Protein Information

General Information of the Protein

Protein ID	PT00836
Protein Name	Carbonic anhydrase 2
Secondarily Protein Name	Carbonate dehydratase II Carbonic anhydrase C Carbonic anhydrase II Cyanamide hydratase CA2
Gene Name	CA2
Sequence	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Lyase
Function	Catalyzes the reversible hydration of carbon dioxide (PubMed:1909891, PubMed:1910042, PubMed:1336460, PubMed:8485129, PubMed:8399159, PubMed:8218160, PubMed:8262987, PubMed:8451242, PubMed:7901850, PubMed:7761440, PubMed:8639494, PubMed:9265618, PubMed:17330962, PubMed:9398308, PubMed:11327835, PubMed:12056894, PubMed:17346964, PubMed:12171926, PubMed:15453828, PubMed:16214338, PubMed:15865431, PubMed:16106378, PubMed:15300855, PubMed:15667203, PubMed:18942852, PubMed:11831900, PubMed:17251017, PubMed:17314045, PubMed:18618712, PubMed:1336460, PubMed:11802772, PubMed:14736236, PubMed:16290146, PubMed:16759856, PubMed:16807956, PubMed:16686544, PubMed:17705204, PubMed:17127057, PubMed:17540563, PubMed:17588751, PubMed:18266323, PubMed:18024029, PubMed:18162396, PubMed:18374572, PubMed:18640037, PubMed:18481843, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19778001, PubMed:19520834). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Show/Hide
Uniprot ID	Primary ID: P00918 Secondarily ID: B2R7G8 Q6FI12 Q96ET9 Show/Hide
Ensembl ID	ENSG00000104267
HGNC ID	HGNC:1373
Subcellular Location	Cytoplasm Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0426192 Compound Info	[4-(1-benzofuran-5-yl)phenyl] 4-fluorobenzenesulfonate Show/Hide	C20H13FO4S	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0532862 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] propane-1-sulfonate Show/Hide	C17H16O3S2	1
1	IC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0540809 Compound Info	[4-(1-benzofuran-5-yl)phenyl] benzenesulfonate Show/Hide	C20H14O4S	1
1	IC50 = 410 nM Bioactivity Info	TI LI LO TS
CP0566420 Compound Info	[4-(1-benzofuran-5-yl)phenyl] 4-methylbenzenesulfonate Show/Hide	C21H16O4S	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0426191 Compound Info	[4-(1-benzofuran-5-yl)phenyl] N-methylsulfamate Show/Hide	C15H13NO4S	1
1	IC50 = 1040 nM Bioactivity Info	TI LI LO TS
CP0034627 Compound Info	AZA Show/Hide	C4H6N4O3S2	1
1	IC50 = 1190 nM Bioactivity Info	TI LI LO TS
CP0412942 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] N-methylsulfamate Show/Hide	C15H13NO3S2	1
1	IC50 = 1210 nM Bioactivity Info	TI LI LO TS
CP0426190 Compound Info	[4-(1-benzofuran-5-yl)phenyl] N,N-dimethylsulfamate Show/Hide	C16H15NO4S	1
1	IC50 = 1230 nM Bioactivity Info	TI LI LO TS
CP0528252 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] ethanesulfonate Show/Hide	C16H14O3S2	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0412941 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] sulfamate Show/Hide	C14H11NO3S2	1
1	IC50 = 1320 nM Bioactivity Info	TI LI LO TS
CP0412939 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] benzenesulfonate Show/Hide	C20H14O3S2	1
1	IC50 = 1490 nM Bioactivity Info	TI LI LO TS
CP0412940 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] methanesulfonate Show/Hide	C15H12O3S2	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0563109 Compound Info	[4-(1-benzofuran-5-yl)phenyl] ethanesulfonate Show/Hide	C16H14O4S	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0528251 Compound Info	[4-(1-benzofuran-5-yl)phenyl] propane-1-sulfonate Show/Hide	C17H16O4S	1
1	IC50 = 1620 nM Bioactivity Info	TI LI LO TS
CP0530321 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] 4-fluorobenzenesulfonate Show/Hide	C20H13FO3S2	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0540808 Compound Info	[4-(1-benzofuran-5-yl)phenyl] methanesulfonate Show/Hide	C15H12O4S	1
1	IC50 = 2130 nM Bioactivity Info	TI LI LO TS
CP0426193 Compound Info	[4-(1-benzofuran-5-yl)phenyl] sulfamate Show/Hide	C14H11NO4S	1
1	IC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0528248 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] 4-methylbenzenesulfonate Show/Hide	C21H16O3S2	1
1	IC50 = 3300 nM Bioactivity Info	TI LI LO TS
CP0528253 Compound Info	[4-(1-benzothiophen-5-yl)phenyl] N,N-dimethylsulfamate Show/Hide	C16H15NO3S2	1
1	IC50 = 5820 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0034627 Compound Info	AZA Show/Hide	C4H6N4O3S2	95
1	IC50 = 3.4 nM
2	IC50 = 6 nM
3	IC50 = 6.7 nM
4	IC50 = 8.9 nM
5	IC50 = 9.9 nM
6	IC50 = 10 nM
7	IC50 = 12 nM
8	IC50 = 12.5 nM
9	IC50 = 13 nM
10	IC50 = 13.7 nM
11	IC50 = 15 nM
12	IC50 = 16 nM
13	IC50 = 16.2 nM
14	IC50 = 18.5 nM
15	IC50 = 22.17 nM
16	IC50 = 23 nM
17	IC50 = 25 nM
18	IC50 = 28 nM
19	IC50 = 29 nM
20	IC50 = 34.3 nM
21	IC50 = 36 nM
22	IC50 = 36.85 nM
23	IC50 = 37.5 nM
24	IC50 = 45.1 nM
25	IC50 = 47.6 nM
26	IC50 = 48.1 nM
27	IC50 = 48.3 nM
28	IC50 = 48.9 nM
29	IC50 = 53.1 nM
30	IC50 = 56.5 nM
31	IC50 = 60.4 nM
32	IC50 = 63 nM
33	IC50 = 68 nM
34	IC50 = 68.6 nM
35	IC50 = 69.7 nM
36	IC50 = 77.8 nM
37	IC50 = 89.9 nM
38	IC50 = 92.5 nM
39	IC50 = 98.3 nM
40	IC50 = 115 nM
41	IC50 = 115.05 nM
42	IC50 = 123.5 nM
43	IC50 = 152 nM
44	IC50 = 220 nM
45	IC50 = 283 nM
46	IC50 = 285 nM
47	IC50 = 309 nM
48	IC50 = 351 nM
49	IC50 = 362 nM
50	IC50 = 441 nM
51	IC50 = 3900 nM
52	IC50 = 4100 nM
53	IC50 = 8200 nM
54	IC50 = 8300 nM
55	Kd = 6.8 nM
56	Kd = 10 nM
57	Kd = 17 nM
58	Kd = 18 nM
59	Kd = 38 nM
60	Kd = 46 nM
61	Ki = 0.3434 nM
62	Ki = 6 nM
63	Ki = 7 nM
64	Ki = 7.943 nM
65	Ki = 9 nM
66	Ki = 10 nM
67	Ki = 12 nM
68	Ki = 12.1 nM
69	Ki = 12.3 nM
70	Ki = 12.5 nM
71	Ki = 12.8 nM
72	Ki = 13.52 nM
73	Ki = 18 nM
74	Ki = 22 nM
75	Ki = 25 nM
76	Ki = 32.15 nM
77	Ki = 32.91 nM
78	Ki = 40 nM
79	Ki = 47.6 nM
80	Ki = 61.1 nM
81	Ki = 93.5 nM
82	Ki = 103 nM
83	Ki = 103.6 nM
84	Ki = 104 nM
85	Ki = 125 nM
86	Ki = 132.6 nM
87	Ki = 159 nM
88	Ki = 250 nM
89	Ki = 370 nM
90	Ki = 2000 nM
91	Ki = 3300 nM
92	Ki = 36200 nM
93	Ki = 74000 nM
94	Ki > 12.1 nM
95	Km = 9300000 nM

Clinical Information about the Protein

Target 1 ( Carbonic anhydrase II (CA-II) )

Target Type	Successful Target
Disease	11 Target-related Diseases				11
1	High blood pressure [ICD-11: BA00]
2	Congestive heart failure [ICD-11: BD10]
3	Chronic glaucoma [ICD-11: 9C61.0Z]
4	Open-angle glaucoma [ICD-11: 9C61]
5	Glaucoma/ocular hypertension [ICD-11: 9C61]
6	Seborrhoeic dermatitis [ICD-11: EA81]
7	Bacterial infection [ICD-11: 1A00-1C4Z]
8	Arthritis [ICD-11: FA20]
9	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
10	Breast cancer [ICD-11: 2C60-2C65]
11	Osteoporosis [ICD-11: FB83.0]
Approved Drug(s)	8 Approved Drugs				8
1	Benzthiazide	Drug Info	Approved	High blood pressure
2	Chlorothiazide	Drug Info	Approved	Congestive heart failure
3	Cyclothiazide	Drug Info	Approved	Congestive heart failure
4	Dichlorphenamide	Drug Info	Approved	Chronic glaucoma
5	Dorzolamide	Drug Info	Approved	Open-angle glaucoma
6	Ethoxzolamide	Drug Info	Approved	Glaucoma/ocular hypertension
7	Salicyclic acid	Drug Info	Approved	Seborrhoeic dermatitis
8	Sulfamylon	Drug Info	Approved	Bacterial infection
Clinical Trial Drug(s)	4 Clinical Trial Drugs				4
1	CG-100649	Drug Info	Phase 3	Arthritis
2	Curcumin	Drug Info	Phase 3	Solid tumour/cancer
3	Coumate	Drug Info	Phase 2	Breast cancer
4	STX-140	Drug Info	Phase 2	Osteoporosis
Investigative Drug(s)	1 Investigative Drug				1
1	CL-5343	Drug Info	Investigative	Solid tumour/cancer

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han