General Information of the Compound
Compound ID
CP0415274
Compound Name
2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phenyl)-pyrimidin-4-ylamine
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Synonyms
130800-90-7
2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine
2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidin-4-amine
4-Amino-2-(4-methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)pyrimidine
4-Pyrimidinamine, 2-(4-methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-
619C89
AC1L1TYB
AC1Q3LMC
BW 619C89
BW-619C89
BW619C89
C16H17Cl3N4
CHEBI:34977
CHEMBL28854
DTXSID20156750
MLS006010764
MolPort-023-277-047
OON9AVW1T3
SCHEMBL135888
SIPATRIGINE
Sipatrigine
Sipatrigine [INN:BAN]
UNII-OON9AVW1T3
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Structure
Formula
C15H16Cl3N5
Molecular Weight
372.687
Canonical SMILES
CN1CCN(CC1)c1ncc(c(N)n1)-c1cc(Cl)cc(Cl)c1Cl
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InChI
InChI=1S/C15H16Cl3N5/c1-22-2-4-23(5-3-22)15-20-8-11(14(19)21-15)10-6-9(16)7-12(17)13(10)18/h6-8H,2-5H2,1H3,(H2,19,20,21)
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InChIKey
PDOCBJADCWMDGL-UHFFFAOYSA-N
CAS
130800-90-7
Physicochemical Property
logP
3.4378
Rotatable Bonds
2
Heavy Atom Count
23
Polar Areas
58.28
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 60803
SID: 14853181
ChEMBL ID
CHEMBL28854
Clinical Information about the Compound
Drug 1 ( SIPATRIGINE )
Drug Name SIPATRIGINE
Indication
Neurological disorder
Discontinued in Phase 2
Target(s)
Voltage-gated sodium channel alpha Nav1.5 (SCN5A)
Inhibitor
Voltage-gated sodium channel alpha Nav1.3 (SCN3A)
Inhibitor
Voltage-gated sodium channel alpha Nav1.4 (SCN4A)
Inhibitor
Voltage-gated sodium channel alpha Nav1.7 (SCN9A)
Inhibitor
Voltage-gated sodium channel alpha Nav1.8 (SCN10A)
Inhibitor
Voltage-gated calcium channel alpha Cav1.3 (CACNA1D)
Inhibitor