General Information of the Protein
Protein ID
PT04108
Protein Name
Atypical chemokine receptor 3
Secondarily
Protein Name
C-X-C chemokine receptor type 7
Chemokine orphan receptor 1
G-protein coupled receptor 159
G-protein coupled receptor RDC1 homolog
Gene Name
ACKR3
Secondarily
Gene Name
CMKOR1
CXCR7
GPR159
RDC1
Sequence
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CXC chemokine receptor
Function
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1 (PubMed:16107333, PubMed:19255243, PubMed:19380869, PubMed:20161793, PubMed:22300987). Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway (PubMed:16940167, PubMed:18653785, PubMed:20018651). Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness (PubMed:16940167, PubMed:18653785). In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival (PubMed:16940167, PubMed:20388803). Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration (PubMed:17804806, PubMed:18653785, PubMed:19641136, PubMed:20887389). Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12 (PubMed:18653785). Required for heart valve development (PubMed:17804806). Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (PubMed:31211835).
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Uniprot ID
Primary ID:
P25106

Secondarily ID:
A8K6J4
Q53RV4
Q8NE10
Q92938
Q92986
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Ensembl ID
ENSG00000144476
HGNC ID
HGNC:23692
Subcellular Location
Cell membrane
Early endosome
Recycling endosome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0389144
 Compound Info 
3-[(2S,5S,8S,11R,14S)-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-1,7-dimethyl-8-(naphthalen-1-ylmethyl)-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C49H58N10O7
  1
1
IC50 = 170 nM
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CP0472888
 Compound Info 
3-[(1S,4R,7S,10S,13S)-7-[3-(diaminomethylideneamino)propyl]-4-[(4-hydroxyphenyl)methyl]-9-methyl-13-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-3,6,9,12,15-pentazatricyclo[13.7.0.016,21]docosa-16,18,20-trien-10-yl]propylurea
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C44H52N10O7
  1
1
IC50 = 190 nM
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CP0521749
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-9-(sulfanylmethyl)-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C37H46N8O6S
  1
1
IC50 = 250 nM
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CP0475176
 Compound Info 
3-[(1S,4R,7S,10S,13S,16S,21S)-7-[3-(diaminomethylideneamino)propyl]-4-[(4-hydroxyphenyl)methyl]-9-methyl-13-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-3,6,9,12,15-pentazatricyclo[13.7.0.016,21]docosan-10-yl]propylurea
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C44H58N10O7
  1
1
IC50 = 350 nM
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CP0472743
 Compound Info 
3-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-12-[(2-fluorophenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C40H51FN10O6
  1
1
IC50 = 410 nM
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CP0471609
 Compound Info 
2-[4-[(2S,5S,8S,11S,14R)-5-[4-(diaminomethylideneamino)butyl]-14-[(2-fluorophenyl)methyl]-4,10-dimethyl-11-(naphthalen-1-ylmethyl)-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]butyl]guanidine
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C51H62FN11O5
  1
1
IC50 = 450 nM
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CP0472891
 Compound Info 
3-[(2S,5S,8S,11R,14S)-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-8-(1H-indol-3-ylmethyl)-1,7-dimethyl-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C47H57N11O7
  1
1
IC50 = 520 nM
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CP0521751
 Compound Info 
3-[(3S,6S,9S,12R,15S)-12-(1-benzothiophen-3-ylmethyl)-9-[3-(diaminomethylideneamino)propyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C42H52N10O6S
  1
1
IC50 = 540 nM
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CP0468869
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-[4-(diaminomethylideneamino)butyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C41H55N11O6
  1
1
IC50 = 560 nM
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CP0470852
 Compound Info 
3-[(2S,5S,8S,11R,14S)-8-benzyl-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-1,7-dimethyl-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C45H56N10O7
  1
1
IC50 = 600 nM
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CP0468870
 Compound Info 
3-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-7-methyl-3,12-bis(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C44H54N10O6
  1
1
IC50 = 690 nM
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CP0471605
 Compound Info 
3-[(3S,6S,9S,12R,15S)-12-[(4-bromophenyl)methyl]-9-[3-(diaminomethylideneamino)propyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C40H51BrN10O6
  1
1
IC50 = 720 nM
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CP0471606
 Compound Info 
3-[(3S,6S,9S,12R,15S)-12-[(4-benzoylphenyl)methyl]-9-[3-(diaminomethylideneamino)propyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C47H56N10O7
  1
1
IC50 = 720 nM
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CP0468863
 Compound Info 
3-[(3S,6S,9S,12R,15S)-12-[(4-chlorophenyl)methyl]-9-[3-(diaminomethylideneamino)propyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C40H51ClN10O6
  1
1
IC50 = 790 nM
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CP0385437
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C40H53N11O6
  2
1
IC50 = 800 nM
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2
IC50 = 860 nM
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CP0432165
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-9-[4-(diaminomethylideneamino)butyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C41H55N11O6
  1
1
IC50 = 840 nM
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CP0471607
 Compound Info 
3-[(2S,5S,8S,11R,14S)-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-8-(1H-indol-3-ylmethyl)-1-methyl-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C46H55N11O7
  1
1
IC50 = 850 nM
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CP0389145
 Compound Info 
3-[(2S,5S,8S,11R,14S)-8-(1-benzothiophen-3-ylmethyl)-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-1,7-dimethyl-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C47H56N10O7S
  1
1
IC50 = 1000 nM
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CP0483104
 Compound Info 
3-[(3S,6S,9S,12R,15S)-12-benzyl-9-[3-(diaminomethylideneamino)propyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C40H52N10O6
  1
1
IC50 = 1100 nM
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CP0472885
 Compound Info 
3-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-12-[(4-fluorophenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C40H51FN10O6
  1
1
IC50 = 1200 nM
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CP0477926
 Compound Info 
7-[2-hydroxy-3-(3-methylpiperidin-1-yl)propoxy]-2,3-dihydro-1H-cyclopenta[c]chromen-4-one
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C21H27NO4
  1
1
IC50 = 1290 nM
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CP0396368
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-(3-aminopropyl)-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C39H51N9O6
  1
1
IC50 = 1300 nM
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CP0513911
 Compound Info 
3-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-12-[(3-fluorophenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C40H51FN10O6
  1
1
IC50 = 1300 nM
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CP0410002
 Compound Info 
N-(1-benzylpiperidin-4-yl)-2-(4,7-dimethyl-2-oxochromen-5-yl)oxyacetamide
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C25H28N2O4
  1
1
IC50 = 1490 nM
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CP0376673
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C39H51N11O6
  1
1
IC50 = 1500 nM
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CP0560428
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-[2-(diaminomethylideneamino)ethyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C39H51N11O6
  1
1
IC50 = 1500 nM
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CP0444549
 Compound Info 
2-[3-[(3S,6S,9R,12S,15S,18R)-12-[(2S)-butan-2-yl]-6-[3-(diaminomethylideneamino)propyl]-15-[(1R)-1-hydroxyethyl]-3-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-9-yl]propyl]guanidine
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C40H60N12O7
  1
1
IC50 = 1700 nM
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CP0471610
 Compound Info 
3-[(2S,5S,8S,11R,14S)-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-1,7-dimethyl-8-(2-methylsulfanylethyl)-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C41H56N10O7S
  1
1
IC50 = 1800 nM
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CP0519963
 Compound Info 
3-[(2S,5S,8S,11R,14S)-14-[3-(diaminomethylideneamino)propyl]-8,11-bis[(4-hydroxyphenyl)methyl]-1,7-dimethyl-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C45H56N10O8
  1
1
IC50 = 1800 nM
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CP0527579
 Compound Info 
5-(4-bromophenyl)-N-[2-(2-methoxyphenyl)-2-(4-methylpiperidin-1-yl)ethyl]-1,2-oxazole-3-carboxamide
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C25H28BrN3O3
  1
1
IC50 = 1870 nM
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CP0417680
 Compound Info 
3-[(2S,5S,8S,11R,14S)-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-1,7-dimethyl-8-(2-methylpropyl)-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C42H58N10O7
  1
1
IC50 = 1900 nM
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CP0389191
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-12-[(4-hydroxyphenyl)methyl]-7-methyl-9-(2-methylpropyl)-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C40H52N8O6
  1
1
IC50 = 2000 nM
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CP0396371
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-9-(hydroxymethyl)-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C37H46N8O7
  1
1
IC50 = 2000 nM
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CP0468864
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-9-[(1R)-1-hydroxyethyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C38H48N8O7
  1
1
IC50 = 2000 nM
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CP0470853
 Compound Info 
2-[3-[(3R,6S,12S,15S,18S)-3-[(4-hydroxyphenyl)methyl]-16-methyl-12-(naphthalen-2-ylmethyl)-2,5,11,14,17-pentaoxo-1,4,10,13,16-pentazatricyclo[16.3.0.06,10]henicosan-15-yl]propyl]guanidine
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C39H48N8O6
  1
1
IC50 = 2000 nM
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CP0470854
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-9,12-bis[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C43H50N8O7
  1
1
IC50 = 2000 nM
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CP0470860
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-9-(4-aminobutyl)-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C40H53N9O6
  1
1
IC50 = 2000 nM
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CP0471608
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-12-[(4-hydroxyphenyl)methyl]-9-(1H-indol-3-ylmethyl)-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C45H51N9O6
  1
1
IC50 = 2000 nM
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CP0471611
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-9-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C39H50N8O6
  1
1
IC50 = 2000 nM
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CP0475178
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-9-[(2S)-butan-2-yl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C40H52N8O6
  1
1
IC50 = 2000 nM
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CP0475179
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-12-[(4-hydroxyphenyl)methyl]-7-methyl-9-(2-methylsulfanylethyl)-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C39H50N8O6S
  1
1
IC50 = 2000 nM
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CP0475180
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-12-[(4-hydroxyphenyl)methyl]-9-(1H-imidazol-5-ylmethyl)-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C40H48N10O6
  1
1
IC50 = 2000 nM
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CP0513909
 Compound Info 
3-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-7-methyl-3-(naphthalen-2-ylmethyl)-12-[(4-nitrophenyl)methyl]-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C40H51N11O8
  1
1
IC50 = 2000 nM
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CP0538841
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-9-benzyl-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C43H50N8O6
  1
1
IC50 = 2000 nM
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CP0521744
 Compound Info 
3-[(1S,4R,7S,10S,13S)-7-[3-(diaminomethylideneamino)propyl]-4-[(4-hydroxyphenyl)methyl]-9-methyl-13-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-3,6,9,12,15,24-hexazatetracyclo[13.11.0.017,25.018,23]hexacosa-17(25),18,20,22-tetraen-10-yl]propylurea
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C47H55N11O7
  1
1
IC50 = 2100 nM
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CP0397532
 Compound Info 
2-(6-chloro-1-methyl-2-oxoquinolin-4-yl)sulfanyl-N-[3-(2-ethylpiperidin-1-yl)propyl]acetamide
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C22H30ClN3O2S
  1
1
IC50 = 2160 nM
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CP0417679
 Compound Info 
3-[(2S,5S,8S,11R,14S)-8-[(2S)-butan-2-yl]-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-1,7-dimethyl-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C42H58N10O7
  1
1
IC50 = 2200 nM
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CP0380467
 Compound Info 
N-[3-[benzyl(methyl)amino]propyl]-5-methyl-4-oxothieno[3,2-c]quinoline-2-carboxamide
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C24H25N3O2S
  1
1
IC50 = 2210 nM
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CP0406995
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-10-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C40H53N11O6
  1
1
IC50 = 2400 nM
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CP0513910
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-9-[2-(diaminomethylideneamino)ethyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C39H51N11O6
  1
1
IC50 = 2600 nM
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CP0513914
 Compound Info 
3-[(2S,5S,8S,11R,14S)-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-1,7-dimethyl-5,8-bis(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C49H58N10O7
  1
1
IC50 = 2600 nM
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CP0573798
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-9-(3-aminopropyl)-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C39H51N9O6
  1
1
IC50 = 2600 nM
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CP0563096
 Compound Info 
8-methyl-N-[2-(2-methylpiperidin-1-yl)ethyl]-4H-chromeno[3,4-d][1,2]oxazole-3-carboxamide
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C20H25N3O3
  1
1
IC50 = 2640 nM
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CP0397475
 Compound Info 
N-[3-[benzyl(ethyl)amino]propyl]-2-(4-methyl-1-oxo-[1]benzothiolo[2,3-d]pyridazin-2-yl)butanamide
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C27H32N4O2S
  1
1
IC50 = 2780 nM
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CP0563095
 Compound Info 
N-[3-(3,5-dimethylpiperidin-1-yl)propyl]-8-methyl-4H-chromeno[3,4-d][1,2]oxazole-3-carboxamide
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C22H29N3O3
  1
1
IC50 = 2920 nM
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CP0381272
 Compound Info 
[5-(2,3-dihydroindol-1-yl)thiophen-2-yl]-(4-piperidin-1-ylpiperidin-1-yl)methanone
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C23H29N3OS
  1
1
IC50 = 3200 nM
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CP0389146
 Compound Info 
3-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-12-(1H-indol-3-ylmethyl)-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C42H53N11O6
  1
1
IC50 = 3200 nM
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CP0446853
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-4-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C40H53N11O6
  1
1
IC50 = 3400 nM
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CP0389244
 Compound Info 
3-[(3S,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propylurea
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C40H52N10O7
  1
1
IC50 = 3600 nM
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CP0477925
 Compound Info 
N-[2-[butyl(ethyl)amino]ethyl]-5-(2,3-dihydroindol-1-yl)thiophene-2-carboxamide
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C21H29N3OS
  1
1
IC50 = 3890 nM
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CP0475177
 Compound Info 
3-[(2S,5S,8S,11R,14S)-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-1,7-dimethyl-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-8-[(4-phenylphenyl)methyl]-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C51H60N10O7
  1
1
IC50 = 4000 nM
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CP0560501
 Compound Info 
2-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]acetamide
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C38H47N9O7
  1
1
IC50 = 4100 nM
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CP0519962
 Compound Info 
3-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazatricyclo[13.8.0.017,22]tricosa-17,19,21-trien-6-yl]propylurea
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C45H54N10O7
  1
1
IC50 = 4200 nM
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CP0540612
 Compound Info 
4-methyl-N-[5-[(3-phenylpyrrolidin-1-yl)methyl]-1,3-thiazol-2-yl]benzamide
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C22H23N3OS
  1
1
IC50 = 4350 nM
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CP0431334
 Compound Info 
2-[3-[(3S,6R,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C40H53N11O6
  1
1
IC50 = 4600 nM
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CP0432529
 Compound Info 
2-[3-[(3S,6S,9R,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C39H51N11O6
  1
1
IC50 = 4600 nM
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CP0417678
 Compound Info 
3-[(2S,5S,8S,11R,14S)-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-1,7-dimethyl-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-8-(sulfanylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C39H52N10O7S
  1
1
IC50 = 4600 nM
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CP0472889
 Compound Info 
3-[(2S,5S,8S,11R,14S)-14-[3-(diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-1,7-dimethyl-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
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C41H56N10O7
  1
1
IC50 = 4900 nM
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CP0389188
 Compound Info 
3-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-12-(2-phenylethyl)-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C41H54N10O6
  1
1
IC50 = 5000 nM
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CP0482405
 Compound Info 
7-chloro-N-[2-(2-methylpiperidin-1-yl)ethyl]-4H-thieno[3,2-c]thiochromene-2-carboxamide
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C20H23ClN2OS2
  1
1
IC50 = 5270 nM
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CP0540611
 Compound Info 
(5Z)-5-[[4-(dimethylamino)phenyl]methylidene]-2-[4-(2-hydroxyethyl)piperazin-1-yl]-1,3-thiazol-4-one
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C18H24N4O2S
  1
1
IC50 = 5360 nM
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CP0463442
 Compound Info 
3-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propanamide
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C39H49N9O7
  1
1
IC50 = 5800 nM
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CP0482404
 Compound Info 
(E)-N-[2-[[cyclohexyl(methyl)amino]methyl]phenyl]-3-(1-phenylpyrazol-4-yl)prop-2-enamide
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C26H30N4O
  1
1
IC50 = 5840 nM
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CP0381271
 Compound Info 
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-[(2Z)-2-[(2-fluorophenyl)methylidene]-3-oxo-1,4-benzothiazin-4-yl]acetamide
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C24H26FN3O2S
  1
1
IC50 = 6190 nM
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CP0399441
 Compound Info 
N-[(1-ethylpyrrolidin-2-yl)methyl]-5-indol-1-ylthiophene-2-carboxamide
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C20H23N3OS
  1
1
IC50 = 6750 nM
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CP0477924
 Compound Info 
N-[2-(azepan-1-yl)ethyl]-8-methyl-4-oxo-5H-thieno[3,2-c]quinoline-2-carboxamide
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C21H25N3O2S
  1
1
IC50 = 7000 nM
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CP0381270
 Compound Info 
7-[2-hydroxy-3-(2-methylpiperidin-1-yl)propoxy]-2,3-dihydro-1H-cyclopenta[c]chromen-4-one
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C21H27NO4
  1
1
IC50 = 8020 nM
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CP0460508
 Compound Info 
3-[(3S,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propanamide
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C39H49N9O7
  1
1
IC50 = 9500 nM
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CP0433064
 Compound Info 
N-[4-[3-(dimethylamino)propylcarbamothioylamino]-2,5-diethoxyphenyl]-4-methylbenzamide
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C24H34N4O3S
  1
1
IC50 = 9790 nM
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CP0365172
 Compound Info 
(3-amino-6-ethyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridin-2-yl)-(3,4-dihydro-1H-isoquinolin-2-yl)methanone
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C22H24N4OS
  1
1
IC50 = 10000 nM
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CP0395374
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-12-[(4-hydroxyphenyl)methyl]-6,7-dimethyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C37H46N8O6
  1
1
IC50 = 11000 nM
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CP0380465
 Compound Info 
N-[3-[cyclopentyl(furan-2-ylmethyl)amino]propyl]-4H-thieno[3,2-c]thiochromene-2-carboxamide
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C25H28N2O2S2
  1
1
IC50 = 11400 nM
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CP0446855
 Compound Info 
2-[3-[(3S,6S,9R,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-10-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C40H53N11O6
  1
1
IC50 = 13000 nM
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CP0510917
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.4.0]nonadecan-9-yl]propyl]guanidine
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C40H53N11O6
  1
1
IC50 = 13000 nM
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CP0521750
 Compound Info 
3-[(3S,6S,9S,12R,15S)-9-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-7-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propylurea
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C40H52N10O7
  1
1
IC50 = 13000 nM
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CP0388842
 Compound Info 
2-[3-[(2S,5S,8S,11S,14R)-5-[3-(diaminomethylideneamino)propyl]-14-[(4-hydroxyphenyl)methyl]-10,11-dimethyl-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
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C38H51N11O6
  1
1
IC50 = 15000 nM
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CP0406996
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-12-[(4-hydroxyphenyl)methyl]-7,9-dimethyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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C37H46N8O6
  1
1
IC50 = 16000 nM
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CP0446854
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-13-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C40H53N11O6
  1
1
IC50 = 18000 nM
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CP0510916
 Compound Info 
2-[3-[(2S,5S,8S,11S,14R)-5-[3-(diaminomethylideneamino)propyl]-14-[(4-hydroxyphenyl)methyl]-11-methyl-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
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C37H49N11O6
  1
1
IC50 = 18000 nM
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CP0432531
 Compound Info 
2-[3-[(3S,6S,9S,12S,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-13-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C40H53N11O6
  1
1
IC50 = 23000 nM
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CP0248152
 Compound Info 
2-[3-[(2S,5S,8S,14R)-5-[3-(diaminomethylideneamino)propyl]-14-[(4-hydroxyphenyl)methyl]-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
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C36H47N11O6
  1
1
IC50 > 30000 nM
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CP0388841
 Compound Info 
2-[3-[(2S,5S,8S,11R,14R)-5-[3-(diaminomethylideneamino)propyl]-14-[(4-hydroxyphenyl)methyl]-11-methyl-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
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C37H49N11O6
  1
1
IC50 > 30000 nM
 Bioactivity Info 
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CP0388907
 Compound Info 
2-[3-[(3S,6S,9S,12S,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C39H51N11O6
  1
1
IC50 > 30000 nM
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CP0431330
 Compound Info 
2-[3-[(3R,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-4-methyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C40H53N11O6
  1
1
IC50 > 30000 nM
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CP0431331
 Compound Info 
2-[3-[(2R,5S,8S,11S)-8-[3-(diaminomethylideneamino)propyl]-2-[(4-hydroxyphenyl)methyl]-11-(naphthalen-2-ylmethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]propyl]guanidine
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C37H49N11O6
  1
1
IC50 > 30000 nM
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CP0431332
 Compound Info 
2-[3-[(3S,6S,9S,12R,15R)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C39H51N11O6
  1
1
IC50 > 30000 nM
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CP0431333
 Compound Info 
2-[3-[(3R,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C39H51N11O6
  1
1
IC50 > 30000 nM
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CP0431335
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-7,12-dimethyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C34H49N11O5
  1
1
IC50 > 30000 nM
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CP0432534
 Compound Info 
2-[3-[(3S,6S,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-3,7-dimethyl-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C30H47N11O6
  1
1
IC50 > 30000 nM
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CP0432577
 Compound Info 
2-[3-[(2S,5S,8S,11R,14R)-5-[3-(diaminomethylideneamino)propyl]-14-[(4-hydroxyphenyl)methyl]-10,11-dimethyl-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
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C38H51N11O6
  1
1
IC50 > 30000 nM
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CP0504621
 Compound Info 
2-[3-[(3S,6S,9S,12R,15R)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.4.0]nonadecan-9-yl]propyl]guanidine
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C40H53N11O6
  1
1
IC50 > 30000 nM
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CP0510918
 Compound Info 
2-[3-[(3S,6R,9S,12R,15S)-6-[3-(diaminomethylideneamino)propyl]-12-[(4-hydroxyphenyl)methyl]-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]propyl]guanidine
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C39H51N11O6
  1
1
IC50 > 30000 nM
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Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000107 , HEK293S
 Cell Line Info 
Cell Line ID: CL000857 , PathHunter CHO-K1 CXCR7 beta-arrestin
 Cell Line Info 
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0236196
 Compound Info 
[4-[[4-(7-ethylimidazo[1,2-a]pyridin-8-yl)-1,4-diazepan-1-yl]methyl]piperidin-1-yl]-[(1R,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]methanone
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C27H39N5O2
  1
1 Ki = 47 nM
Clinical Information about the Protein
Target 1 ( C-X-C chemokine receptor type 7 (ACKR3) )
Target Type Preclinical Target
Disease 1 Target-related Disease  1
1 Asthma [ICD-11: CA23]
Discontinued Drug(s) 1 Discontinued Drug  1
1 GW-766994
 Drug Info 
Discontinued in Phase 2
Asthma
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT07742 Atypical chemokine receptor 3 Canis lupus familiaris, Dog, Canis familiaris
 Protein Info