Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT04958 , Short transient receptor potential channel 6
Gene Name TRPC6
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID Q9Y210
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT04958
 
Compound ID Compound Name Compound Formula
CP0571609
(3R,4R)-1-[5,6-difluoro-1-[(5-methylpyridin-2-yl)methyl]benzimidazol-2-yl]-4-fluoropiperidin-3-amine
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C19H20F3N5
 1
1
IC50 = 0.1 nM
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CP0578416
(3R,4R)-4-fluoro-1-[6-fluoro-1-[(5-fluoropyrimidin-2-yl)methyl]benzimidazol-2-yl]piperidin-3-amine
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C17H17F3N6
 1
1
IC50 = 0.2 nM
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CP0578415
(3R)-1-[1-[(5-chloropyridin-2-yl)methyl]-5-fluorobenzimidazol-2-yl]-4,4-difluoropiperidin-3-amine
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C18H17ClF3N5
 1
1
IC50 = 0.3 nM
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CP0562888
(3R,4R)-4-fluoro-1-[5-fluoro-1-[(5-fluoropyrimidin-2-yl)methyl]benzimidazol-2-yl]piperidin-3-amine
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C17H17F3N6
 1
1
IC50 = 0.4 nM
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CP0562917
(3R,4R)-1-[1-[(5-chloropyrimidin-2-yl)methyl]-4-fluoro-6-methoxybenzimidazol-2-yl]-4-fluoropiperidin-3-amine
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C18H19ClF2N6O
 1
1
IC50 = 0.4 nM
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CP0565053
(3R,4R)-4-fluoro-1-[6-fluoro-1-[(5-fluoropyridin-2-yl)methyl]benzimidazol-2-yl]piperidin-3-amine
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C18H18F3N5
 1
1
IC50 = 0.4 nM
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CP0480989
4-[[(1R,2R,3aR,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-fluoro-7a-methyl-1,2,3,3a,6,7-hexahydroinden-1-yl]oxy]benzonitrile
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C22H28FN3O
 1
1
IC50 = 3 nM
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CP0485521
4-[[(1S,2R,3R,4R,6R,7S)-4-[(3R)-3-aminopiperidin-1-yl]-9-oxo-3-tricyclo[5.2.1.02,6]decanyl]oxy]benzonitrile
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C22H27N3O2
 1
1
IC50 = 8 nM
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CP0127861
4-[[(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile
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C21H22ClN3O
 1
1
IC50 = 9.5 nM
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CP0538675
4-[[(1R,2R,3aR,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-7a-methyl-5-oxo-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile
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C22H29N3O2
 1
1
IC50 = 11 nM
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CP0475136
4-[[(1R,2R,3aR,6aR)-2-[(3R)-3-aminopiperidin-1-yl]-4-oxo-2,3,3a,5,6,6a-hexahydro-1H-pentalen-1-yl]oxy]benzonitrile
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C20H25N3O2
 1
1
IC50 = 22 nM
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CP0456376
4-[[(1R,2R,3aR,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5,5-difluoro-7a-methyl-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile
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C22H29F2N3O
 1
1
IC50 = 30 nM
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CP0478052
4-[[(1R,2R,3aR,5E,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-methoxyimino-7a-methyl-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile
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C23H32N4O2
 1
1
IC50 = 33 nM
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CP0389791
4-[[(1R,2R,3aS,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile
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C22H31N3O
 1
1
IC50 = 37 nM
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CP0475137
4-[[(1R,2R,3aR,5R,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-hydroxy-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile
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C22H31N3O2
 1
1
IC50 = 49 nM
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CP0482699
4-[[(1R,2R,3aR,5R,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-methoxy-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile
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C23H33N3O2
 1
1
IC50 = 52 nM
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CP0390400
4-[[(1R,2R,3R,5R)-3-[(3R)-3-aminopiperidin-1-yl]-6-oxo-2-bicyclo[3.2.0]heptanyl]oxy]benzonitrile
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C19H23N3O2
 1
1
IC50 = 160 nM
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CP0482700
4-[[(1R,2R,3aS,5S,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-(difluoromethyl)-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile
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C23H31F2N3O
 1
1
IC50 = 200 nM
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CP0390399
4-[[(1R,2R,3aR,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-hydroxy-5,7a-dimethyl-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile
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C23H33N3O2
 1
1
IC50 = 210 nM
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CP0480990
(2E)-2-[(1R,2R,3aS,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-1-(4-cyanophenoxy)-7a-methyl-2,3,3a,4,6,7-hexahydro-1H-inden-5-ylidene]-N,N-dimethylacetamide
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C26H36N4O2
 1
1
IC50 = 280 nM
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CP0390426
4-[[(1R,2R,3aS,7aR)-2-[(3R)-3-aminopiperidin-1-yl]-7a-methyl-5-oxo-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile
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C22H29N3O2
 1
1
IC50 = 390 nM
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CP0519974
4-[[(1R,2R,3aR,5S,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-methoxy-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile
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C23H33N3O2
 1
1
IC50 = 440 nM
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CP0540842
4-[(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]cyclopentyl]oxybenzonitrile
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C17H23N3O
 1
1
IC50 = 500 nM
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CP0475138
4-[[(1R,2R,3aR,5S,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-5-hydroxy-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]oxy]benzonitrile
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C22H31N3O2
 1
1
IC50 = 560 nM
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CP0561842
4-[(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]cyclopentyl]oxy-3-chlorobenzonitrile
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C17H22ClN3O
 1
1
IC50 = 660 nM
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CP0163715
5-chloro-4-[3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1H-pyridazin-6-one
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C16H14ClF3N4O2
 1
1
IC50 > 30000 nM
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CP0402285
5-bromo-4-[4-[(2-methylphenyl)methyl]piperazin-1-yl]-1H-pyridazin-6-one
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C16H19BrN4O
 1
1
IC50 > 30000 nM
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