General Information of the Protein
Protein ID
PT01105
Protein Name
Sodium channel protein type 5 subunit alpha
Secondarily
Protein Name
Sodium channel protein cardiac muscle subunit alpha
Sodium channel protein type V subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.5
hH1
Gene Name
SCN5A
Sequence
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Voltage-gated sodium channel
Function
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1309946, PubMed:21447824, PubMed:25370050, PubMed:23420830, PubMed:23085483, PubMed:26279430, PubMed:26392562, PubMed:26776555). It is a tetrodotoxin-resistant Na(+) channel isoform (PubMed:1309946). This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (PubMed:19074138).
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Uniprot ID
Primary ID:
Q14524

Secondarily ID:
A5H1P8
A6N922
A6N923
B2RTU0
E7ET19
E9PEF3
E9PEK2
E9PFW7
Q59H93
Q75RX9
Q75RY0
Q86UR3
Q8IZC9
Q96J69
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HGNC ID
HGNC:10593
Subcellular Location
Cell membrane
Cytoplasm
Perinuclear region
Cell membrane
Sarcolemma
T-tubule
Cell junction
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0375108
 Compound Info 
4-butoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C22H29N3O2
  1
1
IC50 = 560 nM
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CP0444107
 Compound Info 
4-ethoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C20H25N3O2
  1
1
IC50 = 1100 nM
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CP0391416
 Compound Info 
3,4,5-trimethoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C21H27N3O4
  1
1
IC50 = 1510 nM
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CP0453500
 Compound Info 
2-methyl-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C19H23N3O
  1
1
IC50 = 1750 nM
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CP0430912
 Compound Info 
N-[N'-[2-(5-methoxy-1H-indol-3-yl)ethyl]carbamimidoyl]-4-methylbenzamide
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C20H22N4O2
  1
1
IC50 = 1760 nM
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CP0452262
 Compound Info 
N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)benzamide
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C22H24F3N3O3
  1
1
IC50 = 1995.26 nM
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CP0453220
 Compound Info 
4-methoxy-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C19H23N3O2
  1
1
IC50 = 2100 nM
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CP0437894
 Compound Info 
N-[N'-(4-phenylbutyl)carbamimidoyl]thiophene-2-carboxamide
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C16H19N3OS
  1
1
IC50 = 2350 nM
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CP0493834
 Compound Info 
2-(2,4-dimethylphenyl)-5-methyl-N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
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C26H32N6O2
  1
1
IC50 = 2511.89 nM
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CP0375122
 Compound Info 
2,3-dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C18H19Cl2N3O
  1
1
IC50 = 2710 nM
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CP0453181
 Compound Info 
4-methyl-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C19H23N3O
  1
1
IC50 = 2850 nM
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CP0377581
 Compound Info 
N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C22H18F3N3O3
  1
1
IC50 = 3162.28 nM
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CP0452264
 Compound Info 
N-[(3S)-5-pyridin-3-yl-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C22H18F3N3O3
  1
1
IC50 = 3162.28 nM
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CP0506417
 Compound Info 
N-[(3S)-5-pyridin-3-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)benzamide
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C22H17F3N2O3
  1
1
IC50 = 3162.28 nM
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CP0011846
 Compound Info 
1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one
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C21H27NO3
  2
1
IC50 = 3300 nM
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2
IC50 > 5000 nM
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CP0414861
 Compound Info 
4-methyl-N-[N'-(5-phenylpentyl)carbamimidoyl]benzamide
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C20H25N3O
  1
1
IC50 = 3600 nM
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CP0440191
 Compound Info 
4-chloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C18H20ClN3O
  1
1
IC50 = 3600 nM
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CP0434432
 Compound Info 
N-[N'-[2-(4-methoxy-1H-indol-3-yl)ethyl]carbamimidoyl]-4-methylbenzamide
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C20H22N4O2
  1
1
IC50 = 3920 nM
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CP0377578
 Compound Info 
N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)benzamide
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C22H17F3N2O3
  1
1
IC50 = 3981.07 nM
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CP0416294
 Compound Info 
N-[(3S)-5-pyrimidin-5-yl-3,4-dihydro-2H-chromen-3-yl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
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C22H19F3N4O3
  1
1
IC50 = 3981.07 nM
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CP0436277
 Compound Info 
N-[(3S)-5-(5-fluoro-6-methoxypyridin-3-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C23H19F4N3O4
  1
1
IC50 = 3981.07 nM
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CP0452260
 Compound Info 
N-[(3S)-5-(2-methoxypyrimidin-5-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
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C23H21F3N4O4
  1
1
IC50 = 3981.07 nM
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CP0492729
 Compound Info 
N-[N'-(4-phenylbutyl)carbamimidoyl]naphthalene-1-carboxamide
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C22H23N3O
  1
1
IC50 = 4100 nM
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CP0409607
 Compound Info 
4-methyl-N-[N'-(2-propan-2-ylphenyl)carbamimidoyl]benzamide
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C18H21N3O
  1
1
IC50 = 4500 nM
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CP0478841
 Compound Info 
[(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,8,9-tetrahydro-1H-pyrrolo[1,2-c]purin-4-yl]methyl acetate
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C11H18N6O4
  1
1
IC50 = 4566 nM
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CP0377579
 Compound Info 
5-methyl-N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]-2-phenyltriazole-4-carboxamide
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C24H28N6O2
  1
1
IC50 = 5011.87 nM
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CP0416296
 Compound Info 
N-[(3S)-5-(2-methylpyrimidin-5-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C22H19F3N4O3
  1
1
IC50 = 5011.87 nM
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CP0443557
 Compound Info 
N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
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C23H27F3N4O3
  1
1
IC50 = 5011.87 nM
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CP0452263
 Compound Info 
N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C22H25F3N4O3
  1
1
IC50 = 5011.87 nM
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CP0452265
 Compound Info 
N-[(3S)-5-[6-(hydroxymethyl)-5-methylpyridin-3-yl]-3,4-dihydro-2H-chromen-3-yl]-6-[2-(2,2,2-trifluoroethoxy)ethoxy]pyridine-3-carboxamide
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C26H26F3N3O5
  1
1
IC50 = 5011.87 nM
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CP0454740
 Compound Info 
4-methyl-N-[N'-(3-phenylpropyl)carbamimidoyl]benzamide
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C18H21N3O
  1
1
IC50 = 5250 nM
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CP0427278
 Compound Info 
2,6-dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C18H19Cl2N3O
  1
1
IC50 = 5400 nM
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CP0453499
 Compound Info 
4-methyl-N-[N'-(3-phenoxypropyl)carbamimidoyl]benzamide
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C18H21N3O2
  1
1
IC50 = 5600 nM
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CP0526927
 Compound Info 
4-methyl-N-[N'-(2-phenylethyl)carbamimidoyl]benzamide
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C17H19N3O
  1
1
IC50 = 5650 nM
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CP0501921
 Compound Info 
4-methyl-N-[N'-(4-propan-2-yloxyphenyl)carbamimidoyl]benzamide
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C18H21N3O2
  1
1
IC50 = 5750 nM
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CP0076201
 Compound Info 
N-[(3S)-5-[6-(hydroxymethyl)pyridin-3-yl]-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C23H20F3N3O4
  1
1
IC50 = 6309.57 nM
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CP0416293
 Compound Info 
N-[(3S)-5-[2-(hydroxymethyl)pyridin-4-yl]-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C23H20F3N3O4
  1
1
IC50 = 6309.57 nM
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CP0416295
 Compound Info 
N-[(3S)-5-(2-methoxypyrimidin-5-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C22H19F3N4O4
  1
1
IC50 = 6309.57 nM
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CP0441744
 Compound Info 
2,5-dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C18H19Cl2N3O
  1
1
IC50 = 7890 nM
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CP0448195
 Compound Info 
N-[N'-(4-phenylbutyl)carbamimidoyl]furan-2-carboxamide
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C16H19N3O2
  1
1
IC50 = 7900 nM
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CP0443558
 Compound Info 
N-[(3S)-5-[6-(hydroxymethyl)pyridin-3-yl]-3,4-dihydro-2H-chromen-3-yl]-6-[2-(2,2,2-trifluoroethoxy)ethoxy]pyridine-3-carboxamide
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C25H24F3N3O5
  1
1
IC50 = 7943.28 nM
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CP0430923
 Compound Info 
N-[N'-[2-(4-chlorophenyl)ethyl]carbamimidoyl]-4-methylbenzamide
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C17H18ClN3O
  1
1
IC50 = 8500 nM
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CP0497887
 Compound Info 
4-methyl-N-[N'-(naphthalen-1-ylmethyl)carbamimidoyl]benzamide
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C20H19N3O
  1
1
IC50 = 8850 nM
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CP0381027
 Compound Info 
N-(N'-butylcarbamimidoyl)-4-methylbenzamide
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C13H19N3O
  1
1
IC50 = 9000 nM
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CP0406161
 Compound Info 
4-methyl-N-[N'-methyl-N-(4-phenylbutyl)carbamimidoyl]benzamide
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C20H25N3O
  1
1
IC50 = 9000 nM
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CP0377577
 Compound Info 
N-[(3S)-5-[6-(1-hydroxyethyl)pyridin-3-yl]-3,4-dihydro-2H-chromen-3-yl]-6-[2-(2,2,2-trifluoroethoxy)ethoxy]pyridine-3-carboxamide
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C26H26F3N3O5
  1
1
IC50 = 10000 nM
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CP0433781
 Compound Info 
N-[(3S)-5-(2-methoxypyrimidin-5-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxymethyl)pyridine-3-carboxamide
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C23H21F3N4O4
  1
1
IC50 = 10000 nM
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CP0400789
 Compound Info 
(5-chloro-1-methylindol-2-yl)-[6-[(dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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C22H24ClN3O
  1
1
IC50 = 10300 nM
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CP0430694
 Compound Info 
4-methyl-N-[N'-(2-thiophen-2-ylethyl)carbamimidoyl]benzamide
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C15H17N3OS
  1
1
IC50 = 10500 nM
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CP0383088
 Compound Info 
N-[N'-(2-benzylsulfanylethyl)carbamimidoyl]-4-methylbenzamide
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C18H21N3OS
  1
1
IC50 = 10800 nM
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CP0062157
 Compound Info 
N-[(3S)-5-(5-methoxypyrazin-2-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxymethyl)pyridine-3-carboxamide
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C23H21F3N4O4
  1
1
IC50 = 12589.25 nM
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CP0383545
 Compound Info 
4-methyl-N-[N'-(2-phenoxyethyl)carbamimidoyl]benzamide
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C17H19N3O2
  1
1
IC50 = 14200 nM
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CP0524330
 Compound Info 
3,4-dichloro-N-[N'-(4-phenylbutyl)carbamimidoyl]benzamide
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C18H19Cl2N3O
  1
1
IC50 = 15500 nM
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CP0430911
 Compound Info 
4-methyl-N-[N'-(4-propan-2-ylphenyl)carbamimidoyl]benzamide
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C18H21N3O
  1
1
IC50 = 19700 nM
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CP0377582
 Compound Info 
N-[(3S)-5-(5-methylpyrazin-2-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxymethyl)pyridine-3-carboxamide
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C23H21F3N4O3
  1
1
IC50 = 19952.62 nM
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CP0508613
 Compound Info 
4-methyl-N-[N'-(3,4,5-trimethoxyphenyl)carbamimidoyl]benzamide
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C18H21N3O4
  1
1
IC50 = 24350 nM
 Bioactivity Info 
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CP0523038
 Compound Info 
N-[(3S)-5-(5-methoxypyrazin-2-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C22H19F3N4O4
  1
1
IC50 > 25118.86 nM
 Bioactivity Info 
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CP0271660
 Compound Info 
(R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxy-phenyl)-2-imidazolidinone
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C20H25N3O5S
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0163715
 Compound Info 
5-chloro-4-[3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1H-pyridazin-6-one
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C16H14ClF3N4O2
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0372478
 Compound Info 
N-[(5-chloro-6-oxo-1H-pyridin-3-yl)-(4-fluorophenyl)methyl]-2-[1-[[1-[4-(trifluoromethyl)phenyl]pyrrol-3-yl]methyl]piperidin-4-yl]acetamide
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C31H29ClF4N4O2
  1
1
IC50 > 31600 nM
 Bioactivity Info 
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CP0436279
 Compound Info 
2-(2-methoxyethyl)-5-methyl-N-[(3S)-5-pyridin-3-yl-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
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C21H23N5O3
  1
1
IC50 > 31622.78 nM
 Bioactivity Info 
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CP0437804
 Compound Info 
5-methyl-2-phenyl-N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
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C24H21N5O2
  1
1
IC50 > 31622.78 nM
 Bioactivity Info 
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CP0439895
 Compound Info 
2-(2-methoxyethyl)-5-methyl-N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
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C21H23N5O3
  1
1
IC50 > 31622.78 nM
 Bioactivity Info 
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CP0452261
 Compound Info 
5-methyl-2-(2-methylpropyl)-N-[(3S)-5-pyridin-3-yl-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
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C22H25N5O2
  1
1
IC50 > 31622.78 nM
 Bioactivity Info 
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CP0010753
 Compound Info 
N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)piperidin-4-yl]methyl]-3,5-dichlorobenzamide
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C21H32Cl2N4O3
  1
1
IC50 > 33000 nM
 Bioactivity Info 
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CP0053278
 Compound Info 
(5-bromo-1-methylpyrrolo[2,3-c]pyridin-2-yl)-[6-[(dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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C21H23BrN4O
  1
1
IC50 > 33000 nM
 Bioactivity Info 
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CP0094025
 Compound Info 
(5-chloro-1-methylindol-2-yl)-[6-[(dimethylamino)methyl]-7-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone
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C23H26ClN3O
  1
1
IC50 > 33000 nM
 Bioactivity Info 
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CP0381028
 Compound Info 
N-(2,3-dihydroindole-1-carboximidoyl)-4-methylbenzamide
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C17H17N3O
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0436278
 Compound Info 
N-[(3S)-5-(5-methylpyrazin-2-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C22H19F3N4O3
  1
1
IC50 > 3162.28 nM
 Bioactivity Info 
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CP0637108
 Compound Info 
rac-1-(2-(2-hydroxy-3-(4-p-tolylpiperazin-1-yl)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride
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C29H35ClN2O3
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0636848
 Compound Info 
rac-1-(2-(2-hydroxy-3-(4-phenylpiperidin-1-yl)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride
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C29H34ClNO3
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0637784
 Compound Info 
rac-1-(2-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy)-5-fluorophenyl)-3-phenylpropan-1-one hydrochloride
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C35H38ClFN2O3
  1
1
IC50 > 5000 nM
 Bioactivity Info 
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CP0443560
 Compound Info 
4-butoxy-N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]benzamide
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C25H33N3O3
  1
1
IC50 > 6309.57 nM
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Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0032710
 Compound Info 
4-[(3S,4S)-3-(3,4-difluorophenyl)-1-(2,2,2-trifluoroethyl)piperidin-4-yl]oxy-3,5-difluoro-N-(6-fluoropyridin-2-yl)benzenesulfonamide
   Show/Hide
C24H19F8N3O3S
  2
1 IC50 = 110 nM
2 Ki = 370 nM
CP0055093
 Compound Info 
6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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C14H7F6N3O
  1
1 IC50 = 333 nM
CP0303021
 Compound Info 
US8952169, 6
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C19H23ClFNO4S
  1
1 IC50 = 1070 nM
CP0076327
 Compound Info 
1-(2,6-dimethylphenoxy)-2-propanolamine
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C11H17NO
  1
1 IC50 = 3000 nM
CP0034615
 Compound Info 
(6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
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C20H24N2O2
  1
1 IC50 = 6900 nM
CP0189235
 Compound Info 
CHEBI:87690
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C24H33N3O4
  1
1 IC50 = 7000 nM
CP0051021
 Compound Info 
5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
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C19H16ClNO4
  2
1 IC50 = 7440 nM
2 IC50 > 2000 nM
CP0069734
 Compound Info 
2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
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C23H19N3O3S2
  1
1 IC50 = 9200 nM
CP0123958
 Compound Info 
10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diazatetracyclo[7.3.1.13,11.03,8]tetradecane-1,2,7,10,14-pentaol
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C11H17N3O8
  1
1 IC50 > 30 nM
CP0204850
 Compound Info 
4-[2-(3-amino-1,2-benzoxazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
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C21H12ClF2N5O4S2
  1
1 IC50 > 1000 nM
CP0052824
 Compound Info 
4-[[(3S,4R)-4-(4-chlorophenyl)piperidin-3-yl]methoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
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C20H19ClF2N4O3S2
  1
1 IC50 > 10000 nM
CP0095952
 Compound Info 
3-cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamide
   Show/Hide
C20H15N5O3S2
  1
1 IC50 > 10000 nM
Clinical Information about the Protein
Target 1 ( Voltage-gated sodium channel alpha Nav1.5 (SCN5A) )
Target Type Successful Target
Disease 12 Target-related Diseases  12
1 Cough [ICD-11: MD12]
2 Anaesthesia [ICD-11: 9A78.6]
3 Ventricular arrhythmias [ICD-11: BC71]
4 Pain [ICD-11: MG30-MG3Z]
5 Complex partial seizure [ICD-11: 8A68.0]
6 Migraine [ICD-11: 8A80]
7 Epilepsy [ICD-11: 8A60-8A68]
8 Ventricular tachycardia [ICD-11: BC71]
9 Arrhythmia [ICD-11: BC9Z]
10 Bacterial infection [ICD-11: 1A00-1C4Z]
11 Neurological disorder [ICD-11: 6B60]
12 Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Approved Drug(s) 12 Approved Drugs  12
1 Benzonatate
 Drug Info 
Approved
Cough
2 Dibucaine
 Drug Info 
Approved
Anaesthesia
3 Disopyramide
 Drug Info 
Approved
Ventricular arrhythmias
4 Dyclonine
 Drug Info 
Approved
Pain
5 Ethotoin
 Drug Info 
Approved
Complex partial seizure
6 Hexylcaine
 Drug Info 
Approved
Anaesthesia
7 LOMERIZINE
 Drug Info 
Approved
Migraine
8 Mephenytoin
 Drug Info 
Approved
Epilepsy
9 Mexiletine
 Drug Info 
Approved
Ventricular tachycardia
10 Moricizine
 Drug Info 
Approved
Arrhythmia
11 Prilocaine
 Drug Info 
Approved
Pain
12 Tetrodotoxin
 Drug Info 
Approved
Bacterial infection
Discontinued Drug(s) 3 Discontinued Drugs  3
1 LUBELUZOLE
 Drug Info 
Discontinued in Preregistration
Neurological disorder
2 Acecainide
 Drug Info 
Discontinued in Phase 3
Solid tumour/cancer
3 SIPATRIGINE
 Drug Info 
Discontinued in Phase 2
Neurological disorder