General Information of the Compound
Compound ID
CP0571609
Compound Name
(3R,4R)-1-[5,6-difluoro-1-[(5-methylpyridin-2-yl)methyl]benzimidazol-2-yl]-4-fluoropiperidin-3-amine
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Structure
Formula
C19H20F3N5
Molecular Weight
375.398
Canonical SMILES
Cc1ccc(Cn2c(nc3cc(F)c(F)cc23)N2CC[C@@H](F)[C@H](N)C2)nc1
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InChI
InChI=1S/C19H20F3N5/c1-11-2-3-12(24-8-11)9-27-18-7-15(22)14(21)6-17(18)25-19(27)26-5-4-13(20)16(23)10-26/h2-3,6-8,13,16H,4-5,9-10,23H2,1H3/t13-,16-/m1/s1
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InChIKey
XQBAPJWYRODRGP-CZUORRHYSA-N
Physicochemical Property
logP
2.94172
Rotatable Bonds
3
Heavy Atom Count
27
Polar Areas
59.97
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155208677
ChEMBL ID
CHEMBL4764496
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04958, Short transient receptor potential channel 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 0.1 nM
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