Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-tert-butyl-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
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 PubChem ID
CID: 129896681
Canonical SMILES
Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1cc(Nc2ccc(C(=O)N3CCOCC3)c(NC(=O)C=C)c2)c(=O)n(C)c1
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Compound Formula C38H41N5O5
Compound Structure
Protein Name
 Protein Info 
Tyrosine-protein kinase BTK
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Tec family
Uniprot ID
Q06187
Gene Name
BTK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 4.7 nM
   TI
   LI
   LO
   TS
2
EC50 > 100 nM
   TI
   LI
   LO
   TS
CL000176 Pfeiffer
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 < 30 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
2
Ki = 8.9 nM
   TI
   LI
   LO
   TS
CL000177 U-2932
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 < 30 nM
   TI
   LI
   LO
   TS