General Information of the Protein
Protein ID
PT01587
Protein Name
Stearoyl-CoA desaturase
Secondarily
Protein Name
Acyl-CoA desaturase
Delta(9)-desaturase
Fatty acid desaturase
Gene Name
SCD
Secondarily
Gene Name
FADS5
SCD1
SCDOS
Sequence
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
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Uniprot ID
Primary ID:
O00767

Secondarily ID:
B2R5U0
D3DR68
Q16150
Q53GR9
Q5W037
Q5W038
Q6GSS4
Q96KF6
Q9BS07
Q9Y695
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Ensembl ID
ENSG00000099194
HGNC ID
HGNC:10571
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000052 , A-431
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0433973
 Compound Info 
[5-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyridin-2-yl]methanol
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C23H24FN5O
  1
1
IC50 = 0.5 nM
 Bioactivity Info 
   TI
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CP0440005
 Compound Info 
6-fluoro-1-[1-[6-(6-methylpyridin-3-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C23H24FN5
  1
1
IC50 = 2 nM
 Bioactivity Info 
   TI
   LI
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CP0445540
 Compound Info 
2-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]-4-methyl-1,3-thiazole
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C21H22FN5S
  1
1
IC50 = 2 nM
 Bioactivity Info 
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CP0304175
 Compound Info 
[1-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]imidazol-4-yl]methanol
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C21H23FN6O
  1
1
IC50 = 3 nM
 Bioactivity Info 
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CP0324513
 Compound Info 
6-fluoro-1-[1-[6-(6-methoxypyridin-3-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C23H24FN5O
  1
1
IC50 = 4 nM
 Bioactivity Info 
   TI
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CP0213491
 Compound Info 
[1-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-4-yl]methanol
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C21H23FN6O
  1
1
IC50 = 6 nM
 Bioactivity Info 
   TI
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CP0392902
 Compound Info 
6-fluoro-1-[1-[6-(5-methylthiophen-2-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C22H23FN4S
  1
1
IC50 = 6 nM
 Bioactivity Info 
   TI
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CP0432919
 Compound Info 
5-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]-N-methylpyridine-2-carboxamide
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C24H25FN6O
  1
1
IC50 = 6 nM
 Bioactivity Info 
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CP0292970
 Compound Info 
[4-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]phenyl]methanol
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C24H25FN4O
  1
1
IC50 = 8 nM
 Bioactivity Info 
   TI
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CP0079592
 Compound Info 
6-fluoro-1-[1-[6-(4-methylimidazol-1-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C21H23FN6
  1
1
IC50 = 9 nM
 Bioactivity Info 
   TI
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CP0445542
 Compound Info 
1-[1-[6-(4-ethoxypyrazol-1-yl)pyridazin-3-yl]piperidin-4-yl]-6-fluoro-2,3-dihydroindole
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C22H25FN6O
  1
1
IC50 = 9 nM
 Bioactivity Info 
   TI
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CP0392900
 Compound Info 
6-fluoro-1-[1-[6-(4-methylphenyl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C24H25FN4
  1
1
IC50 = 11 nM
 Bioactivity Info 
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CP0466048
 Compound Info 
2-[1-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-4-yl]ethanol
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C22H25FN6O
  1
1
IC50 = 11 nM
 Bioactivity Info 
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CP0432920
 Compound Info 
2-[4-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-1-yl]-N-methylacetamide
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C23H26FN7O
  1
1
IC50 = 12 nM
 Bioactivity Info 
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CP0560917
 Compound Info 
2-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]-5-methyl-1,3-thiazole
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C21H22FN5S
  1
1
IC50 = 12 nM
 Bioactivity Info 
   TI
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CP0560916
 Compound Info 
6-fluoro-1-[1-[6-[6-(trifluoromethyl)pyridin-3-yl]pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C23H21F4N5
  1
1
IC50 = 14 nM
 Bioactivity Info 
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CP0064713
 Compound Info 
BDBM50448680
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C21H23FN6
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0443931
 Compound Info 
2-[4-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-1-yl]ethanol
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C22H25FN6O
  1
1
IC50 = 21 nM
 Bioactivity Info 
   TI
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CP0505141
 Compound Info 
6-fluoro-1-[1-[6-(4-methylpyrazol-1-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C21H23FN6
  1
1
IC50 = 23 nM
 Bioactivity Info 
   TI
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CP0119637
 Compound Info 
BDBM50448674
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C21H21FN6
  1
1
IC50 = 25 nM
 Bioactivity Info 
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CP0440007
 Compound Info 
6-chloro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C21H23ClN6
  1
1
IC50 = 28 nM
 Bioactivity Info 
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CP0466047
 Compound Info 
1-[1-[6-(1-ethylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-6-fluoro-2,3-dihydroindole
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C22H25FN6
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0549748
 Compound Info 
5-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]-N,N-dimethylpyridin-2-amine
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C24H27FN6
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0445541
 Compound Info 
1-[1-[6-[1-(2-ethoxyethyl)pyrazol-4-yl]pyridazin-3-yl]piperidin-4-yl]-6-fluoro-2,3-dihydroindole
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C24H29FN6O
  1
1
IC50 = 41 nM
 Bioactivity Info 
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CP0240700
 Compound Info 
1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-6-(trifluoromethyl)-2,3-dihydroindole
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C22H23F3N6
  1
1
IC50 = 42 nM
 Bioactivity Info 
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CP0432921
 Compound Info 
6-fluoro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]indazole
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C20H20FN7
  1
1
IC50 = 51 nM
 Bioactivity Info 
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CP0217904
 Compound Info 
BDBM50448682
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C23H22F2N4
  1
1
IC50 = 54 nM
 Bioactivity Info 
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CP0440006
 Compound Info 
6-fluoro-1-[1-[6-(1-propylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C23H27FN6
  1
1
IC50 = 72 nM
 Bioactivity Info 
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CP0505142
 Compound Info 
5-fluoro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C21H23FN6
  1
1
IC50 = 99 nM
 Bioactivity Info 
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CP0466038
 Compound Info 
5-chloro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C21H23ClN6
  1
1
IC50 = 218 nM
 Bioactivity Info 
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CP0313371
 Compound Info 
6-methyl-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C22H26N6
  1
1
IC50 = 241 nM
 Bioactivity Info 
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CP0466070
 Compound Info 
4-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]benzoic acid
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C24H23FN4O2
  1
1
IC50 = 390 nM
 Bioactivity Info 
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CP0445543
 Compound Info 
6-methoxy-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C22H26N6O
  1
1
IC50 = 407 nM
 Bioactivity Info 
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Cell Line ID: CL000967 , HCC366
 Cell Line Info 
Cell Line ID: CL000674 , HCC44
 Cell Line Info 
Cell Line ID: CL000675 , HCC95
 Cell Line Info 
Cell Line ID: CL000050 , HEK293-A
 Cell Line Info 
Cell Line ID: CL000063 , Hep-G2
 Cell Line Info 
Cell Line ID: CL000402 , NCI-H1155
 Cell Line Info 
Cell Line ID: CL000281 , NCI-H1993
 Cell Line Info 
Cell Line ID: CL000962 , NCI-H2009
 Cell Line Info 
Cell Line ID: CL000325 , NCI-H2073
 Cell Line Info 
Cell Line ID: CL000401 , NCI-H2122
 Cell Line Info 
Cell Line ID: CL000145 , NCI-H460
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0303266
 Compound Info 
1'-(6-(5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl)pyridazin-3-yl)-5-(trifluoromethyl)spiro[chroman-2,4'-piperidine]
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C26H23F3N6O2
  1
1 IC50 = 0.03 nM
CP0199248
 Compound Info 
2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid
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C17H16BrFN6O4
  1
1 IC50 = 1 nM
CP0090844
 Compound Info 
5-[6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl]pyridine-3-carboxylic acid
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C21H18BrFN4O3
  1
1 IC50 = 7 nM
CP0292970
 Compound Info 
[4-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]phenyl]methanol
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C24H25FN4O
  1
1 IC50 = 7 nM
CP0432921
 Compound Info 
6-fluoro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]indazole
   Show/Hide
C20H20FN7
  1
1 IC50 = 9 nM
CP0505141
 Compound Info 
6-fluoro-1-[1-[6-(4-methylpyrazol-1-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
   Show/Hide
C21H23FN6
  1
1 IC50 = 11 nM
CP0549748
 Compound Info 
5-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]-N,N-dimethylpyridin-2-amine
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C24H27FN6
  1
1 IC50 = 12 nM
CP0443931
 Compound Info 
2-[4-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-1-yl]ethanol
   Show/Hide
C22H25FN6O
  1
1 IC50 = 17 nM
CP0213491
 Compound Info 
[1-[6-[4-(6-fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-4-yl]methanol
   Show/Hide
C21H23FN6O
  1
1 IC50 = 21 nM
CP0096178
 Compound Info 
2-[5-[3-[2-(2-chloro-5-fluorophenyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid
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C18H17ClFN7O3
  1
1 IC50 = 27 nM
CP0341925
 Compound Info 
N-(2-hydroxy-2-pyridin-3-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
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C25H27N5O3
  1
1 IC50 = 28 nM
CP0200792
 Compound Info 
2-[5-[3-[3-(2-bromo-5-fluorophenoxy)propoxy]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid
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C15H13BrFN5O5
  1
1 IC50 = 41 nM
CP0324513
 Compound Info 
6-fluoro-1-[1-[6-(6-methoxypyridin-3-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
   Show/Hide
C23H24FN5O
  1
1 IC50 = 79 nM
CP0313371
 Compound Info 
6-methyl-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole
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C22H26N6
  1
1 IC50 = 422 nM
Clinical Information about the Protein
Target 1 ( Acyl-CoA desaturase (SCD) )
Target Type Successful Target
Disease 3 Target-related Diseases  3
1 Bacterial infection [ICD-11: 1A00-1C4Z]
2 Type-2 diabetes [ICD-11: 5A11]
3 Diabetic complication [ICD-11: 5A2Y]
Approved Drug(s) 1 Approved Drug  1
1 Isoxyl
 Drug Info 
Approved
Bacterial infection
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 MK-8245
 Drug Info 
Phase 2
Type-2 diabetes
Investigative Drug(s) 1 Investigative Drug  1
1 CVT-12012
 Drug Info 
Investigative
Diabetic complication