General Information of the Compound
Compound ID
CP0578415
Compound Name
(3R)-1-[1-[(5-chloropyridin-2-yl)methyl]-5-fluorobenzimidazol-2-yl]-4,4-difluoropiperidin-3-amine
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Structure
Formula
C18H17ClF3N5
Molecular Weight
395.816
Canonical SMILES
N[C@@H]1CN(CCC1(F)F)c1nc2cc(F)ccc2n1Cc1ccc(Cl)cn1
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InChI
InChI=1S/C18H17ClF3N5/c19-11-1-3-13(24-8-11)9-27-15-4-2-12(20)7-14(15)25-17(27)26-6-5-18(21,22)16(23)10-26/h1-4,7-8,16H,5-6,9-10,23H2/t16-/m1/s1
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InChIKey
NTBGMDVYEDDYJR-MRXNPFEDSA-N
Physicochemical Property
logP
3.4448
Rotatable Bonds
3
Heavy Atom Count
27
Polar Areas
59.97
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155208618
ChEMBL ID
CHEMBL4752852
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04958, Short transient receptor potential channel 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 0.3 nM
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