General Information of the Compound
Compound ID
CP0562917
Compound Name
(3R,4R)-1-[1-[(5-chloropyrimidin-2-yl)methyl]-4-fluoro-6-methoxybenzimidazol-2-yl]-4-fluoropiperidin-3-amine
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Structure
Formula
C18H19ClF2N6O
Molecular Weight
408.84
Canonical SMILES
COc1cc(F)c2nc(N3CC[C@@H](F)[C@H](N)C3)n(Cc3ncc(Cl)cn3)c2c1
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InChI
InChI=1S/C18H19ClF2N6O/c1-28-11-4-13(21)17-15(5-11)27(9-16-23-6-10(19)7-24-16)18(25-17)26-3-2-12(20)14(22)8-26/h4-7,12,14H,2-3,8-9,22H2,1H3/t12-,14-/m1/s1
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InChIKey
LAVRDVHZGGEPJZ-TZMCWYRMSA-N
Physicochemical Property
logP
2.5512
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
82.09
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155195074
ChEMBL ID
CHEMBL4776935
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04958, Short transient receptor potential channel 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 0.4 nM
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