| Compound ID |
Compound Name |
Compound Formula |
|
CP0384891
|
US9206198, 78
Show/Hide
|
C23H25ClN2O6
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0450009
|
US9206198, 5
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|
C23H26N2O6
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0577906
|
US9206198, 22
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|
C23H25FN2O6
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0309072
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C22H25N3O4S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0132553
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methoxypyrimidin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H28N4O5
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0260361
|
US9206198, 7
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|
C24H28N2O6
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0518994
|
US9206198, 25
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|
C23H25ClN2O6
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0561521
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C22H26N4O4S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0189728
|
US9018211, 2A
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|
C26H30N2O6
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0352199
|
US9018211, 2C
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|
C26H30N2O6
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0384888
|
US9206198, 9
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|
C25H30N2O6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0412507
|
US9206198, 76
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|
C26H30N2O6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0436116
|
US9206198, 53C
Show/Hide
|
C25H30N2O6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0450011
|
US9206198, 80
Show/Hide
|
C23H25FN2O6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0545608
|
US9206198, 74
Show/Hide
|
C25H30N2O6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0577907
|
US9206198, 23
Show/Hide
|
C24H28N2O6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0488458
|
6-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0555544
|
US9493474, 10A
Show/Hide
|
C29H34N2O6
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0361823
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-pyridin-4-yl-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H27N3O4
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0547096
|
US10513518, Example 11
Show/Hide
|
C24H28N2O5
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0402857
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H27N3O4S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0503622
|
US9018211, 2B
Show/Hide
|
C26H30N2O6
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0481152
|
US9139585, 34B
Show/Hide
|
C23H27N7O4
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0224662
|
5-[1-hydroxy-2-[4-[2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C26H30N2O6
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0575205
|
US10513518, Example 19
Show/Hide
|
C25H30N2O5
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0309069
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H28N4O5
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0455805
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methoxy-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C22H26N4O5S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0441612
|
US9139585, 38A
Show/Hide
|
C27H32N2O6
|
1
|
| 1 |
IC50 = 17.5 nM
|
|
|
|
CP0522602
|
3-[(3R,9aS)-8-[2-[2-(tetrazol-1-yl)pyrimidin-5-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile
Show/Hide
|
C22H22FN9O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0508939
|
US9139585, 44B
Show/Hide
|
C25H30N4O5
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0542846
|
US9206198, 29
Show/Hide
|
C25H30N2O6
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0542847
|
2-(4-ethyl-5-oxo-2H-furan-3-yl)-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C25H30N2O6
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0046632
|
US9056859, 72
Show/Hide
|
C23H25N7O3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0384890
|
US9206198, 30
Show/Hide
|
C25H30N2O6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0423312
|
US9206198, 66
Show/Hide
|
C25H30N2O6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0443044
|
US9206198, 51
Show/Hide
|
C24H28N2O6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0469991
|
US9206198, 11
Show/Hide
|
C25H30N2O6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0545607
|
US9206198, 17
Show/Hide
|
C26H32N2O6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0547580
|
US9206198, 67
Show/Hide
|
C25H30N2O6
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0561358
|
US9206199, 37
Show/Hide
|
C22H21FN8O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0435087
|
US9139585, 30
Show/Hide
|
C26H30N2O5
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0481170
|
US9139585, 36B
Show/Hide
|
C24H29N7O4
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0547102
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H28N2O6
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0376890
|
5-[1-fluoro-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C23H24FN7O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0551386
|
5-[(1R)-1-hydroxy-2-[2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C23H28N2O5
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0386249
|
3-[(3R,9aR)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-2-methylbenzonitrile
Show/Hide
|
C23H24N8O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0459494
|
5-[2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C22H23N7O3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0462906
|
US9139585, 38B
Show/Hide
|
C27H32N2O6
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0568948
|
US9139585, 35A
Show/Hide
|
C24H29N7O4
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0414064
|
5-[(1R)-1-hydroxy-2-[2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C25H31N3O5S
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0499871
|
US9139585, 20
Show/Hide
|
C25H28N4O5
|
1
|
| 1 |
IC50 = 29.5 nM
|
|
|
|
CP0441608
|
US9139585, 18
Show/Hide
|
C28H32N2O7
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0529183
|
US9206198, 12
Show/Hide
|
C25H30N2O6
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0561459
|
US9206198, 69
Show/Hide
|
C26H30N2O6
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0578224
|
US9206198, 10
Show/Hide
|
C24H30N2O5
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0412489
|
US9206199, 13
Show/Hide
|
C22H22FN9O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0475715
|
US9493474, 13A
Show/Hide
|
C27H31N7O4
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0499873
|
US9139585, 37B
Show/Hide
|
C27H32N2O6
|
1
|
| 1 |
IC50 = 31.5 nM
|
|
|
|
CP0441609
|
US9139585, 22
Show/Hide
|
C29H34N2O6
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0441611
|
US9139585, 35B
Show/Hide
|
C24H29N7O4
|
1
|
| 1 |
IC50 = 32.5 nM
|
|
|
|
CP0072053
|
3-[(3R,9aS)-8-[2-[5-(tetrazol-1-yl)pyrazin-2-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile
Show/Hide
|
C22H22FN9O2
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0567810
|
US9139585, 28
Show/Hide
|
C27H32N2O5
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0051539
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-3-one
Show/Hide
|
C24H28N4O6S
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0441610
|
US9139585, 34A
Show/Hide
|
C23H27N7O4
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0386219
|
3-[(3R,9aS)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile
Show/Hide
|
C23H23FN8O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0441184
|
5-[(1R)-1-hydroxy-2-[2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C24H30N4O5S
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0495033
|
US9139585, 33
Show/Hide
|
C26H27F3N2O5
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0115218
|
3-[(3S,9aS)-8-[2-[2-(tetrazol-1-yl)pyrimidin-5-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile
Show/Hide
|
C22H22FN9O2
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0500946
|
US9493474, 11A
Show/Hide
|
C26H30N4O4
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0412488
|
US9206199, 4
Show/Hide
|
C23H23FN8O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0563243
|
US9206199, 6
Show/Hide
|
C22H22FN9O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0504652
|
3-[(3S,9aS)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile
Show/Hide
|
C23H23FN8O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0493283
|
US9139585, 2
Show/Hide
|
C28H34N2O6
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0051541
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-3-one
Show/Hide
|
C25H29N3O6S
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0196247
|
US9206199, 179
Show/Hide
|
C21H21N9O3
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0462904
|
US9139585, 21
Show/Hide
|
C29H34N2O6
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0525121
|
US9139585, 7
Show/Hide
|
C28H32N4O4
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0571857
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-3-one
Show/Hide
|
C23H26N2O6
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0508937
|
US9139585, 32
Show/Hide
|
C27H32N2O5
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0500947
|
US9493474, 19A
Show/Hide
|
C25H28N6O5S
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0517105
|
US9493474, 7A
Show/Hide
|
C25H28N4O4
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0117618
|
2-fluoro-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C23H24FN3O2
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0477756
|
3-[(3R,9aS)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-2-methylbenzonitrile
Show/Hide
|
C23H24N8O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0506843
|
US9206198, 83
Show/Hide
|
C25H30N2O7
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0561458
|
US9206198, 15
Show/Hide
|
C24H28N2O6
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0389764
|
5-[(1R)-1-hydroxy-2-[2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C25H31N3O5S
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0045919
|
1,4-bis[2-(4-nitrophenyl)ethyl]piperazine
Show/Hide
|
C20H24N4O4
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0525268
|
US9108947, 20
Show/Hide
|
C22H24N4O3
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0119734
|
2-ethoxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C25H29N3O3
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0555501
|
US9493474, 11B
Show/Hide
|
C26H30N4O4
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0495012
|
US9139585, 11
Show/Hide
|
C21H22N4O3
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0558881
|
US9139585, 16
Show/Hide
|
C24H26N6O5S
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0495035
|
US9139585, 36A
Show/Hide
|
C24H29N7O4
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0094626
|
US9206199, 1
Show/Hide
|
C24H25N7O4
|
2
|
| 1 |
IC50 = 57 nM
|
|
|
| 2 |
IC50 = 60 nM
|
|
|
|
CP0401083
|
3-[(3R,9aR)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile
Show/Hide
|
C23H23FN8O2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0450010
|
US9206198, 52
Show/Hide
|
C24H26N2O6
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0577905
|
US9206198, 13
Show/Hide
|
C26H32N2O6
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0469799
|
US9206199, 194
Show/Hide
|
C23H24FN9O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0559734
|
US9206199, 26
Show/Hide
|
C23H23N7O4
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0537444
|
US9493474, 8A
Show/Hide
|
C24H25N3O5S
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0069452
|
5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C23H24N6O3
|
2
|
| 1 |
IC50 = 64 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0512079
|
US9139585, 23B
Show/Hide
|
C29H34N2O7
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0515020
|
US9108947, 18
Show/Hide
|
C22H24N4O3
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0181333
|
US9206199, 22
Show/Hide
|
C24H25N7O4
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0108552
|
4-methyl-5-[2-[4-[2-[3-methyl-5-(tetrazol-1-yl)pyridin-2-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H27N7O3
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0438213
|
US9139585, 24B
Show/Hide
|
C30H35NO7
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0545170
|
US9493474, 19B
Show/Hide
|
C25H28N6O5S
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0068097
|
3-[(3S,9aS)-8-[2-[5-(tetrazol-1-yl)pyridin-2-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile
Show/Hide
|
C23H23FN8O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0413455
|
US9206198, 3
Show/Hide
|
C22H24N2O5
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0412490
|
US9206199, 61
Show/Hide
|
C23H23FN8O3
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0419480
|
US9206199, 2
Show/Hide
|
C23H23FN8O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0084615
|
5-[2-[4-[2-[2-methyl-4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H26N6O3
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0478173
|
US9139585, 37A
Show/Hide
|
C27H32N2O6
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0095971
|
4-methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H26N6O3
|
2
|
| 1 |
IC50 = 72 nM
|
|
|
| 2 |
IC50 = 190 nM
|
|
|
|
CP0551420
|
US9206199, 177
Show/Hide
|
C22H23N9O3
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0155267
|
3-[(3R,9aS)-8-[2-[5-(tetrazol-1-yl)pyridin-2-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile
Show/Hide
|
C23H23FN8O2
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0046138
|
2-chloro-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C23H24ClN3O2
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0478174
|
US9139585, 42A
Show/Hide
|
C28H32N2O6
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0356295
|
4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C21H24N4O2
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0561188
|
US9493474, 18A
Show/Hide
|
C26H30N6O5S
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0115217
|
6-[(3R,9aS)-8-[2-[4-(tetrazol-1-yl)phenyl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one
Show/Hide
|
C25H26N6O4
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0563245
|
US9206199, 33
Show/Hide
|
C25H27N7O4
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0400396
|
US9493474, 12A
Show/Hide
|
C29H34N2O6
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0067686
|
US9206199, 176
Show/Hide
|
C22H23N9O3
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0333449
|
US9206199, 23
Show/Hide
|
C24H25N7O4
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0551422
|
3-[(3S,9aS)-8-[2-[6-(tetrazol-1-yl)pyridazin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile
Show/Hide
|
C22H22FN9O2
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0237307
|
US9206199, 21
Show/Hide
|
C24H25N7O4
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0081096
|
2-methoxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C24H27N3O3
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0200085
|
4-[4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]phenyl]-3H-2-benzofuran-1-one
Show/Hide
|
C28H29N3O4
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0356298
|
5-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H26N2O4
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0419995
|
US9206199, 121
Show/Hide
|
C23H24FN9O2
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0475716
|
US9493474, 13B
Show/Hide
|
C27H31N7O4
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0358870
|
4-methyl-5-[1-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]propan-2-yl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H27N7O3
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0462907
|
US9139585, 43B
Show/Hide
|
C25H30N2O6S
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0478175
|
US9139585, 43A
Show/Hide
|
C25H30N2O6S
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0577287
|
2-(2,4-dimethyl-5-oxo-2H-furan-3-yl)-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C25H30N2O6
|
1
|
| 1 |
IC50 = 98 nM
|
|
|
|
CP0339418
|
2-bromo-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C23H24BrN3O2
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0447395
|
US9206199, 166
Show/Hide
|
C24H25N7O3S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0469992
|
US9206198, 14
Show/Hide
|
C26H32N2O6
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0542216
|
US9206199, 3
Show/Hide
|
C23H23FN8O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0518323
|
US9108947, 21
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
IC50 = 103 nM
|
|
|
|
CP0551421
|
US9206199, 180
Show/Hide
|
C21H21N9O3
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0558385
|
US9206199, 24
Show/Hide
|
C24H25N7O4
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
|
CP0424012
|
US9493474, 12B
Show/Hide
|
C29H34N2O6
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
|
CP0385324
|
3-[(3S,9aS)-8-[2-[5-(tetrazol-1-yl)pyrazin-2-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile
Show/Hide
|
C22H22FN9O2
|
1
|
| 1 |
IC50 = 107 nM
|
|
|
|
CP0574121
|
US9493474, 14
Show/Hide
|
C26H29N7O4
|
1
|
| 1 |
IC50 = 108 nM
|
|
|
|
CP0122653
|
4-fluoro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C23H23FN6O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0370828
|
1-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]-2-[4-(tetrazol-1-yl)phenyl]ethanone
Show/Hide
|
C21H23N7O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0196248
|
3-[(3S,9aS)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-2-methylbenzonitrile
Show/Hide
|
C23H24N8O2
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0474524
|
US9139585, 42B
Show/Hide
|
C28H32N2O6
|
1
|
| 1 |
IC50 = 116 nM
|
|
|
|
CP0474879
|
US9493474, 1
Show/Hide
|
C30H36N2O6
|
1
|
| 1 |
IC50 = 117 nM
|
|
|
|
CP0224661
|
5-[1-fluoro-2-[4-[2-fluoro-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C26H28F2N2O4
|
1
|
| 1 |
IC50 = 117 nM
|
|
|
|
CP0474880
|
US9493474, 4B
Show/Hide
|
C28H32N2O6
|
1
|
| 1 |
IC50 = 117.3 nM
|
|
|
|
CP0420173
|
5-[2-[1-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperidin-4-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C23H24N6O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0493298
|
US9139585, 41B
Show/Hide
|
C28H32N2O6
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0558882
|
US9139585, 41A
Show/Hide
|
C28H32N2O6
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0549761
|
US9206199, 38
Show/Hide
|
C22H21FN8O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0539864
|
US9493474, 4A
Show/Hide
|
C28H32N2O6
|
1
|
| 1 |
IC50 = 120.3 nM
|
|
|
|
CP0566351
|
US9493474, 18B
Show/Hide
|
C26H30N6O5S
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0419941
|
US9139585, 13
Show/Hide
|
C26H27N7O4
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0481171
|
US9139585, 40B
Show/Hide
|
C28H32N2O6
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0561360
|
US9206199, 50
Show/Hide
|
C24H26N8O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0493282
|
US9139585, 1
Show/Hide
|
C30H36N2O6
|
1
|
| 1 |
IC50 = 134 nM
|
|
|
|
CP0193431
|
2-methyl-1,4-bis[2-(4-nitrophenyl)ethyl]piperazine
Show/Hide
|
C21H26N4O4
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0447396
|
5-[(7S,9aS)-2-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-1,3,4,6,7,8,9,9a-octahydropyrazino[1,2-a]pyrazin-7-yl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C24H26N8O3
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0508938
|
US9139585, 40A
Show/Hide
|
C28H32N2O6
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0549873
|
US9139585, 12
Show/Hide
|
C24H25N7O4
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0440544
|
US9139585, 29
Show/Hide
|
C27H32N2O5
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
|
CP0567807
|
US9108947, 14
Show/Hide
|
C22H23N3O5S
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0567805
|
US9139585, 15
Show/Hide
|
C25H28N6O5S
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0568949
|
US9139585, 39A
Show/Hide
|
C28H32N2O6
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0572326
|
US9206199, 35
Show/Hide
|
C25H27N7O4
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0435088
|
US9139585, 44A
Show/Hide
|
C25H30N4O5
|
1
|
| 1 |
IC50 = 151 nM
|
|
|
|
CP0133231
|
1-[4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl]-2-[4-(tetrazol-1-yl)phenyl]ethanone
Show/Hide
|
C21H22N8O2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0385323
|
US9206199, 55
Show/Hide
|
C24H25N7O4
|
1
|
| 1 |
IC50 = 165 nM
|
|
|
|
CP0080722
|
5-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]-2,1,3-benzoxadiazole
Show/Hide
|
C20H23N5O3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0493285
|
US9139585, 17A
Show/Hide
|
C24H26N6O5S
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0529413
|
US9493474, 10B
Show/Hide
|
C29H34N2O6
|
1
|
| 1 |
IC50 = 184 nM
|
|
|
|
CP0419481
|
US9206199, 57
Show/Hide
|
C23H23FN8O3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0419939
|
US9139585, 5
Show/Hide
|
C27H30N4O4
|
1
|
| 1 |
IC50 = 197 nM
|
|
|
|
CP0525120
|
US9139585, 3
Show/Hide
|
C23H23N3O5S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0561187
|
US9493474, 15
Show/Hide
|
C25H27N7O4
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0500945
|
US9493474, 6
Show/Hide
|
C31H38N2O6
|
1
|
| 1 |
IC50 = 201 nM
|
|
|
|
CP0567227
|
6-[(3S,9aS)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one
Show/Hide
|
C24H25N7O4
|
1
|
| 1 |
IC50 = 205 nM
|
|
|
|
CP0356297
|
1-[2-(4-nitrophenyl)ethyl]-4-[1-(4-nitrophenyl)propan-2-yl]piperazine
Show/Hide
|
C21H26N4O4
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0133230
|
6-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3,4-dihydroisochromen-1-one
Show/Hide
|
C24H26N6O3
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0516165
|
US9108947, 19
Show/Hide
|
C23H26N6O5S
|
1
|
| 1 |
IC50 = 245 nM
|
|
|
|
CP0157734
|
4-chloro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C23H23ClN6O3
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0155266
|
US9206199, 145
Show/Hide
|
C23H24N8O4
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0578662
|
US9108947, 13
Show/Hide
|
C25H30N4O4
|
1
|
| 1 |
IC50 = 269 nM
|
|
|
|
CP0493284
|
US9139585, 14
Show/Hide
|
C24H26N6O5S
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0537347
|
US9493474, 17
Show/Hide
|
C24H25N7O4
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0531439
|
US9108947, 4
Show/Hide
|
C27H32N2O6
|
1
|
| 1 |
IC50 = 278 nM
|
|
|
|
CP0046139
|
2-cyclopropyloxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C26H29N3O3
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0046135
|
4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0133229
|
4-ethyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C25H28N6O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0568947
|
US9139585, 10
Show/Hide
|
C23H24N4O3
|
1
|
| 1 |
IC50 = 316 nM
|
|
|
|
CP0084603
|
5-[2-[4-[2-[2-cyclopropyl-4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C26H28N6O3
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0178263
|
1-[2-(4-nitrophenyl)ethyl]-4-[2-(4-nitrophenyl)propyl]piperazine
Show/Hide
|
C21H26N4O4
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0524623
|
US9108947, 22
Show/Hide
|
C28H28N4O3
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0474964
|
US9493474, 5
Show/Hide
|
C30H36N2O6
|
1
|
| 1 |
IC50 = 348 nM
|
|
|
|
CP0384889
|
US9206198, 21
Show/Hide
|
C23H26N2O6
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0531438
|
US9108947, 2
Show/Hide
|
C30H36N2O6
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0242098
|
2-(methylamino)-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C24H28N4O2
|
1
|
| 1 |
IC50 = 430 nM
|
|
|
|
CP0368656
|
4-cyclopropyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C26H28N6O3
|
1
|
| 1 |
IC50 = 430 nM
|
|
|
|
CP0369263
|
7-fluoro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C23H23FN6O3
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0515016
|
US9108947, 6
Show/Hide
|
C28H34N2O6
|
1
|
| 1 |
IC50 = 446 nM
|
|
|
|
CP0368106
|
5-[2-[4-[2-[3-methoxy-4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H26N6O4
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0147409
|
6-methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H26N6O3
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0426551
|
6-fluoro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C23H23FN6O3
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0368640
|
3-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C22H23N7O
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0518322
|
US9108947, 3
Show/Hide
|
C27H32N2O6
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0351091
|
5-[2-[4-[2-[4-(tetrazol-1-yl)-2-(trifluoromethyl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H23F3N6O3
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0238291
|
5-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]-2-oxoethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C22H23N3O5
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0178265
|
2-methylsulfanyl-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C24H27N3O2S
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0366642
|
5-[2-oxo-2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-(tetrazol-1-yl)benzonitrile
Show/Hide
|
C24H23N7O3
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0462905
|
US9139585, 31
Show/Hide
|
C26H30N2O5
|
1
|
| 1 |
IC50 = 564 nM
|
|
|
|
CP0531437
|
US9108947, 1
Show/Hide
|
C26H30N2O6
|
1
|
| 1 |
IC50 = 595 nM
|
|
|
|
CP0351092
|
5-[2-[4-[2-[3-fluoro-4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C23H23FN6O3
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0248398
|
4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-(trifluoromethoxy)benzonitrile
Show/Hide
|
C24H24F3N3O3
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0539813
|
US9206198, 24
Show/Hide
|
C24H30N2O5
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0186433
|
4-[2-[4-[2-(4-cyanophenyl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C22H24N4
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
|
CP0147407
|
7-chloro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C23H23ClN6O3
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
|
CP0529377
|
US9493474, 16
Show/Hide
|
C24H25N7O4
|
1
|
| 1 |
IC50 = 850 nM
|
|
|
|
CP0143760
|
4-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C22H23N7O
|
1
|
| 1 |
IC50 = 920 nM
|
|
|
|
CP0492668
|
US9493474, 21
Show/Hide
|
C27H33N3O6S
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0042837
|
7-methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H26N6O3
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0366643
|
5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-2,3-dihydroinden-1-one
Show/Hide
|
C24H26N6O2
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0042838
|
1-[4-[2-(1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl]-2-[4-(tetrazol-1-yl)phenyl]ethanone
Show/Hide
|
C23H26N6O2
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0478168
|
US9108947, 12
Show/Hide
|
C23H26N4O4
|
1
|
| 1 |
IC50 = 1369 nM
|
|
|
|
CP0531441
|
US9108947, 15
Show/Hide
|
C22H23N3O5S
|
1
|
| 1 |
IC50 = 1389 nM
|
|
|
|
CP0368637
|
4-methoxy-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H26N6O4
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0518209
|
US9108947, 17A
Show/Hide
|
C28H32N2O6
|
1
|
| 1 |
IC50 = 1420 nM
|
|
|
|
CP0133228
|
6-methoxy-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H26N6O4
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0541087
|
2-(4-nitrophenyl)-1-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethanone
Show/Hide
|
C20H22N4O5
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0561189
|
US9493474, 23
Show/Hide
|
C24H26N4O4
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0248397
|
4-[2-[4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C21H23N5O
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
|
CP0531440
|
US9108947, 10
Show/Hide
|
C23H26N4O4
|
1
|
| 1 |
IC50 = 2058 nM
|
|
|
|
CP0042840
|
1-[2-(4-nitrophenyl)ethyl]-4-[2-[4-(tetrazol-1-yl)phenyl]ethyl]piperazine
Show/Hide
|
C21H25N7O2
|
1
|
| 1 |
IC50 = 2100 nM
|
|
|
|
CP0046136
|
5-[2-[4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C22H24N4O3
|
1
|
| 1 |
IC50 = 2200 nM
|
|
|
|
CP0474881
|
US9493474, 7B
Show/Hide
|
C25H28N4O4
|
1
|
| 1 |
IC50 = 2404 nM
|
|
|
|
CP0567806
|
US9139585, 23A
Show/Hide
|
C29H34N2O7
|
1
|
| 1 |
IC50 = 2460 nM
|
|
|
|
CP0262640
|
5-[2-[4-[2-[4-(tetrazol-1-yl)-3-(trifluoromethyl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C24H23F3N6O3
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0178261
|
ethyl 4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]benzoate
Show/Hide
|
C23H29N3O4
|
1
|
| 1 |
IC50 = 2900 nM
|
|
|
|
CP0303023
|
1-[2-(4-fluorophenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine
Show/Hide
|
C20H24FN3O2
|
1
|
| 1 |
IC50 = 3100 nM
|
|
|
|
CP0338387
|
3-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C21H24N4O2
|
1
|
| 1 |
IC50 = 3800 nM
|
|
|
|
CP0487011
|
1-[2-(4-nitrophenyl)ethyl]-4-[3-(4-nitrophenyl)propyl]piperazine
Show/Hide
|
C21H26N4O4
|
1
|
| 1 |
IC50 = 3800 nM
|
|
|
|
CP0197612
|
5-[2-[4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl]ethyl]-2,1,3-benzoxadiazole
Show/Hide
|
C20H22N6O2
|
1
|
| 1 |
IC50 = 4200 nM
|
|
|
|
CP0193430
|
2-[4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]phenyl]-1,3-oxazole
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
IC50 = 4300 nM
|
|
|
|
CP0186429
|
1-[2-(4-methoxyphenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine
Show/Hide
|
C21H27N3O3
|
1
|
| 1 |
IC50 = 4600 nM
|
|
|
|
CP0080721
|
1-[2-(4-nitrophenyl)ethyl]piperazine
Show/Hide
|
C12H17N3O2
|
1
|
| 1 |
IC50 = 5200 nM
|
|
|
|
CP0434489
|
6-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C23H24N6O3
|
1
|
| 1 |
IC50 = 7100 nM
|
|
|
|
CP0178262
|
1-[2-(4-methylsulfonylphenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine
Show/Hide
|
C21H27N3O4S
|
1
|
| 1 |
IC50 = 9400 nM
|
|
|
|
CP0396374
|
1-[2-(4-nitrophenyl)ethyl]-4-[2-[4-(trifluoromethyl)phenyl]ethyl]piperazine
Show/Hide
|
C21H24F3N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0435537
|
1-[2-(4-chlorophenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine
Show/Hide
|
C20H24ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0497477
|
1-[2-(4-nitrophenyl)ethyl]-4-[(4-nitrophenyl)methyl]piperazine
Show/Hide
|
C19H22N4O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0521033
|
5-[4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]phenyl]pyrimidine
Show/Hide
|
C24H27N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0525003
|
1-[2-(4-nitrophenyl)ethyl]-4-(2-phenylethyl)piperazine
Show/Hide
|
C20H25N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0247690
|
2-methylsulfonyl-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C24H27N3O4S
|
1
|
| 1 |
IC50 = 12000 nM
|
|
|
|
CP0147410
|
5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-2,3-dihydroisoindol-1-one
Show/Hide
|
C23H25N7O2
|
1
|
| 1 |
IC50 > 32000 nM
|
|
|
|
CP0069559
|
5-[2-[4-[2-[3-ethyl-4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C25H28N6O3
|
1
|
| 1 |
IC50 = 100000 nM
|
|
|
