Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide

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PubChem ID

CID: 3035905

SID: 14922586

Canonical SMILES	S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1 Show/Hide
Compound Formula	C15H24N4S

Compound Structure

Protein Name

Protein Info

Histamine H3 receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Histamine receptor

Uniprot ID

Q9Y5N1

Gene Name

HRH3

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000049	C6 Cell Line Info	Rattus norvegicus (Rat)	1
1	Ki = 72.44 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	EC50 = 100 nM	TI LI LO TS
2	Ki = 14 nM	TI LI LO TS
3	Ki = 60 nM	TI LI LO TS
4	Ki = 158.49 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	IC50 = 140 nM	TI LI LO TS
2	Ki = 6.5 nM	TI LI LO TS
3	Ki = 60 nM	TI LI LO TS
4	Ki = 602.56 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	2
1	Ki = 43.65 nM	TI LI LO TS
2	Ki = 50.12 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	7
1	EC50 = 39.81 nM	TI LI LO TS
2	IC50 = 120 nM	TI LI LO TS
3	IC50 = 517.5 nM	TI LI LO TS
4	Ki = 29.51 nM	TI LI LO TS
5	Ki = 52.48 nM	TI LI LO TS
6	Ki = 60 nM	TI LI LO TS
7	Ki = 70.79 nM	TI LI LO TS
CL000065	HEK293-EBNA Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 16 nM	TI LI LO TS
2	Ki = 51.1 nM	TI LI LO TS
CL000913	HEK293T-SP-FLAG-hH3R-CRE-CBR Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 19.95 nM	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	2
1	EC50 = 97.72 nM	TI LI LO TS
2	Ki = 39.81 nM	TI LI LO TS
CL000074	SK-N-MC Cell Line Info	Homo sapiens (Human)	4
1	Kd = 63.1 nM	TI LI LO TS
2	Ki = 31.62 nM	TI LI LO TS
3	Ki = 50.12 nM	TI LI LO TS
4	Ki = 63 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 1030 nM	TI LI LO TS

Biochemical Assays

1	Kd = 43.65 nM
2	Ki = 25 nM
3	Ki = 28.84 nM
4	Ki = 50.12 nM
5	Ki = 51.1 nM
6	Ki = 63.1 nM

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han