Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10005783, 14
    Show/Hide
 PubChem ID
CID: 46188928
SID: 96042437
Canonical SMILES
O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
    Show/Hide
Compound Formula C21H22F2N6O2
Compound Structure
Protein Name
 Protein Info 
High affinity nerve growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Trk family
Uniprot ID
P04629
Gene Name
NTRK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  3
1
GI50 = 29 nM
   TI
   LI
   LO
   TS
2
GI50 = 602 nM
   TI
   LI
   LO
   TS
3
GI50 = 1190 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 2.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.4 nM
2 IC50 = 1.2 nM
3 IC50 = 1.31 nM
4 IC50 = 1.96 nM
5 IC50 = 2 nM
6 IC50 = 2.9 nM
7 IC50 = 5 nM
8 IC50 = 5.6 nM
9 IC50 = 6.5 nM
10 IC50 = 9.7 nM
11 IC50 = 32.2 nM
12 IC50 = 38.6 nM
13 IC50 = 43.1 nM
14 IC50 = 45 nM
15 IC50 = 69 nM
16 IC50 = 109.4 nM
17 IC50 = 140 nM
18 IC50 = 237.4 nM
19 IC50 = 272 nM
20 IC50 = 1214 nM