| Compound ID |
Compound Name |
Compound Formula |
|
CP0565876
|
4-[6-(prop-2-enoylamino)quinazolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C23H17N5O3
|
1
|
| 1 |
EC50 = 7.2 nM
|
|
|
|
CP0571590
|
4-[[6-(prop-2-enoylamino)quinazolin-4-yl]amino]-N-pyridin-2-ylbenzamide
Show/Hide
|
C23H18N6O2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0578156
|
US9481682, 63
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 0.058 nM
|
|
|
|
CP0563673
|
US9481682, 92
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 0.075 nM
|
|
|
|
CP0561406
|
US9481682, 68
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 0.081 nM
|
|
|
|
CP0555323
|
US9481682, 12
Show/Hide
|
C26H21F4N7O3
|
1
|
| 1 |
IC50 = 0.083 nM
|
|
|
|
CP0255830
|
4-[8-amino-3-[(6R,8aS)-3-oxo-1,5,6,7,8,8a-hexahydro-[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C26H22F3N7O3
|
1
|
| 1 |
IC50 = 0.083 nM
|
|
|
|
CP0387644
|
US9481682, 65
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 0.085 nM
|
|
|
|
CP0512882
|
US9481682, 83
Show/Hide
|
C28H27F3N8O2
|
1
|
| 1 |
IC50 = 0.092 nM
|
|
|
|
CP0492948
|
US9481682, 44
Show/Hide
|
C28H25F4N7O2
|
1
|
| 1 |
IC50 = 0.095 nM
|
|
|
|
CP0563671
|
US9481682, 31
Show/Hide
|
C27H23F4N7O3
|
1
|
| 1 |
IC50 = 0.096 nM
|
|
|
|
CP0255828
|
US9481682, 4
Show/Hide
|
C27H24F3N7O2
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0056961
|
(1S,3R)-3-[8-amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]-1,3-dimethylcyclohexane-1-carboxylic acid
Show/Hide
|
C28H27F3N6O3
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0196918
|
4-(8-amino-1-(2- fluoro-4-((4- (trifluoromethyl) pyridin-2- yl)carbamoyl)phenyl) imidazo[1,5-a]pyrazin- 3-yl)cubane-1- carboxylic acid
Show/Hide
|
C28H18F4N6O3
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0244548
|
(1R,3R,5S,6r)-3-[8- amino-1-(4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3- yl]bicyclo[3.1.0] hexane-6-carboxylic acid
Show/Hide
|
C26H21F3N6O3
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0313624
|
4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-N-(4-chloropyridin-2-yl)-3-fluorobenzamide
Show/Hide
|
C26H23F4N7O2
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0479632
|
US9481682, 39
Show/Hide
|
C27H23F4N7O3
|
2
|
| 1 |
IC50 = 0.1 nM
|
|
|
| 2 |
IC50 = 0.12 nM
|
|
|
|
CP0405842
|
US9481682, 23
Show/Hide
|
C27H23F4N7O2
|
1
|
| 1 |
IC50 = 0.11 nM
|
|
|
|
CP0405845
|
US9481682, 49
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 0.11 nM
|
|
|
|
CP0490871
|
US9481682, 14
Show/Hide
|
C27H24F3N7O2
|
1
|
| 1 |
IC50 = 0.12 nM
|
|
|
|
CP0229478
|
US9481682, 52
Show/Hide
|
C28H26F3N7O3
|
2
|
| 1 |
IC50 = 0.12 nM
|
|
|
| 2 |
IC50 = 0.13 nM
|
|
|
|
CP0387643
|
US9481682, 59
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 0.13 nM
|
|
|
|
CP0387717
|
US9481682, 77
Show/Hide
|
C28H26F3N7O3
|
1
|
| 1 |
IC50 = 0.13 nM
|
|
|
|
CP0428814
|
US9481682, 43
Show/Hide
|
C29H28FN7O3
|
1
|
| 1 |
IC50 = 0.13 nM
|
|
|
|
CP0559271
|
US9481682, 89
Show/Hide
|
C28H26F3N7O4
|
1
|
| 1 |
IC50 = 0.13 nM
|
|
|
|
CP0561405
|
US9481682, 66
Show/Hide
|
C29H29F3N8O3
|
1
|
| 1 |
IC50 = 0.13 nM
|
|
|
|
CP0063954
|
US10005782, Compound 63
Show/Hide
|
C24H21N5O3
|
1
|
| 1 |
IC50 = 0.13 nM
|
|
|
|
CP0070022
|
US10005782, Compound 136
Show/Hide
|
C26H25N5O3
|
1
|
| 1 |
IC50 = 0.13 nM
|
|
|
|
CP0559267
|
US9481682, 48
Show/Hide
|
C27H24F3N7O3
|
2
|
| 1 |
IC50 = 0.13 nM
|
|
|
| 2 |
IC50 = 0.14 nM
|
|
|
|
CP0387720
|
US9481682, 94
Show/Hide
|
C29H28F3N7O2
|
1
|
| 1 |
IC50 = 0.14 nM
|
|
|
|
CP0361457
|
US10005782, Compound 52
Show/Hide
|
C24H21N5O3
|
1
|
| 1 |
IC50 = 0.14 nM
|
|
|
|
CP0163693
|
US10005782, Compound 123
Show/Hide
|
C25H23N5O3
|
1
|
| 1 |
IC50 = 0.15 nM
|
|
|
|
CP0516869
|
4-[8-amino-3-[(3R,6S)-1-[(2S)-2-hydroxypropanoyl]-6-methylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C28H27F4N7O3
|
1
|
| 1 |
IC50 = 0.15 nM
|
|
|
|
CP0565874
|
4-[6-(4-methoxybut-2-ynoylamino)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C26H20N4O4
|
1
|
| 1 |
IC50 = 0.15 nM
|
|
|
|
CP0540645
|
US9481682, 18
Show/Hide
|
C28H29N7O2
|
1
|
| 1 |
IC50 = 0.16 nM
|
|
|
|
CP0559269
|
US9481682, 69
Show/Hide
|
C29H28F3N7O3
|
1
|
| 1 |
IC50 = 0.16 nM
|
|
|
|
CP0576467
|
US9481682, 153
Show/Hide
|
C27H23ClF3N7O2
|
1
|
| 1 |
IC50 = 0.16 nM
|
|
|
|
CP0536951
|
US9481682, 217
Show/Hide
|
C28H24ClF4N7O3
|
1
|
| 1 |
IC50 = 0.17 nM
|
|
|
|
CP0540726
|
US9481682, 33
Show/Hide
|
C27H23F4N7O3
|
1
|
| 1 |
IC50 = 0.17 nM
|
|
|
|
CP0547482
|
US9481682, 47
Show/Hide
|
C29H29N7O3
|
1
|
| 1 |
IC50 = 0.17 nM
|
|
|
|
CP0557169
|
4-[3-[(3R,6S)-1-acetyl-6-methylpiperidin-3-yl]-8-aminoimidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H25F4N7O2
|
1
|
| 1 |
IC50 = 0.17 nM
|
|
|
|
CP0562810
|
4-{8-amino-3-[(3R,6S)-1-(cyclopropylcarbonyl)-6-methylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl}-N-pyridin-2-ylbenzamide
Show/Hide
|
C30H29F4N7O3
|
1
|
| 1 |
IC50 = 0.17 nM
|
|
|
|
CP0512883
|
US9481682, 90
Show/Hide
|
C29H28F3N7O4
|
1
|
| 1 |
IC50 = 0.18 nM
|
|
|
|
CP0559264
|
US9481682, 19
Show/Hide
|
C29H29N7O2
|
1
|
| 1 |
IC50 = 0.18 nM
|
|
|
|
CP0559270
|
US9481682, 82
Show/Hide
|
C30H29F3N8O4
|
1
|
| 1 |
IC50 = 0.19 nM
|
|
|
|
CP0559274
|
US9481682, 106
Show/Hide
|
C30H27N7O2
|
1
|
| 1 |
IC50 = 0.19 nM
|
|
|
|
CP0350897
|
US10005782, Compound 54
Show/Hide
|
C27H28N6O3
|
1
|
| 1 |
IC50 = 0.19 nM
|
|
|
|
CP0549568
|
4-[8-amino-3-[(3R,6S)-1-[(2R)-2-hydroxypropanoyl]-6-methylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C28H27F4N7O3
|
1
|
| 1 |
IC50 = 0.19 nM
|
|
|
|
CP0465876
|
US9481682, 222
Show/Hide
|
C31H32F3N7O3
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0516906
|
US9481682, 16
Show/Hide
|
C29H28FN7O2
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0092554
|
(1S,3R)-3-[8-amino-1- (4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3-yl]-1,3- dimethylcyclopentane carboxylic acid
Show/Hide
|
C27H25F3N6O3
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0114109
|
4-[8-amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]bicyclo[2.2.1]heptane-1-carboxylic acid
Show/Hide
|
C27H23F3N6O3
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0118988
|
4-[8-amino-1-(4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3- yl]bicyclo[2.2.2] octane-1-carboxylic acid
Show/Hide
|
C28H25F3N6O3
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0250873
|
4-[8-amino-3-[(1R,3S)-3-carbamoylcyclohexyl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C26H24F3N7O2
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0072649
|
4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbonyl]azepan-3-yl}imidazo[1,5-a]pyrazin-1-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H25F4N7O3
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0419198
|
US9481682, 102
Show/Hide
|
C33H28F3N9O3
|
1
|
| 1 |
IC50 = 0.21 nM
|
|
|
|
CP0492946
|
US9481682, 32
Show/Hide
|
C29H28FN7O3
|
1
|
| 1 |
IC50 = 0.21 nM
|
|
|
|
CP0516905
|
US9481682, 15
Show/Hide
|
C27H23FN8O2
|
1
|
| 1 |
IC50 = 0.21 nM
|
|
|
|
CP0526121
|
US9481682, 21
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 0.21 nM
|
|
|
|
CP0312491
|
US9481682, 116
Show/Hide
|
C28H26F3N7O3
|
1
|
| 1 |
IC50 = 0.21 nM
|
|
|
|
CP0413156
|
US9481682, 143
Show/Hide
|
C28H25ClF3N7O3
|
1
|
| 1 |
IC50 = 0.22 nM
|
|
|
|
CP0466001
|
US9481682, 108
Show/Hide
|
C29H27F3N8O4
|
1
|
| 1 |
IC50 = 0.22 nM
|
|
|
|
CP0547481
|
US9481682, 40
Show/Hide
|
C27H25F3N8O2
|
1
|
| 1 |
IC50 = 0.22 nM
|
|
|
|
CP0553319
|
4-[8-amino-3-[(3R,6S)-6-methyl-1-(oxolane-2-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C30H29F4N7O3
|
1
|
| 1 |
IC50 = 0.22 nM
|
|
|
|
CP0486340
|
US9481682, 135
Show/Hide
|
C28H28ClF3N8O3
|
1
|
| 1 |
IC50 = 0.23 nM
|
|
|
|
CP0490875
|
US9481682, 105
Show/Hide
|
C34H29F3N8O3
|
1
|
| 1 |
IC50 = 0.23 nM
|
|
|
|
CP0535914
|
oxolan-2-ylmethyl 2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetate
Show/Hide
|
C26H26ClN5O5
|
1
|
| 1 |
IC50 = 0.23 nM
|
|
|
|
CP0484115
|
US9481682, 5
Show/Hide
|
C29H29N7O3
|
1
|
| 1 |
IC50 = 0.24 nM
|
|
|
|
CP0150519
|
4-[8-amino-3-[(3R)-1-(2-methylpropanoyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C28H27F4N7O2
|
1
|
| 1 |
IC50 = 0.25 nM
|
|
|
|
CP0428815
|
US9481682, 50
Show/Hide
|
C28H27F3N8O2
|
1
|
| 1 |
IC50 = 0.26 nM
|
|
|
|
CP0490876
|
US9481682, 107
Show/Hide
|
C26H22F3N7O3
|
1
|
| 1 |
IC50 = 0.26 nM
|
|
|
|
CP0426392
|
4-[6-(4-morpholin-4-ylbut-2-ynoylamino)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C29H25N5O4
|
1
|
| 1 |
IC50 = 0.26 nM
|
|
|
|
CP0568431
|
4-[3-[(7R,9aS)-2-methyl-4-oxo-3,6,7,8,9,9a-hexahydro-1H-pyrido[1,2-a]pyrazin-7-yl]-8-aminoimidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C28H26F4N8O2
|
1
|
| 1 |
IC50 = 0.26 nM
|
|
|
|
CP0486376
|
US9481682, 128
Show/Hide
|
C29H27ClF3N7O3
|
1
|
| 1 |
IC50 = 0.27 nM
|
|
|
|
CP0512881
|
US9481682, 80
Show/Hide
|
C29H29F3N8O2
|
1
|
| 1 |
IC50 = 0.27 nM
|
|
|
|
CP0189278
|
(R)-4-(8-amino-5-deutero-3-(1-(3-methoxypropanoyl) piperidin-3-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide
Show/Hide
|
C29H28F3N7O3
|
2
|
| 1 |
IC50 = 0.27 nM
|
|
|
| 2 |
IC50 = 0.3 nM
|
|
|
|
CP0405013
|
US9481682, 219
Show/Hide
|
C30H29F4N7O3
|
1
|
| 1 |
IC50 = 0.28 nM
|
|
|
|
CP0492994
|
US9481682, 160
Show/Hide
|
C27H23F4N7O2
|
1
|
| 1 |
IC50 = 0.28 nM
|
|
|
|
CP0507374
|
US9481682, 134
Show/Hide
|
C28H25F4N7O3
|
1
|
| 1 |
IC50 = 0.28 nM
|
|
|
|
CP0559268
|
US9481682, 57
Show/Hide
|
C27H25F3N8O2
|
1
|
| 1 |
IC50 = 0.28 nM
|
|
|
|
CP0572205
|
4-{8-amino-3-[(3R,6S)-1-(cyclopropylcarbonyl)-6-methylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl}-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C28H27F4N7O2
|
1
|
| 1 |
IC50 = 0.28 nM
|
|
|
|
CP0492952
|
US9481682, 81
Show/Hide
|
C30H31F3N8O2
|
1
|
| 1 |
IC50 = 0.29 nM
|
|
|
|
CP0007430
|
IBRUTINIB
Show/Hide
|
C25H24N6O2
|
11
|
| 1 |
IC50 = 0.3 nM
|
|
|
| 2 |
IC50 = 0.34 nM
|
|
|
| 3 |
IC50 = 0.4 nM
|
|
|
| 4 |
IC50 = 0.5 nM
|
|
|
| 5 |
IC50 = 1 nM
|
|
|
| 6 |
IC50 = 1.8 nM
|
|
|
| 7 |
IC50 = 3.4 nM
|
|
|
| 8 |
IC50 = 3.89 nM
|
|
|
| 9 |
IC50 = 12 nM
|
|
|
| 10 |
IC50 = 17 nM
|
|
|
| 11 |
Ki = 4.8 nM
|
|
|
|
CP0507475
|
US9481682, 55
Show/Hide
|
C27H26F3N7O2
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0092548
|
4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H27F4N7O2
|
2
|
| 1 |
IC50 = 0.3 nM
|
|
|
| 2 |
IC50 = 0.31 nM
|
|
|
|
CP0196920
|
4-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3- yl]bicyclo[2.2.2] octane-1-carboxylic acid
Show/Hide
|
C30H29F3N6O4
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0244546
|
4-[8-amino-3-[(1R,3S)-3-(1-methyltetrazol-5-yl)cyclohexyl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H25F3N10O
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0244549
|
5-[8-amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]bicyclo[3.2.2]nonane-1-carboxylic acid
Show/Hide
|
C29H27F3N6O3
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0562980
|
4-[8-amino-3-[(1R,3S)-3-(1H-1,2,4-triazol-5-yl)cyclohexyl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H24F3N9O
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0180499
|
4-[8-amino-3-[(3R)-1-(1-methylcyclobutanecarbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C30H29F4N7O2
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0060760
|
US9447106, 27b (peak 2)
Show/Hide
|
C27H29N5O3
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0551909
|
US9481682, 17
Show/Hide
|
C27H25F2N7O2
|
1
|
| 1 |
IC50 = 0.31 nM
|
|
|
|
CP0557171
|
4-(8-amino-3-{(3S,6S)-6-(methoxymethyl)-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C31H32F3N7O4
|
1
|
| 1 |
IC50 = 0.31 nM
|
|
|
|
CP0234526
|
US10005782, Compound 67
Show/Hide
|
C25H19N5O3
|
1
|
| 1 |
IC50 = 0.32 nM
|
|
|
|
CP0322034
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H27F4N7O3
|
1
|
| 1 |
IC50 = 0.32 nM
|
|
|
|
CP0574774
|
4-[8-amino-3-[(3R,6S)-1-(2-hydroxy-2-methylpropanoyl)-6-methylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H29F4N7O3
|
1
|
| 1 |
IC50 = 0.32 nM
|
|
|
|
CP0491863
|
US9446130, 2
Show/Hide
|
C27H23F3N8O2
|
1
|
| 1 |
IC50 = 0.33 nM
|
|
|
|
CP0565875
|
4-[6-(4-hydroxybut-2-ynoylamino)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C25H18N4O4
|
1
|
| 1 |
IC50 = 0.33 nM
|
|
|
|
CP0402753
|
US9481682, 166
Show/Hide
|
C27H22F5N7O2
|
1
|
| 1 |
IC50 = 0.34 nM
|
|
|
|
CP0440278
|
US10005782, Compound 121
Show/Hide
|
C25H23N5O3
|
1
|
| 1 |
IC50 = 0.36 nM
|
|
|
|
CP0570321
|
4-{8-amino-3-[(3R,6S)-6-methyl-1-propanoylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl}-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H29F4N7O3
|
1
|
| 1 |
IC50 = 0.36 nM
|
|
|
|
CP0072648
|
4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C26H23F4N7O4
|
1
|
| 1 |
IC50 = 0.37 nM
|
|
|
|
CP0577624
|
4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-3-fluoro-N-(4-propoxypyridin-2-yl)benzamide
Show/Hide
|
C29H27FN8O3
|
1
|
| 1 |
IC50 = 0.37 nM
|
|
|
|
CP0465986
|
US9481682, 37
Show/Hide
|
C29H28FN7O3
|
1
|
| 1 |
IC50 = 0.39 nM
|
|
|
|
CP0517260
|
US9481682, 194
Show/Hide
|
C27H22Cl2F3N7O2
|
1
|
| 1 |
IC50 = 0.39 nM
|
|
|
|
CP0179426
|
N-[3-[2-[4-(3-morpholin-4-ylpropoxy)anilino]purin-9-yl]phenyl]prop-2-enamide
Show/Hide
|
C27H29N7O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0470665
|
US9481682, 220
Show/Hide
|
C28H24F5N7O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0563323
|
US9481682, 103
Show/Hide
|
C28H27N7O4
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0081924
|
(1R,2R,5R)-5-[8- amino-1-(4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3-yl]-2-(1- methylethyl) cyclohexane- carboxylic acid
Show/Hide
|
C29H29F3N6O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0114110
|
(1R,3R)-3-[8-amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]-3-methyl-1-propan-2-ylcyclopentane-1-carboxylic acid
Show/Hide
|
C29H29F3N6O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0114115
|
US10087188, Example 1
Show/Hide
|
C26H23F3N6O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0323446
|
3-[8-amino-1-(4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3- yl]bicyclo[1.1.1] pentane-1-carboxylic acid
Show/Hide
|
C25H19F3N6O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0108285
|
4-[8-amino-3-[(2R)-4-(2-methylpropanoyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H25F4N7O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0261533
|
4-[8-amino-3-[(2R,5S)-4-(cyclopropanecarbonyl)-5-methylmorpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C28H25F4N7O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0475905
|
4-[3-[(2R)-4-acetylmorpholin-2-yl]-8-aminoimidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C25H21F4N7O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0470660
|
US9481682, 171
Show/Hide
|
C26H25F3N8O2
|
1
|
| 1 |
IC50 = 0.41 nM
|
|
|
|
CP0478330
|
US9481682, 209
Show/Hide
|
C31H32ClN7O3
|
1
|
| 1 |
IC50 = 0.41 nM
|
|
|
|
CP0540646
|
US9481682, 22
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 0.41 nM
|
|
|
|
CP0552116
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(4-ethoxypyridin-2-yl)-3-fluorobenzamide
Show/Hide
|
C30H32FN7O4
|
1
|
| 1 |
IC50 = 0.41 nM
|
|
|
|
CP0578789
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-2,3-difluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H26F5N7O3
|
1
|
| 1 |
IC50 = 0.41 nM
|
|
|
|
CP0560511
|
N-[3-[5-chloro-2-[4-[(4-methoxyphenyl)sulfonylamino]anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Show/Hide
|
C26H22ClN5O5S
|
1
|
| 1 |
IC50 = 0.42 nM
|
|
|
|
CP0552115
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-[chloro(difluoro)methoxy]pyridin-2-yl]-3-fluorobenzamide
Show/Hide
|
C29H27ClF3N7O4
|
1
|
| 1 |
IC50 = 0.42 nM
|
|
|
|
CP0384036
|
US9481682, 145
Show/Hide
|
C29H28ClF3N8O3
|
1
|
| 1 |
IC50 = 0.44 nM
|
|
|
|
CP0576463
|
US9446130, 16
Show/Hide
|
C27H24F3N9O2
|
1
|
| 1 |
IC50 = 0.45 nM
|
|
|
|
CP0413158
|
US9481682, 158
Show/Hide
|
C27H28ClN7O3S
|
1
|
| 1 |
IC50 = 0.45 nM
|
|
|
|
CP0484117
|
US9481682, 72
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 0.45 nM
|
|
|
|
CP0507359
|
US10087188, Example 43
Show/Hide
|
C31H31F3N8O4
|
1
|
| 1 |
IC50 = 0.45 nM
|
|
|
|
CP0540723
|
US9481682, 24
Show/Hide
|
C27H23F4N7O2
|
1
|
| 1 |
IC50 = 0.45 nM
|
|
|
|
CP0572204
|
4-[8-amino-3-[(3R,6S)-6-methyl-1-(5-methyl-1,2-oxazole-4-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C30H26F4N8O3
|
1
|
| 1 |
IC50 = 0.45 nM
|
|
|
|
CP0428817
|
US9481682, 187
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 0.46 nM
|
|
|
|
CP0507358
|
US9481682, 78
Show/Hide
|
C28H24F3N9O
|
1
|
| 1 |
IC50 = 0.46 nM
|
|
|
|
CP0575179
|
4-[7-methoxy-6-(4-morpholin-4-ylbut-2-ynoylamino)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C30H27N5O5
|
1
|
| 1 |
IC50 = 0.47 nM
|
|
|
|
CP0517335
|
US9481682, 71
Show/Hide
|
C28H24F5N7O3
|
1
|
| 1 |
IC50 = 0.48 nM
|
|
|
|
CP0115632
|
N-[3-[2-[4-(4-ethylpiperazin-1-yl)anilino]purin-9-yl]phenyl]prop-2-enamide
Show/Hide
|
C26H28N8O
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0179427
|
N-[3-[2-[4-(4-acetyl-3-methylpiperazin-1-yl)anilino]purin-9-yl]phenyl]prop-2-enamide
Show/Hide
|
C27H28N8O2
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0530651
|
US9481682, 144
Show/Hide
|
C30H27ClF3N7O3
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0561403
|
US9481682, 53
Show/Hide
|
C30H31N7O4
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0196915
|
4-[8-amino-3-[(1R,3S)-3-(2H-tetrazol-5-yl)cyclohexyl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C26H23F3N10O
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0196917
|
4-[8-amino-3-[(1R,3S)-3-(2-oxo-3H-1,3,4-oxadiazol-5-yl)cyclohexyl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H23F3N8O3
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0250874
|
US10087188, Example 158
Show/Hide
|
C26H23F3N6O3
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0540663
|
N-[3-[[5-chloro-2-[3-chloro-4-[3-(4-ethylpiperazin-1-yl)propoxy]anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C28H33Cl2N7O2
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0492955
|
US9481682, 100
Show/Hide
|
C30H30F3N7O3
|
1
|
| 1 |
IC50 = 0.51 nM
|
|
|
|
CP0914761
|
US9446130, 5
Show/Hide
|
C25H20F3N9O
|
1
|
| 1 |
IC50 = 0.52 nM
|
|
|
|
CP0387637
|
US9481682, 42
Show/Hide
|
C27H23ClF3N7O2
|
1
|
| 1 |
IC50 = 0.52 nM
|
|
|
|
CP0492953
|
US9481682, 91
Show/Hide
|
C27H24F3N7O4
|
1
|
| 1 |
IC50 = 0.52 nM
|
|
|
|
CP0516868
|
4-[8-amino-3-[(3R,6S)-1-(1-hydroxycyclobutanecarbonyl)-6-methylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C30H29F4N7O3
|
1
|
| 1 |
IC50 = 0.52 nM
|
|
|
|
CP0574791
|
4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-N-(4-cyanopyridin-2-yl)-3-fluorobenzamide
Show/Hide
|
C31H32FN7O4
|
1
|
| 1 |
IC50 = 0.52 nM
|
|
|
|
CP0578153
|
US9481682, 46
Show/Hide
|
C29H29N7O3
|
1
|
| 1 |
IC50 = 0.53 nM
|
|
|
|
CP0562813
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-(4-pyrazol-1-ylpyridin-2-yl)benzamide
Show/Hide
|
C31H30FN9O3
|
1
|
| 1 |
IC50 = 0.53 nM
|
|
|
|
CP0512884
|
US9481682, 113
Show/Hide
|
C31H32F3N7O3
|
1
|
| 1 |
IC50 = 0.54 nM
|
|
|
|
CP0540724
|
US9481682, 25
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 0.54 nM
|
|
|
|
CP0562809
|
4-[8-amino-3-[(3R,6S)-1-(3-hydroxy-2,2-dimethylpropanoyl)-6-methylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C30H31F4N7O3
|
1
|
| 1 |
IC50 = 0.54 nM
|
|
|
|
CP0538771
|
4-[6-(but-2-ynoylamino)-7-(2-morpholin-4-ylethoxy)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C31H29N5O5
|
1
|
| 1 |
IC50 = 0.54 nM
|
|
|
|
CP0536945
|
US9481682, 133
Show/Hide
|
C29H26ClF4N7O3
|
1
|
| 1 |
IC50 = 0.55 nM
|
|
|
|
CP0486375
|
US9481682, 112
Show/Hide
|
C27H23ClF3N7O2
|
1
|
| 1 |
IC50 = 0.57 nM
|
|
|
|
CP0255832
|
US9481682, 121
Show/Hide
|
C30H28F3N7O3
|
1
|
| 1 |
IC50 = 0.58 nM
|
|
|
|
CP0465875
|
US9481682, 207
Show/Hide
|
C29H30ClN7O3
|
1
|
| 1 |
IC50 = 0.58 nM
|
|
|
|
CP0576143
|
US9481682, 118
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 0.58 nM
|
|
|
|
CP0469608
|
US9481682, 146
Show/Hide
|
C29H29F3N8O3
|
1
|
| 1 |
IC50 = 0.59 nM
|
|
|
|
CP0072650
|
4-[8-amino-3-[(2R)-4-(oxan-4-yl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C28H27F4N7O3
|
1
|
| 1 |
IC50 = 0.59 nM
|
|
|
|
CP0689377
|
SPEBRUTINIB
Show/Hide
|
C22H22FN5O3
|
5
|
| 1 |
IC50 = 0.6 nM
|
|
|
| 2 |
IC50 = 0.72 nM
|
|
|
| 3 |
IC50 = 2.12 nM
|
|
|
| 4 |
IC50 = 9 nM
|
|
|
| 5 |
Ki = 20.7 nM
|
|
|
|
CP0413050
|
4-[8-amino-3-[(1R,3S)-3-(2-methyltetrazol-5-yl)cyclohexyl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H25F3N10O
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0411587
|
N-[3-[[5-chloro-2-[4-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H29ClN6O3
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0384045
|
US9481682, 195
Show/Hide
|
C25H24ClN7O2S
|
1
|
| 1 |
IC50 = 0.63 nM
|
|
|
|
CP0517265
|
US9481682, 159
Show/Hide
|
C27H29N7O3S
|
1
|
| 1 |
IC50 = 0.63 nM
|
|
|
|
CP0070026
|
US10005782, Compound 27b
Show/Hide
|
C27H29N5O3
|
1
|
| 1 |
IC50 = 0.63 nM
|
|
|
|
CP0492567
|
US9481682, 183
Show/Hide
|
C26H24ClF3N8O2
|
1
|
| 1 |
IC50 = 0.64 nM
|
|
|
|
CP0563670
|
US9481682, 28
Show/Hide
|
C30H31N7O2
|
1
|
| 1 |
IC50 = 0.64 nM
|
|
|
|
CP0507360
|
US9481682, 87
Show/Hide
|
C27H26F3N7O
|
1
|
| 1 |
IC50 = 0.67 nM
|
|
|
|
CP0559275
|
US9481682, 115
Show/Hide
|
C28H27ClF4N8O3
|
1
|
| 1 |
IC50 = 0.67 nM
|
|
|
|
CP0075633
|
(E)-4-(dimethylamino)-N-[7-fluoro-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H25FN6O
|
2
|
| 1 |
IC50 = 0.7 nM
|
|
|
| 2 |
IC50 = 1.93 nM
|
|
|
|
CP0313625
|
4-[8-amino-3-[(2R)-4-(1-methylcyclobutanecarbonyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H27F4N7O3
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0405068
|
N-[3-[[5-fluoro-2-[4-methoxy-3-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H31FN6O4
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0457509
|
N-[3-[[5-chloro-2-[3-chloro-4-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H28Cl2N6O3
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0558458
|
4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-3-methyl-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H28F3N7O3
|
1
|
| 1 |
IC50 = 0.71 nM
|
|
|
|
CP0493001
|
US9481682, 206
Show/Hide
|
C30H27F6N7O3
|
1
|
| 1 |
IC50 = 0.72 nM
|
|
|
|
CP0499632
|
US9481682, 131
Show/Hide
|
C28H29F3N8O3
|
1
|
| 1 |
IC50 = 0.74 nM
|
|
|
|
CP0552117
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(4-cyclopropylpyridin-2-yl)-3-fluorobenzamide
Show/Hide
|
C31H32FN7O3
|
1
|
| 1 |
IC50 = 0.74 nM
|
|
|
|
CP0507363
|
US9481682, 151
Show/Hide
|
C29H27F4N7O3
|
1
|
| 1 |
IC50 = 0.75 nM
|
|
|
|
CP0552492
|
US9481682, 147
Show/Hide
|
C32H32ClN7O3
|
1
|
| 1 |
IC50 = 0.75 nM
|
|
|
|
CP0578162
|
US9481682, 204
Show/Hide
|
C31H28F3N7O3
|
1
|
| 1 |
IC50 = 0.75 nM
|
|
|
|
CP0561404
|
US9481682, 64
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 0.77 nM
|
|
|
|
CP0387721
|
US9481682, 136
Show/Hide
|
C31H31ClFN7O3
|
1
|
| 1 |
IC50 = 0.78 nM
|
|
|
|
CP0355611
|
US10087188, Example 13
Show/Hide
|
C25H21F3N6O3
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0132601
|
4-[8-amino-3-[(3R)-1-(oxan-4-yl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H29F4N7O2
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0405070
|
N-[3-[[5-chloro-2-[3-chloro-4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C25H24Cl2N6O4
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0540659
|
N-[3-[[5-chloro-2-[4-methoxy-3-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H31ClN6O4
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0560044
|
4-[6-(5-morpholin-4-ylpent-2-ynoylamino)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C30H27N5O4
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0465899
|
US9446130, 21
Show/Hide
|
C26H19F6N9O
|
1
|
| 1 |
IC50 = 0.81 nM
|
|
|
|
CP0517264
|
US9481682, 154
Show/Hide
|
C25H24ClN7O2S
|
1
|
| 1 |
IC50 = 0.81 nM
|
|
|
|
CP0398676
|
N-[3-[[5-chloro-2-[4-[3-[ethoxy(morpholin-4-yl)phosphoryl]propoxy]anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C28H34ClN6O5P
|
1
|
| 1 |
IC50 = 0.82 nM
|
|
|
|
CP0395331
|
N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-morpholin-4-ylbut-2-ynamide
Show/Hide
|
C26H26N6O3
|
1
|
| 1 |
IC50 = 0.847 nM
|
|
|
|
CP0433232
|
N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-piperidin-1-ylbut-2-ynamide
Show/Hide
|
C27H28N6O2
|
1
|
| 1 |
IC50 = 0.847 nM
|
|
|
|
CP0526122
|
US9481682, 30
Show/Hide
|
C29H30FN7O2
|
1
|
| 1 |
IC50 = 0.85 nM
|
|
|
|
CP0552113
|
4-{8-amino-3-[(3S,6R)-1-propanoyl-6-(trifluoromethyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C30H28F5N7O3
|
1
|
| 1 |
IC50 = 0.86 nM
|
|
|
|
CP0406460
|
(E)-4-(dimethylamino)-N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]but-2-enamide
Show/Hide
|
C24H26N6O2
|
1
|
| 1 |
IC50 = 0.884 nM
|
|
|
|
CP0559443
|
US9481682, 85
Show/Hide
|
C34H30F3N9O4
|
1
|
| 1 |
IC50 = 0.89 nM
|
|
|
|
CP0483603
|
(1S,3R)-3-[8-amino-1- (4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3-yl]-1- methylcyclohexane- carboxylic acid
Show/Hide
|
C27H25F3N6O3
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0231883
|
4-{8-amino-3-[(2R)-4-(3-methoxypropanoyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C28H26F3N7O4
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0560512
|
N-[3-[[5-fluoro-2-[4-[(4-methoxyphenyl)sulfonylamino]anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H23FN6O4S
|
1
|
| 1 |
IC50 = 0.92 nM
|
|
|
|
CP0387716
|
US9481682, 73
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 0.93 nM
|
|
|
|
CP0552497
|
US9481682, 181
Show/Hide
|
C28H30N8O2
|
1
|
| 1 |
IC50 = 0.93 nM
|
|
|
|
CP0576127
|
4-[7-methoxy-6-(4-methoxybut-2-ynoylamino)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C27H22N4O5
|
1
|
| 1 |
IC50 = 0.96 nM
|
|
|
|
CP0405843
|
US9481682, 36
Show/Hide
|
C28H26N8O2
|
1
|
| 1 |
IC50 = 0.98 nM
|
|
|
|
CP0578790
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-2-methoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C30H30F3N7O4
|
1
|
| 1 |
IC50 = 0.98 nM
|
|
|
|
CP0418261
|
US9481682, 161
Show/Hide
|
C29H27F4N7O3
|
1
|
| 1 |
IC50 = 0.99 nM
|
|
|
|
CP0201176
|
4-[8-amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]-1,4-dimethylcyclohexane-1-carboxylic acid
Show/Hide
|
C28H27F3N6O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0405067
|
N-[3-[[5-chloro-2-[4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C25H25ClN6O4
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0560046
|
4-[6-(but-2-ynoylamino)-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C33H34N6O4
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0408300
|
N-[3-[5-chloro-2-[3-methyl-4-[(4-methylphenyl)sulfonylamino]anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Show/Hide
|
C27H24ClN5O4S
|
1
|
| 1 |
IC50 = 1.05 nM
|
|
|
|
CP0563672
|
US9446130, 15
Show/Hide
|
C27H24F3N9O2
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0402754
|
US9481682, 200
Show/Hide
|
C29H28F3N7O4
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0540725
|
US9481682, 27
Show/Hide
|
C29H28FN7O2
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0578152
|
US9481682, 35
Show/Hide
|
C28H26N8O3
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0244547
|
(1S,3R)-3-[8-amino-1- (4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3-yl]-1-(1- methylethyl) cyclopentane carboxylic acid
Show/Hide
|
C28H27F3N6O3
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0570322
|
4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-2-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C30H30F3N7O4
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0523269
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-(pyridin-3-ylmethyl)carbamodithioate
Show/Hide
|
C28H26FN7O2S2
|
1
|
| 1 |
IC50 = 1.15 nM
|
|
|
|
CP0485775
|
N-[3-[[5-chloro-2-[4-[(4-fluorophenyl)sulfonylamino]-3-methoxyanilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H22ClFN6O4S
|
1
|
| 1 |
IC50 = 1.18 nM
|
|
|
|
CP0507367
|
US9481682, 205
Show/Hide
|
C29H31F3N8O3
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0559273
|
US9481682, 104
Show/Hide
|
C26H23F3N8O2
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0559276
|
US9481682, 132
Show/Hide
|
C28H24ClF4N7O3
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0114107
|
4-[8-amino-3-[(1R,3S)-3-(methylsulfonylcarbamoyl)cyclohexyl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H26F3N7O4S
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0323445
|
4-[8-amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]cyclohexane-1-carboxylic acid
Show/Hide
|
C26H23F3N6O3
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0189973
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)pyrrolidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C28H26F3N7O3
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0576751
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-(4-methylpyridin-2-yl)benzamide
Show/Hide
|
C29H30FN7O3
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0565555
|
N-(4-ethylpyridin-2-yl)-4-[6-(prop-2-enoylamino)quinolin-4-yl]oxybenzamide
Show/Hide
|
C26H22N4O3
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0408960
|
N-[3-[[5-chloro-2-[4-(diethoxyphosphorylmethyl)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C24H27ClN5O4P
|
1
|
| 1 |
IC50 = 1.23 nM
|
|
|
|
CP0492975
|
US9446130, 18
Show/Hide
|
C27H24F3N9O2
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0418260
|
US9481682, 152
Show/Hide
|
C28H28F4N8O3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0465919
|
US9481682, 167
Show/Hide
|
C29H27F2N7O2
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0507364
|
US9481682, 162
Show/Hide
|
C28H25F4N7O3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0540644
|
US9481682, 13
Show/Hide
|
C26H21F4N7O3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0563322
|
US9481682, 96
Show/Hide
|
C27H25F3N8O2
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0081927
|
(1S,3R)-3-[8-amino-1- (4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3-yl]-1- methylcyclopentane- carboxylic acid
Show/Hide
|
C26H23F3N6O3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0412987
|
US10005782, Compound 18
Show/Hide
|
C27H29N5O3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0492991
|
US9481682, 148
Show/Hide
|
C32H33N7O3
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0551903
|
US9481682, 210
Show/Hide
|
C28H28ClN7O3
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0196916
|
4-[8-amino-3-[(1R,3S)-3-(5-oxo-4H-1,2,4-oxadiazol-3-yl)cyclohexyl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H23F3N8O3
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0435412
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N,N-dimethylcarbamodithioate
Show/Hide
|
C24H25FN6O2S2
|
1
|
| 1 |
IC50 = 1.44 nM
|
|
|
|
CP0419196
|
US9481682, 99
Show/Hide
|
C29H31N7O3
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0470663
|
US9481682, 196
Show/Hide
|
C25H23Cl2N7O2S
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0490872
|
US9481682, 26
Show/Hide
|
C27H24F3N7O2
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0492996
|
US9481682, 189
Show/Hide
|
C27H26ClF3N8O3
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0552495
|
US9481682, 168
Show/Hide
|
C29H28FN7O2
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0517367
|
4-[6-(but-2-ynoylamino)-7-methoxyquinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C26H20N4O4
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0433224
|
(E)-4-(dimethylamino)-N-[4-(5-hydroxy-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H26N6O2
|
1
|
| 1 |
IC50 = 1.55 nM
|
|
|
|
CP0405846
|
US9481682, 51
Show/Hide
|
C28H27F3N8O2
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0507368
|
US9481682, 208
Show/Hide
|
C28H28ClN7O4
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0163694
|
US10005782, Compound 164
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0548139
|
4-[7-methoxy-6-(5-morpholin-4-ylpent-2-ynoylamino)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C31H29N5O5
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0470664
|
US9481682, 203
Show/Hide
|
C26H26ClN7O3S
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0558522
|
US9481682, 45
Show/Hide
|
C28H25F4N7O2
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0405012
|
US9481682, 218
Show/Hide
|
C28H24Cl2F3N7O3
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0428816
|
US9481682, 56
Show/Hide
|
C27H26F3N7O2
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0492993
|
US9481682, 150
Show/Hide
|
C29H27ClF4N8O3
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0406459
|
(E)-N-[4-(2-chloroanilino)-7-fluoroimidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
Show/Hide
|
C23H22ClFN6O
|
1
|
| 1 |
IC50 = 1.82 nM
|
|
|
|
CP0390470
|
(E)-4-(dimethylamino)-N-[4-(3-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H25FN6O
|
1
|
| 1 |
IC50 = 1.89 nM
|
|
|
|
CP0405844
|
US9481682, 38
Show/Hide
|
C30H31N7O3
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0492570
|
US9481682, 199
Show/Hide
|
C31H31F3N6O4
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0492997
|
US9481682, 191
Show/Hide
|
C26H23Cl2F3N8O2
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0507365
|
US9481682, 164
Show/Hide
|
C27H28FN7O3S
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0516907
|
US9481682, 29
Show/Hide
|
C29H28FN7O3
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0339333
|
US10005782, Compound 151
Show/Hide
|
C22H20FN5O2
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0479638
|
US9446130, 3
Show/Hide
|
C27H23F3N8O2
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0516908
|
US9481682, 137
Show/Hide
|
C31H32FN7O3
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0559263
|
US9481682, 6
Show/Hide
|
C26H25N7O2
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0418274
|
US9446130, 17
Show/Hide
|
C27H24F3N9O2
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0555620
|
US9481682, 117
Show/Hide
|
C28H23F3N8O2
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0507366
|
US9481682, 190
Show/Hide
|
C26H24ClF3N8O2
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0516904
|
US9481682, 8
Show/Hide
|
C25H25N7O2S
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0559265
|
US9481682, 20
Show/Hide
|
C26H23F3N8O2
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0577872
|
US9481682, 214
Show/Hide
|
C28H25F4N7O2
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0576468
|
US9481682, 165
Show/Hide
|
C27H23F4N7O3
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0575088
|
3-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]propyl N-(pyridin-3-ylmethyl)carbamodithioate
Show/Hide
|
C29H28FN7O2S2
|
1
|
| 1 |
IC50 = 2.39 nM
|
|
|
|
CP0413159
|
US9481682, 130
Show/Hide
|
C28H25F4N7O3
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0559266
|
US9481682, 34
Show/Hide
|
C27H23FN8O2
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0570436
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-cyclopropylcarbamodithioate
Show/Hide
|
C25H25FN6O2S2
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0562811
|
4-[8-amino-5-(hydroxymethyl)-3-{(3R)-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H27F4N7O3
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0560045
|
4-[6-[4-(4-ethylpiperazin-1-yl)but-2-ynoylamino]quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C31H30N6O3
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0440316
|
N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-2-(morpholin-4-ylmethyl)prop-2-enamide
Show/Hide
|
C26H28N6O3
|
1
|
| 1 |
IC50 = 2.52 nM
|
|
|
|
CP0078281
|
(E)-N-[7-chloro-4-(5-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
Show/Hide
|
C24H24ClFN6O
|
2
|
| 1 |
IC50 = 2.6 nM
|
|
|
| 2 |
IC50 = 3.98 nM
|
|
|
|
CP0559444
|
US9481682, 93
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0383940
|
US9446130, 9
Show/Hide
|
C26H22F3N9O
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0384044
|
US9481682, 188
Show/Hide
|
C27H27F3N8O3
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0577871
|
US9481682, 213
Show/Hide
|
C29H25F6N7O3
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0205238
|
US10005782, Compound 50
Show/Hide
|
C27H21N5O3
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0205241
|
US10005782, Compound 22
Show/Hide
|
C25H27N5O4
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0566017
|
5-amino-1-[(3R)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)pyrazole-4-carboxamide
Show/Hide
|
C22H22N6O2
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0519597
|
N-[3-[[2-[4-[2-[bis(2-methoxyethyl)amino]-2-oxoethoxy]anilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H31ClN6O5
|
1
|
| 1 |
IC50 = 2.83 nM
|
|
|
|
CP0390612
|
(E)-4-(dimethylamino)-N-[4-(4-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H25FN6O
|
1
|
| 1 |
IC50 = 2.96 nM
|
|
|
|
CP0387719
|
US9481682, 84
Show/Hide
|
C28H27F3N8O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0114111
|
(1S,3R)-3-[8-amino-1- (4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3-yl]-1-(1- methylethyl) cyclohexane- carboxylic acid
Show/Hide
|
C29H29F3N6O3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0868767
|
(R)-N-methyl-2-(3-((quinoxalin-6-ylamino)methyl)furan-2-carbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
Show/Hide
|
C27H24N6O3
|
2
|
| 1 |
IC50 = 3.04 nM
|
|
|
| 2 |
IC50 = 3.78 nM
|
|
|
|
CP0384039
|
US9481682, 163
Show/Hide
|
C28H28F4N8O3
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0465896
|
US9446130, 11
Show/Hide
|
C27H24F3N9O
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0576462
|
US9446130, 8
Show/Hide
|
C26H22F3N9O
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0492571
|
US9481682, 201
Show/Hide
|
C31H32F3N7O4
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0552114
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-(1,3-thiazol-2-yl)benzamide
Show/Hide
|
C26H26FN7O3S
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0466002
|
US9481682, 119
Show/Hide
|
C26H23F3N8O2
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0319439
|
4-[8-amino-3-[(2R)-4-(3-methoxypropanoyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H26F3N7O4
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0459025
|
(E)-4-(dimethylamino)-N-[4-(5-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H25FN6O
|
1
|
| 1 |
IC50 = 3.33 nM
|
|
|
|
CP0319444
|
4-[8-amino-3-[1-(3-methyloxetane-3-carbonyl)piperidin-4-yl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H28F3N7O3
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0474172
|
US10005782, Compound 108
Show/Hide
|
C25H25N5O3
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0571589
|
4-[6-(prop-2-enoylamino)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C24H18N4O3
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0384041
|
US9481682, 169
Show/Hide
|
C29H26F5N7O3
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0555619
|
US9481682, 67
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0557170
|
4-[8-amino-3-[(3R,6R)-1-(3-methyloxetane-3-carbonyl)-6-(trifluoromethyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C30H26F7N7O3
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0507369
|
US9481682, 212
Show/Hide
|
C30H27F4N7O2
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0575177
|
4-[6-(but-2-ynoylamino)-7-(oxan-4-yloxy)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C30H26N4O5
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0552493
|
US9481682, 155
Show/Hide
|
C29H26F3N7O4
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0523439
|
(E)-4-(dimethylamino)-N-methyl-N-[4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]but-2-enamide
Show/Hide
|
C24H26N6O
|
1
|
| 1 |
IC50 = 3.99 nM
|
|
|
|
CP0492947
|
US9481682, 41
Show/Hide
|
C27H25F3N8O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0516945
|
US9481682, 215
Show/Hide
|
C29H28F6N8O3
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0578155
|
US9481682, 58
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 4.1 nM
|
|
|
|
CP0234528
|
US10005782, Compound 161
Show/Hide
|
C23H20F3N5O2
|
1
|
| 1 |
IC50 = 4.2 nM
|
|
|
|
CP0361464
|
US10005782, Compound 149
Show/Hide
|
C23H20F3N5O3
|
1
|
| 1 |
IC50 = 4.2 nM
|
|
|
|
CP0552494
|
US9481682, 156
Show/Hide
|
C29H26F3N7O4
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0118989
|
4-[8-amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclohexane-1-carboxylic acid
Show/Hide
|
C27H25F3N6O3
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0484418
|
US9481682, 140
Show/Hide
|
C31H30F3N7O3
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0507356
|
US9481682, 74
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0540642
|
US9481682, 193
Show/Hide
|
C27H22ClF4N7O2
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0264919
|
US10005782, Compound 14
Show/Hide
|
C29H27N5O3
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0555487
|
4-[6-(but-2-ynoylamino)quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C25H18N4O3
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0563325
|
US9481682, 120
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0390472
|
(E)-N-[7-chloro-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
Show/Hide
|
C24H25ClN6O
|
1
|
| 1 |
IC50 = 4.83 nM
|
|
|
|
CP0574862
|
N-[3-[[2-[4-[bis(2-methoxyethyl)amino]anilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C25H29ClN6O3
|
1
|
| 1 |
IC50 = 4.94 nM
|
|
|
|
CP0495995
|
(E)-N-[7-chloro-4-(2-chloroanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
Show/Hide
|
C23H22Cl2N6O
|
1
|
| 1 |
IC50 = 5.03 nM
|
|
|
|
CP0486374
|
US9481682, 111
Show/Hide
|
C28H27F3N8O2
|
1
|
| 1 |
IC50 = 5.2 nM
|
|
|
|
CP0576470
|
US9481682, 202
Show/Hide
|
C26H27N7O3S
|
1
|
| 1 |
IC50 = 5.2 nM
|
|
|
|
CP0564512
|
4-[8-amino-3-(1-ethyl-2-oxopiperidin-4-yl)imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)-pyridin-2-yl]benzamide
Show/Hide
|
C30H30F3N7O3
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
|
CP0456249
|
(E)-4-(dimethylamino)-N-[7-fluoro-4-(4-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H24F2N6O
|
1
|
| 1 |
IC50 = 5.35 nM
|
|
|
|
CP0559442
|
US9481682, 1
Show/Hide
|
C26H22F3N7O3
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0433186
|
(E)-4-(dimethylamino)-N-[7-fluoro-4-(2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H24FN5O2
|
1
|
| 1 |
IC50 = 5.51 nM
|
|
|
|
CP0554867
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-[(4-methoxyphenyl)methyl]carbamodithioate
Show/Hide
|
C30H29FN6O3S2
|
1
|
| 1 |
IC50 = 5.68 nM
|
|
|
|
CP0387678
|
US9481682, 139
Show/Hide
|
C30H30F3N7O3
|
1
|
| 1 |
IC50 = 5.7 nM
|
|
|
|
CP0467528
|
4-(dimethylamino)-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
|
C36H38N6O5
|
2
|
| 1 |
IC50 = 5.8 nM
|
|
|
| 2 |
Ki = 113 nM
|
|
|
|
CP0404991
|
US9446130, 13
Show/Hide
|
C27H24F3N9O
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0563319
|
US9446130, 7
Show/Hide
|
C26H22F3N9O
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0560337
|
4-[8-amino-3-[1-(3-methyloxetane-3-carbonyl)azetidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0500951
|
US9481682, 123
Show/Hide
|
C28H23F3N8O2
|
1
|
| 1 |
IC50 = 6.3 nM
|
|
|
|
CP0578157
|
US9481682, 109
Show/Hide
|
C28H24F3N7O3
|
1
|
| 1 |
IC50 = 6.3 nM
|
|
|
|
CP0556139
|
4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-2-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C29H27ClF3N7O3
|
1
|
| 1 |
IC50 = 6.3 nM
|
|
|
|
CP0470661
|
US9481682, 175
Show/Hide
|
C26H28N8O2
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0559128
|
methyl 2-[[2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetyl]amino]acetate
Show/Hide
|
C24H23ClN6O5
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0456250
|
(E)-4-(dimethylamino)-N-[4-(4-fluoro-2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H24FN5O2
|
1
|
| 1 |
IC50 = 6.58 nM
|
|
|
|
CP0549628
|
US9481682, 216
Show/Hide
|
C29H25ClF5N7O3
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0150521
|
4-(8-amino-3-{4-[(1-cyanocyclopropyl)carbonyl]-1,1-dioxidothiomorpholin-2-yl}imidazo[1,5-a]pyrazin-1-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C27H26F3N7O3S
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0512879
|
US9481682, 62
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 6.7 nM
|
|
|
|
CP0433227
|
(E)-4-(dimethylamino)-N-[7-fluoro-4-(5-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H24F2N6O
|
1
|
| 1 |
IC50 = 6.76 nM
|
|
|
|
CP0576469
|
US9481682, 186
Show/Hide
|
C27H27F3N8O2
|
1
|
| 1 |
IC50 = 6.9 nM
|
|
|
|
CP0575086
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-[(3-fluorophenyl)methyl]carbamodithioate
Show/Hide
|
C29H26F2N6O2S2
|
1
|
| 1 |
IC50 = 6.9 nM
|
|
|
|
CP0414116
|
4-tert-butyl-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
|
C38H41N5O5
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
Ki = 8.9 nM
|
|
|
|
CP0574863
|
N-[3-[[2-[4-[bis(2-methoxyethyl)amino]anilino]-5-fluoropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C25H29FN6O3
|
1
|
| 1 |
IC50 = 7.12 nM
|
|
|
|
CP0492970
|
US9446130, 1
Show/Hide
|
C27H23F3N8O2
|
1
|
| 1 |
IC50 = 7.2 nM
|
|
|
|
CP0466179
|
US9481682, 3
Show/Hide
|
C27H25F3N8O2
|
1
|
| 1 |
IC50 = 7.2 nM
|
|
|
|
CP0560043
|
4-[6-[[(E)-4-(dimethylamino)but-2-enoyl]amino]quinolin-4-yl]oxy-N-pyridin-2-ylbenzamide
Show/Hide
|
C27H25N5O3
|
1
|
| 1 |
IC50 = 7.2 nM
|
|
|
|
CP0492951
|
US9481682, 79
Show/Hide
|
C29H26F3N7O4
|
1
|
| 1 |
IC50 = 7.3 nM
|
|
|
|
CP0493760
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-(pyridin-4-ylmethyl)carbamodithioate
Show/Hide
|
C28H26FN7O2S2
|
1
|
| 1 |
IC50 = 7.36 nM
|
|
|
|
CP0496024
|
(E)-N-[4-(4-chloro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
Show/Hide
|
C24H25ClN6O
|
1
|
| 1 |
IC50 = 7.56 nM
|
|
|
|
CP0507357
|
US9481682, 75
Show/Hide
|
C27H24F3N7O3
|
1
|
| 1 |
IC50 = 7.6 nM
|
|
|
|
CP0405007
|
US9481682, 197
Show/Hide
|
C28H24ClF4N7O2
|
1
|
| 1 |
IC50 = 7.8 nM
|
|
|
|
CP0059735
|
4-tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzamide
Show/Hide
|
C34H35N7O3
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0516944
|
US9481682, 198
Show/Hide
|
C28H25F4N7O2
|
1
|
| 1 |
IC50 = 8.2 nM
|
|
|
|
CP0570434
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-methylcarbamodithioate
Show/Hide
|
C23H23FN6O2S2
|
1
|
| 1 |
IC50 = 8.21 nM
|
|
|
|
CP0552482
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-(pyrazin-2-ylmethyl)carbamodithioate
Show/Hide
|
C27H25FN8O2S2
|
1
|
| 1 |
IC50 = 8.49 nM
|
|
|
|
CP0523262
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-[(4-cyanophenyl)methyl]carbamodithioate
Show/Hide
|
C30H26FN7O2S2
|
1
|
| 1 |
IC50 = 8.58 nM
|
|
|
|
CP0438691
|
methyl 1-[2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetyl]pyrrolidine-2-carboxylate
Show/Hide
|
C27H27ClN6O5
|
1
|
| 1 |
IC50 = 8.7 nM
|
|
|
|
CP0554434
|
methyl 2-[[2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetyl]amino]propanoate
Show/Hide
|
C25H25ClN6O5
|
1
|
| 1 |
IC50 = 8.7 nM
|
|
|
|
CP0420610
|
4-tert-butyl-N-[2-methyl-3-[5-[4-(morpholine-4-carbonyl)anilino]-6-oxo-1H-pyrazin-3-yl]phenyl]benzamide
Show/Hide
|
C33H35N5O4
|
2
|
| 1 |
IC50 = 8.9 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0493002
|
US9481682, 211
Show/Hide
|
C28H22ClF6N7O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0392618
|
N-[3-[[5-chloro-2-[4-[(4-methoxyphenyl)sulfonylamino]anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H23ClN6O4S
|
1
|
| 1 |
IC50 = 9.14 nM
|
|
|
|
CP0332245
|
4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide
Show/Hide
|
C26H22FN7O3
|
2
|
| 1 |
IC50 = 9.5 nM
|
|
|
| 2 |
Ki = 209.2 nM
|
|
|
|
CP0205240
|
US10005782, Compound 99
Show/Hide
|
C28H25N5O3
|
1
|
| 1 |
IC50 = 9.5 nM
|
|
|
|
CP0406463
|
(E)-4-(dimethylamino)-N-[7-fluoro-4-(4-fluoro-2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H23F2N5O2
|
1
|
| 1 |
IC50 = 9.53 nM
|
|
|
|
CP0433228
|
(E)-N-[7-chloro-4-(4-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
Show/Hide
|
C24H24ClFN6O
|
1
|
| 1 |
IC50 = 9.53 nM
|
|
|
|
CP0578154
|
US9481682, 54
Show/Hide
|
C27H25F3N8O2
|
1
|
| 1 |
IC50 = 9.6 nM
|
|
|
|
CP0559272
|
US9481682, 97
Show/Hide
|
C28H29N7O3
|
1
|
| 1 |
IC50 = 9.7 nM
|
|
|
|
CP0511987
|
4-[8-amino-3-[(6R,8aS)-3-oxo-2,5,6,7,8,8a-hexahydro-1H-indolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl]-3-(trifluoromethoxy)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C28H23F6N7O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0534623
|
N-[3-[2-[4-(4-methylpiperazin-1-yl)anilino]purin-9-yl]phenyl]prop-2-enamide
Show/Hide
|
C25H26N8O
|
1
|
| 1 |
IC50 = 10.2 nM
|
|
|
|
CP0525044
|
(E)-N-[4-(2-chloro-6-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
Show/Hide
|
C24H25ClN6O
|
1
|
| 1 |
IC50 = 10.3 nM
|
|
|
|
CP0459027
|
(E)-4-(dimethylamino)-N-[4-(2-hydroxy-6-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H26N6O2
|
1
|
| 1 |
IC50 = 10.4 nM
|
|
|
|
CP0549135
|
N-[3-[[5-chloro-2-[3-methoxy-4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H27ClN6O5
|
1
|
| 1 |
IC50 = 10.5 nM
|
|
|
|
CP0446076
|
N-[3-[[5-chloro-2-[4-(3-diethoxyphosphorylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H31ClN5O5P
|
1
|
| 1 |
IC50 = 10.6 nM
|
|
|
|
CP0512880
|
US9481682, 70
Show/Hide
|
C34H30F3N7O3
|
1
|
| 1 |
IC50 = 10.7 nM
|
|
|
|
CP0207023
|
4-(8-amino-3-((trans)-3-isobutyramidocyclohexyl) imidazo [1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide
Show/Hide
|
C30H30F3N7O3
|
1
|
| 1 |
IC50 = 10.7 nM
|
|
|
|
CP0489692
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-benzylcarbamodithioate
Show/Hide
|
C29H27FN6O2S2
|
1
|
| 1 |
IC50 = 10.8 nM
|
|
|
|
CP0577865
|
US9446130, 22
Show/Hide
|
C26H19F6N9O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0168515
|
US9447106, 27a (peak 1)
Show/Hide
|
C27H29N5O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0563838
|
4-[8-amino-3-[(6R,8aS)-3-oxo-2,5,6,7,8,8a-hexahydro-1H-indolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl]-3-phenoxy-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C33H28F3N7O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0464545
|
2-[[2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetyl]amino]acetic acid
Show/Hide
|
C23H21ClN6O5
|
1
|
| 1 |
IC50 = 11.2 nM
|
|
|
|
CP0559445
|
US9481682, 95
Show/Hide
|
C29H28F3N7O2
|
1
|
| 1 |
IC50 = 11.4 nM
|
|
|
|
CP0068199
|
9-(1-methylpyrazol-4-yl)-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-2-one
Show/Hide
|
C27H21N5O2
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
Ki = 14.2 nM
|
|
|
|
CP0564456
|
US9446130, 4
Show/Hide
|
C28H25F3N8O2
|
1
|
| 1 |
IC50 = 12.04 nM
|
|
|
|
CP0489641
|
N-[3-[[5-chloro-2-[4-(oxolan-2-ylmethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C24H24ClN5O3
|
1
|
| 1 |
IC50 = 12.1 nM
|
|
|
|
CP0406458
|
(E)-4-(dimethylamino)-N-[4-(4-hydroxy-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H26N6O2
|
1
|
| 1 |
IC50 = 12.2 nM
|
|
|
|
CP0493431
|
US9481682, 122
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 12.4 nM
|
|
|
|
CP0466000
|
US9481682, 60
Show/Hide
|
C28H26F3N7O2
|
1
|
| 1 |
IC50 = 12.7 nM
|
|
|
|
CP0433229
|
(E)-4-(dimethylamino)-N-[7-fluoro-4-(5-fluoro-2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H23F2N5O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0465897
|
US9446130, 12
Show/Hide
|
C27H24F3N9O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0574790
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(6-ethylpyrimidin-4-yl)-3-fluorobenzamide
Show/Hide
|
C29H31FN8O3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0525045
|
(E)-N-[4-(5-chloro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
Show/Hide
|
C24H25ClN6O
|
1
|
| 1 |
IC50 = 13.2 nM
|
|
|
|
CP0199017
|
N-[3-[2-[4-(3-methyl-4-methylsulfonylpiperazin-1-yl)anilino]purin-9-yl]phenyl]prop-2-enamide
Show/Hide
|
C26H28N8O3S
|
1
|
| 1 |
IC50 = 13.2 nM
|
|
|
|
CP0520485
|
3-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]propyl N,N-dimethylcarbamodithioate
Show/Hide
|
C25H27FN6O2S2
|
1
|
| 1 |
IC50 = 13.9 nM
|
|
|
|
CP0063953
|
US10005782, Compound 130
Show/Hide
|
C25H19N5O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0563669
|
US9481682, 10
Show/Hide
|
C27H24F3N7O2
|
1
|
| 1 |
IC50 = 14.7 nM
|
|
|
|
CP0536939
|
US9481682, 176
Show/Hide
|
C24H24N8O2S
|
1
|
| 1 |
IC50 = 14.9 nM
|
|
|
|
CP0466449
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-ethylcarbamodithioate
Show/Hide
|
C24H25FN6O2S2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0573045
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-(5-methylpyrazin-2-yl)benzamide
Show/Hide
|
C28H29FN8O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0132530
|
N-[3-[2-(4-morpholin-4-ylanilino)purin-9-yl]phenyl]prop-2-enamide
Show/Hide
|
C24H23N7O2
|
1
|
| 1 |
IC50 = 15.1 nM
|
|
|
|
CP0393376
|
US9481682, 11
Show/Hide
|
C27H24F3N7O2
|
1
|
| 1 |
IC50 = 15.3 nM
|
|
|
|
CP0478810
|
US9481682, 2
Show/Hide
|
C26H22F3N7O3
|
1
|
| 1 |
IC50 = 15.6 nM
|
|
|
|
CP0447341
|
N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide
Show/Hide
|
C36H37N5O5S
|
2
|
| 1 |
IC50 = 16.5 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
|
CP0570441
|
4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]butyl N-(pyridin-3-ylmethyl)carbamodithioate
Show/Hide
|
C30H30FN7O2S2
|
1
|
| 1 |
IC50 = 16.5 nM
|
|
|
|
CP0495854
|
N-[3-[[8-[[(E)-4-(dimethylamino)but-2-enoyl]-methylamino]imidazo[1,5-a]quinoxalin-4-yl]amino]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C32H30F3N7O2
|
1
|
| 1 |
IC50 = 16.8 nM
|
|
|
|
CP0497614
|
US9481682, 110
Show/Hide
|
C28H24F3N7O3
|
1
|
| 1 |
IC50 = 16.8 nM
|
|
|
|
CP0413195
|
4-tert-butyl-N-[2-methyl-3-[9-methyl-6-[4-(4-methylpiperazine-1-carbonyl)anilino]purin-2-yl]phenyl]benzamide
Show/Hide
|
C36H40N8O2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0473355
|
5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazole-4-carboxamide
Show/Hide
|
C24H23F2N5O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0525586
|
US10005782, Compound 66
Show/Hide
|
C22H17N5O2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0196497
|
N-[3-[2-[4-(4-methylsulfonylpiperazin-1-yl)anilino]purin-9-yl]phenyl]prop-2-enamide
Show/Hide
|
C25H26N8O3S
|
1
|
| 1 |
IC50 = 17.1 nM
|
|
|
|
CP0478757
|
N-[3-[[5-fluoro-2-[3-methoxy-4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H27FN6O5
|
1
|
| 1 |
IC50 = 17.1 nM
|
|
|
|
CP0556714
|
US9481682, 142
Show/Hide
|
C32H34F3N7O3
|
1
|
| 1 |
IC50 = 17.5 nM
|
|
|
|
CP0492949
|
US9481682, 61
Show/Hide
|
C30H29F3N8O3
|
1
|
| 1 |
IC50 = 17.7 nM
|
|
|
|
CP0559024
|
1-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]-3-phenylurea
Show/Hide
|
C30H28N8O3
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0570442
|
[2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]anilino]-2-oxoethyl] N-(pyridin-3-ylmethyl)carbamodithioate
Show/Hide
|
C28H25FN8O2S2
|
1
|
| 1 |
IC50 = 18.4 nM
|
|
|
|
CP0575087
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-(pyridin-2-ylmethyl)carbamodithioate
Show/Hide
|
C28H26FN7O2S2
|
1
|
| 1 |
IC50 = 18.5 nM
|
|
|
|
CP0497402
|
4-tert-butyl-N-[2-methyl-3-[9-methyl-6-(4-piperazin-1-ylanilino)purin-2-yl]phenyl]benzamide
Show/Hide
|
C34H38N8O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0519436
|
4-tert-butyl-N-[2-methyl-3-[1-methyl-6-oxo-5-[3-(prop-2-enoylamino)-4-(pyrrolidine-1-carbonyl)anilino]pyridin-3-yl]phenyl]benzamide
Show/Hide
|
C38H41N5O4
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0433233
|
(E)-4-(dimethylamino)-N-ethyl-N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]but-2-enamide
Show/Hide
|
C26H30N6O2
|
1
|
| 1 |
IC50 = 19.1 nM
|
|
|
|
CP0547155
|
N-[3-[[2-[4-[[2-[bis(2-methoxyethyl)amino]acetyl]amino]-3-methylanilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C28H34ClN7O4
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0414120
|
4-tert-butyl-N-[3-[5-[4-(3-hydroxypiperidine-1-carbonyl)-3-(prop-2-enoylamino)anilino]-1-methyl-6-oxopyridin-3-yl]-2-methylphenyl]benzamide
Show/Hide
|
C39H43N5O5
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0467527
|
4-tert-butyl-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
|
C35H38N4O4
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0508479
|
N-[3-[[2-[4-(3-diethoxyphosphorylpropoxy)anilino]-5-fluoropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H31FN5O5P
|
1
|
| 1 |
IC50 = 21.6 nM
|
|
|
|
CP0538964
|
N-[3-[[5-fluoro-2-[4-(oxolan-2-ylmethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C24H24FN5O3
|
1
|
| 1 |
IC50 = 22.4 nM
|
|
|
|
CP0519598
|
N-[3-[[2-[4-[[2-[bis(2-methoxyethyl)amino]acetyl]amino]anilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H32ClN7O4
|
1
|
| 1 |
IC50 = 22.6 nM
|
|
|
|
CP0923105
|
N4-((R)-1-((R)-3-(methylcarbamoyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-1-oxo-3-phenylpropan-2-yl)-1H-pyrrole-2,4-dicarboxamide
Show/Hide
|
C28H28N6O4
|
2
|
| 1 |
IC50 = 22.7 nM
|
|
|
| 2 |
IC50 = 56.2 nM
|
|
|
|
CP0489690
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N,N-diethylcarbamodithioate
Show/Hide
|
C26H29FN6O2S2
|
1
|
| 1 |
IC50 = 23.3 nM
|
|
|
|
CP0413155
|
US9481682, 141
Show/Hide
|
C32H32F3N7O3
|
1
|
| 1 |
IC50 = 23.7 nM
|
|
|
|
CP0482829
|
[3-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]anilino]-3-oxopropyl] N-(pyridin-3-ylmethyl)carbamodithioate
Show/Hide
|
C29H27FN8O2S2
|
1
|
| 1 |
IC50 = 23.7 nM
|
|
|
|
CP0408301
|
N-[3-[[2-[4-[(4-methoxyphenyl)sulfonylamino]anilino]-5-nitropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H23N7O6S
|
1
|
| 1 |
IC50 = 23.8 nM
|
|
|
|
CP0492998
|
US9481682, 192
Show/Hide
|
C26H22Cl2F4N8O2
|
1
|
| 1 |
IC50 = 24.6 nM
|
|
|
|
CP0492950
|
US9481682, 76
Show/Hide
|
C25H20F3N7O4
|
1
|
| 1 |
IC50 = 24.9 nM
|
|
|
|
CP0481320
|
4-tert-butyl-N-[2-methyl-3-[9-methyl-6-[4-(piperazine-1-carbonyl)anilino]purin-2-yl]phenyl]benzamide
Show/Hide
|
C35H38N8O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0113747
|
2-methyl-N-[2-[3-(prop-2-enoylamino)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide
Show/Hide
|
C29H23F3N6O3
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
Ki = 27.2 nM
|
|
|
|
CP0574237
|
4-[8-amino-3-[(6R,8aS)-3-oxo-5,6,8,8a-tetrahydro-1H-[1,3]oxazolo[4,3-c][1,4]oxazin-6-yl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C25H20F3N7O4
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0443096
|
4-tert-butyl-N-[2-methyl-5-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzamide
Show/Hide
|
C34H35N7O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0448391
|
4-tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzenesulfonamide
Show/Hide
|
C33H35N7O4S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0570438
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl 2,6-dimethylmorpholine-4-carbodithioate
Show/Hide
|
C28H31FN6O3S2
|
1
|
| 1 |
IC50 = 27.1 nM
|
|
|
|
CP0548978
|
N-[3-[[2-[4-[2-[bis(2-methoxyethyl)amino]-2-oxoethoxy]anilino]-5-fluoropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H31FN6O5
|
1
|
| 1 |
IC50 = 27.2 nM
|
|
|
|
CP0384043
|
US9481682, 178
Show/Hide
|
C25H26N8O2S
|
1
|
| 1 |
IC50 = 27.6 nM
|
|
|
|
CP0413194
|
4-tert-butyl-N-[3-[6-[4-[4-(2-hydroxyethyl)piperazine-1-carbonyl]anilino]-9-methylpurin-2-yl]-2-methylphenyl]benzamide
Show/Hide
|
C37H42N8O3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0435414
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl morpholine-4-carbodithioate
Show/Hide
|
C26H27FN6O3S2
|
1
|
| 1 |
IC50 = 29.9 nM
|
|
|
|
CP0520434
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-methyl-N-(pyridin-3-ylmethyl)carbamodithioate
Show/Hide
|
C29H28FN7O2S2
|
1
|
| 1 |
IC50 = 30.7 nM
|
|
|
|
CP0513285
|
N-[3-[[5-chloro-2-[3-methoxy-4-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H31ClN6O4
|
1
|
| 1 |
IC50 = 31.3 nM
|
|
|
|
CP0448390
|
4-tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]cyclohexane-1-carboxamide
Show/Hide
|
C34H41N7O3
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0507009
|
N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-4-propan-2-ylbenzamide
Show/Hide
|
C37H39N5O5
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0555490
|
N-[3-[[2-[4-(diethoxyphosphorylmethyl)anilino]-5-fluoropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C24H27FN5O4P
|
1
|
| 1 |
IC50 = 32.1 nM
|
|
|
|
CP0565388
|
4-tert-butyl-N-[3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzamide
Show/Hide
|
C33H33N7O3
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0539589
|
5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-[(3R)-1-[(E)-4-hydroxybut-2-enoyl]piperidin-3-yl]pyrazole-4-carboxamide
Show/Hide
|
C25H25F2N5O4
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0534734
|
4-[[5-[3-[(4-tert-butylbenzoyl)amino]-2-methylphenyl]-1-methyl-2-oxopyridin-3-yl]amino]-N,N-dimethyl-2-(prop-2-enoylamino)benzamide
Show/Hide
|
C36H39N5O4
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0715572
|
US9447106, 117
Show/Hide
|
C25H23N5O3
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0559023
|
[4-[[2-(2,3-dimethylphenyl)-7H-purin-6-yl]amino]phenyl]-morpholin-4-ylmethanone
Show/Hide
|
C24H24N6O2
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0554868
|
4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]butyl N,N-dimethylcarbamodithioate
Show/Hide
|
C26H29FN6O2S2
|
1
|
| 1 |
IC50 = 35.4 nM
|
|
|
|
CP0570439
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl 4-methylpiperazine-1-carbodithioate
Show/Hide
|
C27H30FN7O2S2
|
1
|
| 1 |
IC50 = 35.6 nM
|
|
|
|
CP0488072
|
5-amino-1-[(3R)-1-cyanopiperidin-3-yl]-3-[4-[6-(trifluoromethyl)pyridin-2-yl]oxyphenyl]pyrazole-4-carboxamide
Show/Hide
|
C22H20F3N7O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0914762
|
US9481682, 170
Show/Hide
|
C25H23F3N8O2
|
1
|
| 1 |
IC50 = 36.9 nM
|
|
|
|
CP0467839
|
4-tert-butyl-N-[2-methyl-3-[9-methyl-6-[4-(morpholine-4-carbonyl)anilino]purin-2-yl]phenyl]benzamide
Show/Hide
|
C35H37N7O3
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0571514
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-(trifluoromethoxy)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C30H27F6N7O4
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0433231
|
7-fluoro-8-N-methyl-4-N-(2-methylphenyl)imidazo[1,5-a]quinoxaline-4,8-diamine
Show/Hide
|
C18H16FN5
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0467841
|
N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]methanesulfonamide
Show/Hide
|
C24H25N7O4S
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0534731
|
4-[[5-[3-[(4-tert-butylbenzoyl)amino]-2-methylphenyl]-1-methyl-2-oxopyridin-3-yl]amino]-N-cyclopropyl-2-(prop-2-enoylamino)benzamide
Show/Hide
|
C37H39N5O4
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0459751
|
US10005782, Compound 109
Show/Hide
|
C25H27N5O3
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0473853
|
4-tert-butyl-N-[3-[6-[4-(dimethylcarbamoyl)anilino]-9-methylpurin-2-yl]-2-methylphenyl]benzamide
Show/Hide
|
C33H35N7O2
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0465900
|
US9446130, 25
Show/Hide
|
C27H25F3N10O2
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0329552
|
5-amino-1-[(3R)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]pyrazole-4-carboxamide
Show/Hide
|
C22H20F2N6O2
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0440317
|
(E)-N-(cyclopropylmethyl)-4-(dimethylamino)-N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]but-2-enamide
Show/Hide
|
C28H32N6O2
|
1
|
| 1 |
IC50 = 45.3 nM
|
|
|
|
CP0490874
|
US9481682, 101
Show/Hide
|
C30H30F3N7O3
|
1
|
| 1 |
IC50 = 45.4 nM
|
|
|
|
CP0467840
|
N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]-4-(trifluoromethyl)benzamide
Show/Hide
|
C31H26F3N7O3
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0230300
|
5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-[(3R)-1-cyanopiperidin-3-yl]pyrazole-4-carboxamide
Show/Hide
|
C22H21ClN6O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0545983
|
N-[3-[[2-[3-methyl-4-[(4-methylphenyl)sulfonylamino]anilino]-5-nitropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H25N7O5S
|
1
|
| 1 |
IC50 = 48.6 nM
|
|
|
|
CP0476612
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-[(3,4,5-trimethoxyphenyl)methyl]carbamodithioate
Show/Hide
|
C32H33FN6O5S2
|
1
|
| 1 |
IC50 = 48.6 nM
|
|
|
|
CP0524482
|
1-cyclohexyl-3-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]urea
Show/Hide
|
C30H34N8O3
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0490873
|
US9481682, 98
Show/Hide
|
C29H31N7O3
|
1
|
| 1 |
IC50 = 49.3 nM
|
|
|
|
CP0873753
|
US9481682, 172
Show/Hide
|
C24H24N8O2
|
1
|
| 1 |
IC50 = 50.7 nM
|
|
|
|
CP0563320
|
US9446130, 14
Show/Hide
|
C27H24F3N9O
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0465898
|
US9446130, 20
Show/Hide
|
C28H24F3N9O
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0523261
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl 4-propan-2-ylpiperazine-1-carbodithioate
Show/Hide
|
C29H34FN7O2S2
|
1
|
| 1 |
IC50 = 56.9 nM
|
|
|
|
CP0546754
|
N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-5,6,7,8-tetrahydronaphthalene-2-carboxamide
Show/Hide
|
C38H39N5O5
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0313019
|
(2S)-N-[(2S,3R)-1-[[(2R)-3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]-2-methyloxirane-2-carboxamide
Show/Hide
|
C23H32N4O5
|
3
|
| 1 |
IC50 = 58.1 nM
|
|
|
| 2 |
IC50 > 5920 nM
|
|
|
| 3 |
Ki = 1250 nM
|
|
|
|
CP0563303
|
N-[3-[[5-chloro-2-[4-[(4-methylphenyl)sulfonylamino]anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H23ClN6O3S
|
1
|
| 1 |
IC50 = 58.5 nM
|
|
|
|
CP0969654
|
US9446130, 6
Show/Hide
|
C25H20F3N9O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0433223
|
(E)-N-[4-(3-chloro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
Show/Hide
|
C24H25ClN6O
|
1
|
| 1 |
IC50 = 60.6 nM
|
|
|
|
CP0536938
|
US9481682, 7
Show/Hide
|
C30H31N7O2
|
1
|
| 1 |
IC50 = 60.6 nM
|
|
|
|
CP0462354
|
2-[3-[(3-chloro-4-fluorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
|
C28H26ClFN6O2S
|
2
|
| 1 |
IC50 = 61 nM
|
|
|
| 2 |
IC50 = 90 nM
|
|
|
|
CP0567156
|
4-tert-butyl-N-[3-[5-[3-[(2-chloroacetyl)amino]-4-(morpholine-4-carbonyl)anilino]-1-methyl-6-oxopyridin-3-yl]-2-methylphenyl]benzamide
Show/Hide
|
C37H40ClN5O5
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0520080
|
3-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]propyl 4-propan-2-ylpiperazine-1-carbodithioate
Show/Hide
|
C30H36FN7O2S2
|
1
|
| 1 |
IC50 = 63.2 nM
|
|
|
|
CP0524480
|
4-[[2-[3-[(4-tert-butylbenzoyl)amino]-2-methylphenyl]-9-methylpurin-6-yl]amino]benzoic acid
Show/Hide
|
C31H30N6O3
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0443094
|
4-tert-butyl-N-[4-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzamide
Show/Hide
|
C34H35N7O3
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0447344
|
4-tert-butyl-N-[3-[5-[4-(4-methoxypiperidine-1-carbonyl)-3-(prop-2-enoylamino)anilino]-1-methyl-6-oxopyridin-3-yl]-2-methylphenyl]benzamide
Show/Hide
|
C40H45N5O5
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0571780
|
5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]piperidin-3-yl]pyrazole-4-carboxamide
Show/Hide
|
C27H30F2N6O3
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0553320
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-pyridazin-3-ylbenzamide
Show/Hide
|
C27H27FN8O3
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0520807
|
5-amino-1-[(3R)-1-[(E)-but-2-enoyl]piperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]pyrazole-4-carboxamide
Show/Hide
|
C25H25F2N5O3
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0571420
|
4-tert-butyl-N-[3-[9-methyl-6-[4-(morpholine-4-carbonyl)anilino]purin-2-yl]phenyl]benzamide
Show/Hide
|
C34H35N7O3
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0564457
|
US9446130, 19
Show/Hide
|
C28H24F3N9O
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0492065
|
tert-butyl 4-[4-[[5-[3-[(4-tert-butylbenzoyl)amino]-2-methylphenyl]-1-methyl-2-oxopyridin-3-yl]amino]-2-(prop-2-enoylamino)benzoyl]piperazine-1-carboxylate
Show/Hide
|
C43H50N6O6
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0570440
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl 4-(2-hydroxyethyl)piperazine-1-carbodithioate
Show/Hide
|
C28H32FN7O3S2
|
1
|
| 1 |
IC50 = 68.3 nM
|
|
|
|
CP0578161
|
US9481682, 179
Show/Hide
|
C26H28N8O2S
|
1
|
| 1 |
IC50 = 68.9 nM
|
|
|
|
CP0433210
|
4-N-(5-fluoro-2-methylphenyl)-8-N-methylimidazo[1,5-a]quinoxaline-4,8-diamine
Show/Hide
|
C18H16FN5
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0538215
|
2-[3-(furan-2-carbonylamino)phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
|
C26H26N6O3S
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0414121
|
N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-4-(trifluoromethyl)benzamide
Show/Hide
|
C35H32F3N5O5
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0433183
|
(E)-4-(dimethylamino)-N-[4-(3-hydroxy-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
Show/Hide
|
C24H26N6O2
|
1
|
| 1 |
IC50 = 76.5 nM
|
|
|
|
CP0413196
|
[4-[[2-(3-amino-2-methylphenyl)-7H-purin-6-yl]amino]phenyl]-morpholin-4-ylmethanone
Show/Hide
|
C23H23N7O2
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0471890
|
N-[3-[[5-chloro-2-[4-[(4-fluorophenyl)sulfonylamino]-3-methylanilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H22ClFN6O3S
|
1
|
| 1 |
IC50 = 78.6 nM
|
|
|
|
CP0549088
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl 4-acetylpiperazine-1-carbodithioate
Show/Hide
|
C28H30FN7O3S2
|
1
|
| 1 |
IC50 = 80.3 nM
|
|
|
|
CP0483297
|
US9481682, 129
Show/Hide
|
C27H27N7O3
|
1
|
| 1 |
IC50 = 81.2 nM
|
|
|
|
CP0450972
|
N-[3-[[5-chloro-2-[2-methyl-4-[3-(4-methylpiperazin-1-yl)propoxy]anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C28H34ClN7O2
|
1
|
| 1 |
IC50 = 81.7 nM
|
|
|
|
CP0559022
|
N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzamide
Show/Hide
|
C30H27N7O3
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0465895
|
US9446130, 10
Show/Hide
|
C26H22F3N9O
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0466003
|
US9481682, 127
Show/Hide
|
C28H24F3N7O4
|
2
|
| 1 |
IC50 = 83 nM
|
|
|
| 2 |
IC50 = 83.5 nM
|
|
|
|
CP0478863
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl piperidine-1-carbodithioate
Show/Hide
|
C27H29FN6O2S2
|
1
|
| 1 |
IC50 = 83.6 nM
|
|
|
|
CP0531484
|
(2S)-N-[(1S)-2-[[(2R)-3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl]amino]-2-oxo-1-phenylethyl]oxirane-2-carboxamide
Show/Hide
|
C22H22N4O4
|
3
|
| 1 |
IC50 = 84.2 nM
|
|
|
| 2 |
IC50 > 5920 nM
|
|
|
| 3 |
Ki = 1930 nM
|
|
|
|
CP0539829
|
N-[3-[[2-[4-[(4-fluorophenyl)sulfonylamino]-3-methylanilino]-5-nitropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H22FN7O5S
|
1
|
| 1 |
IC50 = 85.4 nM
|
|
|
|
CP0548655
|
N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-4-pyrrolidin-1-ylbenzamide
Show/Hide
|
C38H40N6O5
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0463309
|
4-tert-butyl-N-[3-[6-[4-[2-(dimethylamino)ethylcarbamoyl]anilino]-9-methylpurin-2-yl]-2-methylphenyl]benzamide
Show/Hide
|
C35H40N8O2
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0492066
|
N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide
Show/Hide
|
C36H35N5O7
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0457510
|
N-[3-[[5-chloro-2-[2-methyl-4-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H31ClN6O3
|
1
|
| 1 |
IC50 = 89.32 nM
|
|
|
|
CP0482354
|
N-[3-[[2-[4-[3-(4-ethylpiperazin-1-yl)propoxy]-2-methylanilino]-5-fluoropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C29H36FN7O2
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0520806
|
5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-[(3R)-1-[(E)-4-fluorobut-2-enoyl]piperidin-3-yl]pyrazole-4-carboxamide
Show/Hide
|
C25H24F3N5O3
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0489640
|
N-[3-[[2-[4-[[2-[bis(2-methoxyethyl)amino]acetyl]amino]anilino]-5-fluoropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H32FN7O4
|
1
|
| 1 |
IC50 = 91.3 nM
|
|
|
|
CP0554866
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-prop-2-enylcarbamodithioate
Show/Hide
|
C25H25FN6O2S2
|
1
|
| 1 |
IC50 = 91.7 nM
|
|
|
|
CP0403101
|
5-amino-3-[4-(5-chloropyridin-2-yl)oxyphenyl]-1-[(3R)-1-cyanopiperidin-3-yl]pyrazole-4-carboxamide
Show/Hide
|
C21H20ClN7O2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0577868
|
US9481682, 149
Show/Hide
|
C29H30F3N9O3
|
1
|
| 1 |
IC50 = 96.7 nM
|
|
|
|
CP0196495
|
N-[3-[2-(4-methoxyanilino)purin-9-yl]phenyl]prop-2-enamide
Show/Hide
|
C21H18N6O2
|
1
|
| 1 |
IC50 = 97.1 nM
|
|
|
|
CP0520079
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-propan-2-ylcarbamodithioate
Show/Hide
|
C25H27FN6O2S2
|
1
|
| 1 |
IC50 = 98.2 nM
|
|
|
|
CP0562812
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-(4-methylpyrimidin-2-yl)benzamide
Show/Hide
|
C28H29FN8O3
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0538055
|
2-[3-[(4-methylcyclohexanecarbonyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
|
C29H36N6O2S
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
|
CP0017985
|
N-[4-[8-(6-methoxypyridin-3-yl)-2-oxo-[1]benzofuro[3,2-b]pyridin-1-yl]phenyl]-2-piperidin-1-ylacetamide
Show/Hide
|
C30H28N4O4
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0565896
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-(3-methylpyridin-2-yl)benzamide
Show/Hide
|
C29H30FN7O3
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0524481
|
2,2-dimethyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]propanamide
Show/Hide
|
C28H31N7O3
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0555489
|
N-[3-[[5-chloro-2-[4-[[ethoxy(morpholin-4-yl)phosphoryl]methyl]anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H30ClN6O4P
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0567155
|
4-methyl-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
|
C35H35N5O5
|
1
|
| 1 |
IC50 = 114 nM
|
|
|
|
CP0549498
|
5-amino-1-[(3R)-1-[(E)-4,4-difluorobut-2-enoyl]piperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]pyrazole-4-carboxamide
Show/Hide
|
C25H23F4N5O3
|
1
|
| 1 |
IC50 = 115 nM
|
|
|
|
CP0435413
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-cyclohexylcarbamodithioate
Show/Hide
|
C28H31FN6O2S2
|
1
|
| 1 |
IC50 = 115.2 nM
|
|
|
|
CP0565895
|
4-[8-amino-3-[(3R)-1-(3-methyloxetane-3-carbonyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-N-(5-cyano-1,3-thiazol-2-yl)-3-fluorobenzamide
Show/Hide
|
C27H25FN8O3S
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0570435
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N,N-dibutylcarbamodithioate
Show/Hide
|
C30H37FN6O2S2
|
1
|
| 1 |
IC50 = 125.2 nM
|
|
|
|
CP0497401
|
4-tert-butyl-N-[3-[6-[4-(2-hydroxyethylcarbamoyl)anilino]-9-methylpurin-2-yl]-2-methylphenyl]benzamide
Show/Hide
|
C33H35N7O3
|
1
|
| 1 |
IC50 = 126 nM
|
|
|
|
CP0548653
|
4-tert-butyl-N-[2-methyl-3-[1-methyl-5-[4-(4-methylpiperazine-1-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
|
C39H44N6O4
|
1
|
| 1 |
IC50 = 127 nM
|
|
|
|
CP0530929
|
4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]butyl 4-propan-2-ylpiperazine-1-carbodithioate
Show/Hide
|
C31H38FN7O2S2
|
1
|
| 1 |
IC50 = 130.6 nM
|
|
|
|
CP0207024
|
4-[8-amino-3-(morpholin-4-ylmethyl)imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
|
C24H22F3N7O2
|
1
|
| 1 |
IC50 = 132 nM
|
|
|
|
CP0518597
|
2-[3-[(4-chlorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylic acid
Show/Hide
|
C28H26ClN5O3S
|
1
|
| 1 |
IC50 = 134 nM
|
|
|
|
CP0465904
|
US9481682, 138
Show/Hide
|
C33H34F3N7O3
|
1
|
| 1 |
IC50 = 135.3 nM
|
|
|
|
CP0013015
|
N-[4-(2-oxo-8-pyridin-3-yl-[1]benzofuro[3,2-b]pyridin-1-yl)phenyl]prop-2-enamide
Show/Hide
|
C25H17N3O3
|
1
|
| 1 |
IC50 = 136 nM
|
|
|
|
CP0032295
|
N-[4-[8-(6-methoxypyridin-3-yl)-2-oxo-[1]benzofuro[3,2-b]pyridin-1-yl]phenyl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
|
C30H29N5O4
|
1
|
| 1 |
IC50 = 139 nM
|
|
|
|
CP0559021
|
4-tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-9-(2-phenylethyl)purin-2-yl]phenyl]benzamide
Show/Hide
|
C42H43N7O3
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0463308
|
2-(dimethylamino)ethyl 4-[[2-[3-[(4-tert-butylbenzoyl)amino]-2-methylphenyl]-9-methylpurin-6-yl]amino]benzoate
Show/Hide
|
C35H39N7O3
|
1
|
| 1 |
IC50 = 143 nM
|
|
|
|
CP0920712
|
US9481682, 177
Show/Hide
|
C25H23F3N8O2
|
1
|
| 1 |
IC50 = 144.2 nM
|
|
|
|
CP0497399
|
4-tert-butyl-N-[3-[1-methyl-4-[4-(morpholine-4-carbonyl)anilino]imidazo[4,5-c]pyridin-6-yl]phenyl]benzamide
Show/Hide
|
C35H36N6O3
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0168512
|
US10005782, Compound 48
Show/Hide
|
C27H21N5O3
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0478862
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl pyrrolidine-1-carbodithioate
Show/Hide
|
C26H27FN6O2S2
|
1
|
| 1 |
IC50 = 154.5 nM
|
|
|
|
CP0540641
|
US9481682, 184
Show/Hide
|
C28H26F3N7O5
|
1
|
| 1 |
IC50 = 155.3 nM
|
|
|
|
CP0452683
|
2-(3-benzamidophenyl)-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
|
C28H28N6O2S
|
1
|
| 1 |
IC50 = 159 nM
|
|
|
|
CP0538080
|
ethyl 2-[3-(furan-2-carbonylamino)phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylate
Show/Hide
|
C28H29N5O4S
|
1
|
| 1 |
IC50 = 161 nM
|
|
|
|
CP0447342
|
4-tert-butyl-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(propanoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
|
C38H43N5O5
|
1
|
| 1 |
IC50 = 163 nM
|
|
|
|
CP0473855
|
N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]cyclohexanecarboxamide
Show/Hide
|
C30H33N7O3
|
1
|
| 1 |
IC50 = 169 nM
|
|
|
|
CP0481321
|
4-tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-9-propylpurin-2-yl]phenyl]benzamide
Show/Hide
|
C37H41N7O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0539590
|
5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-[(3R)-1-(2-fluoroprop-2-enoyl)piperidin-3-yl]pyrazole-4-carboxamide
Show/Hide
|
C24H22F3N5O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0554298
|
5-amino-3-[4-(2,4-difluorophenoxy)phenyl]-1-[(3R)-1-(2-methylprop-2-enoyl)piperidin-3-yl]pyrazole-4-carboxamide
Show/Hide
|
C25H25F2N5O3
|
1
|
| 1 |
IC50 = 176 nM
|
|
|
|
CP0029123
|
N-[4-[8-(6-methoxypyridin-3-yl)-2-oxo-[1]benzofuro[3,2-b]pyridin-1-yl]phenyl]-2-pyrrolidin-1-ylacetamide
Show/Hide
|
C29H26N4O4
|
1
|
| 1 |
IC50 = 183 nM
|
|
|
|
CP0567151
|
4-(dimethylamino)-N-[3-[5-[4-(4-hydroxypiperidine-1-carbonyl)-3-(prop-2-enoylamino)anilino]-1-methyl-6-oxopyridin-3-yl]-2-methylphenyl]benzamide
Show/Hide
|
C37H40N6O5
|
1
|
| 1 |
IC50 = 187 nM
|
|
|
|
CP0489602
|
US9481682, 9
Show/Hide
|
C26H25N7O2
|
1
|
| 1 |
IC50 = 194 nM
|
|
|
|
CP0567152
|
methyl 4-[[5-[3-[(4-tert-butylbenzoyl)amino]-2-methylphenyl]-1-methyl-2-oxopyridin-3-yl]amino]-2-(prop-2-enoylamino)benzoate
Show/Hide
|
C35H36N4O5
|
1
|
| 1 |
IC50 = 197 nM
|
|
|
|
CP0031672
|
N-[4-[8-(6-methoxypyridin-3-yl)-2-oxo-[1]benzofuro[3,2-b]pyridin-1-yl]phenyl]-2-morpholin-4-ylacetamide
Show/Hide
|
C29H26N4O5
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0319723
|
US10005782, Compound 5
Show/Hide
|
C25H23N5O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0452681
|
4-[4-(4-methylpiperazin-1-yl)anilino]-2-[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]-1,3-thiazole-5-carboxamide
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C29H27F3N6O2S
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1
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| 1 |
IC50 = 206 nM
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CP0414122
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4-ethyl-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
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C36H37N5O5
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1
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| 1 |
IC50 = 210 nM
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CP0413193
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4-tert-butyl-N-[2-methyl-3-[8-[4-(morpholine-4-carbonyl)anilino]imidazo[1,2-b]pyridazin-6-yl]phenyl]benzamide
Show/Hide
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C35H36N6O3
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1
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| 1 |
IC50 = 213 nM
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CP0538054
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N-[3-[5-carbamoyl-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-2-yl]phenyl]thiadiazole-4-carboxamide
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C24H24N8O2S2
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1
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| 1 |
IC50 = 213 nM
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CP0030657
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N-[4-[8-(1-methylpyrazol-4-yl)-2-oxo-[1]benzofuro[3,2-b]pyridin-1-yl]phenyl]prop-2-enamide
Show/Hide
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C24H18N4O3
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1
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| 1 |
IC50 = 217 nM
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CP0539592
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(R)-5-amino-3-(4-((5-chloro-3-fluoropyridin-2-yl)oxy)phenyl)-1-(1-cyanopiperidin-3-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C21H19ClFN7O2
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1
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| 1 |
IC50 = 230 nM
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CP0467533
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4-tert-butyl-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-2-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
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C38H41N5O5
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1
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| 1 |
IC50 = 231 nM
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CP0923107
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(3R)-2-((3R)-4-(3-fluorophenyl)-3-(oxirane-2-carboxamido)butanoyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
Show/Hide
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C26H27FN4O4
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3
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| 1 |
IC50 = 232 nM
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| 2 |
IC50 > 5920 nM
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| 3 |
Ki = 9270 nM
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CP0032229
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2-(dimethylamino)-N-[4-[8-(6-methoxypyridin-3-yl)-2-oxo-[1]benzofuro[3,2-b]pyridin-1-yl]phenyl]acetamide
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C27H24N4O4
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1
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| 1 |
IC50 = 237 nM
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CP0419199
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US9481682, 185
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C27H27F3N8O2
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1
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| 1 |
IC50 = 237.4 nM
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CP0418263
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US9481682, 174
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C25H22F3N7O3
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1
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| 1 |
IC50 = 240.6 nM
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CP0451318
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2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N,N-dipropylcarbamodithioate
Show/Hide
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C28H33FN6O2S2
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1
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| 1 |
IC50 = 240.8 nM
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CP0534729
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4-(dimethylamino)-N-[3-[5-[4-(3-hydroxypiperidine-1-carbonyl)-3-(prop-2-enoylamino)anilino]-1-methyl-6-oxopyridin-3-yl]-2-methylphenyl]benzamide
Show/Hide
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C37H40N6O5
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1
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| 1 |
IC50 = 244 nM
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CP0552496
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US9481682, 173
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C25H22F3N7O3
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1
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| 1 |
IC50 = 245.4 nM
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CP0538220
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2-[3-[(4-fluorobenzoyl)amino]phenyl]-4-(4-morpholin-4-ylanilino)-1,3-thiazole-5-carboxamide
Show/Hide
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C27H24FN5O3S
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1
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| 1 |
IC50 = 258 nM
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CP0489691
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tert-butyl 4-[2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethylsulfanylcarbothioyl]piperazine-1-carboxylate
Show/Hide
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C31H36FN7O4S2
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1
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| 1 |
IC50 = 263.7 nM
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CP0491056
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US9481682, 182
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C24H24N8O2S
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1
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| 1 |
IC50 = 272.1 nM
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CP0507089
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N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-4-morpholin-4-ylbenzamide
Show/Hide
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C38H40N6O6
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1
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| 1 |
IC50 = 273 nM
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CP0466029
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US9481682, 125
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C30H30F3N7O2
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1
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| 1 |
IC50 = 278.3 nM
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CP0492067
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N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-1,3-benzodioxole-5-carboxamide
Show/Hide
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C35H33N5O7
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1
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| 1 |
IC50 = 282 nM
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CP0456251
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(E)-4-(dimethylamino)-N-methyl-N-[4-(2-methylphenyl)sulfanylimidazo[1,5-a]quinoxalin-8-yl]but-2-enamide
Show/Hide
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C24H25N5OS
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1
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| 1 |
IC50 = 283 nM
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CP0466450
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2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl 4-benzylpiperazine-1-carbodithioate
Show/Hide
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C33H34FN7O2S2
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1
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| 1 |
IC50 = 283.5 nM
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CP0465920
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US9481682, 180
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C30H31F3N8O2
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1
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| 1 |
IC50 = 284.9 nM
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CP0413157
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US9481682, 157
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C30H30F3N7O4
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1
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| 1 |
IC50 = 291.6 nM
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CP0261532
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4-[8-amino-3-[4-(3-methoxypropanoyl)-1,1-dioxo-1,4-thiazinan-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
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C27H26F3N7O5S
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1
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| 1 |
IC50 = 294 nM
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CP0539337
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2-[3-[(4-tert-butylbenzoyl)amino]phenyl]-4-[4-(morpholine-4-carbonyl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
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C32H33N5O4S
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1
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| 1 |
IC50 = 333 nM
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CP0560069
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US9481682, 124
Show/Hide
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C28H25F3N8O3
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2
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| 1 |
IC50 = 347.5 nM
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| 2 |
IC50 = 348 nM
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CP0410699
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4-tert-butyl-N-[2-methyl-3-[1-methyl-5-[4-methyl-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
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C34H36N4O3
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1
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| 1 |
IC50 = 365 nM
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CP0227868
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4-(8-amino-3-{(2R)-4-[(1-methylcyclopropyl)carbonyl] piperazin-2-yl}imidazo[1,5-a]pyrazin-1-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
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C27H27F3N8O3
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1
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| 1 |
IC50 = 377 nM
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CP0553245
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2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl 4-phenylpiperazine-1-carbodithioate
Show/Hide
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C32H32FN7O2S2
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1
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| 1 |
IC50 = 385.9 nM
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CP0497400
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4-tert-butyl-N-[2-methyl-3-[8-[4-(morpholine-4-carbonyl)anilino]imidazo[1,2-a]pyridin-6-yl]phenyl]benzamide
Show/Hide
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C36H37N5O3
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1
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| 1 |
IC50 = 574 nM
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CP0492064
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4-(dimethylamino)-N-[3-[5-[4-(4-methoxypiperidine-1-carbonyl)-3-(prop-2-enoylamino)anilino]-1-methyl-6-oxopyridin-3-yl]-2-methylphenyl]benzamide
Show/Hide
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C38H42N6O5
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1
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| 1 |
IC50 = 596 nM
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CP0563581
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2-[3-[(4-chlorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
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C28H27ClN6O2S
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1
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| 1 |
IC50 = 614 nM
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CP0533231
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4-[4-(morpholine-4-carbonyl)anilino]-2-[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]-1,3-thiazole-5-carboxamide
Show/Hide
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C29H24F3N5O4S
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1
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| 1 |
IC50 = 617 nM
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CP0485546
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4-[4-(4-methylpiperazin-1-yl)anilino]-2-[3-[[5-(trifluoromethyl)pyridine-2-carbonyl]amino]phenyl]-1,3-thiazole-5-carboxamide
Show/Hide
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C28H26F3N7O2S
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1
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| 1 |
IC50 = 637 nM
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CP0545647
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4-[[5-[3-[[4-(dimethylamino)benzoyl]amino]-2-methylphenyl]-1-methyl-2-oxopyridin-3-yl]amino]-N-(2-methoxyethyl)-2-(prop-2-enoylamino)benzamide
Show/Hide
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C35H38N6O5
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1
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| 1 |
IC50 = 667 nM
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CP0390478
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7-fluoro-N-methyl-4-(2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-amine
Show/Hide
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C18H15FN4O
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1
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| 1 |
IC50 = 670 nM
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CP0452685
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2-[3-[(4-fluorobenzoyl)amino]phenyl]-4-[4-(morpholine-4-carbonyl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
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C28H24FN5O4S
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1
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| 1 |
IC50 = 733 nM
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CP0564458
|
US9446130, 24
Show/Hide
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C27H23F3N8O
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1
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| 1 |
IC50 = 740 nM
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CP0536944
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US9481682, 126
Show/Hide
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C31H30F3N7O2
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1
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| 1 |
IC50 = 765.9 nM
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CP0486119
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US9481682, 114
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C29H26F5N7O2
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2
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| 1 |
IC50 = 830.9 nM
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| 2 |
IC50 = 831 nM
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CP0525587
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US10005782, Compound 8
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C28H21N5O3
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1
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| 1 |
IC50 = 860 nM
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CP0559757
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2-[3-[(4-fluorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
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C28H27FN6O2S
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1
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| 1 |
IC50 = 862 nM
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CP0448389
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2-[2-[3-[(4-tert-butylbenzoyl)amino]-2-methylphenyl]-6-[4-(morpholine-4-carbonyl)anilino]purin-9-yl]acetic acid
Show/Hide
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C36H37N7O5
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1
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| 1 |
IC50 = 970 nM
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CP0563321
|
US9446130, 23
Show/Hide
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C27H23F3N8O
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1
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| 1 |
IC50 = 1000 nM
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CP0474173
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US10005782, Compound 13
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C26H25N5O2
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1
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| 1 |
IC50 = 1000 nM
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CP0538219
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2-[3-[(4-fluorobenzoyl)amino]phenyl]-4-(4-morpholin-4-ylanilino)-1,3-thiazole-5-carboxylic acid
Show/Hide
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C27H23FN4O4S
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1
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| 1 |
IC50 = 1120 nM
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CP0507088
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3-methoxy-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
|
C35H35N5O6
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1
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| 1 |
IC50 = 1191 nM
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CP0513524
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4-(4-fluoro-2-methylphenoxy)-N-methylimidazo[1,5-a]quinoxalin-8-amine
Show/Hide
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C18H15FN4O
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1
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| 1 |
IC50 = 1220 nM
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CP0534735
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4-methyl-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C36H34F3N5O5
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1
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| 1 |
IC50 = 1261 nM
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CP0548654
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3,4,5-trimethoxy-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
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C37H39N5O8
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1
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| 1 |
IC50 = 1426 nM
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CP0545649
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4-tert-butyl-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)anilino]-6-oxopyridin-3-yl]-4-(prop-2-enoylamino)phenyl]benzamide
Show/Hide
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C38H41N5O5
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1
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| 1 |
IC50 = 1697 nM
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CP0452684
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ethyl 2-[3-[(2-fluorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylate
Show/Hide
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C30H30FN5O3S
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1
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| 1 |
IC50 = 2096 nM
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CP0538056
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2-[3-[(4-tert-butylbenzoyl)amino]phenyl]-4-(4-morpholin-4-ylanilino)-1,3-thiazole-5-carboxamide
Show/Hide
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C31H33N5O3S
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1
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| 1 |
IC50 = 2229 nM
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CP0534478
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ethyl 4-(4-morpholin-4-ylanilino)-2-[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]-1,3-thiazole-5-carboxylate
Show/Hide
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C30H27F3N4O4S
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1
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| 1 |
IC50 = 2422 nM
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CP0507008
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4-methoxy-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
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C35H35N5O6
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1
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| 1 |
IC50 = 2610 nM
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CP0489534
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2-[3-[(2-fluorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
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C28H27FN6O2S
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1
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| 1 |
IC50 = 2671 nM
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CP0545645
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4-(dimethylamino)-N-[2-methyl-3-[1-methyl-6-oxo-5-[[3-(prop-2-enoylamino)cyclohexyl]amino]pyridin-3-yl]phenyl]benzamide
Show/Hide
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C31H37N5O3
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1
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| 1 |
IC50 = 2946 nM
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CP0546752
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4-[[5-[3-[[4-(dimethylamino)benzoyl]amino]-2-methylphenyl]-1-methyl-2-oxopyridin-3-yl]amino]-N,N-bis(2-ethoxyethyl)-2-(prop-2-enoylamino)benzamide
Show/Hide
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C40H48N6O6
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1
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| 1 |
IC50 = 3187 nM
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CP0548656
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N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
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C34H33N5O5
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1
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| 1 |
IC50 = 3736 nM
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CP0533232
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ethyl 2-[3-[[4-(dimethylamino)benzoyl]amino]phenyl]-4-(4-morpholin-4-ylanilino)-1,3-thiazole-5-carboxylate
Show/Hide
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C31H33N5O4S
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1
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| 1 |
IC50 = 4195 nM
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CP0406461
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(E)-N-(4-chloroimidazo[1,5-a]quinoxalin-8-yl)-4-(dimethylamino)-N-methylbut-2-enamide
Show/Hide
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C17H18ClN5O
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1
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| 1 |
IC50 = 4290 nM
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CP0944384
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(R)-2-(2-((R)-1-acryloylpiperidin-3-yl)acetyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
Show/Hide
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C23H28N4O3
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2
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| 1 |
IC50 = 4760 nM
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| 2 |
IC50 > 5920 nM
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CP0447327
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3,4-dimethoxy-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
Show/Hide
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C36H37N5O7
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1
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| 1 |
IC50 = 4996 nM
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CP0518599
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ethyl 2-[3-[(4-cyanobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylate
Show/Hide
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C31H30N6O3S
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1
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| 1 |
IC50 = 5169 nM
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CP0452686
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2-[3-[(4-tert-butylbenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
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C32H36N6O2S
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1
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| 1 |
IC50 = 5254 nM
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CP0485547
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2-[3-[(4-tert-butylbenzoyl)amino]phenyl]-4-(4-morpholin-4-ylanilino)-1,3-thiazole-5-carboxylic acid
Show/Hide
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C31H32N4O4S
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1
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| 1 |
IC50 = 5323 nM
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CP0538217
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4-(4-morpholin-4-ylanilino)-2-[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]-1,3-thiazole-5-carboxamide
Show/Hide
|
C28H24F3N5O3S
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1
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| 1 |
IC50 = 6754 nM
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CP0482298
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2-[3-[(4-tert-butylbenzoyl)amino]phenyl]-N-methyl-4-(4-morpholin-4-ylanilino)-1,3-thiazole-5-carboxamide
Show/Hide
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C32H35N5O3S
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1
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| 1 |
IC50 = 8529 nM
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CP0414119
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4-(dimethylamino)-N-[2-methyl-3-[1-methyl-6-oxo-5-[3-(prop-2-enoylamino)piperidin-1-yl]pyridin-3-yl]phenyl]benzamide
Show/Hide
|
C30H35N5O3
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1
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| 1 |
IC50 > 10000 nM
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CP0447343
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4-(dimethylamino)-N-[2-methyl-3-[1-methyl-6-oxo-5-[4-(prop-2-enoylamino)piperidin-1-yl]pyridin-3-yl]phenyl]benzamide
Show/Hide
|
C30H35N5O3
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1
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| 1 |
IC50 > 10000 nM
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CP0545646
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4-(dimethylamino)-N-[2-methyl-3-[1-methyl-6-oxo-5-[(1-prop-2-enoylpiperidin-4-yl)amino]pyridin-3-yl]phenyl]benzamide
Show/Hide
|
C30H35N5O3
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1
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| 1 |
IC50 > 10000 nM
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CP0548652
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4-(dimethylamino)-N-[2-methyl-3-[1-methyl-6-oxo-5-[(1-prop-2-enoylpiperidin-3-yl)amino]pyridin-3-yl]phenyl]benzamide
Show/Hide
|
C30H35N5O3
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1
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| 1 |
IC50 > 10000 nM
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CP0567153
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4-tert-butyl-N-[2-methyl-3-[1-methyl-6-oxo-5-[3-(prop-2-enoylamino)anilino]pyridin-3-yl]phenyl]benzamide
Show/Hide
|
C33H34N4O3
|
1
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| 1 |
IC50 > 10000 nM
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CP0567154
|
N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C35H32F3N5O5
|
1
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| 1 |
IC50 > 10000 nM
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CP0497398
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4-tert-butyl-N-[3-[1-methyl-4-[4-(morpholine-4-carbonyl)anilino]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]benzamide
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C34H35N7O3
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1
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| 1 |
IC50 = 12700 nM
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CP0447832
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ethyl 2-[3-[(3-fluorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylate
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C30H30FN5O3S
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1
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| 1 |
IC50 = 19155 nM
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CP0563582
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2-[3-[[4-(dimethylamino)benzoyl]amino]phenyl]-4-(4-morpholin-4-ylanilino)-1,3-thiazole-5-carboxylic acid
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C29H29N5O4S
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1
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| 1 |
IC50 = 21045 nM
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CP0533230
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2-[3-[(2-fluorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylic acid
Show/Hide
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C28H26FN5O3S
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1
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| 1 |
IC50 = 21888 nM
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CP0576080
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2-[3-[(3-fluorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylic acid
Show/Hide
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C28H26FN5O3S
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1
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| 1 |
IC50 = 27822 nM
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CP0473854
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tert-butyl 2-[2-[3-[(4-tert-butylbenzoyl)amino]-2-methylphenyl]-6-[4-(morpholine-4-carbonyl)anilino]purin-9-yl]acetate
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C40H45N7O5
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1
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| 1 |
IC50 = 29000 nM
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|
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CP0558801
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(2S,3aS,7aS)-N-[(2S)-3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl]-1-prop-2-enoyl-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxamide
Show/Hide
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C23H28N4O3
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2
|
| 1 |
IC50 = 36400 nM
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|
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| 2 |
IC50 > 5920 nM
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CP0484101
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ethyl 2-(3-benzamidophenyl)-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylate
Show/Hide
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C30H31N5O3S
|
1
|
| 1 |
IC50 = 37114 nM
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CP0538218
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4-(4-morpholin-4-ylanilino)-2-[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]-1,3-thiazole-5-carboxylic acid
Show/Hide
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C28H23F3N4O4S
|
1
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| 1 |
IC50 = 38109 nM
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|
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CP0395468
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4-tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-9-(3-phenylpropyl)purin-2-yl]phenyl]benzamide
Show/Hide
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C43H45N7O3
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1
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| 1 |
IC50 > 50000 nM
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|
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CP0443092
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4-tert-butyl-N-[3-[4-[4-(morpholine-4-carbonyl)anilino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]phenyl]benzamide
Show/Hide
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C34H34N6O3
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1
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| 1 |
IC50 > 50000 nM
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|
|
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CP0481319
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4-tert-butyl-N-[3-[4-[4-(morpholine-4-carbonyl)anilino]pyrimidin-2-yl]phenyl]benzamide
Show/Hide
|
C32H33N5O3
|
1
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| 1 |
IC50 > 50000 nM
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|
|
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CP0452687
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2-[3-[(4-tert-butylbenzoyl)amino]phenyl]-4-(4-morpholin-4-ylanilino)-N-propan-2-yl-1,3-thiazole-5-carboxamide
Show/Hide
|
C34H39N5O3S
|
1
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| 1 |
IC50 = 62845 nM
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|
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CP0179373
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N-[3-[2-(2-methoxy-4-morpholin-4-ylanilino)-8-oxo-7H-purin-9-yl]phenyl]prop-2-enamide
Show/Hide
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C25H25N7O4
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1
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| 1 |
IC50 > 100 nM
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|
|
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CP0179428
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N-[3-[2-[2-methoxy-4-(4-methylsulfonylpiperazin-1-yl)anilino]purin-9-yl]phenyl]prop-2-enamide
Show/Hide
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C26H28N8O4S
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1
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| 1 |
IC50 > 100 nM
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|
|
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CP0326218
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N-[3-[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]purin-9-yl]phenyl]prop-2-enamide
Show/Hide
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C26H28N8O2
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1
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| 1 |
IC50 > 100 nM
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|
|
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CP0445949
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N-[3-[2-[4-(4-ethylpiperazin-1-yl)-2-methoxyanilino]purin-9-yl]phenyl]prop-2-enamide
Show/Hide
|
C27H30N8O2
|
1
|
| 1 |
IC50 > 100 nM
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|
|
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CP0563699
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N-[3-[2-[4-(4-ethylpiperazin-1-yl)anilino]-8-oxo-7H-purin-9-yl]phenyl]prop-2-enamide
Show/Hide
|
C26H28N8O2
|
1
|
| 1 |
IC50 > 100 nM
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|
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CP0481300
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N-[3-[[2-[4-[[2-[bis(2-methoxyethyl)amino]acetyl]amino]-3-methoxyanilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C28H34ClN7O5
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1
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| 1 |
IC50 > 100 nM
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|
|
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CP0574425
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N-[3-[[2-[4-[2-[bis(2-methoxyethyl)amino]-2-oxoethoxy]-3-chloroanilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H30Cl2N6O5
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1
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| 1 |
IC50 > 100 nM
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|
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CP0539270
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N-[3-[[2-[3-methoxy-4-[(4-methylphenyl)sulfonylamino]anilino]-5-nitropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H25N7O6S
|
1
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| 1 |
IC50 > 100 nM
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|
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CP0553592
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N-[3-[[5-chloro-2-[4-[3-(4-ethylpiperazin-1-yl)propoxy]-2-methylanilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C29H36ClN7O2
|
1
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| 1 |
IC50 > 100 nM
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|
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CP0508234
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2-[4-[[5-fluoro-4-[3-(propanoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-(pyridin-3-ylmethyl)carbamodithioate
Show/Hide
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C28H28FN7O2S2
|
1
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| 1 |
IC50 > 500 nM
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|
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CP0530928
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2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl 3,4-dihydro-1H-isoquinoline-2-carbodithioate
Show/Hide
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C31H29FN6O2S2
|
1
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| 1 |
IC50 > 500 nM
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|
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CP0574238
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4-[8-amino-3-[(6R,8aS)-3-oxo-2,5,6,7,8,8a-hexahydro-1H-indolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl]-3-(trifluoromethyl)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
Show/Hide
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C28H23F6N7O2
|
1
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| 1 |
IC50 > 1000 nM
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