General Information of the Compound
Compound ID
CP0437804
Compound Name
5-methyl-2-phenyl-N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]triazole-4-carboxamide
    Show/Hide
Structure
Formula
C24H21N5O2
Molecular Weight
411.465
Canonical SMILES
Cc1nn(nc1C(=O)N[C@@H]1COc2cccc(-c3ccncc3)c2C1)-c1ccccc1
    Show/Hide
InChI
InChI=1S/C24H21N5O2/c1-16-23(28-29(27-16)19-6-3-2-4-7-19)24(30)26-18-14-21-20(17-10-12-25-13-11-17)8-5-9-22(21)31-15-18/h2-13,18H,14-15H2,1H3,(H,26,30)/t18-/m0/s1
    Show/Hide
InChIKey
YQIDSLFXPFOWIF-SFHVURJKSA-N
Physicochemical Property
logP
3.37122
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
81.93
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 66813703
SID: 163453161
ChEMBL ID
CHEMBL2069416
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3981.07 nM
   TI
   LI
   LO
   TS
Protein ID: PT01105, Sodium channel protein type 5 subunit alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 31622.78 nM
   TI
   LI
   LO
   TS
Protein ID: PT01000, Sodium channel protein type 9 subunit alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1258.93 nM
   TI
   LI
   LO
   TS