Protein Information

General Information of the Protein

Protein ID	PT01689
Protein Name	Steryl-sulfatase
Secondarily Protein Name	Arylsulfatase C Estrone sulfatase Steroid sulfatase Steryl-sulfate sulfohydrolase
Gene Name	STS
Secondarily Gene Name	ARSC1
Sequence	MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Hydrolase
Function	Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. Show/Hide
Uniprot ID	Primary ID: P08842 Secondarily ID: B2RA47 Show/Hide
Ensembl ID	ENSG00000101846
HGNC ID	HGNC:11425
Subcellular Location	Cytoplasmic vesicle Secretory vesicle Microneme membrane Endoplasmic reticulum membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0057612 Compound Info	[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfamate Show/Hide	C18H23NO4S	2
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
2	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0090287 Compound Info	[2-(1-adamantyl)-4-oxochromen-6-yl] sulfamate Show/Hide	C19H21NO5S	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0124667 Compound Info	[2-(1-adamantyl)-4-oxothiochromen-6-yl] sulfamate Show/Hide	C19H21NO4S2	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0306019 Compound Info	2-Adamantan-1-yl-4-oxo-4H-thiochromene-6-carboxylic acid Show/Hide	C20H20O3S	1
1	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0268929 Compound Info	4-(4-Bromo-2,5-dichloro-thiophene-3-sulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester Show/Hide	C15H19BrCl2N2O5S2	1
1	IC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0257149 Compound Info	4-(3,5-Bis-trifluoromethyl-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester Show/Hide	C19H22F6N2O5S	1
1	IC50 = 780 nM Bioactivity Info	TI LI LO TS
CP0279787 Compound Info	4-(3,5-Dichloro-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester Show/Hide	C17H22Cl2N2O5S	1
1	IC50 = 1260 nM Bioactivity Info	TI LI LO TS
CP0083400 Compound Info	[(1R,5S)-8-[[3,5-bis(trifluoromethyl)phenyl]sulfonylcarbamoyl]-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylacetate Show/Hide	C24H22F6N2O5S	1
1	IC50 = 1890 nM Bioactivity Info	TI LI LO TS
CP0275823 Compound Info	8-[N-(4-chlorophenylsulfonamido)-carbonyl amino]-8-azabicyclo[3.2.1]oct-3-yl 2-phenylacetate Show/Hide	C22H24ClN3O5S	1
1	IC50 = 3840 nM Bioactivity Info	TI LI LO TS
CP0100227 Compound Info	[(1S,5R)-8-[2-(4-chlorophenyl)sulfonylacetyl]-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylacetate Show/Hide	C23H24ClNO5S	1
1	IC50 = 4320 nM Bioactivity Info	TI LI LO TS
CP0178399 Compound Info	[(1R,5S)-8-[(4-bromophenyl)sulfonylcarbamoyl]-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylacetate Show/Hide	C22H23BrN2O5S	1
1	IC50 = 6150 nM Bioactivity Info	TI LI LO TS
CP0061865 Compound Info	[(1R,5S)-8-[(4-chlorophenyl)sulfonylcarbamoyl]-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylacetate Show/Hide	C22H23ClN2O5S	2
1	IC50 = 6270 nM Bioactivity Info	TI LI LO TS
2	IC50 = 6720 nM Bioactivity Info	TI LI LO TS
CP0083806 Compound Info	[(1S,5R)-8-[[4-(trifluoromethyl)phenyl]sulfonylcarbamoyl]-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylacetate Show/Hide	C23H23F3N2O5S	1
1	IC50 = 7470 nM Bioactivity Info	TI LI LO TS
CP0207559 Compound Info	2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic acid Show/Hide	C20H20O4	1
1	IC50 = 9400 nM Bioactivity Info	TI LI LO TS
CP0111687 Compound Info	4-(4-Chloro-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester Show/Hide	C17H23ClN2O5S	1
1	IC50 = 9800 nM Bioactivity Info	TI LI LO TS
CP0245139 Compound Info	4-(2,6-Dichloro-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester Show/Hide	C17H22Cl2N2O5S	1
1	IC50 = 9900 nM Bioactivity Info	TI LI LO TS
CP0175644 Compound Info	[(1R,5S)-8-[(4-chlorobenzoyl)carbamoyl]-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylacetate Show/Hide	C23H23ClN2O4	1
1	IC50 = 10400 nM Bioactivity Info	TI LI LO TS
CP0285303 Compound Info	4-(4-Chloro-benzenesulfonylaminocarbonyl)-piperazine-1-carboxylic acid tert-butyl ester Show/Hide	C16H22ClN3O5S	1
1	IC50 = 12000 nM Bioactivity Info	TI LI LO TS
CP0132984 Compound Info	(2-Adamantan-1-yl-4-oxo-4H-chromen-6-yl)-oxo-acetic acid Show/Hide	C21H20O5	1
1	IC50 = 12300 nM Bioactivity Info	TI LI LO TS
CP0177917 Compound Info	[1-[(4-chlorophenyl)sulfonylcarbamoyl]-4-cyanopiperidin-4-yl] 2-phenylacetate Show/Hide	C21H20ClN3O5S	1
1	IC50 = 24500 nM Bioactivity Info	TI LI LO TS
CP0244557 Compound Info	[(1S,5R)-8-(benzenesulfonylcarbamoyl)-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylacetate Show/Hide	C22H24N2O5S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0285030 Compound Info	[1-[(4-chlorophenyl)sulfonylcarbamoyl]piperidin-4-yl] 2-phenylacetate Show/Hide	C20H21ClN2O5S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0068080 Compound Info	2-Adamantan-1-yl-6-(2-hydroxy-acetyl)-chromen-4-one Show/Hide	C21H22O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0068081 Compound Info	2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic acid methyl ester Show/Hide	C21H22O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0077442 Compound Info	2-Adamantan-1-yl-4-oxo-4H-chromene-6-carbaldehyde Show/Hide	C20H20O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0077444 Compound Info	(2-Adamantan-1-yl-4-oxo-4H-chromen-6-yl)-acetic acid Show/Hide	C21H22O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0277392 Compound Info	2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic acid amide Show/Hide	C20H21NO3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0281838 Compound Info	2-Adamantan-1-yl-4-oxo-4H-thiochromene-6-carbonitrile Show/Hide	C20H19NOS	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0037702 Compound Info	[(1S,5R)-8-[(4-methylphenyl)sulfonylcarbamoyl]-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylacetate Show/Hide	C23H26N2O5S	1
1	IC50 = 37100 nM Bioactivity Info	TI LI LO TS
CP0050738 Compound Info	[(1R,5S)-8-[(4-fluorophenyl)sulfonylcarbamoyl]-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylacetate Show/Hide	C22H23FN2O5S	1
1	IC50 = 39200 nM Bioactivity Info	TI LI LO TS
CP0256733 Compound Info	2-Adamantan-1-yl-6-hydroxymethyl-chromen-4-one Show/Hide	C20H22O3	1
1	IC50 ~ 30000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000208 , JEG-3

Cell Line Info

Cell Line ID: CL000083 , MCF-7

Cell Line Info

Cell Line ID: CL000078 , T-47D

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0057612 Compound Info	[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfamate Show/Hide	C18H23NO4S	9
1	IC50 = 0.065 nM
2	IC50 = 8 nM
3	IC50 = 50 nM
4	IC50 = 56 nM
5	IC50 = 100 nM
6	IC50 = 500 nM
7	IC50 = 22000 nM
8	Ki = 670 nM
9	Km = 95000 nM
CP0368825 Compound Info	[(8R,9S,13S,14S,17R)-17-[(4-tert-butylphenyl)methyl]-17-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfamate Show/Hide	C29H39NO4S	2
1	IC50 = 0.15 nM
2	IC50 = 1.4 nM
CP0124667 Compound Info	[2-(1-adamantyl)-4-oxothiochromen-6-yl] sulfamate Show/Hide	C19H21NO4S2	2
1	IC50 = 0.34 nM
2	Ki = 210 nM
CP0438268 Compound Info	[(8R,9S,13S,14S,17R)-17-benzyl-17-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfamate Show/Hide	C25H31NO4S	2
1	IC50 = 0.39 nM
2	IC50 = 4.1 nM
CP0664560 Compound Info	Sulfamic acid 2-adamantan-2-ylidene methyl-benzooxazol-6-yl ester Show/Hide	C18H20N2O4S	3
1	IC50 = 0.75 nM
2	IC50 = 2.3 nM
3	IC50 = 970 nM
CP0343750 Compound Info	[(4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(3,3,3-trifluoropropyl)-4,4a,4b,5,6,10b,11,12-octahydronaphtho[2,1-f]isoquinolin-8-yl] sulfamate Show/Hide	C21H25F3N2O5S	1
1	IC50 = 3 nM
CP0090287 Compound Info	[2-(1-adamantyl)-4-oxochromen-6-yl] sulfamate Show/Hide	C19H21NO5S	2
1	IC50 = 5.6 nM
2	Ki = 190 nM
CP0055053 Compound Info	6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate Show/Hide	C14H15NO5S	2
1	IC50 = 8 nM
2	IC50 = 210 nM
CP0163248 Compound Info	(8R,9S,13S,14S,17R)-17-[(3-bromophenyl)methyl]-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol Show/Hide	C25H29BrO2	1
1	IC50 = 24 nM
CP0268929 Compound Info	4-(4-Bromo-2,5-dichloro-thiophene-3-sulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester Show/Hide	C15H19BrCl2N2O5S2	2
1	IC50 = 26 nM
2	Ki = 12 nM
CP0207557 Compound Info	[1-chloro-6-[[4-cyano-N-(1,2,4-triazol-4-yl)anilino]methyl]naphthalen-2-yl] sulfamate Show/Hide	C20H15ClN6O3S	1
1	IC50 = 26 nM
CP0399910 Compound Info	(8R,9S,13S,14S,17R)-17-[(4-tert-butylphenyl)methyl]-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol Show/Hide	C29H38O2	1
1	IC50 = 28 nM
CP0157172 Compound Info	(3,4-dimethyl-2-oxochromen-7-yl) sulfamate Show/Hide	C11H11NO5S	1
1	IC50 = 30 nM
CP0048280 Compound Info	4-methyl-2-oxo-2H-chromen-7-yl sulfamate Show/Hide	C10H9NO5S	5
1	IC50 = 30 nM
2	IC50 = 380 nM
3	IC50 = 12000 nM
4	IC50 = 13800 nM
5	Km = 275000 nM
CP0259310 Compound Info	(2-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl) sulfamate Show/Hide	C16H13BrN6O3S	1
1	IC50 = 39 nM
CP0083400 Compound Info	CHEMBL331089 Show/Hide	C24H22F6N2O5S	2
1	IC50 = 84 nM
2	Ki = 76 nM
CP0276089 Compound Info	(8R,9S,13S,14S,17R)-13-methyl-17-[[3-(trifluoromethyl)phenyl]methyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol Show/Hide	C26H29F3O2	1
1	IC50 = 126 nM
CP0281838 Compound Info	2-Adamantan-1-yl-4-oxo-4H-thiochromene-6-carbonitrile Show/Hide	C20H19NOS	3
1	IC50 = 180 nM
2	IC50 > 530 nM
3	Ki > 50000 nM
CP0429110 Compound Info	[1-bromo-6-[[4-cyano-N-(1,2,4-triazol-4-yl)anilino]methyl]naphthalen-2-yl] sulfamate Show/Hide	C20H15BrN6O3S	1
1	IC50 = 205 nM
CP0257149 Compound Info	4-(3,5-Bis-trifluoromethyl-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester Show/Hide	C19H22F6N2O5S	2
1	IC50 = 210 nM
2	Ki = 220 nM
CP0078703 Compound Info	[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] formate Show/Hide	C19H22O3	1
1	IC50 = 420 nM
CP0279787 Compound Info	4-(3,5-Dichloro-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester Show/Hide	C17H22Cl2N2O5S	1
1	IC50 = 450 nM
CP0061865 Compound Info	CHEMBL124349 Show/Hide	C22H23ClN2O5S	2
1	IC50 = 910 nM
2	Ki = 2400 nM
CP0285303 Compound Info	4-(4-Chloro-benzenesulfonylaminocarbonyl)-piperazine-1-carboxylic acid tert-butyl ester Show/Hide	C16H22ClN3O5S	2
1	IC50 = 3600 nM
2	Ki = 14500 nM
CP0245139 Compound Info	4-(2,6-Dichloro-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester Show/Hide	C17H22Cl2N2O5S	1
1	IC50 = 6100 nM
CP0100227 Compound Info	CHEMBL120868 Show/Hide	C23H24ClNO5S	1
1	IC50 = 6200 nM
CP0111687 Compound Info	4-(4-Chloro-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester Show/Hide	C17H23ClN2O5S	2
1	IC50 = 8600 nM
2	Ki = 16100 nM
CP0207559 Compound Info	2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic acid Show/Hide	C20H20O4	3
1	IC50 = 9400 nM
2	IC50 > 530 nM
3	Ki = 500 nM
CP0177917 Compound Info	[1-[(4-chlorophenyl)sulfonylcarbamoyl]-4-cyanopiperidin-4-yl] 2-phenylacetate Show/Hide	C21H20ClN3O5S	1
1	IC50 = 13000 nM
CP0037702 Compound Info	CHEMBL122840 Show/Hide	C23H26N2O5S	1
1	IC50 = 16600 nM
CP0050738 Compound Info	CHEMBL122686 Show/Hide	C22H23FN2O5S	1
1	IC50 = 50000 nM
CP0068080 Compound Info	2-Adamantan-1-yl-6-(2-hydroxy-acetyl)-chromen-4-one Show/Hide	C21H22O4	2
1	IC50 > 530 nM
2	Ki = 3200 nM
CP0068081 Compound Info	2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic acid methyl ester Show/Hide	C21H22O4	2
1	IC50 > 530 nM
2	Ki > 50000 nM
CP0077442 Compound Info	2-Adamantan-1-yl-4-oxo-4H-chromene-6-carbaldehyde Show/Hide	C20H20O3	2
1	IC50 > 530 nM
2	Ki > 20000 nM
CP0077444 Compound Info	(2-Adamantan-1-yl-4-oxo-4H-chromen-6-yl)-acetic acid Show/Hide	C21H22O4	2
1	IC50 > 530 nM
2	Ki > 50000 nM
CP0132984 Compound Info	(2-Adamantan-1-yl-4-oxo-4H-chromen-6-yl)-oxo-acetic acid Show/Hide	C21H20O5	2
1	IC50 > 530 nM
2	Ki = 2200 nM
CP0256733 Compound Info	2-Adamantan-1-yl-6-hydroxymethyl-chromen-4-one Show/Hide	C20H22O3	2
1	IC50 > 530 nM
2	Ki = 32000 nM
CP0277392 Compound Info	2-Adamantan-1-yl-4-oxo-4H-chromene-6-carboxylic acid amide Show/Hide	C20H21NO3	2
1	IC50 > 530 nM
2	Ki > 50000 nM
CP0244557 Compound Info	CHEMBL123397 Show/Hide	C22H24N2O5S	1
1	IC50 > 100000 nM
CP0285030 Compound Info	[1-[(4-chlorophenyl)sulfonylcarbamoyl]piperidin-4-yl] 2-phenylacetate Show/Hide	C20H21ClN2O5S	1
1	IC50 > 100000 nM
CP0191536 Compound Info	(8R,9S,13S,14S,17R)-17-benzyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol Show/Hide	C25H30O2	1
1	Ki = 250 nM
CP0306019 Compound Info	2-Adamantan-1-yl-4-oxo-4H-thiochromene-6-carboxylic acid Show/Hide	C20H20O3S	2
1	Ki = 500 nM
2	Ki = 530 nM
CP0083806 Compound Info	CHEMBL332811 Show/Hide	C23H23F3N2O5S	1
1	Ki = 530 nM
CP0275823 Compound Info	8-[N-(4-chlorophenylsulfonamido)-carbonyl amino]-8-azabicyclo[3.2.1]oct-3-yl 2-phenylacetate Show/Hide	C22H24ClN3O5S	1
1	Ki = 890 nM
CP0178399 Compound Info	CHEMBL440159 Show/Hide	C22H23BrN2O5S	1
1	Ki = 1850 nM
CP0175644 Compound Info	CHEMBL121068 Show/Hide	C23H23ClN2O4	1
1	Ki = 5800 nM
CP0127632 Compound Info	ESTRONE Show/Hide	C18H22O5S	2
1	Ki = 60000 nM
2	Km = 21000 nM

Clinical Information about the Protein

Target 1 ( Steryl-sulfatase (STS) )

Target Type	Successful Target
Disease	5 Target-related Diseases				5
1	Ocular allergy [ICD-11: 4A81]
2	Breast cancer [ICD-11: 2C60-2C65]
3	Endometriosis [ICD-11: GA10]
4	Osteoporosis [ICD-11: FB83.0]
5	Prostate cancer [ICD-11: 2C82.0]
Approved Drug(s)	1 Approved Drug				1
1	Tranilast	Drug Info	Approved	Ocular allergy
Clinical Trial Drug(s)	4 Clinical Trial Drugs				4
1	Coumate	Drug Info	Phase 2	Breast cancer
2	PGL-2001	Drug Info	Phase 2	Endometriosis
3	STX-140	Drug Info	Phase 2	Osteoporosis
4	STX 64	Drug Info	Phase 1	Prostate cancer

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han