General Information of the Compound
Compound ID
CP0057612
Compound Name
[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfamate
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Synonyms
148672-09-7
3-((Aminosulfonyl)oxy)estra-1,3,5(10)-trien-17-one
3-[(Aminosulfonyl)oxy]estra-1,3,5(10)-trien-17-one
AC1L2SFZ
AKOS030241107
BDBM50134329
C18H23NO4S
CHEMBL122708
CTK8F0296
EMATE
Emate compound
Estra-1,3,5(10)-trien-17-one, 3-((aminosulfonyl)oxy)-
Estra-1,3,5(10)-trien-17-one-3-sulfamate
Estrone 3-O-Sulfamate
Estrone 3-Sulfamate
Estrone O-Sulfamate
Estrone Sulfamate
Estrone-3-O-sulfamate
NSC685426
Oestrone-3-O-sulphamate
RVKFQAJIXCZXQY-CBZIJGRNSA-N
SCHEMBL305660
ZINC5832614
estrone3-O-sulfamate
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Structure
Formula
C18H23NO4S
Molecular Weight
349.452
Canonical SMILES
C[C@]12CC[C@H]3[C@@H](CCc4cc(OS(N)(=O)=O)ccc34)[C@@H]1CCC2=O
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InChI
InChI=1S/C18H23NO4S/c1-18-9-8-14-13-5-3-12(23-24(19,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16H,2,4,6-9H2,1H3,(H2,19,21,22)/t14-,15-,16+,18+/m1/s1
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InChIKey
RVKFQAJIXCZXQY-CBZIJGRNSA-N
CAS
148672-09-7
Physicochemical Property
logP
2.6941
Rotatable Bonds
2
Heavy Atom Count
24
Polar Areas
86.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127676
SID: 57304377
ChEMBL ID
CHEMBL122708
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01689, Steryl-sulfatase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7 Homo sapiens (Human)  3
1
IC50 = 0.065 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.83 nM
   TI
   LI
   LO
   TS
3
IC50 = 80 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  4
1
IC50 = 1.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 2.1 nM
   TI
   LI
   LO
   TS
3
IC50 = 2.4 nM
   TI
   LI
   LO
   TS
4
IC50 = 5.6 nM
   TI
   LI
   LO
   TS
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 30 nM
   TI
   LI
   LO
   TS
CL000208 JEG-3 Homo sapiens (Human)  1
1
IC50 = 7600 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.065 nM
2 IC50 = 8 nM
3 IC50 = 50 nM
4 IC50 = 56 nM
5 IC50 = 100 nM
6 IC50 = 500 nM
7 IC50 = 22000 nM
8 Ki = 670 nM
9 Km = 95000 nM
Clinical Information about the Compound
Drug 1 ( EMATE )
Drug Name EMATE
Target(s)
Carbonic anhydrase II (CA-II)
Inhibitor
Steryl-sulfatase (STS)
Inhibitor