General Information of the Compound
Compound ID
CP0390400
Compound Name
4-[[(1R,2R,3R,5R)-3-[(3R)-3-aminopiperidin-1-yl]-6-oxo-2-bicyclo[3.2.0]heptanyl]oxy]benzonitrile
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Structure
Formula
C19H23N3O2
Molecular Weight
325.412
Canonical SMILES
N[C@@H]1CCCN(C1)[C@@H]1C[C@@H]2[C@@H](CC2=O)[C@H]1Oc1ccc(cc1)C#N
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InChI
InChI=1S/C19H23N3O2/c20-10-12-3-5-14(6-4-12)24-19-16-9-18(23)15(16)8-17(19)22-7-1-2-13(21)11-22/h3-6,13,15-17,19H,1-2,7-9,11,21H2/t13-,15-,16-,17-,19-/m1/s1
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InChIKey
ZHFFQIKHYAWUBX-OAIGWWADSA-N
Physicochemical Property
logP
1.70628
Rotatable Bonds
3
Heavy Atom Count
24
Polar Areas
79.35
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145961840
ChEMBL ID
CHEMBL4130214
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT04958, Short transient receptor potential channel 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
Protein ID: PT01105, Sodium channel protein type 5 subunit alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS