Protein Information

General Information of the Protein

Protein ID	PT02805
Protein Name	CREB-binding protein
Secondarily Protein Name	Histone lysine acetyltransferase CREBBP Protein-lysine acetyltransferase CREBBP
Gene Name	CREBBP
Secondarily Gene Name	CBP
Sequence	MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Epigenetic regulator > Reader > Bromodomain
Function	Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). Show/Hide
Uniprot ID	Primary ID: Q92793 Secondarily ID: D3DUC9 O00147 Q16376 Q4LE28 Show/Hide
Ensembl ID	ENSG00000005339
HGNC ID	HGNC:2348
Subcellular Location	Cytoplasm Nucleus

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0065231 Compound Info	methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate Show/Hide	C14H11N3O3S	1
1	Potency = 794.3 nM Bioactivity Info	TI LI LO TS
CP0784528 Compound Info	SID11114001 Show/Hide	C46H58N4O9	2
1	Potency = 1000 nM Bioactivity Info	TI LI LO TS
2	Potency = 7943.3 nM Bioactivity Info	TI LI LO TS
CP0112250 Compound Info	BMCL181297 Compound 5A Show/Hide	C19H18N4O3S	1
1	Potency = 1995.3 nM Bioactivity Info	TI LI LO TS
CP0115456 Compound Info	MLS000574946 Show/Hide	C20H17NO5	1
1	Potency = 3162.3 nM Bioactivity Info	TI LI LO TS
CP0232948 Compound Info	2-[(4-methoxy-6-methyl-2-quinazolinyl)amino]-1H-quinazolin-4-one Show/Hide	C18H15N5O2	1
1	Potency = 3981.1 nM Bioactivity Info	TI LI LO TS
CP0672009 Compound Info	SID11114002 Show/Hide	C46H56N4O10	1
1	Potency = 6309.6 nM Bioactivity Info	TI LI LO TS
CP0044275 Compound Info	9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine Show/Hide	C13H8ClN5O	1
1	Potency = 7943.3 nM Bioactivity Info	TI LI LO TS
CP0083432 Compound Info	1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline Show/Hide	C20H21NO4	1
1	Potency = 7943.3 nM Bioactivity Info	TI LI LO TS
CP0105047 Compound Info	2-[2-(5,6-dimethyl-4-oxidanylidene-3-prop-2-enyl-thieno[2,3-d]pyrimidin-2-yl)sulfanylethanoylamino]thiophene-3-carboxamide Show/Hide	C18H18N4O3S3	2
1	Potency = 7943.3 nM Bioactivity Info	TI LI LO TS
2	Potency = 15848.9 nM Bioactivity Info	TI LI LO TS
CP0833617 Compound Info	SID860987 Show/Hide	C18H22N4O3S	2
1	Potency = 7943.3 nM Bioactivity Info	TI LI LO TS
2	Potency = 12589.3 nM Bioactivity Info	TI LI LO TS
CP0903186 Compound Info	SID3712382 Show/Hide	C18H14N6OS2	1
1	Potency = 7943.3 nM Bioactivity Info	TI LI LO TS
CP0194821 Compound Info	1-[4,6-bis(p-anisidino)-s-triazin-2-yl]-4,5-dimethyl-3-pyrazolin-3-one Show/Hide	C22H23N7O3	2
1	Potency = 7943.3 nM Bioactivity Info	TI LI LO TS
2	Potency = 12589.3 nM Bioactivity Info	TI LI LO TS
CP0096282 Compound Info	EHT-0202 Show/Hide	C14H19N5O2	1
1	Potency = 10000 nM Bioactivity Info	TI LI LO TS
CP0093822 Compound Info	CAS_5522 Show/Hide	C16H24N4O2	1
1	Potency = 12589.3 nM Bioactivity Info	TI LI LO TS
CP0151430 Compound Info	N,N-diethyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine Show/Hide	C13H15N5	1
1	Potency = 12589.3 nM Bioactivity Info	TI LI LO TS
CP0246931 Compound Info	4-(1H-benzimidazol-2-ylmethylsulfanyl)-[1]benzofuro[3,2-d]pyrimidine Show/Hide	C18H12N4OS	1
1	Potency = 12589.3 nM Bioactivity Info	TI LI LO TS
CP0526181 Compound Info	3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-tert-butylcarbamoyl-ethyl)-furan-2-ylmethyl-amide Show/Hide	C25H28N4O3S	1
1	Potency = 12589.3 nM Bioactivity Info	TI LI LO TS
CP0658529 Compound Info	SID7969228 Show/Hide	C24H23N3O5	1
1	Potency = 12589.3 nM Bioactivity Info	TI LI LO TS
CP0819853 Compound Info	SID7976354 Show/Hide	C18H16N4S	1
1	Potency = 12589.3 nM Bioactivity Info	TI LI LO TS
CP0848660 Compound Info	SID26668783 Show/Hide	C25H24N4O4S	2
1	Potency = 12589.3 nM Bioactivity Info	TI LI LO TS
2	Potency = 15848.9 nM Bioactivity Info	TI LI LO TS
CP0920709 Compound Info	SID4261669 Show/Hide	C21H18N4O2S2	1
1	Potency = 12589.3 nM Bioactivity Info	TI LI LO TS
CP0230036 Compound Info	6-(3,4-dichlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine Show/Hide	C16H12Cl2N6S	1
1	Potency = 15848.9 nM Bioactivity Info	TI LI LO TS
CP0314294 Compound Info	(9-ethylcarbazol-3-yl)-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine Show/Hide	C20H18N6	1
1	Potency = 15848.9 nM Bioactivity Info	TI LI LO TS
CP0667392 Compound Info	SID4241098 Show/Hide	C17H16N8	1
1	Potency = 15848.9 nM Bioactivity Info	TI LI LO TS
CP0784397 Compound Info	SID3711670 Show/Hide	C18H19N3OS	1
1	Potency = 15848.9 nM Bioactivity Info	TI LI LO TS
CP0799674 Compound Info	SID26668753 Show/Hide	C25H24N4O3	1
1	Potency = 15848.9 nM Bioactivity Info	TI LI LO TS
CP0799685 Compound Info	SID4243027 Show/Hide	C20H18N4O4S	1
1	Potency = 15848.9 nM Bioactivity Info	TI LI LO TS
CP0700431 Compound Info	SID4258831 Show/Hide	C21H22N4O	1
1	Potency = 19952.6 nM Bioactivity Info	TI LI LO TS
CP0049421 Compound Info	2-(3-methoxy-4-oxidanyl-phenyl)chromen-4-one Show/Hide	C16H12O4	1
1	Potency = 25118.9 nM Bioactivity Info	TI LI LO TS
CP0407405 Compound Info	2-N-phenyl-6-[(5-phenyl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,5-triazine-2,4-diamine Show/Hide	C18H16N8S	1
1	Potency = 25118.9 nM Bioactivity Info	TI LI LO TS
CP0499434 Compound Info	3-Methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (tert-butylcarbamoyl-methyl)-furan-2-ylmethyl-amide Show/Hide	C24H26N4O3S	1
1	Potency = 25118.9 nM Bioactivity Info	TI LI LO TS
CP0720198 Compound Info	SID7973720 Show/Hide	C19H23N7O2S2	1
1	Potency = 25118.9 nM Bioactivity Info	TI LI LO TS
CP0446506 Compound Info	3-(5-methyl-1H-pyrazol-3-yl)-6-(4-phenylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine Show/Hide	C20H16N6S	1
1	Potency = 31622.8 nM Bioactivity Info	TI LI LO TS
CP0463537 Compound Info	MLS000082661 Show/Hide	C22H19N3O4S	1
1	Potency = 31622.8 nM Bioactivity Info	TI LI LO TS
CP0801129 Compound Info	SID862358 Show/Hide	C23H24ClN5O2	1
1	Potency = 31622.8 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000091 , MV4-11

Cell Line Info

Cell Line ID: CL000752 , PBMC iPSC #1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0067394 Compound Info	SGC-CBP30 Show/Hide	C28H33ClN4O3	7
1	EC50 < 1000 nM
2	IC50 = 28 nM
3	IC50 = 30 nM
4	IC50 = 64 nM
5	IC50 = 69 nM
6	IC50 = 79 nM
7	Kd = 21 nM
CP0072530 Compound Info	3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-methyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide Show/Hide	C27H33F2N7O2	1
1	IC50 = 0.94 nM
CP0370048 Compound Info	1-[4-[5-acetyl-3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]piperidin-1-yl]ethanone Show/Hide	C29H35F2N7O2	1
1	IC50 = 1 nM
CP0548842 Compound Info	3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide Show/Hide	C26H31F2N7O2	1
1	IC50 = 1 nM
CP0127942 Compound Info	1-[3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C27H32F2N6O2	1
1	IC50 = 1.1 nM
CP0364997 Compound Info	1-[3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(1,1-dioxothian-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C27H32F2N6O3S	1
1	IC50 = 1.2 nM
CP0558854 Compound Info	1-[3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(1-methylsulfonylpiperidin-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C28H35F2N7O3S	1
1	IC50 = 1.2 nM
CP0232265 Compound Info	1-[3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C26H30F2N6O2	1
1	IC50 = 1.4 nM
CP0470504 Compound Info	1-[3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-piperidin-4-yl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C27H33F2N7O	1
1	IC50 = 1.5 nM
CP0562866 Compound Info	1-[3-[6-(1-methylpyrazol-4-yl)-7-(trifluoromethyl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C26H29F3N6O2	1
1	IC50 = 1.5 nM
CP0558856 Compound Info	1-[3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-(1-methylpiperidin-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C28H35F2N7O	1
1	IC50 = 2 nM
CP0072531 Compound Info	1-[1-cyclohexyl-3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C28H34F2N6O	1
1	IC50 = 3.1 nM
CP0072532 Compound Info	1-[3-[7-chloro-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C25H29ClN6O2	1
1	IC50 = 4.3 nM
CP0370049 Compound Info	1-[3-[7-methyl-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C26H32N6O2	1
1	IC50 = 4.4 nM
CP0327569 Compound Info	1-[3-[7-methoxy-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C26H32N6O3	1
1	IC50 = 4.7 nM
CP0072533 Compound Info	1-[3-[6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C25H30N6O2	1
1	IC50 = 16 nM
CP0086089 Compound Info	1-[3-[2-fluoro-4-(1-methylpyrazol-4-yl)anilino]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone Show/Hide	C22H25FN6O2	1
1	IC50 = 20 nM
CP0177566 Compound Info	(4R)-4-methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one Show/Hide	C22H22N6O	2
1	IC50 = 30 nM
2	Kd = 30 nM
CP0127939 Compound Info	3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-ethyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide Show/Hide	C28H35F2N7O2	1
1	IC50 = 31 nM
CP0177567 Compound Info	(4R)-6-(3-cyclopropyl-1-methylindazol-5-yl)-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one Show/Hide	C21H22N4O	1
1	IC50 = 33 nM
CP0068059 Compound Info	(4R)-4-methyl-N-[3-(1,3-oxazol-5-yl)phenyl]-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide Show/Hide	C20H18N4O3	1
1	IC50 = 39 nM
CP0099079 Compound Info	1-methyl-5-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepin-6-yl]indazole-3-carboxamide Show/Hide	C19H19N5O2	1
1	IC50 = 77 nM
CP0474064 Compound Info	(4R)-4-methyl-6-(3-phenylmethoxyphenyl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one Show/Hide	C23H22N2O2	1
1	IC50 = 110 nM
CP0177568 Compound Info	(4R)-6-(3,4-dimethoxyphenyl)-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one Show/Hide	C18H20N2O3	1
1	IC50 = 130 nM
CP0071990 Compound Info	PF-CBP1 Show/Hide	C29H36N4O3	3
1	IC50 = 130 nM
2	IC50 = 190 nM
3	Kd = 190 nM
CP0231170 Compound Info	(4R)-4-methyl-6-[1-(1-phenylethyl)pyrazol-4-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one Show/Hide	C21H22N4O	1
1	IC50 = 160 nM
CP0071989 Compound Info	1-[7-(3,4-dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]propan-1-one Show/Hide	C27H36N2O5	4
1	IC50 = 170 nM
2	IC50 = 440 nM
3	Kd = 151 nM
4	Kd = 170 nM
CP0560432 Compound Info	2-[(E)-2-[(4R)-4-methyl- Show/Hide	C18H19N3O3S	1
1	IC50 = 180 nM
CP0098924 Compound Info	(4R)-4-methyl-6-(1-methylindazol-5-yl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one Show/Hide	C18H18N4O	1
1	IC50 = 240 nM
CP0231171 Compound Info	1-methyl-5-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepin-6-yl]indazole-3-carbonitrile Show/Hide	C19H17N5O	1
1	IC50 = 250 nM
CP0370050 Compound Info	3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N,N-dimethyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide Show/Hide	C28H35F2N7O2	1
1	IC50 = 310 nM
CP0223544 Compound Info	(3R)-N-[3-(7-methoxy-3,4-dihydro-2H-quinolin-1-yl)propyl]-3-methyl-2-oxo-3,4-dihydro-1H-quinoxaline-5-carboxamide Show/Hide	C23H28N4O3	4
1	IC50 = 316.23 nM
2	IC50 = 323 nM
3	IC50 = 580 nM
4	Kd = 0.39 nM
CP0565971 Compound Info	(4R)-6-(1-tert-butylpyrazol-4- Show/Hide	C17H22N4O	1
1	IC50 = 470 nM
CP0445084 Compound Info	(4R)-4-methyl-N-[(1R)-1-(1,3-oxazol-5-yl)propyl]-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide Show/Hide	C17H20N4O3	1
1	IC50 = 620 nM
CP0098927 Compound Info	(4R)-N-(3,4-dihydro-2H-chromen-4-yl)-4-methyl-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide Show/Hide	C20H21N3O3	1
1	IC50 = 670 nM
CP0231172 Compound Info	(4R)-4-methyl-2-oxo-N-[(1R)-1-phenylethyl]-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide Show/Hide	C19H21N3O2	1
1	IC50 = 900 nM
CP0223128 Compound Info	(4S)-4-methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one Show/Hide	C22H22N6O	1
1	IC50 = 3400 nM
CP0063220 Compound Info	Ischemin Show/Hide	C15H17N3O4S	3
1	IC50 = 5000 nM
2	Kd = 19000 nM
3	Kd = 19600 nM
CP0573814 Compound Info	(4R)-4-methyl-2-oxo-N-[(1S)-1-phenylethyl]-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide Show/Hide	C19H21N3O2	1
1	IC50 = 5000 nM
CP0068060 Compound Info	(4R)-4-methyl-N-(1,3-oxazol-5-ylmethyl)-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepine-6-carboxamide Show/Hide	C15H16N4O3	1
1	IC50 = 6500 nM

Clinical Information about the Protein

Target 1 ( CREB-binding protein (CREBBP) )

Target Type	Clinical trial Target
Disease	1 Target-related Disease				1
1	Scleroderma [ICD-11: 4A42]
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	C 82	Drug Info	Phase 1/2	Scleroderma

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About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han