General Information of the Compound
Compound ID
CP0099079
Compound Name
1-methyl-5-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepin-6-yl]indazole-3-carboxamide
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Structure
Formula
C19H19N5O2
Molecular Weight
349.394
Canonical SMILES
C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(C(N)=O)c4c3)c2N1
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InChI
InChI=1S/C19H19N5O2/c1-10-8-16(25)22-14-5-3-4-12(17(14)21-10)11-6-7-15-13(9-11)18(19(20)26)23-24(15)2/h3-7,9-10,21H,8H2,1-2H3,(H2,20,26)(H,22,25)/t10-/m1/s1
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InChIKey
SYEXTYCMJGDJHE-SNVBAGLBSA-N
Physicochemical Property
logP
2.4818
Rotatable Bonds
2
Heavy Atom Count
26
Polar Areas
102.04
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 121271742
ChEMBL ID
CHEMBL3813929
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02805, CREB-binding protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 1900 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 77 nM