| Compound ID |
Compound Name |
Compound Formula |
|
CP0367994
|
6-(cyclopropanecarbonylamino)-4-[3-[[3-fluoro-4-(pyrrolidine-1-carbonyl)phenyl]carbamoyl]-2-methoxyanilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C29H30FN7O5
|
1
|
| 1 |
IC50 = 0.85 nM
|
|
|
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CP0548101
|
6-(cyclopropanecarbonylamino)-4-[3-[[4-(diethylcarbamoyl)phenyl]carbamoyl]-2-methoxyanilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C29H33N7O5
|
1
|
| 1 |
IC50 = 0.98 nM
|
|
|
|
CP0543349
|
4-[2-methoxy-3-[[4-(pyrrolidine-1-carbonyl)phenyl]carbamoyl]anilino]-6-(pyridin-2-ylamino)-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C30H30N8O4
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0576991
|
6-[(5-fluoropyridin-2-yl)amino]-4-[2-methoxy-3-[[4-(pyrrolidine-1-carbonyl)phenyl]carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C30H29FN8O4
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
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CP0577622
|
4-[3-[[4-(7-azabicyclo[2.2.1]heptane-7-carbonyl)phenyl]carbamoyl]-2-methoxyanilino]-6-(cyclopropanecarbonylamino)-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C31H33N7O5
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
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CP0578880
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[[4-(pyrrolidine-1-carbonyl)phenyl]carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C29H31N7O5
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0546947
|
4-[3-[[4-[(1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexane-2-carbonyl]phenyl]carbamoyl]-2-methoxyanilino]-6-(cyclopropanecarbonylamino)-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C31H30N8O5
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0570313
|
6-(cyclopropanecarbonylamino)-4-[3-[[4-[[(2S)-1,4-dioxan-2-yl]methylamino]phenyl]carbamoyl]-5-fluoro-2-methoxyanilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C29H32FN7O6
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0576989
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[[4-(2,2,5,5-tetradeuteriopyrrolidine-1-carbonyl)phenyl]carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C29H31N7O5
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0014937
|
6-(cyclopropanecarbonylamino)-4-[3-[[4-[[(2S)-1,4-dioxan-2-yl]methylamino]phenyl]carbamoyl]-2-methoxyanilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C29H33N7O6
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0576990
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[[4-(1,3-thiazolidine-3-carbonyl)phenyl]carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C28H29N7O5S
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0579294
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[[6-(pyrrolidine-1-carbonyl)pyridin-3-yl]carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C28H30N8O5
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0572657
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[(4-pyrrolidin-1-ylsulfonylphenyl)carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C28H31N7O6S
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0004109
|
Bms-986165
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|
C20H22N8O3
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0577499
|
4-[3-[[4-[[(2S)-1,4-dioxan-2-yl]methylamino]phenyl]carbamoyl]-2-methoxyanilino]-6-(pyridin-2-ylamino)-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C30H32N8O5
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0540378
|
6-(cyclopropanecarbonylamino)-4-[3-[[4-[[(2R)-1,4-dioxan-2-yl]methylamino]phenyl]carbamoyl]-2-methoxyanilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C29H33N7O6
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0572658
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[[4-(oxan-4-ylmethylamino)phenyl]carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C30H35N7O5
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0576722
|
6-(cyclopropanecarbonylamino)-4-[3-[[4-(ethylcarbamoyl)phenyl]carbamoyl]-2-methoxyanilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C27H29N7O5
|
1
|
| 1 |
IC50 = 9.6 nM
|
|
|
|
CP0572950
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[(2-oxo-1,3-dihydroindol-5-yl)carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C26H25N7O5
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0568126
|
4-[3-[[4-(cyclopentylcarbamoyl)phenyl]carbamoyl]-2-methoxyanilino]-6-(cyclopropanecarbonylamino)-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C30H33N7O5
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0578520
|
6-(cyclopropanecarbonylamino)-4-[3-[(2-cyclopropyl-1-oxo-3H-isoindol-5-yl)carbamoyl]-2-methoxyanilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C29H29N7O5
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0570312
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[(1-oxo-2,3-dihydroisoindol-5-yl)carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C26H25N7O5
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0577710
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[[4-(methylcarbamoyl)phenyl]carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C26H27N7O5
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0577623
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[[4-(pyrrolidine-1-carbonyl)cyclohexyl]carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C29H37N7O5
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0575549
|
4-[3-[(4-carbamoylphenyl)carbamoyl]-2-methoxyanilino]-6-(cyclopropanecarbonylamino)-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C25H25N7O5
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0548104
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[(3-oxo-1,2-dihydroisoindol-5-yl)carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C26H25N7O5
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0079054
|
3-amino-5-[(2S)-3-methylbutan-2-yl]-7-(5-morpholin-4-ylpyridin-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C20H26N6O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
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CP0079047
|
3-amino-5-(3-methylbutan-2-yl)-7-(5-morpholin-4-ylpyridin-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C20H26N6O2
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
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CP0568125
|
4-[3-[(5-carbamoylthiophen-3-yl)carbamoyl]-2-methoxyanilino]-6-(cyclopropanecarbonylamino)-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C23H23N7O5S
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
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CP0578881
|
6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-[(3-oxo-1,2-dihydroisoindol-4-yl)carbamoyl]anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C26H25N7O5
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
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CP0182426
|
3-amino-5-[(2S)-3-methylbutan-2-yl]-7-[1-methyl-5-(oxan-4-yl)pyrazol-3-yl]-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C20H28N6O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
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CP0575550
|
4-[3-[(5-carbamoylpyridin-2-yl)carbamoyl]-2-methoxyanilino]-6-(cyclopropanecarbonylamino)-N-(trideuteriomethyl)pyridazine-3-carboxamide
Show/Hide
|
C24H24N8O5
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
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CP0121619
|
3-amino-5-[(2S)-3-methylbutan-2-yl]-7-(1-methylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C15H20N6O
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
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CP0339308
|
(4R,5S)-4-cyclopropyl-3,9-dioxo-7-oxa-2,10,19,21,25-pentazatetracyclo[18.3.1.12,5.114,18]hexacosa-1(24),14(25),15,17,20,22-hexaene-4-carbonitrile
Show/Hide
|
C24H26N6O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
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CP0018829
|
3-amino-7-[5-(2-hydroxypropan-2-yl)-1-methylpyrazol-3-yl]-5-[(2R)-3-methylbutan-2-yl]-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C18H26N6O2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
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CP0133018
|
3-amino-5-[(2S)-3-methylbutan-2-yl]-7-(1-methyl-5-morpholin-4-ylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C19H27N7O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
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CP0096531
|
(4R,5S)-4-cyclopropyl-3-oxo-7,12-dioxa-2,19,21,25-tetrazatetracyclo[18.3.1.12,5.114,18]hexacosa-1(24),14(25),15,17,20,22-hexaene-4-carbonitrile
Show/Hide
|
C24H27N5O3
|
1
|
| 1 |
IC50 = 210 nM
|
|
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CP0133876
|
(4R,5S)-4-cyclopropyl-3,9-dioxo-7-oxa-2,10,18,20,24-pentazatetracyclo[17.3.1.12,5.113,17]pentacosa-1(23),13(24),14,16,19,21-hexaene-4-carbonitrile
Show/Hide
|
C23H24N6O3
|
1
|
| 1 |
IC50 = 210 nM
|
|
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CP0122206
|
3-amino-7-[5-(1,1-dioxo-1,4-thiazinan-4-yl)-1-methylpyrazol-3-yl]-5-[(2S)-3-methylbutan-2-yl]-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C19H27N7O3S
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
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CP0096534
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(4R,5S,9Z)-4-cyclopropyl-3-oxo-7,12-dioxa-2,19,21,25-tetrazatetracyclo[18.3.1.12,5.114,18]hexacosa-1(24),9,14(25),15,17,20,22-heptaene-4-carbonitrile
Show/Hide
|
C24H25N5O3
|
1
|
| 1 |
IC50 = 260 nM
|
|
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CP0121622
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3-amino-5-(3-methylbutan-2-yl)-7-(1-methylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C15H20N6O
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
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CP0121616
|
3-amino-5-[(2R)-3-methylbutan-2-yl]-7-(5-morpholin-4-ylpyridin-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C20H26N6O2
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
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CP0096528
|
(4R,5S,9E)-4-cyclopropyl-3-oxo-7,12-dioxa-2,19,21,25-tetrazatetracyclo[18.3.1.12,5.114,18]hexacosa-1(24),9,14(25),15,17,20,22-heptaene-4-carbonitrile
Show/Hide
|
C24H25N5O3
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
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CP0182423
|
3-amino-5-butan-2-yl-7-(1-methylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C14H18N6O
|
1
|
| 1 |
IC50 = 650 nM
|
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|
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CP0079051
|
3-amino-5-(2-methylpropyl)-7-(1-methylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C14H18N6O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
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CP0552840
|
(4R,5S)-4-cyclopropyl-3,9-dioxo-7-oxa-2,10,17,19,23-pentazatetracyclo[16.3.1.12,5.112,16]tetracosa-1(22),12(23),13,15,18,20-hexaene-4-carbonitrile
Show/Hide
|
C22H22N6O3
|
1
|
| 1 |
IC50 = 1300 nM
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CP0079048
|
3-amino-5-(2-methylpentan-3-yl)-7-(1-methylpyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-4-one
Show/Hide
|
C16H22N6O
|
1
|
| 1 |
IC50 = 6900 nM
|
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