2-amino-1-(4-(5-(2-(6-bromopyridin-2-ylamino)thiazol-5-ylthio)-2-methylbenzoyl)piperazin-1-yl)ethanone

5-(carbamoylamino)-3-[(5R)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylsulfanyl]-1,2-thiazole-4-carboxamide

3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one

US10005783, 14

Loxo-195

4-aminopyrazolylpyrimidine analogue, 10k

3-(5-Hydroxy-indan-1-ylidene)-1,3-dihydro-indol-2-one

GW278681X

GW284408X

5,18-dimethyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-14-oxo-9-oxa-15,18,23,25,26-pentazatetracyclo[17.5.2.14,8.022,25]heptacosa-1(24),4,6,8(27),19(26),20,22-heptaen-2-yne-6-carboxamide

5-Bromo-3-(5-bromo-6-hydroxy-2'-methoxy-biphenyl-3-ylmethylene)-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one

GW301789X

Oxindole (Scaffold V)

(2R)-2-({5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)-2-(4-fluorophenyl)ethan-1-ol

3-(1-Methyl-1H-indol-3-ylmethylene)-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one

(3S)-3-({5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)-3-(4-fluorophenyl)-N,N-dimethylpropanamide

5,18-dimethyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-14-oxo-9-oxa-15,18,23,25,26-pentazatetracyclo[17.5.2.14,8.022,25]heptacosa-1(24),4,6,8(27),19(26),20,22-heptaen-2-yne-6-carboxamide

(3S)-3-({5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)-3-(4-fluorophenyl)-N-methylpropanamide

(6S)-N-[3-chloro-5-(trifluoromethyl)phenyl]-18-methyl-8-oxo-13-oxa-2,7,14,24,28,29-hexazapentacyclo[20.5.2.12,6.115,19.025,29]hentriaconta-1(28),15(30),16,18,22,24,26-heptaen-20-yne-17-carboxamide

3-[2-[6-[(3S)-3-aminopiperidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]ethynyl]-N-[3-chloro-5-(trifluoromethyl)phenyl]-2-methylbenzamide

1-[4-[2-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]ethyl]phenyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]urea

1-(5-chloro-2-methoxyphenyl)-3-[4-[2-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]ethyl]phenyl]urea

1-[4-[2-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]ethyl]phenyl]-3-[3-(trifluoromethyl)phenyl]urea

1-(3-chlorophenyl)-3-[5-[2-[[7-[3-(dimethylamino)propoxy]quinazolin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea

5-Bromo-3-(3-phenoxy-benzylidene)-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one

4-[(2-hydroxy-1H-indol-3-yl)methylideneamino]benzenesulfonamide

(6S)-N-[3-chloro-5-(trifluoromethyl)phenyl]-19-methyl-14-oxo-2,7,15,25,29,30-hexazapentacyclo[21.5.2.12,6.116,20.026,30]dotriaconta-1(29),16(31),17,19,23,25,27-heptaen-21-yne-18-carboxamide

1-(3-chlorophenyl)-3-[4-[2-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]ethyl]phenyl]urea

4-aminopyrazolylpyrimidine analogue, 10e

4-aminopyrazolylpyrimidine analogue, 10g

(2R)-2-({5-bromo-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)-2-phenylethan-1-ol

4-aminopyrazolylpyrimidine analogue, 10d

N-[3-chloro-5-(trifluoromethyl)phenyl]-5,18-dimethyl-14-oxo-9-oxa-15,18,23,25,26-pentazatetracyclo[17.5.2.14,8.022,25]heptacosa-1(24),4,6,8(27),19(26),20,22-heptaen-2-yne-6-carboxamide

(6S)-N-[3-chloro-5-(trifluoromethyl)phenyl]-20-methyl-15-oxo-2,7,16,26,30,31-hexazapentacyclo[22.5.2.12,6.117,21.027,31]tritriaconta-1(30),17(32),18,20,24,26,28-heptaen-22-yne-19-carboxamide

4-aminopyrazolylpyrimidine analogue, 5

4-aminopyrazolylpyrimidine analogue, 10f

(6S)-N-[3-chloro-5-(trifluoromethyl)phenyl]-18-methyl-13-oxo-2,7,14,24,28,29-hexazapentacyclo[20.5.2.12,6.115,19.025,29]hentriaconta-1(28),15(30),16,18,22,24,26-heptaen-20-yne-17-carboxamide

1-(3-chlorophenyl)-3-[4-[2-[(6-ethoxy-7-fluoroquinazolin-4-yl)amino]ethyl]phenyl]urea

4-aminopyrazolylpyrimidine analogue, 10h

4-aminopyrazolylpyrimidine analogue, 10b

2-N-benzyl-5-bromo-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

4-aminopyrazolylpyrimidine analogue, 10c

(2S)-2-({5-bromo-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)-2-phenylethan-1-ol

1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[4-[2-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]ethyl]phenyl]urea

1-(3-chloro-4-fluorophenyl)-3-[4-[2-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]ethyl]phenyl]urea

1-(3-chlorophenyl)-3-[4-[2-[(6,7-difluoroquinazolin-4-yl)amino]ethyl]phenyl]urea

1-[4-[2-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]ethyl]phenyl]-3-(3-fluorophenyl)urea

1-(3-chlorophenyl)-3-[4-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]phenyl]urea

N-(4-fluorophenyl)-1-methyl-3-[[methyl-[2-(4-phenylphenyl)ethyl]amino]methyl]indole-5-carboxamide

1-[4-[2-[(7-ethoxy-6-fluoroquinazolin-4-yl)amino]ethyl]phenyl]-3-phenylurea

3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide

3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide