464
|
US10112937, Example 233
Show/Hide
|
C19H17Cl2N5O
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0487012
|
US10053462, 54
Show/Hide
|
C17H12Cl2FN5OS
|
1
|
| 1 |
IC50 = 6.1 nM
|
|
|
|
CP0451340
|
US10150765, Example 225
Show/Hide
|
C18H16Cl2N6O
|
1
|
| 1 |
IC50 = 6.2 nM
|
|
|
|
CP0529375
|
US10112937, Example 100
Show/Hide
|
C19H15Cl2N3O
|
1
|
| 1 |
IC50 = 6.2 nM
|
|
|
|
CP0544319
|
US10112937, Example 79
Show/Hide
|
C18H12ClF3N6O
|
1
|
| 1 |
IC50 = 6.2 nM
|
|
|
|
CP0384797
|
US10053462, 41
Show/Hide
|
C20H15ClF3N5O
|
1
|
| 1 |
IC50 = 6.3 nM
|
|
|
|
CP0516307
|
US10112937, Example 65
Show/Hide
|
C17H12ClF3N6O
|
1
|
| 1 |
IC50 = 6.3 nM
|
|
|
|
CP0488595
|
US10112937, Example 276
Show/Hide
|
C18H15F3N6O
|
1
|
| 1 |
IC50 = 6.4 nM
|
|
|
|
CP0488342
|
US10112937, Example 98
Show/Hide
|
C18H13ClF3N5O
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0141334
|
(2,3-dichlorophenyl)-[(6S)-6-methyl-3-pyridin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C18H15Cl2N5O
|
1
|
| 1 |
IC50 = 6.7 nM
|
|
|
|
CP0451346
|
US10112937, Example 288
Show/Hide
|
C20H16ClF3N4O
|
2
|
| 1 |
IC50 = 6.8 nM
|
|
|
| 2 |
IC50 = 8 nM
|
|
|
|
CP0541424
|
US10047092, 37
Show/Hide
|
C17H13ClF3N5OS
|
1
|
| 1 |
IC50 = 6.9 nM
|
|
|
|
CP0178125
|
(2,3-dichlorophenyl)-[(6S)-3-(4-fluoropyridin-2-yl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0488597
|
US10112937, Example 287
Show/Hide
|
C21H18ClF3N4O
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0406861
|
US10112937, Example 227
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 7.2 nM
|
|
|
|
CP0476684
|
US10112937, Example 278
Show/Hide
|
C19H17F3N6O
|
1
|
| 1 |
IC50 = 7.2 nM
|
|
|
|
CP0402637
|
US10112937, Example 70
Show/Hide
|
C16H12Cl2N6O
|
1
|
| 1 |
IC50 = 7.5 nM
|
|
|
|
CP0483508
|
US10112937, Example 273
Show/Hide
|
C18H14F4N6O
|
1
|
| 1 |
IC50 = 7.6 nM
|
|
|
|
CP0065303
|
(2,3-dichlorophenyl)-[(6S)-3-(4-fluorophenyl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C19H15Cl2FN4O
|
1
|
| 1 |
IC50 = 7.7 nM
|
|
|
|
CP0345601
|
(2,3-dichlorophenyl)-[(6S)-3-(4-methoxypyridin-2-yl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C19H17Cl2N5O2
|
1
|
| 1 |
IC50 = 7.7 nM
|
|
|
|
CP0385435
|
US10053462, 7
Show/Hide
|
C19H15ClF3N5OS
|
1
|
| 1 |
IC50 = 7.7 nM
|
|
|
|
CP0385779
|
US10053462, 44
Show/Hide
|
C21H18F3N5O
|
1
|
| 1 |
IC50 = 7.7 nM
|
|
|
|
CP0911517
|
US9096596, 62
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 7.8 nM
|
|
|
|
CP0235731
|
(2,3-dichlorophenyl)-(3-pyridin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Show/Hide
|
C17H13Cl2N5O
|
1
|
| 1 |
IC50 = 7.9 nM
|
|
|
|
CP0403042
|
US10047092, 70
Show/Hide
|
C20H15ClF4N6O
|
1
|
| 1 |
IC50 = 7.9 nM
|
|
|
|
CP0554079
|
US10112937, Example 93
Show/Hide
|
C19H14ClF3N4O
|
1
|
| 1 |
IC50 = 7.9 nM
|
|
|
|
CP0078424
|
(2,3-dichlorophenyl)-[(6S)-6-methyl-3-pyrazin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C17H14Cl2N6O
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0403398
|
US10323032, Example 33
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0087202
|
(4S)-N-[4-fluoro-2-methyl-5-(2-methyl-3-oxopyridazin-4-yl)phenyl]-4-(4-fluorophenyl)-1-methyl-2-oxo-3,4-dihydropyridine-5-carboxamide
Show/Hide
|
C25H22F2N4O3
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0483498
|
US10112937, Example 176
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0537422
|
US10112937, Example 299
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 8.1 nM
|
|
|
|
CP0926656
|
US9464084, 267
Show/Hide
|
C18H15ClF3N5O
|
1
|
| 1 |
IC50 = 8.1 nM
|
|
|
|
CP0141333
|
(2,3-dichlorophenyl)-(6-methyl-3-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Show/Hide
|
C19H16Cl2N4O
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0540780
|
US10047092, 36
Show/Hide
|
C18H15ClF3N5OS
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0476891
|
US10112937, Example 148
Show/Hide
|
C19H14ClF4N5O
|
2
|
| 1 |
IC50 = 8.318 nM
|
|
|
| 2 |
IC50 = 8.5 nM
|
|
|
|
CP0141331
|
[2-chloro-3-(trifluoromethyl)phenyl]-(8-methyl-3-pyridin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 8.5 nM
|
|
|
|
CP0402627
|
US10112937, Example 279
Show/Hide
|
C17H14Cl2N6O
|
1
|
| 1 |
IC50 = 8.6 nM
|
|
|
|
CP0406864
|
US10112937, Example 250
Show/Hide
|
C17H13ClF3N5O2
|
1
|
| 1 |
IC50 = 8.6 nM
|
|
|
|
CP0488621
|
US10112937, Example 199
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 8.6 nM
|
|
|
|
CP0078333
|
[2-chloro-3-(trifluoromethyl)phenyl]-[(6S)-3-(4-fluorophenyl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C20H15ClF4N4O
|
1
|
| 1 |
IC50 = 8.7 nM
|
|
|
|
CP0529415
|
US10112937, Example 116
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 8.8 nM
|
|
|
|
CP0483497
|
US10112937, Example 170
Show/Hide
|
C18H16ClF3N6O
|
1
|
| 1 |
IC50 = 8.9 nM
|
|
|
|
CP0535975
|
US10112937, Example 173
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 8.9 nM
|
|
|
|
CP0406738
|
(2S)-N-(2-bromo-4,5-dimethoxyphenyl)-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide
Show/Hide
|
C20H18BrFN2O4
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0406739
|
(4S)-4-(4-fluorophenyl)-N-(5-methoxy-2,3-dimethylphenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide
Show/Hide
|
C21H21FN2O3
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0420488
|
(2S)-N-[4-chloro-5-(2-hydroxyethoxy)-2-methylphenyl]-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide
Show/Hide
|
C21H20ClFN2O4
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0568114
|
(4S)-N-(2-bromo-4,5-dimethoxyphenyl)-4-(3-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide
Show/Hide
|
C20H18BrFN2O4
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0339244
|
US10112937, Example 6
Show/Hide
|
C18H13ClF3N5O
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 9.4 nM
|
|
|
|
CP0468005
|
US10112937, Example 21
Show/Hide
|
C20H15ClF4N4O
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 78.5 nM
|
|
|
|
CP0447237
|
1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine
Show/Hide
|
C19H17N5
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0893892
|
US9464084, 310
Show/Hide
|
C18H16ClF3N6O
|
1
|
| 1 |
IC50 = 9.2 nM
|
|
|
|
CP0389346
|
US10047092, 47
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 9.3 nM
|
|
|
|
CP0555545
|
US10112937, Example 136
Show/Hide
|
C19H15ClF3N5O2
|
1
|
| 1 |
IC50 = 9.3 nM
|
|
|
|
CP0375035
|
US10053462, 3
Show/Hide
|
C20H16ClF3N6O
|
1
|
| 1 |
IC50 = 9.6 nM
|
|
|
|
CP0154755
|
[2-chloro-3-(trifluoromethyl)phenyl]-(3-pyridin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Show/Hide
|
C18H13ClF3N5O
|
1
|
| 1 |
IC50 = 9.7 nM
|
|
|
|
CP0407681
|
US10053462, 8
Show/Hide
|
C19H15ClF3N5OS
|
1
|
| 1 |
IC50 = 9.7 nM
|
|
|
|
CP0419432
|
US10112937, Example 144
Show/Hide
|
C17H13Cl2FN6O
|
1
|
| 1 |
IC50 = 9.7 nM
|
|
|
|
CP0406871
|
US10112937, Example 26
Show/Hide
|
C23H19ClF3N3O3
|
1
|
| 1 |
IC50 = 9.8 nM
|
|
|
|
CP0141332
|
[2-chloro-3-(trifluoromethyl)phenyl]-[3-(4-fluorophenyl)-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C20H15ClF4N4O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0141335
|
(2,3-dichlorophenyl)-[(6S)-3-(5-fluoropyrimidin-2-yl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C17H13Cl2FN6O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0690977
|
US9096596, 66
Show/Hide
|
C20H16ClF4N5O
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
Ki = 50.1 nM
|
|
|
|
CP0866477
|
US9096596, 119
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0874169
|
US9096596, 74
Show/Hide
|
C20H17F4N5O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0515335
|
US10053462, 14
Show/Hide
|
C21H17ClF3N5O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0524252
|
US10053462, 26
Show/Hide
|
C22H19ClF3N5O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0402594
|
US10112937, Example 22
Show/Hide
|
C19H14ClF4N5O
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 13.1 nM
|
|
|
|
CP0491723
|
US10112937, Example 110
Show/Hide
|
C20H14ClF4N3O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0460109
|
N'-quinolin-5-yladamantane-1-carbohydrazide
Show/Hide
|
C20H23N3O
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 10.23 nM
|
|
|
|
CP0407838
|
US10053462, 52
Show/Hide
|
C18H12ClF4N5OS
|
1
|
| 1 |
IC50 = 10.2 nM
|
|
|
|
CP0893891
|
US9464084, 210
Show/Hide
|
C17H14ClF3N6O
|
1
|
| 1 |
IC50 = 10.2 nM
|
|
|
|
CP0489782
|
3-chloro-N'-quinolin-5-yladamantane-1-carbohydrazide
Show/Hide
|
C20H22ClN3O
|
1
|
| 1 |
IC50 = 10.23 nM
|
|
|
|
CP0469296
|
US10323032, Example 18
Show/Hide
|
C18H13ClF3N5O
|
1
|
| 1 |
IC50 = 10.3 nM
|
|
|
|
CP0555543
|
US10112937, Example 90
Show/Hide
|
C18H11ClF3N5O
|
1
|
| 1 |
IC50 = 10.3 nM
|
|
|
|
CP0408165
|
US10047092, 40
Show/Hide
|
C18H15ClF3N5OS
|
1
|
| 1 |
IC50 = 10.4 nM
|
|
|
|
CP0420624
|
US10053462, 50
Show/Hide
|
C19H13ClF4N6O
|
1
|
| 1 |
IC50 = 10.4 nM
|
|
|
|
CP0935337
|
US9096596, 81
Show/Hide
|
C19H16Cl2FN5O
|
1
|
| 1 |
IC50 = 10.5 nM
|
|
|
|
CP0483502
|
US10112937, Example 203
Show/Hide
|
C17H13Cl2FN6O
|
1
|
| 1 |
IC50 = 10.5 nM
|
|
|
|
CP0537321
|
US10112937, Example 32
Show/Hide
|
C20H15ClF4N4O
|
1
|
| 1 |
IC50 = 10.5 nM
|
|
|
|
CP0902265
|
US9096596, 121
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 10.6 nM
|
|
|
|
CP0555921
|
US10112937, Example 58
Show/Hide
|
C20H14Cl2F3N3O
|
1
|
| 1 |
IC50 = 10.7 nM
|
|
|
|
CP0554751
|
US10112937, Example 294
Show/Hide
|
C20H18ClF3N6O
|
1
|
| 1 |
IC50 = 10.8 nM
|
|
|
|
CP0903792
|
US9096596, 84
Show/Hide
|
C19H17Cl2N5O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0548851
|
[3-chloro-2-(trifluoromethyl)pyridin-4-yl]-[(6S)-1-(1-ethylpyrazol-3-yl)-6-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridin-5-yl]methanone
Show/Hide
|
C18H17ClF3N7O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0879023
|
US9096596, 58
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 11.1 nM
|
|
|
|
CP0476858
|
US10112937, Example 147
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 11.3 nM
|
|
|
|
CP0462535
|
N'-(2-chlorophenyl)adamantane-1-carbohydrazide
Show/Hide
|
C17H21ClN2O
|
1
|
| 1 |
IC50 = 11.48 nM
|
|
|
|
CP0423962
|
US10112937, Example 99
Show/Hide
|
C20H15ClF3N3O
|
1
|
| 1 |
IC50 = 11.5 nM
|
|
|
|
CP0458587
|
US10112937, Example 302
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 11.6 nM
|
|
|
|
CP0419433
|
US10112937, Example 172
Show/Hide
|
C19H17ClF4N6O
|
1
|
| 1 |
IC50 = 11.7 nM
|
|
|
|
CP0441262
|
N'-(2-methylphenyl)adamantane-1-carbohydrazide
Show/Hide
|
C18H24N2O
|
1
|
| 1 |
IC50 = 11.75 nM
|
|
|
|
CP0078324
|
[2-chloro-3-(trifluoromethyl)phenyl]-[(6S)-6-methyl-3-pyrazin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0345603
|
[2-chloro-3-(trifluoromethyl)phenyl]-(6-methyl-3-phenyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Show/Hide
|
C20H16ClF3N4O
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0552193
|
(2S)-N-(4,5-dimethoxy-2-methylphenyl)-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide
Show/Hide
|
C21H21FN2O4
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0339243
|
US10112937, Example 2
Show/Hide
|
C20H15ClF3N3O
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 18.4 nM
|
|
|
|
CP0536009
|
US10112937, Example 183
Show/Hide
|
C17H12ClF4N7O
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 20.4 nM
|
|
|
|
CP0509221
|
US10323032, Example 109
Show/Hide
|
C17H12ClF3N6O
|
1
|
| 1 |
IC50 = 12.1 nM
|
|
|
|
CP0524278
|
US10323032, Example 37
Show/Hide
|
C18H12ClF3N4OS
|
1
|
| 1 |
IC50 = 12.1 nM
|
|
|
|
CP0488358
|
US10112937, Example 191
Show/Hide
|
C19H16Cl2N4O
|
1
|
| 1 |
IC50 = 12.2 nM
|
|
|
|
CP0447443
|
US10112937, Example 218
Show/Hide
|
C17H12Cl2F2N6O
|
1
|
| 1 |
IC50 = 12.4 nM
|
|
|
|
CP0512285
|
US10112937, Example 94
Show/Hide
|
C19H13ClF4N4O
|
1
|
| 1 |
IC50 = 12.4 nM
|
|
|
|
CP0518413
|
US10112937, Example 5
Show/Hide
|
C17H13ClF3N5O
|
1
|
| 1 |
IC50 = 12.4 nM
|
|
|
|
CP0407519
|
3-[[5-[2-chloro-3-(trifluoromethyl)phenyl]tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C14H9ClF3N5
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0439769
|
3-[[1-[2-chloro-3-(trifluoromethyl)phenyl]tetrazol-5-yl]methyl]pyridine
Show/Hide
|
C14H9ClF3N5
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0514389
|
3-[[5-(2,3-dichloro-4-fluorophenyl)tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C13H8Cl2FN5
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0407608
|
US10053462, 40
Show/Hide
|
C21H15ClF4N4O
|
1
|
| 1 |
IC50 = 12.6 nM
|
|
|
|
CP0406869
|
US10112937, Example 13
Show/Hide
|
C19H15ClF3N5O
|
2
|
| 1 |
IC50 = 12.6 nM
|
|
|
| 2 |
IC50 = 77 nM
|
|
|
|
CP0454644
|
US10112937, Example 208
Show/Hide
|
C19H16F4N6O
|
2
|
| 1 |
IC50 = 12.6 nM
|
|
|
| 2 |
IC50 = 14 nM
|
|
|
|
CP0454646
|
US10112937, Example 216
Show/Hide
|
C17H12Cl2F2N6O
|
1
|
| 1 |
IC50 = 12.6 nM
|
|
|
|
CP0488344
|
US10112937, Example 108
Show/Hide
|
C20H16ClF3N4O
|
1
|
| 1 |
IC50 = 12.6 nM
|
|
|
|
CP0868205
|
US9096596, 68
Show/Hide
|
C19H17Cl2N5O
|
1
|
| 1 |
IC50 = 12.7 nM
|
|
|
|
CP0931107
|
US9096596, 75
Show/Hide
|
C20H17F4N5O
|
1
|
| 1 |
IC50 = 12.7 nM
|
|
|
|
CP0483506
|
US10112937, Example 249
Show/Hide
|
C20H20ClF3N6O2
|
1
|
| 1 |
IC50 = 12.7 nM
|
|
|
|
CP0515461
|
US10112937, Example 266
Show/Hide
|
C20H19ClF3N5O
|
1
|
| 1 |
IC50 = 12.7 nM
|
|
|
|
CP0861884
|
US9096596, 112
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 12.9 nM
|
|
|
|
CP0957353
|
US9464084, 86
Show/Hide
|
C17H12ClF3N6O
|
1
|
| 1 |
IC50 = 12.9 nM
|
|
|
|
CP0515228
|
US10112937, Example 290
Show/Hide
|
C20H16ClF3N4O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0378096
|
N'-(3,5-dichloropyridin-4-yl)-3,5-dimethyladamantane-1-carbohydrazide
Show/Hide
|
C18H23Cl2N3O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0407607
|
US10053462, 45
Show/Hide
|
C20H14ClF4N5O
|
1
|
| 1 |
IC50 = 13.1 nM
|
|
|
|
CP0515165
|
US10112937, Example 269
Show/Hide
|
C19H16F4N6O
|
1
|
| 1 |
IC50 = 13.1 nM
|
|
|
|
CP0462711
|
US10047092, 48
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 13.2 nM
|
|
|
|
CP0407675
|
US10053462, 48
Show/Hide
|
C20H15ClF3N5O
|
1
|
| 1 |
IC50 = 13.2 nM
|
|
|
|
CP0396418
|
US10053462, 12
Show/Hide
|
C21H16ClF4N5O
|
1
|
| 1 |
IC50 = 13.3 nM
|
|
|
|
CP0451463
|
US10112937, Example 213
Show/Hide
|
C17H12Cl2F2N6O
|
1
|
| 1 |
IC50 = 13.3 nM
|
|
|
|
CP0400904
|
US10053462, 33
Show/Hide
|
C21H17ClF3N5O
|
1
|
| 1 |
IC50 = 13.4 nM
|
|
|
|
CP0253003
|
[2-chloro-3-(trifluoromethyl)phenyl]-[3-(4-fluorophenyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C19H13ClF4N4O
|
1
|
| 1 |
IC50 = 13.5 nM
|
|
|
|
CP0894646
|
US9096596, 67
Show/Hide
|
C19H17Cl2N5O
|
1
|
| 1 |
IC50 = 13.5 nM
|
|
|
|
CP0863315
|
US9096596, 78
Show/Hide
|
C21H20F3N5O
|
1
|
| 1 |
IC50 = 13.6 nM
|
|
|
|
CP0555504
|
US10112937, Example 28
Show/Hide
|
C21H17ClF3N5O3
|
1
|
| 1 |
IC50 = 13.8 nM
|
|
|
|
CP0861656
|
US9096596, 99
Show/Hide
|
C21H19ClF3N5O
|
1
|
| 1 |
IC50 = 13.9 nM
|
|
|
|
CP0880918
|
US9096596, 115
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 13.9 nM
|
|
|
|
CP0465970
|
US10112937, Example 230
Show/Hide
|
C19H15ClF4N6O
|
1
|
| 1 |
IC50 = 13.9 nM
|
|
|
|
CP0078322
|
(2,3-dichlorophenyl)-[3-(4-fluorophenyl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C19H15Cl2FN4O
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0468010
|
US9464084, 11
Show/Hide
|
C20H15ClF4N4O
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
IC50 = 22.3 nM
|
|
|
|
CP0517770
|
US10112937, Example 429
Show/Hide
|
C17H13F4N7O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0926461
|
US9464084, 85
Show/Hide
|
C17H14ClF3N6O
|
1
|
| 1 |
IC50 = 14.1 nM
|
|
|
|
CP0483505
|
US10112937, Example 209
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 14.2 nM
|
|
|
|
CP0846324
|
US9096596, 56
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 14.3 nM
|
|
|
|
CP0544285
|
US10112937, Example 64
Show/Hide
|
C17H11ClF4N6O
|
1
|
| 1 |
IC50 = 14.3 nM
|
|
|
|
CP0564187
|
US10112937, Example 38
Show/Hide
|
C21H14ClF6N3O
|
1
|
| 1 |
IC50 = 14.3 nM
|
|
|
|
CP0863244
|
US9102686, 51
Show/Hide
|
C19H16ClF3N6O
|
1
|
| 1 |
IC50 = 14.4 nM
|
|
|
|
CP0554746
|
US10112937, Example 156
Show/Hide
|
C17H13ClF2N6O
|
1
|
| 1 |
IC50 = 14.4 nM
|
|
|
|
CP0495191
|
US10112937, Example 73
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 14.5 nM
|
|
|
|
CP0408243
|
US10053462, 60
Show/Hide
|
C18H12Cl2F3N5OS
|
1
|
| 1 |
IC50 = 14.9 nM
|
|
|
|
CP0224331
|
[2-fluoro-3-(trifluoromethyl)phenyl]-(8-methyl-3-pyridin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Show/Hide
|
C19H15F4N5O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0447770
|
US10112937, Example 44
Show/Hide
|
C20H16ClF3N4O
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
Ki = 32 nM
|
|
|
|
CP0541397
|
US10053462, 46
Show/Hide
|
C19H14ClF3N6O
|
1
|
| 1 |
IC50 = 15.2 nM
|
|
|
|
CP0457267
|
US10112937, Example 305
Show/Hide
|
C19H15ClF4N6O
|
1
|
| 1 |
IC50 = 15.5 nM
|
|
|
|
CP0403003
|
US10323032, Example 43
Show/Hide
|
C18H12ClF3N4OS
|
1
|
| 1 |
IC50 = 15.8 nM
|
|
|
|
CP0407229
|
US10323032, Example 47
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 15.8 nM
|
|
|
|
CP0554082
|
US10112937, Example 107
Show/Hide
|
C20H16ClF3N4O
|
1
|
| 1 |
IC50 = 15.8 nM
|
|
|
|
CP0404877
|
5-(2,3-dichlorophenyl)-1-[(2-methylphenyl)methyl]tetrazole
Show/Hide
|
C15H12Cl2N4
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0515164
|
US10112937, Example 206
Show/Hide
|
C19H16F4N6O
|
1
|
| 1 |
IC50 = 15.9 nM
|
|
|
|
CP0447446
|
US10112937, Example 243
Show/Hide
|
C21H17ClF4N4O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0561648
|
US10112937, Example 255
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0406866
|
US10112937, Example 263
Show/Hide
|
C21H18F4N4O
|
1
|
| 1 |
IC50 = 16.1 nM
|
|
|
|
CP0896500
|
US9096596, 64
Show/Hide
|
C20H16ClF4N5O
|
1
|
| 1 |
IC50 = 16.4 nM
|
|
|
|
CP0403490
|
US10323032, Example 57
Show/Hide
|
C21H17ClF3N5O
|
1
|
| 1 |
IC50 = 16.5 nM
|
|
|
|
CP0908177
|
US9464084, 154
Show/Hide
|
C18H17F3N6O
|
1
|
| 1 |
IC50 = 16.5 nM
|
|
|
|
CP0515160
|
US10112937, Example 55
Show/Hide
|
C20H15ClF3N5O
|
1
|
| 1 |
IC50 = 16.7 nM
|
|
|
|
CP0419427
|
US10112937, Example 83
Show/Hide
|
C20H15ClF4N4O
|
1
|
| 1 |
IC50 = 16.9 nM
|
|
|
|
CP0507329
|
US10112937, Example 68
Show/Hide
|
C16H12ClF3N6O
|
1
|
| 1 |
IC50 = 16.9 nM
|
|
|
|
CP0474346
|
US10053462, 55
Show/Hide
|
C19H13Cl2F3N4OS
|
1
|
| 1 |
IC50 = 17.1 nM
|
|
|
|
CP0863273
|
US9096596, 89
Show/Hide
|
C19H17ClFN5O
|
1
|
| 1 |
IC50 = 17.2 nM
|
|
|
|
CP0413503
|
US10112937, Example 82
Show/Hide
|
C19H12ClF4N5O
|
1
|
| 1 |
IC50 = 17.3 nM
|
|
|
|
CP0435051
|
US10323032, Example 130
Show/Hide
|
C20H13ClF4N4O
|
1
|
| 1 |
IC50 = 17.4 nM
|
|
|
|
CP0537325
|
US10112937, Example 66
Show/Hide
|
C17H12F4N6O
|
1
|
| 1 |
IC50 = 17.4 nM
|
|
|
|
CP0524290
|
US10047092, 42
Show/Hide
|
C18H13BrClF3N6O
|
1
|
| 1 |
IC50 = 17.5 nM
|
|
|
|
CP0517259
|
US10112937, Example 84
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 17.7 nM
|
|
|
|
CP0476689
|
US10112937, Example 311
Show/Hide
|
C18H13F5N6O
|
1
|
| 1 |
IC50 = 17.9 nM
|
|
|
|
CP0413783
|
US10047092, 65
Show/Hide
|
C20H16ClF3N6O
|
1
|
| 1 |
IC50 = 18.1 nM
|
|
|
|
CP0488354
|
US10112937, Example 175
Show/Hide
|
C18H13F5N6O
|
1
|
| 1 |
IC50 = 18.1 nM
|
|
|
|
CP0516344
|
US10112937, Example 161
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 18.1 nM
|
|
|
|
CP0511292
|
2-methyl-N'-quinolin-5-ylbicyclo[2.2.1]hept-5-ene-2-carbohydrazide
Show/Hide
|
C18H19N3O
|
1
|
| 1 |
IC50 = 18.62 nM
|
|
|
|
CP0861572
|
US9096596, 70
Show/Hide
|
C19H16Cl2FN5O
|
1
|
| 1 |
IC50 = 18.7 nM
|
|
|
|
CP0476683
|
US10112937, Example 252
Show/Hide
|
C19H16ClF3N6O
|
1
|
| 1 |
IC50 = 18.8 nM
|
|
|
|
CP0462213
|
US10112937, Example 406
Show/Hide
|
C19H18ClF3N6O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0863311
|
US9096596, 104
Show/Hide
|
C20H18Cl2FN5O
|
1
|
| 1 |
IC50 = 19.1 nM
|
|
|
|
CP0507334
|
US10112937, Example 261
Show/Hide
|
C19H14Cl2F2N4O
|
1
|
| 1 |
IC50 = 19.4 nM
|
|
|
|
CP0945719
|
US9102686, 62
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 19.6 nM
|
|
|
|
CP0378778
|
3-[[1-[2-chloro-4-fluoro-3-(trifluoromethyl)phenyl]tetrazol-5-yl]methyl]pyridine
Show/Hide
|
C14H8ClF4N5
|
1
|
| 1 |
IC50 = 19.95 nM
|
|
|
|
CP0407605
|
US10047092, 69
Show/Hide
|
C21H16ClF4N5O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0429645
|
US10047092, 19
Show/Hide
|
C19H16ClF3N6O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0382104
|
US10323032, Example 42
Show/Hide
|
C19H14ClF3N4O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0414717
|
US10053462, 42
Show/Hide
|
C19H14ClF3N6O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0422523
|
US10053462, 43
Show/Hide
|
C20H14ClF4N5O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0386756
|
A-839977
Show/Hide
|
C19H14Cl2N6O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0388923
|
US10053462, 47
Show/Hide
|
C18H13Cl2FN6O
|
1
|
| 1 |
IC50 = 20.3 nM
|
|
|
|
CP0407563
|
US10323032, Example 7
Show/Hide
|
C17H13Cl2N5O
|
2
|
| 1 |
IC50 = 20.7 nM
|
|
|
| 2 |
Ki = 15.4 nM
|
|
|
|
CP0554076
|
US10112937, Example 80
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 20.7 nM
|
|
|
|
CP0407210
|
US10323032, Example 54
Show/Hide
|
C20H18ClF3N6O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0543925
|
(6S)-6-(4-fluorophenyl)-3-methyl-N-[2-methyl-5-(2-oxopyridin-1-yl)phenyl]-2-oxo-1,6-dihydropyrimidine-5-carboxamide
Show/Hide
|
C24H21FN4O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0516301
|
US10112937, Example 127
Show/Hide
|
C17H14ClF3N6O
|
1
|
| 1 |
IC50 = 22.1 nM
|
|
|
|
CP0517287
|
US10112937, Example 254
Show/Hide
|
C21H19ClF3N5O
|
1
|
| 1 |
IC50 = 22.3 nM
|
|
|
|
CP0385693
|
US10047092, 39
Show/Hide
|
C19H17ClF3N5OS
|
1
|
| 1 |
IC50 = 22.4 nM
|
|
|
|
CP0511791
|
3-ethyl-N'-quinolin-5-yladamantane-1-carbohydrazide
Show/Hide
|
C22H27N3O
|
1
|
| 1 |
IC50 = 22.91 nM
|
|
|
|
CP0175197
|
(2,3-dichlorophenyl)-[(6S)-3-(6-fluoropyridin-2-yl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0019322
|
(4S)-N-[4-chloro-5-(2-hydroxyethoxy)-2-methylphenyl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide
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|
C21H20ClFN2O4
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0406740
|
(4S)-4-(4-fluorophenyl)-N-[1-(2-hydroxyethyl)-5-methylindazol-6-yl]-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide
Show/Hide
|
C22H21FN4O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0492561
|
US10112937, Example 76
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|
C23H14ClF3N6O
|
1
|
| 1 |
IC50 = 24.4 nM
|
|
|
|
CP0861307
|
US9464084, 223
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0385845
|
US10323032, Example 14
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|
C18H13Cl2N5O
|
1
|
| 1 |
IC50 = 25.1 nM
|
|
|
|
CP0892017
|
US9096596, 80
Show/Hide
|
C19H16Cl2FN5O
|
1
|
| 1 |
IC50 = 25.1 nM
|
|
|
|
CP0537324
|
US10112937, Example 56
Show/Hide
|
C19H13ClF3N5O
|
1
|
| 1 |
IC50 = 25.1 nM
|
|
|
|
CP0455095
|
3-[[1-(2,3-dichloro-4-fluorophenyl)tetrazol-5-yl]methyl]pyridine
Show/Hide
|
C13H8Cl2FN5
|
1
|
| 1 |
IC50 = 25.12 nM
|
|
|
|
CP0848326
|
US9096596, 98
Show/Hide
|
C21H19ClF3N5O
|
1
|
| 1 |
IC50 = 25.5 nM
|
|
|
|
CP0447766
|
US10112937, Example 17
Show/Hide
|
C20H16ClF3N4O
|
2
|
| 1 |
IC50 = 25.9 nM
|
|
|
| 2 |
IC50 = 34 nM
|
|
|
|
CP0385388
|
(4S)-N-[2-fluoro-5-(6-oxo-1H-pyridazin-5-yl)phenyl]-4-(4-fluorophenyl)-1-methyl-2-oxo-3,4-dihydropyridine-5-carboxamide
Show/Hide
|
C23H18F2N4O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0558987
|
[(6S)-1-(5-fluoropyrimidin-2-yl)-6-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridin-5-yl]-[3-methyl-2-(trifluoromethyl)pyridin-4-yl]methanone
Show/Hide
|
C18H15F4N7O
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0420230
|
US10323032, Example 19
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 26.1 nM
|
|
|
|
CP0420025
|
US10047092, 41
Show/Hide
|
C17H13ClF3N5O2
|
1
|
| 1 |
IC50 = 26.4 nM
|
|
|
|
CP0519399
|
US10047092, 89
Show/Hide
|
C17H15N7O3
|
1
|
| 1 |
IC50 = 26.4 nM
|
|
|
|
CP0445138
|
US10112937, Example 260
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|
C20H17ClF3N5O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0518504
|
US10112937, Example 238
Show/Hide
|
C21H17ClF4N4O
|
1
|
| 1 |
IC50 = 27.1 nM
|
|
|
|
CP0902249
|
US9096596, 102
Show/Hide
|
C22H21ClF3N5O
|
1
|
| 1 |
IC50 = 27.3 nM
|
|
|
|
CP0439222
|
1,2,2,3-tetramethyl-N'-quinolin-5-ylcyclopentane-1-carbohydrazide
Show/Hide
|
C19H25N3O
|
1
|
| 1 |
IC50 = 27.54 nM
|
|
|
|
CP0439401
|
N'-quinolin-5-yltricyclo[3.3.1.03,7]nonane-3-carbohydrazide
Show/Hide
|
C19H21N3O
|
1
|
| 1 |
IC50 = 27.54 nM
|
|
|
|
CP0551273
|
US10112937, Example 315
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|
C19H13ClF4N4O
|
2
|
| 1 |
IC50 = 28 nM
|
|
|
| 2 |
IC50 = 39.8 nM
|
|
|
|
CP0305154
|
US10323032, Example 12
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|
C20H14ClF3N4O
|
2
|
| 1 |
IC50 = 28.1 nM
|
|
|
| 2 |
Ki = 58.9 nM
|
|
|
|
CP0863136
|
US9096596, 93
Show/Hide
|
C19H17F2N5O
|
1
|
| 1 |
IC50 = 28.5 nM
|
|
|
|
CP0078323
|
[2-chloro-3-(trifluoromethyl)phenyl]-[3-(4-fluorophenyl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C20H15ClF4N4O
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0487017
|
US10323032, Example 128
Show/Hide
|
C23H23ClF3N5O2
|
1
|
| 1 |
IC50 = 29.6 nM
|
|
|
|
CP0400901
|
US10323032, Example 1
Show/Hide
|
C21H15ClF3N3O
|
1
|
| 1 |
IC50 = 29.9 nM
|
|
|
|
CP0133786
|
(4S)-4-(4-fluorophenyl)-N-[5-[4-[(2R)-2-hydroxy-3-methoxypropyl]-3,5-dioxo-1,2,4-triazin-2-yl]-2-methylphenyl]-1-methyl-2-oxo-3,4-dihydropyridine-5-carboxamide
Show/Hide
|
C27H28FN5O6
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0385118
|
US10112937, Example 23
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|
C19H15ClF3N5O
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 34.4 nM
|
|
|
|
CP0456469
|
US10053462, 56
Show/Hide
|
C19H15ClF3N5OS
|
1
|
| 1 |
IC50 = 30.8 nM
|
|
|
|
CP0385544
|
US10323032, Example 124
Show/Hide
|
C22H20ClF4N5O
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0462690
|
US10323032, Example 15
Show/Hide
|
C20H16F3N5O
|
1
|
| 1 |
IC50 = 31.6 nM
|
|
|
|
CP0449512
|
3-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]-2-methylpyridine
Show/Hide
|
C14H11Cl2N5
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0408267
|
(2S)-N-(2-bromo-4-fluoro-5-methoxyphenyl)-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide
Show/Hide
|
C19H15BrF2N2O3
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0391491
|
(2S)-N-(2-bromo-4-chloro-5-methoxyphenyl)-4-oxo-2-phenyl-2,3-dihydropyridine-1-carboxamide
Show/Hide
|
C19H16BrClN2O3
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0852696
|
US9096596, 87
Show/Hide
|
C19H17ClFN5O
|
1
|
| 1 |
IC50 = 33.6 nM
|
|
|
|
CP0439226
|
N'-(2-methylphenyl)cycloheptanecarbohydrazide
Show/Hide
|
C15H22N2O
|
1
|
| 1 |
IC50 = 33.88 nM
|
|
|
|
CP0462534
|
N'-isoquinolin-5-yladamantane-1-carbohydrazide
Show/Hide
|
C20H23N3O
|
1
|
| 1 |
IC50 = 33.88 nM
|
|
|
|
CP0443224
|
US10112937, Example 193
Show/Hide
|
C19H14ClF4N5O
|
3
|
| 1 |
IC50 = 34 nM
|
|
|
| 2 |
IC50 = 53.2 nM
|
|
|
| 3 |
Ki = 22 nM
|
|
|
|
CP0564477
|
N-[(2-chloropyridin-3-yl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
Show/Hide
|
C14H10ClN3O3S
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0489784
|
N'-(2,3-dichlorophenyl)adamantane-1-carbohydrazide
Show/Hide
|
C17H20Cl2N2O
|
1
|
| 1 |
IC50 = 34.67 nM
|
|
|
|
CP0396423
|
US10323032, Example 44
Show/Hide
|
C19H14ClF3N4OS
|
1
|
| 1 |
IC50 = 34.8 nM
|
|
|
|
CP0495273
|
US10112937, Example 24
Show/Hide
|
C22H18ClF3N4O3
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0495272
|
US10112937, Example 19
Show/Hide
|
C20H16F4N4O
|
1
|
| 1 |
IC50 = 35.2 nM
|
|
|
|
CP0414028
|
US10323032, Example 2
Show/Hide
|
C20H15Cl2N3O
|
1
|
| 1 |
IC50 = 36.5 nM
|
|
|
|
CP0414577
|
US10053462, 36
Show/Hide
|
C19H15ClF3N5OS
|
1
|
| 1 |
IC50 = 36.5 nM
|
|
|
|
CP0468108
|
(2S)-N-(2-bromo-4-chloro-5-methoxyphenyl)-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide
Show/Hide
|
C19H15BrClFN2O3
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0554087
|
US10112937, Example 200
Show/Hide
|
C18H13ClF4N6O
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0554754
|
US9464084, 321
Show/Hide
|
C21H17ClF4N4
|
1
|
| 1 |
IC50 = 37.4 nM
|
|
|
|
CP0391490
|
(2S)-1-[2-(2-iodo-4,5-dimethoxyphenyl)acetyl]-2-phenyl-2,3-dihydropyridin-4-one
Show/Hide
|
C21H20INO4
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0460108
|
2-cyclohexyl-N'-(2-methylphenyl)acetohydrazide
Show/Hide
|
C15H22N2O
|
1
|
| 1 |
IC50 = 38.9 nM
|
|
|
|
CP0385414
|
N-(2-bromo-4,5-dimethoxyphenyl)-4-oxo-2-phenyl-2,3-dihydropyridine-1-carboxamide
Show/Hide
|
C20H19BrN2O4
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0460008
|
US10047092, 22
Show/Hide
|
C17H13ClF3N5O2
|
1
|
| 1 |
IC50 = 39.8 nM
|
|
|
|
CP0164688
|
1-benzyl-5-(2,3-dichlorophenyl)tetrazole
Show/Hide
|
C14H10Cl2N4
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0439223
|
N'-(2-fluorophenyl)adamantane-1-carbohydrazide
Show/Hide
|
C17H21FN2O
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0568113
|
(2S)-N-[2-bromo-4-chloro-5-(2-hydroxyethoxy)phenyl]-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide
Show/Hide
|
C20H17BrClFN2O4
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0473488
|
US10053462, 23
Show/Hide
|
C22H19ClF3N5O
|
1
|
| 1 |
IC50 = 40.4 nM
|
|
|
|
CP0488362
|
US10112937, Example 259
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 40.6 nM
|
|
|
|
CP0434796
|
US10047092, 78
Show/Hide
|
C17H14ClFN6O
|
1
|
| 1 |
IC50 = 42.5 nM
|
|
|
|
CP0509249
|
US10047092, 87
Show/Hide
|
C19H20N6O
|
1
|
| 1 |
IC50 = 42.5 nM
|
|
|
|
CP0539442
|
US10047092, 3
Show/Hide
|
C17H12ClF3N6O
|
2
|
| 1 |
IC50 = 44.2 nM
|
|
|
| 2 |
IC50 = 440 nM
|
|
|
|
CP0561671
|
US10112937, Example 187
Show/Hide
|
C18H15F4N7O
|
1
|
| 1 |
IC50 = 44.6 nM
|
|
|
|
CP0544049
|
N-[2-(4-sulfamoylphenyl)ethylcarbamothioyl]-1,3-benzodioxole-5-carboxamide
Show/Hide
|
C17H17N3O5S2
|
2
|
| 1 |
IC50 = 45 nM
|
|
|
| 2 |
IC50 = 47 nM
|
|
|
|
CP0470140
|
US10323032, Example 55
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 45.9 nM
|
|
|
|
CP0385144
|
US10323032, Example 10
Show/Hide
|
C19H16F3N5O
|
1
|
| 1 |
IC50 = 46.1 nM
|
|
|
|
CP0529397
|
US10112937, Example 4
Show/Hide
|
C18H14Cl2N4O
|
1
|
| 1 |
IC50 = 46.5 nM
|
|
|
|
CP0507335
|
US10112937, Example 275
Show/Hide
|
C17H14ClFN6O
|
1
|
| 1 |
IC50 = 46.9 nM
|
|
|
|
CP0458582
|
US10112937, Example 135
Show/Hide
|
C18H12ClF4N5O
|
1
|
| 1 |
IC50 = 48.2 nM
|
|
|
|
CP0406949
|
US10323032, Example 35
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 48.3 nM
|
|
|
|
CP0572295
|
US10150765, Example 71
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0904284
|
US9096596, 96
Show/Hide
|
C19H18ClN5O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0554083
|
US10112937, Example 123
Show/Hide
|
C18H13F4N5O
|
1
|
| 1 |
IC50 = 50.1 nM
|
|
|
|
CP0461649
|
5-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]-2,4-dimethyl-1,3-thiazole
Show/Hide
|
C13H11Cl2N5S
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0513238
|
US10047092, 9
Show/Hide
|
C18H13ClF3N5O
|
1
|
| 1 |
IC50 = 50.2 nM
|
|
|
|
CP0420629
|
US10053462, 39
Show/Hide
|
C20H17ClF3N5OS
|
1
|
| 1 |
IC50 = 51.1 nM
|
|
|
|
CP0489783
|
N'-(2-chloroquinolin-5-yl)adamantane-1-carbohydrazide
Show/Hide
|
C20H22ClN3O
|
1
|
| 1 |
IC50 = 51.29 nM
|
|
|
|
CP0460101
|
1-(4-methoxyphenyl)-N'-quinolin-5-ylcyclohexane-1-carbohydrazide
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
IC50 = 52.48 nM
|
|
|
|
CP0178124
|
[2-chloro-3-(trifluoromethyl)phenyl]-(8-methyl-3-pyrazin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0495275
|
US10150765, Example 42
Show/Hide
|
C20H16F4N4O
|
1
|
| 1 |
IC50 = 55.7 nM
|
|
|
|
CP0561901
|
US10112937, Example 60
Show/Hide
|
C16H13Cl2N5O
|
1
|
| 1 |
IC50 = 55.7 nM
|
|
|
|
CP0460103
|
N'-(2,5-dimethylphenyl)adamantane-1-carbohydrazide
Show/Hide
|
C19H26N2O
|
1
|
| 1 |
IC50 = 57.54 nM
|
|
|
|
CP0509799
|
2-(1-adamantyl)-N'-quinolin-5-ylacetohydrazide
Show/Hide
|
C21H25N3O
|
1
|
| 1 |
IC50 = 57.54 nM
|
|
|
|
CP0860052
|
US9096596, 91
Show/Hide
|
C19H17ClFN5O
|
1
|
| 1 |
IC50 = 58.7 nM
|
|
|
|
CP0401003
|
US10112937, Example 46
Show/Hide
|
C21H16ClF4N3O
|
3
|
| 1 |
IC50 = 60.3 nM
|
|
|
| 2 |
IC50 = 67 nM
|
|
|
| 3 |
Ki = 40 nM
|
|
|
|
CP0472205
|
N-(1-adamantylmethyl)-2,3-dichlorobenzamide
Show/Hide
|
C18H21Cl2NO
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0532356
|
3-[[5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C14H9F4N5
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0850480
|
US9096596, 77
Show/Hide
|
C21H20F3N5O
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0529414
|
US10112937, Example 114
Show/Hide
|
C19H14Cl2FN3O
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0914247
|
US9464084, 78
Show/Hide
|
C19H14ClF3N4O
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0382526
|
US10323032, Example 38
Show/Hide
|
C17H12Cl2N4OS
|
1
|
| 1 |
IC50 = 63.4 nM
|
|
|
|
CP0425425
|
US10053462, 5
Show/Hide
|
C22H17ClF4N4O
|
1
|
| 1 |
IC50 = 63.4 nM
|
|
|
|
CP0867838
|
US9096596, 95
Show/Hide
|
C19H17F2N5O
|
1
|
| 1 |
IC50 = 64.7 nM
|
|
|
|
CP0385627
|
US10047092, 93
Show/Hide
|
C19H16ClF3N6O
|
2
|
| 1 |
IC50 = 65 nM
|
|
|
| 2 |
IC50 = 88.1 nM
|
|
|
|
CP0409841
|
US10323032, Example 60
Show/Hide
|
C19H12ClF6N5O
|
1
|
| 1 |
IC50 = 65.5 nM
|
|
|
|
CP0416388
|
US10047092, 56
Show/Hide
|
C19H14Cl2F3N5O
|
1
|
| 1 |
IC50 = 65.9 nM
|
|
|
|
CP0410779
|
5-chloro-N-(3,5-dichlorophenyl)-2-hydroxybenzamide
Show/Hide
|
C13H8Cl3NO2
|
1
|
| 1 |
IC50 = 70.4 nM
|
|
|
|
CP0509800
|
1-(4-fluorophenyl)-N'-quinolin-5-ylcyclohexane-1-carbohydrazide
Show/Hide
|
C22H22FN3O
|
1
|
| 1 |
IC50 = 70.79 nM
|
|
|
|
CP0522884
|
1-methyl-N'-(2-methylphenyl)cyclohexane-1-carbohydrazide
Show/Hide
|
C15H22N2O
|
1
|
| 1 |
IC50 = 70.79 nM
|
|
|
|
CP0425315
|
US10047092, 86
Show/Hide
|
C17H14Cl2N6O
|
2
|
| 1 |
IC50 = 72 nM
|
|
|
| 2 |
IC50 = 97.1 nM
|
|
|
|
CP0451554
|
US10112937, Example 316
Show/Hide
|
C21H19ClF3N5O2
|
1
|
| 1 |
IC50 = 72.3 nM
|
|
|
|
CP0529412
|
US10112937, Example 81
Show/Hide
|
C20H13ClF4N4O
|
1
|
| 1 |
IC50 = 73.5 nM
|
|
|
|
CP0515225
|
US10112937, Example 274
Show/Hide
|
C17H14ClFN6O
|
1
|
| 1 |
IC50 = 74.5 nM
|
|
|
|
CP0402636
|
US10150765, Example 62
Show/Hide
|
C18H14Cl2N4O
|
1
|
| 1 |
IC50 = 76.2 nM
|
|
|
|
CP0455219
|
US10112937, Example 18
Show/Hide
|
C21H16ClF4N3O
|
2
|
| 1 |
IC50 = 77.3 nM
|
|
|
| 2 |
IC50 = 78 nM
|
|
|
|
CP0483509
|
US10112937, Example 301
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 77.6 nM
|
|
|
|
CP0563459
|
US10112937, Example 132
Show/Hide
|
C18H15F2N5O
|
1
|
| 1 |
IC50 = 78.3 nM
|
|
|
|
CP0554081
|
US10112937, Example 105
Show/Hide
|
C21H16ClF4N3O
|
1
|
| 1 |
IC50 = 79.4 nM
|
|
|
|
CP0495274
|
US10112937, Example 29
Show/Hide
|
C20H17Cl2N5O3
|
1
|
| 1 |
IC50 = 79.8 nM
|
|
|
|
CP0385117
|
US10112937, Example 3
Show/Hide
|
C19H15Cl2N3O
|
2
|
| 1 |
IC50 = 81.1 nM
|
|
|
| 2 |
IC50 = 89 nM
|
|
|
|
CP0445035
|
US10112937, Example 242
Show/Hide
|
C20H17Cl2FN4O
|
1
|
| 1 |
IC50 = 81.5 nM
|
|
|
|
CP0866306
|
US9096596, 101
Show/Hide
|
C22H21ClF3N5O
|
1
|
| 1 |
IC50 = 82.4 nM
|
|
|
|
CP0559156
|
US10112937, Example 14
Show/Hide
|
C19H15F4N5O
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0409865
|
US10323032, Example 53
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 83.4 nM
|
|
|
|
CP0402625
|
US10112937, Example 258
Show/Hide
|
C21H19ClF3N5O2
|
1
|
| 1 |
IC50 = 85.5 nM
|
|
|
|
CP0406853
|
US10112937, Example 126
Show/Hide
|
C21H17ClF4N4O2
|
1
|
| 1 |
IC50 = 85.5 nM
|
|
|
|
CP0411397
|
US10323032, Example 34
Show/Hide
|
C18H15Cl2N5O
|
1
|
| 1 |
IC50 = 86.1 nM
|
|
|
|
CP0411939
|
US10047092, 94
Show/Hide
|
C18H18N6O
|
1
|
| 1 |
IC50 = 86.5 nM
|
|
|
|
CP0494979
|
US10112937, Example 15
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 87.5 nM
|
|
|
|
CP0406737
|
1-[2-(2-bromo-4,5-dimethoxyphenyl)acetyl]-2-phenyl-2,3-dihydropyridin-4-one
Show/Hide
|
C21H20BrNO4
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0476694
|
US10112937, Example 181
Show/Hide
|
C20H18ClF3N6O
|
1
|
| 1 |
IC50 = 94.4 nM
|
|
|
|
CP0564152
|
US10112937, Example 277
Show/Hide
|
C16H12Cl2N6O
|
1
|
| 1 |
IC50 = 94.6 nM
|
|
|
|
CP0411350
|
US10053462, 21
Show/Hide
|
C19H15Cl2FN6O
|
1
|
| 1 |
IC50 = 94.8 nM
|
|
|
|
CP0491218
|
US10053462, 4
Show/Hide
|
C22H17ClF4N4O
|
1
|
| 1 |
IC50 = 95.3 nM
|
|
|
|
CP0865045
|
US9040534, 25
Show/Hide
|
C17H14ClF3N6O
|
1
|
| 1 |
IC50 = 96.6 nM
|
|
|
|
CP0545289
|
US10323032, Example 73
Show/Hide
|
C21H19ClF3N5O
|
1
|
| 1 |
IC50 = 96.6 nM
|
|
|
|
CP0389387
|
US10053462, 57
Show/Hide
|
C18H13ClF3N5OS
|
1
|
| 1 |
IC50 = 97.7 nM
|
|
|
|
CP0545079
|
N-[(2-chloropyridin-3-yl)carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C17H20ClN3OS
|
2
|
| 1 |
IC50 = 99 nM
|
|
|
| 2 |
IC50 = 155 nM
|
|
|
|
CP0554749
|
US10112937, Example 291
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 99.1 nM
|
|
|
|
CP0537322
|
US10112937, Example 37
Show/Hide
|
C21H17ClF3N3O
|
1
|
| 1 |
IC50 = 99.3 nM
|
|
|
|
CP0526981
|
3-[[1-(2,3-dichlorophenyl)tetrazol-5-yl]methyl]pyridine
Show/Hide
|
C13H9Cl2N5
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0527398
|
US10047092, 45
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0388932
|
US10323032, Example 39
Show/Hide
|
C20H14ClF6N5O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0476853
|
US10112937, Example 240
Show/Hide
|
C21H18ClF3N4O
|
1
|
| 1 |
IC50 = 100.2 nM
|
|
|
|
CP0420519
|
US10053462, 59
Show/Hide
|
C19H15ClF3N5OS
|
1
|
| 1 |
IC50 = 100.5 nM
|
|
|
|
CP0512277
|
US10112937, Example 333
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 101.4 nM
|
|
|
|
CP0445140
|
US10112937, Example 16
Show/Hide
|
C21H19ClF3N5O
|
1
|
| 1 |
IC50 = 103.8 nM
|
|
|
|
CP0406736
|
1-[2-(2-iodo-4,5-dimethoxyphenyl)acetyl]-2-phenyl-2,3-dihydropyridin-4-one
Show/Hide
|
C21H20INO4
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0495190
|
US10112937, Example 69
Show/Hide
|
C17H12F4N6O
|
1
|
| 1 |
IC50 = 105.8 nM
|
|
|
|
CP0535919
|
US10112937, Example 184
Show/Hide
|
C23H21ClF3N3O
|
1
|
| 1 |
IC50 = 105.9 nM
|
|
|
|
CP0375674
|
US10323032, Example 129
Show/Hide
|
C19H12Cl2F2N4O
|
1
|
| 1 |
IC50 = 106.2 nM
|
|
|
|
CP0385776
|
US10047092, 92
Show/Hide
|
C18H18N6O
|
1
|
| 1 |
IC50 = 109.4 nM
|
|
|
|
CP0509802
|
N'-phenyladamantane-1-carbohydrazide
Show/Hide
|
C17H22N2O
|
1
|
| 1 |
IC50 = 109.65 nM
|
|
|
|
CP0548432
|
N-[(3-sulfamoylphenyl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
Show/Hide
|
C15H13N3O5S2
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 173 nM
|
|
|
|
CP0517257
|
US10112937, Example 25
Show/Hide
|
C21H18Cl2N4O3
|
1
|
| 1 |
IC50 = 111.4 nM
|
|
|
|
CP0454652
|
US10112937, Example 304
Show/Hide
|
C18H14F4N6O
|
1
|
| 1 |
IC50 = 112.7 nM
|
|
|
|
CP0065493
|
US10112937, Example 312
Show/Hide
|
C20H16F4N4O
|
2
|
| 1 |
IC50 = 114 nM
|
|
|
| 2 |
IC50 = 157.4 nM
|
|
|
|
CP0560290
|
US10323032, Example 27
Show/Hide
|
C21H17Cl2N3O
|
1
|
| 1 |
IC50 = 117 nM
|
|
|
|
CP0472506
|
US10053462, 30
Show/Hide
|
C21H16Cl2F3N5O
|
1
|
| 1 |
IC50 = 118.3 nM
|
|
|
|
CP0406865
|
US10112937, Example 251
Show/Hide
|
C19H16ClF3N6O
|
1
|
| 1 |
IC50 = 123.7 nM
|
|
|
|
CP0078785
|
A-438079
Show/Hide
|
C13H9Cl2N5
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0539931
|
US10112937, Example 77
Show/Hide
|
C23H16ClF3N6O
|
1
|
| 1 |
IC50 = 125.9 nM
|
|
|
|
CP0554401
|
US10112937, Example 112
Show/Hide
|
C19H16Cl2N4O
|
1
|
| 1 |
IC50 = 125.9 nM
|
|
|
|
CP0454648
|
US10112937, Example 262
Show/Hide
|
C20H15F5N4O
|
1
|
| 1 |
IC50 = 127.6 nM
|
|
|
|
CP0489786
|
N'-(2-methylphenyl)-1-phenylcyclopentane-1-carbohydrazide
Show/Hide
|
C19H22N2O
|
1
|
| 1 |
IC50 = 131.83 nM
|
|
|
|
CP0457552
|
US10047092, 82
Show/Hide
|
C18H17ClN6O3S
|
1
|
| 1 |
IC50 = 132.1 nM
|
|
|
|
CP0864614
|
US9096596, 114
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 133.7 nM
|
|
|
|
CP0509801
|
1-(3-fluorophenyl)-N'-quinolin-5-ylcyclohexane-1-carbohydrazide
Show/Hide
|
C22H22FN3O
|
1
|
| 1 |
IC50 = 141.25 nM
|
|
|
|
CP0387003
|
5-chloro-2-hydroxy-N-[3-nitro-5-(trifluoromethyl)phenyl]benzamide
Show/Hide
|
C14H8ClF3N2O4
|
1
|
| 1 |
IC50 = 143 nM
|
|
|
|
CP0456513
|
US10047092, 24
Show/Hide
|
C18H16ClF3N6O
|
1
|
| 1 |
IC50 = 143.2 nM
|
|
|
|
CP0469293
|
US10047092, 8
Show/Hide
|
C17H13Cl2N5O
|
1
|
| 1 |
IC50 = 146.6 nM
|
|
|
|
CP0474497
|
US10047092, 1
Show/Hide
|
C19H13ClF4N4O
|
1
|
| 1 |
IC50 = 147.6 nM
|
|
|
|
CP0451467
|
US10112937, Example 331
Show/Hide
|
C20H17Cl2N3O
|
1
|
| 1 |
IC50 = 147.9 nM
|
|
|
|
CP0439227
|
4-methyl-N'-(2-methylphenyl)pentanehydrazide
Show/Hide
|
C13H20N2O
|
1
|
| 1 |
IC50 = 147.91 nM
|
|
|
|
CP0537323
|
US10112937, Example 47
Show/Hide
|
C21H16ClF4N3O
|
1
|
| 1 |
IC50 = 148.6 nM
|
|
|
|
CP0937121
|
US9096596, 123
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 152.4 nM
|
|
|
|
CP0516302
|
US10150765, Example 31
Show/Hide
|
C22H21ClF3N5O
|
1
|
| 1 |
IC50 = 156.3 nM
|
|
|
|
CP0503957
|
4-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]-3,5-dimethyl-1,2-oxazole
Show/Hide
|
C13H11Cl2N5O
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0406872
|
US10112937, Example 34
Show/Hide
|
C22H19ClF3N5O2
|
1
|
| 1 |
IC50 = 158.5 nM
|
|
|
|
CP0488343
|
US10112937, Example 106
Show/Hide
|
C21H16ClF4N3O
|
1
|
| 1 |
IC50 = 158.5 nM
|
|
|
|
CP0492562
|
US10112937, Example 125
Show/Hide
|
C20H16ClF3N4O2
|
1
|
| 1 |
IC50 = 158.5 nM
|
|
|
|
CP0544320
|
US10112937, Example 111
Show/Hide
|
C19H16Cl2N4O
|
1
|
| 1 |
IC50 = 158.5 nM
|
|
|
|
CP0479706
|
5-chloro-N-(3,5-difluorophenyl)-2-hydroxybenzamide
Show/Hide
|
C13H8ClF2NO2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0451604
|
US10112937, Example 245
Show/Hide
|
C20H16ClF3N4O
|
1
|
| 1 |
IC50 = 160.7 nM
|
|
|
|
CP0866497
|
US9096596, 97
Show/Hide
|
C19H18ClN5O
|
1
|
| 1 |
IC50 = 166.3 nM
|
|
|
|
CP0402629
|
US10112937, Example 300
Show/Hide
|
C21H19ClF3N5O
|
1
|
| 1 |
IC50 = 171 nM
|
|
|
|
CP0460104
|
N'-(2-methylphenyl)cyclohexanecarbohydrazide
Show/Hide
|
C14H20N2O
|
1
|
| 1 |
IC50 = 173.78 nM
|
|
|
|
CP0072340
|
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
Show/Hide
|
C15H8ClF6NO2
|
1
|
| 1 |
IC50 = 175 nM
|
|
|
|
CP0429726
|
US10047092, 44
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 176.6 nM
|
|
|
|
CP0487340
|
N-[3,5-bis(trifluoromethyl)phenyl]-3-chloro-2-hydroxybenzamide
Show/Hide
|
C15H8ClF6NO2
|
1
|
| 1 |
IC50 = 177 nM
|
|
|
|
CP0476686
|
US10112937, Example 293
Show/Hide
|
C22H21ClF3N5O2
|
1
|
| 1 |
IC50 = 179.1 nM
|
|
|
|
CP0537424
|
US10112937, Example 27
Show/Hide
|
C22H19Cl2N3O3
|
1
|
| 1 |
IC50 = 179.9 nM
|
|
|
|
CP0554086
|
US10112937, Example 198
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 180.3 nM
|
|
|
|
CP0483507
|
US10112937, Example 253
Show/Hide
|
C20H18ClF3N6O
|
1
|
| 1 |
IC50 = 184.9 nM
|
|
|
|
CP0439224
|
1-(2-fluorophenyl)-N'-quinolin-5-ylcyclohexane-1-carbohydrazide
Show/Hide
|
C22H22FN3O
|
1
|
| 1 |
IC50 = 190.55 nM
|
|
|
|
CP0479699
|
N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide
Show/Hide
|
C15H8ClF6NO2
|
1
|
| 1 |
IC50 = 196 nM
|
|
|
|
CP0411930
|
US10323032, Example 22
Show/Hide
|
C17H13Cl2N5O
|
1
|
| 1 |
IC50 = 197.7 nM
|
|
|
|
CP0544318
|
US10112937, Example 54
Show/Hide
|
C18H11ClF3N5O
|
1
|
| 1 |
IC50 = 198.4 nM
|
|
|
|
CP0451465
|
US10112937, Example 234
Show/Hide
|
C19H18ClF3N6O
|
1
|
| 1 |
IC50 = 199.5 nM
|
|
|
|
CP0503941
|
3-[[5-(2,3,4-trichlorophenyl)tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C13H8Cl3N5
|
1
|
| 1 |
IC50 = 199.53 nM
|
|
|
|
CP0460107
|
2,2,3,3-tetramethyl-N'-quinolin-5-ylcyclopropane-1-carbohydrazide
Show/Hide
|
C17H21N3O
|
1
|
| 1 |
IC50 = 199.53 nM
|
|
|
|
CP0512290
|
US10112937, Example 95
Show/Hide
|
C19H13ClF4N4O
|
1
|
| 1 |
IC50 = 204.2 nM
|
|
|
|
CP0559162
|
US10112937, Example 104
Show/Hide
|
C18H14Cl2N4O
|
1
|
| 1 |
IC50 = 204.6 nM
|
|
|
|
CP0531138
|
US10047092, 80
Show/Hide
|
C17H15ClN6O
|
2
|
| 1 |
IC50 = 216 nM
|
|
|
| 2 |
IC50 = 248.3 nM
|
|
|
|
CP0466131
|
US10112937, Example 332
Show/Hide
|
C21H19Cl2N3O
|
1
|
| 1 |
IC50 = 216.8 nM
|
|
|
|
CP0460102
|
N'-pyridin-2-yladamantane-1-carbohydrazide
Show/Hide
|
C16H21N3O
|
1
|
| 1 |
IC50 = 218.78 nM
|
|
|
|
CP0546809
|
US10047092, 57
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 218.8 nM
|
|
|
|
CP0492939
|
US10112937, Example 177
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 227 nM
|
|
|
|
CP0481120
|
US10112937, Example 246
Show/Hide
|
C20H15ClF4N4O
|
1
|
| 1 |
IC50 = 229.6 nM
|
|
|
|
CP0402628
|
US10112937, Example 284
Show/Hide
|
C21H17ClF4N4O
|
1
|
| 1 |
IC50 = 240.4 nM
|
|
|
|
CP0544786
|
US10323032, Example 8
Show/Hide
|
C18H16ClN5O
|
1
|
| 1 |
IC50 = 243.8 nM
|
|
|
|
CP0422521
|
US10047092, 62
Show/Hide
|
C20H16ClF3N6O
|
1
|
| 1 |
IC50 = 249.5 nM
|
|
|
|
CP0503956
|
5-(2,3-dimethylphenyl)-1-[(2-methylphenyl)methyl]tetrazole
Show/Hide
|
C17H18N4
|
1
|
| 1 |
IC50 = 251.19 nM
|
|
|
|
CP0545521
|
US10112937, Example 109
Show/Hide
|
C20H16Cl2FN3O
|
1
|
| 1 |
IC50 = 251.2 nM
|
|
|
|
CP0420027
|
US10323032, Example 32
Show/Hide
|
C22H17ClF3N3O
|
1
|
| 1 |
IC50 = 265.2 nM
|
|
|
|
CP0481450
|
3-hydroxy-N'-quinolin-5-yladamantane-1-carbohydrazide
Show/Hide
|
C20H23N3O2
|
1
|
| 1 |
IC50 = 275.42 nM
|
|
|
|
CP0403429
|
US10323032, Example 21
Show/Hide
|
C17H13ClFN5O
|
1
|
| 1 |
IC50 = 279.9 nM
|
|
|
|
CP0462536
|
N'-(4-fluorophenyl)adamantane-1-carbohydrazide
Show/Hide
|
C17H21FN2O
|
1
|
| 1 |
IC50 = 281.84 nM
|
|
|
|
CP0512278
|
US10112937, Example 336
Show/Hide
|
C19H17Cl2N5O
|
1
|
| 1 |
IC50 = 289.1 nM
|
|
|
|
CP0375413
|
US10047092, 55
Show/Hide
|
C20H14ClF6N5O
|
1
|
| 1 |
IC50 = 314.8 nM
|
|
|
|
CP0472734
|
N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxybenzamide
Show/Hide
|
C15H9F6NO2
|
1
|
| 1 |
IC50 = 315 nM
|
|
|
|
CP0913936
|
US9096596, 63
Show/Hide
|
C19H16ClF3N6O
|
1
|
| 1 |
IC50 = 316.2 nM
|
|
|
|
CP0529411
|
US10112937, Example 35
Show/Hide
|
C23H19ClF3N5O2
|
1
|
| 1 |
IC50 = 316.2 nM
|
|
|
|
CP0441260
|
N'-(3-fluorophenyl)adamantane-1-carbohydrazide
Show/Hide
|
C17H21FN2O
|
1
|
| 1 |
IC50 = 323.59 nM
|
|
|
|
CP0874178
|
US9096596, 134
Show/Hide
|
C20H20FN5O
|
1
|
| 1 |
IC50 = 331.1 nM
|
|
|
|
CP0409796
|
US10047092, 84
Show/Hide
|
C18H15ClN6O3
|
1
|
| 1 |
IC50 = 340.4 nM
|
|
|
|
CP0544596
|
US10323032, Example 111
Show/Hide
|
C18H13F4N5O
|
1
|
| 1 |
IC50 = 353.2 nM
|
|
|
|
CP0419431
|
US10112937, Example 129
Show/Hide
|
C17H13ClFN5O
|
1
|
| 1 |
IC50 = 366.4 nM
|
|
|
|
CP0543965
|
US10047092, 50
Show/Hide
|
C17H16ClF3N4O
|
1
|
| 1 |
IC50 = 370.7 nM
|
|
|
|
CP0479707
|
5-chloro-2-hydroxy-N-[4-(trifluoromethyl)phenyl]benzamide
Show/Hide
|
C14H9ClF3NO2
|
1
|
| 1 |
IC50 = 371 nM
|
|
|
|
CP0386451
|
N'-(2,4-dichlorophenyl)adamantane-1-carbohydrazide
Show/Hide
|
C17H20Cl2N2O
|
1
|
| 1 |
IC50 = 371.54 nM
|
|
|
|
CP0555505
|
US10112937, Example 59
Show/Hide
|
C17H13F4N5O
|
1
|
| 1 |
IC50 = 378.4 nM
|
|
|
|
CP0395038
|
US10047092, 49
Show/Hide
|
C18H18ClF3N4O
|
1
|
| 1 |
IC50 = 386.4 nM
|
|
|
|
CP0429640
|
US10323032, Example 4
Show/Hide
|
C17H13Cl2N5O
|
1
|
| 1 |
IC50 = 388.2 nM
|
|
|
|
CP0406860
|
US10112937, Example 196
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 390.8 nM
|
|
|
|
CP0555923
|
US10112937, Example 103
Show/Hide
|
C20H17Cl2N3O
|
1
|
| 1 |
IC50 = 391.7 nM
|
|
|
|
CP0875430
|
US9096596, 76
Show/Hide
|
C20H17F4N5O
|
1
|
| 1 |
IC50 = 406.4 nM
|
|
|
|
CP0462770
|
N'-(2-methylphenyl)heptanehydrazide
Show/Hide
|
C14H22N2O
|
1
|
| 1 |
IC50 = 407.38 nM
|
|
|
|
CP0417817
|
US10323032, Example 11
Show/Hide
|
C19H14Cl2N4O
|
1
|
| 1 |
IC50 = 415.9 nM
|
|
|
|
CP0414124
|
US10047092, 2
Show/Hide
|
C16H12Cl2N6O
|
1
|
| 1 |
IC50 = 438.5 nM
|
|
|
|
CP0949207
|
US9096596, 61
Show/Hide
|
C21H20N6O
|
1
|
| 1 |
IC50 = 447.7 nM
|
|
|
|
CP0385160
|
US10323032, Example 28
Show/Hide
|
C21H16Cl2FN3O
|
1
|
| 1 |
IC50 = 451.9 nM
|
|
|
|
CP0470020
|
US10053462, 9
Show/Hide
|
C19H15ClF3N5OS
|
1
|
| 1 |
IC50 = 481.9 nM
|
|
|
|
CP0852359
|
US9096596, 135
Show/Hide
|
C20H20FN5O
|
1
|
| 1 |
IC50 = 492 nM
|
|
|
|
CP0481118
|
US10112937, Example 231
Show/Hide
|
C20H19Cl2N5O
|
1
|
| 1 |
IC50 = 498.9 nM
|
|
|
|
CP0453745
|
2-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C13H9Cl2N5
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0458004
|
US10112937, Example 221
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 505.8 nM
|
|
|
|
CP0912593
|
US9096596, 132
Show/Hide
|
C21H23N5O
|
1
|
| 1 |
IC50 = 532.1 nM
|
|
|
|
CP0488596
|
US10112937, Example 280
Show/Hide
|
C16H12ClFN6O
|
1
|
| 1 |
IC50 = 567.5 nM
|
|
|
|
CP0535917
|
US10112937, Example 180
Show/Hide
|
C18H16Cl2N6O
|
1
|
| 1 |
IC50 = 591.6 nM
|
|
|
|
CP0472736
|
5-chloro-N-(3-chlorophenyl)-2-hydroxybenzamide
Show/Hide
|
C13H9Cl2NO2
|
1
|
| 1 |
IC50 = 599 nM
|
|
|
|
CP0928567
|
US9464084, 268
Show/Hide
|
C17H15Cl2N5O
|
1
|
| 1 |
IC50 = 599.8 nM
|
|
|
|
CP0445139
|
US10112937, Example 272
Show/Hide
|
C16H12ClFN6O
|
1
|
| 1 |
IC50 = 622.3 nM
|
|
|
|
CP0520194
|
3-[[5-[3-fluoro-2-(trifluoromethyl)phenyl]tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C14H9F4N5
|
1
|
| 1 |
IC50 = 630.96 nM
|
|
|
|
CP0564179
|
US10112937, Example 257
Show/Hide
|
C16H12Cl2N6O
|
1
|
| 1 |
IC50 = 651.6 nM
|
|
|
|
CP0904299
|
US9096596, 120
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 656.1 nM
|
|
|
|
CP0488620
|
US10112937, Example 197
Show/Hide
|
C19H17F3N6O
|
1
|
| 1 |
IC50 = 662.2 nM
|
|
|
|
CP0454650
|
US10112937, Example 285
Show/Hide
|
C21H17ClF4N4O
|
1
|
| 1 |
IC50 = 671.4 nM
|
|
|
|
CP0545077
|
N-[(2-sulfamoylphenyl)carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C18H23N3O3S2
|
2
|
| 1 |
IC50 = 699 nM
|
|
|
| 2 |
IC50 = 796 nM
|
|
|
|
CP0495276
|
US10112937, Example 57
Show/Hide
|
C21H14F7N3O
|
1
|
| 1 |
IC50 = 717.8 nM
|
|
|
|
CP0470123
|
US10047092, 51
Show/Hide
|
C20H22ClF3N4O
|
1
|
| 1 |
IC50 = 765.6 nM
|
|
|
|
CP0526984
|
4-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C13H9Cl2N5
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0411512
|
US10323032, Example 29
Show/Hide
|
C20H16Cl2N4O
|
1
|
| 1 |
IC50 = 796.2 nM
|
|
|
|
CP0402500
|
N-[3,5-bis(trifluoromethyl)phenyl]-1-hydroxynaphthalene-2-carboxamide
Show/Hide
|
C19H11F6NO2
|
1
|
| 1 |
IC50 = 797 nM
|
|
|
|
CP0861478
|
US9096596, 3
Show/Hide
|
C21H20N6O
|
1
|
| 1 |
IC50 = 798 nM
|
|
|
|
CP0951045
|
US9096596, 85
Show/Hide
|
C19H17Cl2N5O
|
1
|
| 1 |
IC50 = 820.4 nM
|
|
|
|
CP0415703
|
US10047092, 83
Show/Hide
|
C18H15F3N6O2
|
1
|
| 1 |
IC50 = 822.2 nM
|
|
|
|
CP0439225
|
N'-pyridin-3-yladamantane-1-carbohydrazide
Show/Hide
|
C16H21N3O
|
1
|
| 1 |
IC50 = 831.76 nM
|
|
|
|
CP0544417
|
US10112937, Example 113
Show/Hide
|
C19H15ClF3N5O
|
1
|
| 1 |
IC50 = 855.1 nM
|
|
|
|
CP0387004
|
N-[3,5-bis(trifluoromethyl)phenyl]-3-fluoro-2-hydroxybenzamide
Show/Hide
|
C15H8F7NO2
|
1
|
| 1 |
IC50 = 857 nM
|
|
|
|
CP0443221
|
US10112937, Example 313
Show/Hide
|
C18H13Cl2FN4O
|
2
|
| 1 |
IC50 = 880 nM
|
|
|
| 2 |
IC50 = 1111.7 nM
|
|
|
|
CP0569984
|
N-[(4-hydroxyphenyl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
Show/Hide
|
C15H12N2O4S
|
2
|
| 1 |
IC50 = 902 nM
|
|
|
| 2 |
IC50 = 1112 nM
|
|
|
|
CP0859902
|
US9096596, 133
Show/Hide
|
C20H20FN5O
|
1
|
| 1 |
IC50 = 918.3 nM
|
|
|
|
CP0384829
|
US10047092, 12
Show/Hide
|
C17H14Cl2N6O
|
1
|
| 1 |
IC50 = 931.1 nM
|
|
|
|
CP0406870
|
US10112937, Example 20
Show/Hide
|
C21H16F5N3O
|
1
|
| 1 |
IC50 = 931.1 nM
|
|
|
|
CP0425398
|
US10047092, 5
Show/Hide
|
C16H12Cl2N6O
|
1
|
| 1 |
IC50 = 941.9 nM
|
|
|
|
CP0863204
|
US9096596, 117
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 968.3 nM
|
|
|
|
CP0492559
|
US10112937, Example 53
Show/Hide
|
C22H19ClF3N3O
|
1
|
| 1 |
IC50 = 975 nM
|
|
|
|
CP0462724
|
US10047092, 38
Show/Hide
|
C18H12ClF6N5OS
|
1
|
| 1 |
IC50 = 977.2 nM
|
|
|
|
CP0481451
|
N'-(4-methoxyphenyl)adamantane-1-carbohydrazide
Show/Hide
|
C18H24N2O2
|
1
|
| 1 |
IC50 = 977.24 nM
|
|
|
|
CP0458003
|
US10112937, Example 152
Show/Hide
|
C20H17ClF3N5O2
|
1
|
| 1 |
IC50 = 979.5 nM
|
|
|
|
CP0427143
|
US10047092, 90
Show/Hide
|
C17H14ClN7O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0867235
|
US9096596, 103
Show/Hide
|
C22H21ClF3N5O
|
1
|
| 1 |
IC50 = 1032.8 nM
|
|
|
|
CP0406856
|
US10150765, Example 179
Show/Hide
|
C19H18Cl2N6O
|
1
|
| 1 |
IC50 = 1056.8 nM
|
|
|
|
CP0529376
|
US10112937, Example 115
Show/Hide
|
C18H14Cl2N4O
|
1
|
| 1 |
IC50 = 1069.1 nM
|
|
|
|
CP0454647
|
US10112937, Example 244
Show/Hide
|
C19H16Cl2N4O
|
1
|
| 1 |
IC50 = 1142.9 nM
|
|
|
|
CP0191527
|
[2,6-dimethyl-4-(1H-pyrazol-5-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-(2-fluoro-3-methoxyphenyl)methanone
Show/Hide
|
C20H20FN5O2
|
1
|
| 1 |
IC50 = 1156.1 nM
|
|
|
|
CP0544275
|
US10112937, Example 236
Show/Hide
|
C18H12ClF3N6O
|
1
|
| 1 |
IC50 = 1185.8 nM
|
|
|
|
CP0495270
|
US10112937, Example 289
Show/Hide
|
C20H16ClF3N4O
|
1
|
| 1 |
IC50 = 1188.5 nM
|
|
|
|
CP0849369
|
US9096596, 100
Show/Hide
|
C21H19ClF3N5O
|
1
|
| 1 |
IC50 = 1194 nM
|
|
|
|
CP0546749
|
US10047092, 91
Show/Hide
|
C17H16ClN7O
|
1
|
| 1 |
IC50 = 1219 nM
|
|
|
|
CP0548425
|
N-[[3-bromo-5-(trifluoromethyl)phenyl]carbamothioyl]-1,3-benzodioxole-5-carboxamide
Show/Hide
|
C16H10BrF3N2O3S
|
1
|
| 1 |
IC50 = 1250 nM
|
|
|
|
CP0413502
|
US10112937, Example 201
Show/Hide
|
C18H13ClF4N6O
|
1
|
| 1 |
IC50 = 1250.3 nM
|
|
|
|
CP0545080
|
N-[(4-hydroxyphenyl)carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C18H22N2O2S
|
2
|
| 1 |
IC50 = 1259 nM
|
|
|
| 2 |
IC50 = 1395 nM
|
|
|
|
CP0902222
|
US9096596, 82
Show/Hide
|
C19H16Cl2FN5O
|
1
|
| 1 |
IC50 = 1315.2 nM
|
|
|
|
CP0515152
|
US10112937, Example 30
Show/Hide
|
C21H17ClF3N3O2
|
1
|
| 1 |
IC50 = 1367.7 nM
|
|
|
|
CP0294614
|
[2-chloro-3-(trifluoromethyl)phenyl]-[3-(4-fluorophenyl)-5-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C20H15ClF4N4O
|
1
|
| 1 |
IC50 = 1370 nM
|
|
|
|
CP0460105
|
7,7-dimethyl-2-oxo-N'-quinolin-5-ylbicyclo[2.2.1]heptane-1-carbohydrazide
Show/Hide
|
C19H21N3O2
|
1
|
| 1 |
IC50 = 1380.38 nM
|
|
|
|
CP0940774
|
US9096596, 72
Show/Hide
|
C19H16Cl2FN5O
|
1
|
| 1 |
IC50 = 1452.1 nM
|
|
|
|
CP0567790
|
N-[(2-hydroxyphenyl)carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C18H22N2O2S
|
1
|
| 1 |
IC50 = 1474 nM
|
|
|
|
CP0492935
|
US10112937, Example 157
Show/Hide
|
C18H13ClF4N6O
|
1
|
| 1 |
IC50 = 1534.6 nM
|
|
|
|
CP0476851
|
US10112937, Example 190
Show/Hide
|
C18H13F5N6O
|
1
|
| 1 |
IC50 = 1556 nM
|
|
|
|
CP0154756
|
(2,3-dichlorophenyl)-[(6R)-3-(4-fluorophenyl)-6-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C19H15Cl2FN4O
|
1
|
| 1 |
IC50 = 1560 nM
|
|
|
|
CP0868953
|
US9096596, 92
Show/Hide
|
C19H17ClFN5O
|
1
|
| 1 |
IC50 = 1592.2 nM
|
|
|
|
CP0516304
|
US10112937, Example 45
Show/Hide
|
C20H16ClF3N4O
|
1
|
| 1 |
IC50 = 1610.6 nM
|
|
|
|
CP0488341
|
US10112937, Example 41
Show/Hide
|
C20H15ClF4N4O
|
1
|
| 1 |
IC50 = 1611.8 nM
|
|
|
|
CP0548426
|
N-[(3,5-dichloro-4-hydroxyphenyl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
Show/Hide
|
C15H10Cl2N2O4S
|
1
|
| 1 |
IC50 = 1642 nM
|
|
|
|
CP0065306
|
(2,3-dichlorophenyl)-[3-(4-fluorophenyl)-5-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C19H15Cl2FN4O
|
1
|
| 1 |
IC50 = 1670 nM
|
|
|
|
CP0896808
|
US9096596, 59
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 1745.8 nM
|
|
|
|
CP0866387
|
US9096596, 69
Show/Hide
|
C19H17Cl2N5O
|
1
|
| 1 |
IC50 = 1786.5 nM
|
|
|
|
CP0403438
|
US10047092, 59
Show/Hide
|
C24H29ClF3N5O3
|
1
|
| 1 |
IC50 = 1790.6 nM
|
|
|
|
CP0577060
|
N-[(4-nitrophenyl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
Show/Hide
|
C15H11N3O5S
|
1
|
| 1 |
IC50 = 1886 nM
|
|
|
|
CP0538936
|
US10053462, 27
Show/Hide
|
C22H19ClF3N5O2
|
1
|
| 1 |
IC50 = 1905.5 nM
|
|
|
|
CP0474963
|
US10112937, Example 171
Show/Hide
|
C19H17ClF4N6O
|
1
|
| 1 |
IC50 = 2027.7 nM
|
|
|
|
CP0419430
|
US10112937, Example 128
Show/Hide
|
C17H14ClF3N6O
|
1
|
| 1 |
IC50 = 2108.6 nM
|
|
|
|
CP0406852
|
US10112937, Example 117
Show/Hide
|
C17H13ClFN5O
|
1
|
| 1 |
IC50 = 2218.2 nM
|
|
|
|
CP0397110
|
US10053462, 6
Show/Hide
|
C22H17ClF4N4O
|
1
|
| 1 |
IC50 = 2296.2 nM
|
|
|
|
CP0553576
|
US10112937, Example 145
Show/Hide
|
C20H17ClF3N5O2
|
1
|
| 1 |
IC50 = 2306.8 nM
|
|
|
|
CP0554088
|
US10112937, Example 247
Show/Hide
|
C19H15Cl2FN4O
|
1
|
| 1 |
IC50 = 2328.1 nM
|
|
|
|
CP0481121
|
US10112937, Example 256
Show/Hide
|
C19H15ClF2N4O
|
1
|
| 1 |
IC50 = 2387.8 nM
|
|
|
|
CP0577518
|
N-[(3,5-dichloro-4-hydroxyphenyl)carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C18H20Cl2N2O2S
|
1
|
| 1 |
IC50 = 2453 nM
|
|
|
|
CP0457298
|
US10112937, Example 149
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 2491.7 nM
|
|
|
|
CP0545082
|
1-amino-4-[4-[[4-chloro-6-(3-sulfinoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid
Show/Hide
|
C29H20ClN7O10S3
|
1
|
| 1 |
IC50 = 2492 nM
|
|
|
|
CP0554077
|
US10112937, Example 87
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 2505 nM
|
|
|
|
CP0488359
|
US10112937, Example 192
Show/Hide
|
C19H16Cl2N4O
|
1
|
| 1 |
IC50 = 2511.9 nM
|
|
|
|
CP0545078
|
N-[(2-chloro-5-nitrophenyl)carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C18H20ClN3O3S
|
1
|
| 1 |
IC50 = 2530 nM
|
|
|
|
CP0406863
|
US10112937, Example 241
Show/Hide
|
C21H18ClF3N4O
|
1
|
| 1 |
IC50 = 2582.3 nM
|
|
|
|
CP0472414
|
US10047092, 4
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 2685.3 nM
|
|
|
|
CP0483495
|
US10112937, Example 146
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 2704 nM
|
|
|
|
CP0942762
|
US9096596, 65
Show/Hide
|
C20H16ClF4N5O
|
1
|
| 1 |
IC50 = 2818.4 nM
|
|
|
|
CP0346941
|
US10112937, Example 314
Show/Hide
|
C19H13F5N4O
|
2
|
| 1 |
IC50 = 2831.4 nM
|
|
|
| 2 |
IC50 = 3538 nM
|
|
|
|
CP0516303
|
US10112937, Example 36
Show/Hide
|
C29H19Cl2F6N3O3
|
1
|
| 1 |
IC50 = 3083.2 nM
|
|
|
|
CP0862351
|
US9096596, 79
Show/Hide
|
C21H20F3N5O
|
1
|
| 1 |
IC50 = 3235.9 nM
|
|
|
|
CP0462702
|
US10047092, 7
Show/Hide
|
C17H15ClN6O3S
|
1
|
| 1 |
IC50 = 3404.1 nM
|
|
|
|
CP0408283
|
US10047092, 6
Show/Hide
|
C16H12F2N6O
|
1
|
| 1 |
IC50 = 3451.4 nM
|
|
|
|
CP0548427
|
N-[[2,6-dibromo-3-(trifluoromethyl)phenyl]carbamothioyl]-1,3-benzodioxole-5-carboxamide
Show/Hide
|
C16H9Br2F3N2O3S
|
1
|
| 1 |
IC50 = 3563 nM
|
|
|
|
CP0463167
|
US10053462, 24
Show/Hide
|
C22H19ClF3N5O
|
1
|
| 1 |
IC50 = 3698.3 nM
|
|
|
|
CP0578532
|
N-[(2-bromo-4-methylphenyl)carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C19H23BrN2OS
|
1
|
| 1 |
IC50 = 3707 nM
|
|
|
|
CP0408266
|
(2R)-1-[2-(2-iodo-4,5-dimethoxyphenyl)acetyl]-2-phenyl-2,3-dihydropyridin-4-one
Show/Hide
|
C21H20INO4
|
1
|
| 1 |
IC50 = 3800 nM
|
|
|
|
CP0545726
|
US10047092, 53
Show/Hide
|
C19H20ClF3N4O2
|
1
|
| 1 |
IC50 = 3872.6 nM
|
|
|
|
CP0526982
|
3-[[5-(3,4-dichlorophenyl)tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C13H9Cl2N5
|
1
|
| 1 |
IC50 = 3981.07 nM
|
|
|
|
CP0532351
|
1-[(2-chlorophenyl)methyl]-5-(2,3-dimethoxyphenyl)tetrazole
Show/Hide
|
C16H15ClN4O2
|
1
|
| 1 |
IC50 = 3981.07 nM
|
|
|
|
CP0458584
|
US10112937, Example 194
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 3981.1 nM
|
|
|
|
CP0545081
|
N-[[3-bromo-5-(trifluoromethyl)phenyl]carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C19H20BrF3N2OS
|
1
|
| 1 |
IC50 = 4024 nM
|
|
|
|
CP0517771
|
[(6S)-1-(5-fluoropyrimidin-2-yl)-6-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridin-5-yl]-[5-(trifluoromethyl)-1H-pyrazol-4-yl]methanone
Show/Hide
|
C15H12F4N8O
|
1
|
| 1 |
IC50 = 4034 nM
|
|
|
|
CP0408298
|
US10047092, 15
Show/Hide
|
C18H14ClF3N6O
|
2
|
| 1 |
IC50 = 4710 nM
|
|
|
| 2 |
IC50 = 9247 nM
|
|
|
|
CP0569002
|
N-[(3,4-dimethoxyphenyl)carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C20H26N2O3S
|
1
|
| 1 |
IC50 = 4896 nM
|
|
|
|
CP0384846
|
US10323032, Example 48
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 5011.9 nM
|
|
|
|
CP0516300
|
US10112937, Example 43
Show/Hide
|
C20H16F4N4O
|
1
|
| 1 |
IC50 = 5236 nM
|
|
|
|
CP0481119
|
US10112937, Example 232
Show/Hide
|
C18H13F5N6O
|
1
|
| 1 |
IC50 = 5597.6 nM
|
|
|
|
CP0417261
|
US10053462, 11
Show/Hide
|
C21H16ClF4N5O
|
1
|
| 1 |
IC50 = 5688.5 nM
|
|
|
|
CP0451603
|
US10112937, Example 211
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 = 6309.6 nM
|
|
|
|
CP0472737
|
5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide
Show/Hide
|
C14H9ClF3NO2
|
1
|
| 1 |
IC50 = 6320 nM
|
|
|
|
CP0963000
|
US9464084, 134
Show/Hide
|
C17H14ClF3N6O
|
1
|
| 1 |
IC50 = 6698.9 nM
|
|
|
|
CP0402630
|
US9464084, 306
Show/Hide
|
C20H16ClF4N5O
|
1
|
| 1 |
IC50 = 6870.7 nM
|
|
|
|
CP0515227
|
US10112937, Example 286
Show/Hide
|
C21H17ClF4N4O
|
1
|
| 1 |
IC50 = 6902.4 nM
|
|
|
|
CP0507336
|
US10112937, Example 303
Show/Hide
|
C25H28ClF4N5O2Si
|
1
|
| 1 |
IC50 = 6918.3 nM
|
|
|
|
CP0425104
|
US10047092, 79
Show/Hide
|
C17H16N6O
|
2
|
| 1 |
IC50 = 6960 nM
|
|
|
| 2 |
IC50 = 9616.1 nM
|
|
|
|
CP0476852
|
US10112937, Example 219
Show/Hide
|
C18H13F5N6O
|
1
|
| 1 |
IC50 = 7413.1 nM
|
|
|
|
CP0543809
|
3-[[5-(3-chlorophenyl)tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C13H10ClN5
|
1
|
| 1 |
IC50 = 7943.28 nM
|
|
|
|
CP0468160
|
US10047092, 95
Show/Hide
|
C18H18N6O
|
1
|
| 1 |
IC50 = 8241.4 nM
|
|
|
|
CP0535940
|
US10112937, Example 214
Show/Hide
|
C17H12Cl2F2N6O
|
1
|
| 1 |
IC50 = 8491.8 nM
|
|
|
|
CP0429999
|
[[(2R,3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2-phenyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;azane
Show/Hide
|
C17H32N9O13P3
|
1
|
| 1 |
IC50 = 8530 nM
|
|
|
|
CP0483504
|
US10112937, Example 207
Show/Hide
|
C19H16F4N6O
|
1
|
| 1 |
IC50 = 8550.7 nM
|
|
|
|
CP0578260
|
N-[(4-bromophenyl)carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C18H21BrN2OS
|
1
|
| 1 |
IC50 = 8801 nM
|
|
|
|
CP0488619
|
US10112937, Example 186
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 9036.5 nM
|
|
|
|
CP0516343
|
US10112937, Example 141
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 9594 nM
|
|
|
|
CP0529378
|
US10112937, Example 165
Show/Hide
|
C18H14Cl2FN5O
|
1
|
| 1 |
IC50 = 9794.9 nM
|
|
|
|
CP0461670
|
1-benzyl-5-(2,3-dimethyl-4-pyrrolidin-1-ylphenyl)tetrazole
Show/Hide
|
C20H23N5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0065304
|
(2,3-dichlorophenyl)-[(8S)-8-methyl-3-pyridin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Show/Hide
|
C18H15Cl2N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0429635
|
US10047092, 60
Show/Hide
|
C19H21ClF3N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0407611
|
US10323032, Example 127
Show/Hide
|
C23H23ClF3N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0470359
|
US10323032, Example 110
Show/Hide
|
C17H12ClF3N6O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0913943
|
US9096596, 94
Show/Hide
|
C19H17F2N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0550852
|
US10053462, 2
Show/Hide
|
C20H16ClF3N6O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0552194
|
(2R)-N-(2-bromo-4-chloro-5-methoxyphenyl)-4-oxo-2-phenyl-2,3-dihydropyridine-1-carboxamide
Show/Hide
|
C19H16BrClN2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0403803
|
5-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-pyrazin-2-yl-6,7-dihydrotriazolo[4,5-c]pyridin-4-one
Show/Hide
|
C17H12ClF3N6O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0419461
|
US10112937, Example 328
Show/Hide
|
C19H16Cl2N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0445137
|
US10112937, Example 159
Show/Hide
|
C21H19ClF3N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0451605
|
US10112937, Example 307
Show/Hide
|
C18H13F5N6O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0466130
|
US10112937, Example 327
Show/Hide
|
C20H16ClF3N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0483494
|
US10112937, Example 143
Show/Hide
|
C17H13Cl2FN6O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0488593
|
US10112937, Example 264
Show/Hide
|
C19H16F2N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0492937
|
US10112937, Example 160
Show/Hide
|
C20H19Cl2N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0512276
|
US10112937, Example 317
Show/Hide
|
C21H19ClF3N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0554753
|
US10112937, Example 295
Show/Hide
|
C21H20F3N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0557208
|
US10112937, Example 329
Show/Hide
|
C18H15Cl2N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0558627
|
US10112937, Example 330
Show/Hide
|
C17H13Cl2N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0564186
|
US10112937, Example 334
Show/Hide
|
C18H14ClF3N6O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0926473
|
US9464084, 308
Show/Hide
|
C16H12ClF6N3O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0926474
|
US9464084, 319
Show/Hide
|
C18H16ClF3N6O
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0476685
|
US10112937, Example 292
Show/Hide
|
C20H17ClF3N5O
|
1
|
| 1 |
IC50 = 10447.2 nM
|
|
|
|
CP0451546
|
US10112937, Example 167
Show/Hide
|
C19H14ClF4N5O
|
1
|
| 1 |
IC50 = 10471.3 nM
|
|
|
|
CP0830551
|
US9096596, 88
Show/Hide
|
C19H17ClFN5O
|
1
|
| 1 |
IC50 = 11040.8 nM
|
|
|
|
CP0953540
|
US9096596, 131
Show/Hide
|
C21H23N5O
|
1
|
| 1 |
IC50 = 11402.5 nM
|
|
|
|
CP0509255
|
US10047092, 58
Show/Hide
|
C23H27ClF3N5O3
|
1
|
| 1 |
IC50 = 12218 nM
|
|
|
|
CP0526983
|
3-[2-[5-(2,3-dichlorophenyl)tetrazol-1-yl]ethyl]pyridine
Show/Hide
|
C14H11Cl2N5
|
1
|
| 1 |
IC50 = 12589.25 nM
|
|
|
|
CP0472392
|
US10323032, Example 5
Show/Hide
|
C18H15Cl2N5O
|
1
|
| 1 |
IC50 = 12764.4 nM
|
|
|
|
CP0571691
|
N-[(2-bromo-4-propan-2-ylphenyl)carbamothioyl]-1,3-benzodioxole-5-carboxamide
Show/Hide
|
C18H17BrN2O3S
|
1
|
| 1 |
IC50 = 13105 nM
|
|
|
|
CP0402974
|
US10323032, Example 16
Show/Hide
|
C18H12ClF2N5O
|
1
|
| 1 |
IC50 = 13182.6 nM
|
|
|
|
CP0529710
|
3-[[5-(2-chlorophenyl)tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C13H10ClN5
|
1
|
| 1 |
IC50 = 15848.93 nM
|
|
|
|
CP0532349
|
5-(1-benzyltetrazol-5-yl)quinoline
Show/Hide
|
C17H13N5
|
1
|
| 1 |
IC50 = 15848.93 nM
|
|
|
|
CP0559644
|
3-[[5-(2,5-dichlorophenyl)tetrazol-1-yl]methyl]pyridine
Show/Hide
|
C13H9Cl2N5
|
1
|
| 1 |
IC50 = 15848.93 nM
|
|
|
|
CP0449516
|
3-[(5-phenyltetrazol-1-yl)methyl]pyridine
Show/Hide
|
C13H11N5
|
1
|
| 1 |
IC50 = 25118.86 nM
|
|
|
|
CP0456954
|
8-(1-benzyltetrazol-5-yl)quinoline
Show/Hide
|
C17H13N5
|
1
|
| 1 |
IC50 = 25118.86 nM
|
|
|
|
CP0550005
|
N-[(2-bromo-4-propan-2-ylphenyl)carbamothioyl]adamantane-1-carboxamide
Show/Hide
|
C21H27BrN2OS
|
1
|
| 1 |
IC50 = 25230 nM
|
|
|
|
CP0430000
|
5-[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxycarbonyl]benzene-1,2,4-tricarboxylic acid
Show/Hide
|
C23H21N5O11
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0493771
|
(2S)-2-[[(3aR,4R,6S,6aS)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole-6-carbonyl]amino]pentanedioic acid
Show/Hide
|
C18H22N6O8
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0455096
|
4-(1-benzyltetrazol-5-yl)pyridine
Show/Hide
|
C13H11N5
|
1
|
| 1 |
IC50 = 31622.78 nM
|
|
|
|
CP0014670
|
CHEMBL3040216
Show/Hide
|
C51H40N6O23S6
|
3
|
| 1 |
IC50 = 33210 nM
|
|
|
| 2 |
IC50 = 34820 nM
|
|
|
| 3 |
IC50 = 35190 nM
|
|
|
|
CP0246924
|
N-cyclohexylbenzo[b][1]benzazepine-11-carboxamide
Show/Hide
|
C21H22N2O
|
1
|
| 1 |
IC50 = 40800 nM
|
|
|
|
CP0134749
|
N,N-diethylbenzo[b][1]benzazepine-11-carboxamide
Show/Hide
|
C19H20N2O
|
1
|
| 1 |
IC50 = 69800 nM
|
|
|
|
CP0246925
|
N,N-di(propan-2-yl)benzo[b][1]benzazepine-11-carboxamide
Show/Hide
|
C21H24N2O
|
1
|
| 1 |
IC50 = 95200 nM
|
|
|
|
CP0054492
|
benzo[b][1]benzazepin-11-yl(pyrrolidin-1-yl)methanone
Show/Hide
|
C19H18N2O
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0054493
|
N,N-dipropylbenzo[b][1]benzazepine-11-carboxamide
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C21H24N2O
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1
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| 1 |
IC50 > 100000 nM
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CP0167727
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benzo[b][1]benzazepin-11-yl(piperidin-1-yl)methanone
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C20H20N2O
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1
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| 1 |
IC50 > 100000 nM
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CP0149500
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[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)spiro[3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole-2,1'-cyclohexane]-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;azane
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C16H36N9O13P3
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1
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| 1 |
IC50 > 100000 nM
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CP0149504
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[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)spiro[3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole-2,1'-cyclohexane]-6-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid;azane
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C17H38N9O12P3
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1
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| 1 |
IC50 > 100000 nM
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CP0232343
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[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;azane
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C13H32N9O13P3
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1
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| 1 |
IC50 > 100000 nM
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CP0347185
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[[(2S,3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2-phenyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;azane
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C17H32N9O13P3
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1
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| 1 |
IC50 > 100000 nM
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CP0487903
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[[(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;azane
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C11H28N9O13P3
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1
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| 1 |
IC50 > 100000 nM
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