General Information of the Compound
Compound ID
CP0406996
Compound Name
2-[3-[(3S,6S,9S,12R,15S)-12-[(4-hydroxyphenyl)methyl]-7,9-dimethyl-3-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]propyl]guanidine
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Structure
Formula
C37H46N8O6
Molecular Weight
698.825
Canonical SMILES
C[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)N(C)C1=O
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InChI
InChI=1S/C37H46N8O6/c1-22-35(50)44(2)30(9-5-17-40-37(38)39)33(48)43-29(21-24-11-14-25-7-3-4-8-26(25)19-24)36(51)45-18-6-10-31(45)34(49)42-28(32(47)41-22)20-23-12-15-27(46)16-13-23/h3-4,7-8,11-16,19,22,28-31,46H,5-6,9-10,17-18,20-21H2,1-2H3,(H,41,47)(H,42,49)(H,43,48)(H4,38,39,40)/t22-,28+,29-,30-,31-/m0/s1
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InChIKey
ZWJNZBNMHNBXPR-VGTIASRQSA-N
Physicochemical Property
logP
0.89977
Rotatable Bonds
8
Heavy Atom Count
51
Polar Areas
210.05
Hydrogen Bond Donor Count
7
Hydrogen Bond Acceptor Count
7
Complexity
51

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122178730
ChEMBL ID
CHEMBL3581283
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04108, Atypical chemokine receptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 16000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02059, C-X-C chemokine receptor type 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS