General Information of the Compound
| Compound ID |
CP0447341
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| Compound Name |
N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide
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| Structure |
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| Formula |
C36H37N5O5S
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| Molecular Weight |
651.789
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| Canonical SMILES |
Cc1c(NC(=O)c2cc3CCCCc3s2)cccc1-c1cc(Nc2ccc(C(=O)N3CCOCC3)c(NC(=O)C=C)c2)c(=O)n(C)c1
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| InChI |
InChI=1S/C36H37N5O5S/c1-4-33(42)38-29-20-25(12-13-27(29)35(44)41-14-16-46-17-15-41)37-30-18-24(21-40(3)36(30)45)26-9-7-10-28(22(26)2)39-34(43)32-19-23-8-5-6-11-31(23)47-32/h4,7,9-10,12-13,18-21,37H,1,5-6,8,11,14-17H2,2-3H3,(H,38,42)(H,39,43)
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| InChIKey |
UQDKCJOIUBVSRC-UHFFFAOYSA-N
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01669, Cytoplasmic tyrosine-protein kinase BMX
Protein ID: PT00922, Epidermal growth factor receptor
Protein ID: PT01308, Tyrosine-protein kinase BTK
Protein ID: PT00892, Tyrosine-protein kinase JAK3
Cell Viability or Cytotoxicity Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000003 | Ramos | Homo sapiens (Human) | 1 |
| 1 |
GI50 = 1200 nM
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TI
LI
LO
TS
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| CL000519 | NB4 | Homo sapiens (Human) | 1 |
| 1 |
GI50 = 2400 nM
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TI
LI
LO
TS
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