Brief Information of the Compound and Protein
Compound Name
 Compound Info 
Loxo-195
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 PubChem ID
CID: 129103609
Canonical SMILES
C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2
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Compound Formula C20H21FN6O
Compound Structure
Protein Name
 Protein Info 
High affinity nerve growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Trk family
Uniprot ID
P04629
Gene Name
NTRK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.07 nM
2 IC50 = 0.98 nM
3 IC50 < 1 nM
4 IC50 = 2 nM
5 IC50 = 2.1 nM
6 IC50 = 3.7 nM
7 IC50 = 5.5 nM
8 IC50 = 5.8 nM
9 IC50 = 6.2 nM
10 IC50 = 6.7 nM
11 IC50 = 7.6 nM
12 IC50 = 9.3 nM
13 IC50 = 9.8 nM
14 IC50 = 12.6 nM
15 IC50 = 110 nM
16 IC50 = 300 nM