| Compound ID |
Compound Name |
Compound Formula |
|
CP0480287
|
N-[2-[7-[[4-chloro-3-(trifluoromethyl)phenyl]methylamino]-3-(4-methoxyphenyl)-2-oxoquinoxalin-1-yl]ethyl]acetamide
Show/Hide
|
C27H24ClF3N4O3
|
1
|
| 1 |
IC50 = 0.05 nM
|
|
|
|
CP0447931
|
N-[2-[6-[(3,4-dichlorophenyl)methylamino]-3-oxo-1,4-benzoxazin-4-yl]ethyl]-2-hydroxyacetamide
Show/Hide
|
C19H19Cl2N3O4
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0529089
|
(3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)thiazol-5-yl)-1,2,4-oxadiazol-5-yl)methanol
Show/Hide
|
C18H17F3N4O3S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0496250
|
2-hydroxy-N-(2-(2-oxo-3-(trifluoromethyl)-7-(3-(trifluoromethyl)benzylamino)quinoxalin-1(2H)-yl)ethyl)acetamide
Show/Hide
|
C21H18F6N4O3
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0468425
|
3-(2-(4-methoxyphenyl)-3-oxo-6-(3-(trifluoromethyl)benzylamino)pyrido[2,3-b]pyrazin-4(3H)-yl)propanamide
Show/Hide
|
C25H22F3N5O3
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0465305
|
N-(4-chlorophenyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C23H19ClF3N5O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0522805
|
N-[2-[7-[(4-fluoro-3-methylphenyl)methylamino]-3-(4-methoxyphenyl)-2-oxoquinoxalin-1-yl]ethyl]acetamide
Show/Hide
|
C27H27FN4O3
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0455127
|
N-[2-[3-(4-ethylphenyl)-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide
Show/Hide
|
C28H27F3N4O2
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0480286
|
N-[2-[3-(4-methoxyphenyl)-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide
Show/Hide
|
C27H25F3N4O3
|
2
|
| 1 |
IC50 = 3.3 nM
|
|
|
| 2 |
IC50 = 33 nM
|
|
|
|
CP0467587
|
3-(6-(4-methoxyphenyl)-7-oxo-2-(3-(trifluoromethyl)benzylamino)pteridin-8(7H)-yl)propanamide
Show/Hide
|
C24H21F3N6O3
|
1
|
| 1 |
IC50 = 5.6 nM
|
|
|
|
CP0535200
|
2-hydroxy-N-(2-(3-methyl-2-oxo-7-(3-(trifluoromethyl)benzylamino)quinoxalin-1(2H)-yl)ethyl)acetamide
Show/Hide
|
C21H21F3N4O3
|
1
|
| 1 |
IC50 = 6.1 nM
|
|
|
|
CP0514720
|
N-[2-[3-(4-methoxyphenyl)-2-oxo-7-[[4-(trifluoromethyl)pyridin-2-yl]methylamino]quinoxalin-1-yl]ethyl]acetamide
Show/Hide
|
C26H24F3N5O3
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0496097
|
5-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-1,3,4-thiadiazole-2-carboxamide
Show/Hide
|
C15H15F3N4O2S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0222020
|
4-methyl-2-[2-oxo-3-(3-phenylpropyl)imidazolidin-1-yl]-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C23H25N5O2S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0398476
|
4-methyl-2-[5-oxo-1-[[5-(trifluoromethyl)furan-2-yl]methyl]-1,2,4-triazol-4-yl]-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C19H15F3N6O3S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0504903
|
N-[2-[7-[(3,4-dichlorophenyl)methylamino]-3-(4-methoxyphenyl)-2-oxoquinoxalin-1-yl]ethyl]acetamide
Show/Hide
|
C26H24Cl2N4O3
|
1
|
| 1 |
IC50 = 8.6 nM
|
|
|
|
CP0183215
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(1,3-thiazol-2-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C18H15FN6O2S2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0504698
|
2-[1-[2-(4-fluorophenoxy)ethyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H19FN6O3S
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0502592
|
3-(7-oxo-6-p-tolyl-2-(3-(trifluoromethyl)benzylamino)pteridin-8(7H)-yl)propanamide
Show/Hide
|
C24H21F3N6O2
|
1
|
| 1 |
IC50 = 9.6 nM
|
|
|
|
CP0401645
|
2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)thiazole-5-carboxamide
Show/Hide
|
C16H16F3N3O2S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0465306
|
N-(3-cyclopropylpropyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C23H26F3N5O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0229991
|
2-[3-[(4-fluorophenyl)methyl]-2-oxoimidazolidin-1-yl]-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H20FN5O2S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0500829
|
N-(2-cyclopropylethyl)-6-[4-[5-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C22H23F4N5O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0181797
|
N-benzyl-2-[4-(2-cyclopropylethoxy)-2-oxopyridin-1-yl]-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C22H23N3O3S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0489992
|
N-[2-[2-oxo-3-pyridin-3-yl-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide
Show/Hide
|
C25H22F3N5O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0522793
|
N-[2-[6-[(3-chloro-4-fluorophenyl)methylamino]-3-oxo-2-pyridin-3-ylpyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C23H20ClFN6O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0527025
|
N-[2-[3-(4-methoxyphenyl)-7-[(3-methylphenyl)methylamino]-2-oxoquinoxalin-1-yl]ethyl]acetamide
Show/Hide
|
C27H28N4O3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0471450
|
3-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)isoxazole-5-carboxamide
Show/Hide
|
C16H16F3N3O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0522792
|
N-[2-[6-[(3,4-dichlorophenyl)methylamino]-3-oxo-2-pyridin-3-ylpyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C23H20Cl2N6O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0268764
|
(R)-N-(2-hydroxy-2-phenylethyl)-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamide
Show/Hide
|
C25H24F3N5O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0459574
|
3-(6-(3,4-dichlorobenzylamino)-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)propanamide
Show/Hide
|
C24H21Cl2N5O3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0529760
|
N-[2-[6-[[4-fluoro-3-(trifluoromethyl)phenyl]methylamino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C26H23F4N5O3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0510623
|
3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)thiazol-5-yl)-1,2,4-oxadiazole
Show/Hide
|
C17H15F3N4O2S
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0310923
|
5-(hydroxymethyl)-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-6H-[1,3]thiazolo[4,5-d]pyrimidin-7-one
Show/Hide
|
C18H17F3N4O3S
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0233744
|
5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Show/Hide
|
C16H15BrFN5OS
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0427994
|
N-(2-phenylethyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C25H24F3N5O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0465299
|
6-[4-[5-chloro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-N-(2-cyclopropylethyl)pyridazine-3-carboxamide
Show/Hide
|
C22H23ClF3N5O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0551333
|
US8962837, 12
Show/Hide
|
C16H16Cl2FN3O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0527024
|
N-[2-[7-[(3,4-dichlorophenyl)methylamino]-2-oxo-3-pyridin-3-ylpyrido[3,4-b]pyrazin-1-yl]ethyl]acetamide
Show/Hide
|
C23H20Cl2N6O2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0192252
|
2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole
Show/Hide
|
C19H18F3N5OS
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0528771
|
N-phenacyl-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C25H22F3N5O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0529087
|
2-(4-(2-(trifluoromethyl)phenylthio)piperidin-1-yl)thiazole-5-carboxamide
Show/Hide
|
C16H16F3N3OS2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0510892
|
N-hexyl-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C23H28F3N5O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0528768
|
N-(2-cyclopropylethyl)-6-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C22H23F4N5O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0257901
|
N-benzyl-4-methyl-2-(2-oxo-4-phenylmethoxypyridin-1-yl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C24H21N3O3S
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0481514
|
N-pentyl-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C22H26F3N5O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0086588
|
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-6H-[1,3]thiazolo[4,5-d]pyrimidin-7-one
Show/Hide
|
C17H15F3N4O2S
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0144001
|
N-[(4-fluorophenyl)methyl]-2-(4-hydroxy-2-oxopyridin-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C17H14FN3O3S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0399864
|
US8962837, 18
Show/Hide
|
C14H14ClFN4O
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0464968
|
US8962837, 36
Show/Hide
|
C15H16F3N5
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0280108
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-[(2-methyl-1,3-thiazol-5-yl)methyl]-1,3-thiazole-5-carboxamide
Show/Hide
|
C19H17FN6O2S2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0480285
|
N-[2-[7-[(3,4-dichlorophenyl)methylamino]-3-(4-methoxyphenyl)-2-oxopyrido[3,4-b]pyrazin-1-yl]ethyl]acetamide
Show/Hide
|
C25H23Cl2N5O3
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0175009
|
N-benzyl-2-(4-hydroxy-2-oxopyridin-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C17H15N3O3S
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0467588
|
3-(2-(3,4-dichlorobenzylamino)-7-oxo-6-(pyridin-3-yl)pteridin-8(7H)-yl)propanamide
Show/Hide
|
C21H17Cl2N7O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0143150
|
N-(3-methylbutyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C22H26F3N5O2
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0382800
|
5-methyl-3-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)thiazol-5-yl)-1,2,4-oxadiazole
Show/Hide
|
C18H17F3N4O2S
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0252854
|
6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-7H-purine
Show/Hide
|
C16H15BrFN5O
|
1
|
| 1 |
IC50 < 39 nM
|
|
|
|
CP0470797
|
N-(2-cyclopropylethyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C22H24F3N5O2
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0463246
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(1,3-oxazol-4-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C18H15FN6O3S
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0514719
|
N-[2-[7-[(3,4-dichlorophenyl)methylamino]-3-(4-methylphenyl)-2-oxopyrido[3,4-b]pyrazin-1-yl]ethyl]acetamide
Show/Hide
|
C25H23Cl2N5O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0122250
|
2-[3-[(4-fluorophenyl)methyl]-2-oxoimidazolidin-1-yl]-4-methyl-N-(pyridin-2-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H20FN5O2S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0428759
|
N-benzyl-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C24H22F3N5O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0398477
|
4-methyl-2-[5-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]-1,2,4-triazol-4-yl]-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H17F3N6O2S
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0508211
|
N-[2-[6-[(3-chloro-4-fluorophenyl)methylamino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C25H23ClFN5O3
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0527028
|
N-[2-[2-(4-methoxyphenyl)-3-oxo-6-[[3-(trifluoromethyl)phenyl]methylamino]pyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C26H24F3N5O3
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0310928
|
2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-7H-purine
Show/Hide
|
C16H15BrFN5O
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0205186
|
6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-7H-purine
Show/Hide
|
C17H16F3N5O
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0149673
|
N-[(3,4-difluorophenyl)methyl]-2-(4-hydroxy-2-oxopyridin-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C17H13F2N3O3S
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0540275
|
N-[3-[(3,4-dichlorophenyl)methyl]-4-oxopyrido[2,3-d]pyrimidin-6-yl]-2-hydroxyacetamide
Show/Hide
|
C16H12Cl2N4O3
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0257900
|
N-benzyl-4-methyl-2-[2-oxo-4-(2-phenylethyl)pyridin-1-yl]-1,3-thiazole-5-carboxamide
Show/Hide
|
C25H23N3O2S
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0527029
|
N-[2-[6-[[3,5-bis(trifluoromethyl)phenyl]methylamino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C27H23F6N5O3
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0452516
|
2-[[5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]oxy]acetic acid
Show/Hide
|
C18H16BrFN4O4S
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0159132
|
N-benzyl-2-(3-benzyl-2-oxoimidazolidin-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C22H22N4O2S
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0502570
|
2-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)thiazol-5-yl)oxazole
Show/Hide
|
C18H16F3N3O2S
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0203101
|
2-[3-[(4-fluorophenyl)methyl]-2-oxoimidazolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C15H15FN4O2S
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0351990
|
N-benzyl-4-methyl-2-[2-oxo-4-(1,3-thiazol-4-ylmethoxy)pyridin-1-yl]-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H18N4O3S2
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0555080
|
US8962837, 33
Show/Hide
|
C14H13BrF2N4O
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0341252
|
5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-6H-[1,3]thiazolo[4,5-d]pyrimidin-7-one
Show/Hide
|
C18H17F3N4O2S
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0281223
|
(S)-N-(2-hydroxy-2-phenylethyl)-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamide
Show/Hide
|
C25H24F3N5O3
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0148059
|
N-benzyl-2-(4-methoxy-2-oxopyridin-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C18H17N3O3S
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0465300
|
N-(2-cyclopropylethyl)-6-[4-[5-methyl-2-(trifluoromethyl)furan-3-carbonyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C21H24F3N5O3
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0159129
|
2-[3-(cyclopropylmethyl)-2-oxoimidazolidin-1-yl]-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C18H21N5O2S
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0506438
|
2-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)thiazol-5-yl)-1,3,4-oxadiazole
Show/Hide
|
C17H15F3N4O2S
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0484784
|
US8962837, 32
Show/Hide
|
C14H14ClN5O3
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0426182
|
N-(2-cyclopropylethyl)-6-[4-[3-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C22H23F4N5O2
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0510356
|
2-[1-[1-(4-fluorophenyl)ethyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(pyridin-2-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H19FN6O2S
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0444980
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(pyridin-2-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C20H17FN6O2S
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0502427
|
N-[3-[(3,4-dichlorophenyl)methyl]-4-oxoquinazolin-6-yl]-2-phenoxyacetamide
Show/Hide
|
C23H17Cl2N3O3
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0418738
|
(+/-)-2,3-dihydroxy-N-(2-(3-methyl-2-oxo-7-(3-(trifluoromethyl)benzylamino)quinoxalin-1(2H)-yl)ethyl)propanamide
Show/Hide
|
C22H23F3N4O4
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0465303
|
N-[(5-methylfuran-2-yl)methyl]-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C23H22F3N5O3
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0426187
|
N-(1H-benzimidazol-2-yl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C24H20F3N7O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0514092
|
N-[3-[(4-chlorophenyl)methyl]-4-oxoquinazolin-6-yl]-2-hydroxyacetamide
Show/Hide
|
C17H14ClN3O3
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0468424
|
N-[2-[6-[(3,4-dichlorophenyl)methylamino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C25H23Cl2N5O3
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0428901
|
(S)-2-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)thiazole-5-carboxamide
Show/Hide
|
C15H14F3N3O2S
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0509855
|
3-(7-oxo-6-(pyridin-3-yl)-2-(3-(trifluoromethyl)benzylamino)pteridin-8(7H)-yl)propanamide
Show/Hide
|
C22H18F3N7O2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0443568
|
2-[3-[(4-fluorophenyl)methyl]-2-oxoimidazolidin-1-yl]-4-methyl-N-(1,3-oxazol-2-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C19H18FN5O3S
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0439791
|
N-[2-[2-(4-methoxyphenyl)-6-[(3-methylphenyl)methylamino]-3-oxopyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C26H27N5O3
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0500963
|
N-[2-[6-[(3-chlorophenyl)methylamino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C25H24ClN5O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0460543
|
N-(4-cyclopropylbutyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C24H28F3N5O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0460544
|
N-(3-methylbutyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridine-3-carboxamide
Show/Hide
|
C23H27F3N4O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0520708
|
US8962837, 25
Show/Hide
|
C15H16ClFN4O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0536992
|
US8962837, 17
Show/Hide
|
C15H14ClF3N4O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0561056
|
US8962837, 30
Show/Hide
|
C15H16ClFN4O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0563950
|
US8962837, 11
Show/Hide
|
C17H18F3N3O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0528769
|
N-(2-cyclopropylethyl)-6-[4-(2,5-dichlorobenzoyl)piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C21H23Cl2N5O2
|
1
|
| 1 |
IC50 = 101 nM
|
|
|
|
CP0523144
|
3-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide
Show/Hide
|
C19H16FN7O2
|
1
|
| 1 |
IC50 = 103 nM
|
|
|
|
CP0389007
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(1H-pyrazol-5-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C18H16FN7O2S
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
|
CP0418737
|
N-[3-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-4-oxoquinazolin-6-yl]-2-hydroxyacetamide
Show/Hide
|
C18H13ClF3N3O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0522791
|
N-[2-[6-[(4-chlorophenyl)methylamino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C25H24ClN5O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0430014
|
N-[3-[(3,4-dichlorophenyl)methyl]-4-oxoquinazolin-6-yl]-2-hydroxyacetamide
Show/Hide
|
C17H13Cl2N3O3
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0426186
|
N-(2-cyclopropylethyl)-6-[4-[3,3,3-trifluoro-2-methyl-2-(trifluoromethyl)propanoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C19H23F6N5O2
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0500964
|
N-[2-[3-oxo-2-pyridin-3-yl-6-[[3-(trifluoromethyl)phenyl]methylamino]pyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C24H21F3N6O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0509846
|
3-(2-(4-methoxyphenyl)-3-oxo-6-(3-(trifluoromethyl)benzylamino)pyrido[2,3-b]pyrazin-4(3H)-yl)-N-methylpropanamide
Show/Hide
|
C26H24F3N5O3
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0175007
|
N-[2-(4-fluorophenyl)ethyl]-2-(4-hydroxy-2-oxopyridin-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C18H16FN3O3S
|
1
|
| 1 |
IC50 = 121 nM
|
|
|
|
CP0500831
|
6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-N-[[5-(trifluoromethyl)furan-2-yl]methyl]pyridazine-3-carboxamide
Show/Hide
|
C23H19F6N5O3
|
1
|
| 1 |
IC50 = 124 nM
|
|
|
|
CP0426188
|
N-phenyl-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C23H20F3N5O2
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0465304
|
N-(3-phenylpropyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C26H26F3N5O2
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0444978
|
2-[1-[(3,5-difluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C20H16F2N6O2S
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0278616
|
6-[6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl]pyridine-3-carboxylic acid
Show/Hide
|
C21H18BrFN4O3
|
1
|
| 1 |
IC50 = 128 nM
|
|
|
|
CP0474899
|
N-[2-[7-[(3,4-dimethylphenyl)methylamino]-3-(4-methoxyphenyl)-2-oxoquinoxalin-1-yl]ethyl]acetamide
Show/Hide
|
C28H30N4O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0122252
|
2-[3-(cyclohexylmethyl)-2-oxoimidazolidin-1-yl]-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H27N5O2S
|
1
|
| 1 |
IC50 = 135 nM
|
|
|
|
CP0122226
|
N-[(3-fluorophenyl)methyl]-2-(4-hydroxy-2-oxopyridin-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C17H14FN3O3S
|
1
|
| 1 |
IC50 = 137 nM
|
|
|
|
CP0412560
|
3-(2-(3,4-dichlorobenzylamino)-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl)propanamide
Show/Hide
|
C23H20Cl2N6O3
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0564991
|
2-[1-(cyclopropylmethyl)-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C17H18N6O2S
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0447506
|
2-(4-(2-(trifluoromethyl)benzyl)piperazin-1-yl)thiazole-5-carboxamide
Show/Hide
|
C16H17F3N4OS
|
1
|
| 1 |
IC50 = 153 nM
|
|
|
|
CP0417565
|
N-[(5-chlorothiophen-2-yl)methyl]-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-3H-benzimidazole-5-carboxamide
Show/Hide
|
C27H17ClF3N3O2S
|
1
|
| 1 |
IC50 = 157 nM
|
|
|
|
CP0265891
|
2-(3-benzyl-2-oxoimidazolidin-1-yl)-4-methyl-N-(pyridin-2-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H21N5O2S
|
1
|
| 1 |
IC50 = 158 nM
|
|
|
|
CP0310979
|
8-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-7H-purin-6-amine
Show/Hide
|
C17H17F3N6O
|
1
|
| 1 |
IC50 = 162 nM
|
|
|
|
CP0505633
|
2-[[5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]amino]acetic acid
Show/Hide
|
C18H17BrFN5O3S
|
1
|
| 1 |
IC50 = 168 nM
|
|
|
|
CP0433739
|
1-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)thiazol-5-yl)pyrrolidin-2-one
Show/Hide
|
C19H20F3N3O2S
|
1
|
| 1 |
IC50 = 174 nM
|
|
|
|
CP0454390
|
N-(1,3-thiazol-2-ylmethyl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-3H-benzimidazole-5-carboxamide
Show/Hide
|
C26H17F3N4O2S
|
1
|
| 1 |
IC50 = 179 nM
|
|
|
|
CP0443437
|
N-[3-[(3,4-dichlorophenyl)methyl]-4-oxoquinazolin-7-yl]-2-hydroxyacetamide
Show/Hide
|
C17H13Cl2N3O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0489991
|
N-[2-[2-(4-methoxyphenyl)-3-oxo-6-[[4-(trifluoromethyl)pyridin-2-yl]methylamino]pyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C25H23F3N6O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0237160
|
5-methyl-2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-[1,3]thiazolo[4,5-d]pyrimidine
Show/Hide
|
C18H17F3N4OS
|
1
|
| 1 |
IC50 = 182 nM
|
|
|
|
CP0180928
|
N-benzyl-4-methyl-2-(4-methyl-2-oxopyridin-1-yl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C18H17N3O2S
|
1
|
| 1 |
IC50 = 191 nM
|
|
|
|
CP0470793
|
6-[4-(2-chloro-5-fluorobenzoyl)piperazin-1-yl]-N-(2-cyclopropylethyl)pyridazine-3-carboxamide
Show/Hide
|
C21H23ClFN5O2
|
1
|
| 1 |
IC50 = 192 nM
|
|
|
|
CP0505111
|
benzyl N-[3-[(3,4-dichlorophenyl)methyl]-4-oxoquinazolin-6-yl]carbamate
Show/Hide
|
C23H17Cl2N3O3
|
1
|
| 1 |
IC50 = 193 nM
|
|
|
|
CP0176318
|
2-(3-benzyl-2-oxoimidazolidin-1-yl)-N-[(4-fluorophenyl)methyl]-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C22H21FN4O2S
|
1
|
| 1 |
IC50 = 194 nM
|
|
|
|
CP0448316
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-[(5-methylpyrazin-2-yl)methyl]-1,3-thiazole-5-carboxamide
Show/Hide
|
C20H18FN7O2S
|
1
|
| 1 |
IC50 = 194 nM
|
|
|
|
CP0428902
|
5-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-1,3,4-oxadiazole-2-carboxamide
Show/Hide
|
C15H15F3N4O3
|
1
|
| 1 |
IC50 = 199 nM
|
|
|
|
CP0399880
|
US8962837, 40
Show/Hide
|
C17H17ClF3N3O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0400536
|
US8962837, 8
Show/Hide
|
C17H16Cl2F3N3O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0563949
|
US8962837, 7
Show/Hide
|
C17H17ClF3N3O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0403139
|
N-[2-[2-(4-methoxyphenyl)-3-oxo-6-[[3-(trifluoromethoxy)phenyl]methylamino]pyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C26H24F3N5O4
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0272171
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(1,3-oxazol-2-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C18H15FN6O3S
|
1
|
| 1 |
IC50 = 214 nM
|
|
|
|
CP0414799
|
2-(3-benzyl-2-oxoimidazolidin-1-yl)-N-[(3-fluorophenyl)methyl]-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C22H21FN4O2S
|
1
|
| 1 |
IC50 = 219 nM
|
|
|
|
CP0514113
|
benzyl N-[3-[(3-chloro-4-fluorophenyl)methyl]-4-oxoquinazolin-6-yl]carbamate
Show/Hide
|
C23H17ClFN3O3
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0387030
|
4-methyl-2-[5-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]-1,2,4-triazol-4-yl]-N-(pyridin-2-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H17F3N6O2S
|
1
|
| 1 |
IC50 = 227 nM
|
|
|
|
CP0203104
|
N-benzyl-2-(5-benzyl-1H-1,2,4-triazol-3-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H19N5OS
|
1
|
| 1 |
IC50 = 236 nM
|
|
|
|
CP0514112
|
benzyl N-[3-[(4-chlorophenyl)methyl]-4-oxoquinazolin-6-yl]carbamate
Show/Hide
|
C23H18ClN3O3
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0459572
|
N-[2-[2-[(3,4-dichlorophenyl)methylamino]-7-oxo-6-pyridin-3-ylpteridin-8-yl]ethyl]acetamide
Show/Hide
|
C22H19Cl2N7O2
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0387994
|
2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxamide
Show/Hide
|
C16H15F3N4O2S
|
1
|
| 1 |
IC50 = 254 nM
|
|
|
|
CP0197231
|
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-7H-purine
Show/Hide
|
C17H16F3N5O
|
1
|
| 1 |
IC50 = 257 nM
|
|
|
|
CP0245090
|
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-5H-[1,3]thiazolo[5,4-c]pyridin-4-one
Show/Hide
|
C18H16F3N3O2S
|
1
|
| 1 |
IC50 = 268 nM
|
|
|
|
CP0387029
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C20H17FN6O2S
|
1
|
| 1 |
IC50 = 268 nM
|
|
|
|
CP0510354
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-[(5-methyl-1H-pyrazol-3-yl)methyl]-1,3-thiazole-5-carboxamide
Show/Hide
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C19H18FN7O2S
|
1
|
| 1 |
IC50 = 280 nM
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CP0465301
|
N-(2-cyclopropylethyl)-6-[4-[2-(trifluoromethyl)furan-3-carbonyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C20H22F3N5O3
|
1
|
| 1 |
IC50 = 290 nM
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CP0427140
|
[2-(4-phenylmethoxyphenyl)-3H-benzimidazol-5-yl]-[2-(trifluoromethyl)phenyl]methanol
Show/Hide
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C28H21F3N2O2
|
1
|
| 1 |
IC50 = 295 nM
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CP0530595
|
US8962837, Sterculic acid
Show/Hide
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C19H34O2
|
1
|
| 1 |
IC50 = 300 nM
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CP0542008
|
US8962837, 27
Show/Hide
|
C16H16ClF3N4O
|
1
|
| 1 |
IC50 = 300 nM
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CP0510355
|
2-[1-[(2,2-difluorocyclopropyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C17H16F2N6O2S
|
1
|
| 1 |
IC50 = 306 nM
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CP0460045
|
N-(1,3-thiazol-2-ylmethyl)-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-3H-benzimidazole-5-carboxamide
Show/Hide
|
C25H17F3N4O2S
|
1
|
| 1 |
IC50 = 313 nM
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CP0352726
|
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-7,9-dihydropurin-8-one
Show/Hide
|
C17H16F3N5O2
|
1
|
| 1 |
IC50 = 319 nM
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CP0493843
|
N-(1,3-thiazol-2-ylmethyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C21H19F3N6O2S
|
1
|
| 1 |
IC50 = 325 nM
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CP0116053
|
N-benzyl-4-methyl-2-[2-oxo-4-(oxolan-2-ylmethoxy)pyridin-1-yl]-1,3-thiazole-5-carboxamide
Show/Hide
|
C22H23N3O4S
|
1
|
| 1 |
IC50 = 329 nM
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CP0191770
|
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,7-dihydropurin-6-one
Show/Hide
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C17H16F3N5O2
|
1
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| 1 |
IC50 = 378 nM
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CP0504710
|
4-methyl-2-[5-oxo-1-(4,4,4-trifluorobutyl)-1,2,4-triazol-4-yl]-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C17H17F3N6O2S
|
1
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| 1 |
IC50 = 398 nM
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CP0489987
|
N-[2-[2-[(3,4-dichlorophenyl)methylamino]-6-(4-methoxyphenyl)-7-oxopteridin-8-yl]ethyl]acetamide
Show/Hide
|
C24H22Cl2N6O3
|
1
|
| 1 |
IC50 = 410 nM
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CP0527750
|
N-[(5-chlorothiophen-2-yl)methyl]-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-3H-benzimidazole-5-carboxamide
Show/Hide
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C26H17ClF3N3O2S
|
1
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| 1 |
IC50 = 439 nM
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CP0224872
|
N-benzyl-2-(4-cyclopropyl-2-oxopyridin-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
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C20H19N3O2S
|
1
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| 1 |
IC50 = 458 nM
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CP0398478
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-[(1-methylpyrazol-4-yl)methyl]-1,3-thiazole-5-carboxamide
Show/Hide
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C19H18FN7O2S
|
1
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| 1 |
IC50 = 477 nM
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CP0510353
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-N-[(1-methylimidazol-4-yl)methyl]-1,3-thiazole-5-carboxamide
Show/Hide
|
C19H18FN7O2S
|
1
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| 1 |
IC50 = 504 nM
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CP0467463
|
2-(3-benzyl-2-oxoimidazolidin-1-yl)-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
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C21H21N5O2S
|
1
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| 1 |
IC50 = 524 nM
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CP0220525
|
4-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]benzoic acid
Show/Hide
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C23H20F3N3O3
|
1
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| 1 |
IC50 = 550 nM
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CP0399865
|
US8962837, 35
Show/Hide
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C14H15N5O3
|
1
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| 1 |
IC50 = 550 nM
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CP0400537
|
US8962837, 14
Show/Hide
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C15H15F3N4O
|
1
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| 1 |
IC50 = 550 nM
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CP0542007
|
US8962837, 6
Show/Hide
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C16H17Cl2N3O2
|
1
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| 1 |
IC50 = 550 nM
|
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CP0551334
|
US8962837, 19
Show/Hide
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C17H18ClF3N4O
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1
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| 1 |
IC50 = 550 nM
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CP0555081
|
US8962837, 37
Show/Hide
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C16H16ClF3N4O
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1
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| 1 |
IC50 = 550 nM
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CP0557588
|
US8962837, 9
Show/Hide
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C17H20ClN3O2
|
1
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| 1 |
IC50 = 550 nM
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CP0561376
|
US8962837, 13
Show/Hide
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C14H15ClN4O
|
1
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| 1 |
IC50 = 550 nM
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CP0122254
|
N-benzyl-2-(6-benzylpyrazin-2-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C23H20N4OS
|
1
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| 1 |
IC50 = 618 nM
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CP0464967
|
US8962837, 28
Show/Hide
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C15H17ClN4O
|
1
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| 1 |
IC50 = 650 nM
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CP0484785
|
US8962837, 38
Show/Hide
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C15H16Cl2N4O
|
1
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| 1 |
IC50 = 650 nM
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CP0536198
|
US8962837, 42
Show/Hide
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C14H12ClF3N4O
|
1
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| 1 |
IC50 = 650 nM
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CP0251445
|
2-(3-benzyl-2-oxoimidazolidin-1-yl)-4-methyl-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H21N5O2S
|
1
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| 1 |
IC50 = 656 nM
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CP0500833
|
N-(2-phenylpropyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C26H26F3N5O2
|
1
|
| 1 |
IC50 = 660 nM
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CP0364002
|
N-benzyl-2-(4-benzyltriazol-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H19N5OS
|
1
|
| 1 |
IC50 = 675 nM
|
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CP0498144
|
3-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-N-(pyridin-2-ylmethyl)-1H-pyrazole-5-carboxamide
Show/Hide
|
C19H16FN7O2
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
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CP0175026
|
2-(3-butyl-2-oxoimidazolidin-1-yl)-4-methyl-N-(pyridin-3-ylmethyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C18H23N5O2S
|
1
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| 1 |
IC50 = 748 nM
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CP0282432
|
2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-[1,3]thiazolo[4,5-b]pyridine
Show/Hide
|
C18H16F3N3OS
|
1
|
| 1 |
IC50 = 755 nM
|
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CP0502569
|
methyl N-[2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl]carbamate
Show/Hide
|
C17H18F3N3O3S
|
1
|
| 1 |
IC50 = 775 nM
|
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CP0278617
|
2-[5-[6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl]pyridin-3-yl]acetic acid
Show/Hide
|
C22H20BrFN4O3
|
1
|
| 1 |
IC50 = 780 nM
|
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CP0224871
|
N-(2-cyclopropylethyl)-2-(4-hydroxy-2-oxopyridin-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C15H17N3O3S
|
1
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| 1 |
IC50 = 783 nM
|
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CP0514114
|
benzyl N-[3-[(3,4-dimethylphenyl)methyl]-4-oxoquinazolin-6-yl]carbamate
Show/Hide
|
C25H23N3O3
|
1
|
| 1 |
IC50 = 790 nM
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CP0461024
|
2-[5-[5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl]tetrazol-2-yl]acetic acid
Show/Hide
|
C16H15BrFN7O3S
|
1
|
| 1 |
IC50 = 904 nM
|
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CP0504906
|
2-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C14H12FN5O2S
|
1
|
| 1 |
IC50 = 945 nM
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CP0457170
|
2-[5-[2-[3-[2-bromo-5-(trifluoromethoxy)phenoxy]propoxy]-1,3-thiazol-5-yl]tetrazol-2-yl]acetic acid
Show/Hide
|
C16H13BrF3N5O5S
|
1
|
| 1 |
IC50 = 969 nM
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CP0502568
|
2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)thiazole-5-sulfonamide
Show/Hide
|
C15H16F3N3O3S2
|
1
|
| 1 |
IC50 = 1019 nM
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CP0199248
|
2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid
Show/Hide
|
C17H16BrFN6O4
|
2
|
| 1 |
IC50 = 1066 nM
|
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| 2 |
IC50 = 1070 nM
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CP0460542
|
N-heptyl-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C24H30F3N5O2
|
1
|
| 1 |
IC50 = 1100 nM
|
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CP0278615
|
3-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]benzoic acid
Show/Hide
|
C23H20F3N3O3
|
1
|
| 1 |
IC50 = 1113 nM
|
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CP0381833
|
benzyl N-[3-[(3,4-dichlorophenyl)methylcarbamoyl]-4-pyridin-3-yloxyphenyl]carbamate
Show/Hide
|
C27H21Cl2N3O4
|
1
|
| 1 |
IC50 = 1150 nM
|
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CP0500392
|
2-[4-(2-chlorophenoxy)phenyl]-N-(1,3-thiazol-2-ylmethyl)-3H-benzimidazole-5-carboxamide
Show/Hide
|
C24H17ClN4O2S
|
1
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| 1 |
IC50 = 1160 nM
|
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CP0511243
|
2-[4-(2-chlorophenoxy)phenyl]-N-[(5-chlorothiophen-2-yl)methyl]-3H-benzimidazole-5-carboxamide
Show/Hide
|
C25H17Cl2N3O2S
|
1
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| 1 |
IC50 = 1360 nM
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CP0224873
|
N-benzyl-4-methyl-2-[2-oxo-4-(trifluoromethyl)pyridin-1-yl]-1,3-thiazole-5-carboxamide
Show/Hide
|
C18H14F3N3O2S
|
1
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| 1 |
IC50 = 1510 nM
|
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CP0427749
|
2-(2-(3,4-dichlorobenzylamino)-6-(4-methoxyphenyl)-7-oxopteridin-8(7H)-yl)ethylsulfamic acid
Show/Hide
|
C23H22Cl2N6O4S
|
1
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| 1 |
IC50 = 1670 nM
|
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CP0116107
|
N-(cyclopropylmethyl)-2-(4-hydroxy-2-oxopyridin-1-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C14H15N3O3S
|
1
|
| 1 |
IC50 = 1692 nM
|
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CP0122255
|
N-benzyl-2-(5-benzyl-1,2,4-oxadiazol-3-yl)-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C21H18N4O2S
|
1
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| 1 |
IC50 = 1925 nM
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CP0203105
|
N-benzyl-2-[(4R)-4-benzyl-2-oxoimidazolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxamide
Show/Hide
|
C22H22N4O2S
|
1
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| 1 |
IC50 = 2175 nM
|
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CP0440859
|
N-[(5-methylpyrazin-2-yl)methyl]-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C23H22F3N7O2
|
1
|
| 1 |
IC50 = 2249 nM
|
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CP0490904
|
2-[4-(2-chlorophenoxy)phenyl]-N-(2-cyclopropylethyl)-3H-benzimidazole-5-carboxamide
Show/Hide
|
C25H22ClN3O2
|
1
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| 1 |
IC50 = 2340 nM
|
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CP0465307
|
N-(3-methylbutyl)-5-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridine-2-carboxamide
Show/Hide
|
C23H27F3N4O2
|
1
|
| 1 |
IC50 = 2400 nM
|
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CP0287220
|
5-[6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyridin-3-yl]pyridine-3-carboxylic acid
Show/Hide
|
C22H19BrFN3O3
|
1
|
| 1 |
IC50 = 2412 nM
|
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CP0078568
|
2-[5-[2-[2-(2-chloro-5-methoxyphenyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-1,3-thiazol-5-yl]tetrazol-2-yl]acetic acid
Show/Hide
|
C19H20ClN7O3S
|
1
|
| 1 |
IC50 = 2450 nM
|
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CP0459573
|
N-[2-[2-(4-methoxyphenyl)-3-oxo-6-[[4-(trifluoromethyl)phenyl]methylamino]pyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
Show/Hide
|
C26H24F3N5O3
|
1
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| 1 |
IC50 = 2500 nM
|
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CP0122228
|
N-benzyl-4-methyl-2-(2-oxopyridin-1-yl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C17H15N3O2S
|
1
|
| 1 |
IC50 = 2536 nM
|
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CP0122225
|
N-benzyl-4-methyl-2-(2-oxo-4-phenylpyridin-1-yl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C23H19N3O2S
|
1
|
| 1 |
IC50 = 2578 nM
|
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CP0203102
|
N-benzyl-4-methyl-2-[(2-phenylacetyl)amino]-1,3-thiazole-5-carboxamide
Show/Hide
|
C20H19N3O2S
|
1
|
| 1 |
IC50 = 2677 nM
|
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CP0539402
|
5-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-1H-1,2,4-triazole-3-carboxamide
Show/Hide
|
C15H16F3N5O2
|
1
|
| 1 |
IC50 = 2823 nM
|
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CP0459953
|
2-[5-[2-[3-(2-bromo-5-fluorophenoxy)propoxy]-1,3-thiazol-5-yl]tetrazol-2-yl]acetic acid
Show/Hide
|
C15H13BrFN5O4S
|
1
|
| 1 |
IC50 = 3870 nM
|
|
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CP0459571
|
N-[2-[2-[(3,4-dichlorophenyl)methylamino]-6-(4-methoxyphenyl)-7-oxopteridin-8-yl]ethyl]thiophene-3-carboxamide
Show/Hide
|
C27H22Cl2N6O3S
|
1
|
| 1 |
IC50 = 4000 nM
|
|
|
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CP0170175
|
2-[5-[2-[4-(2-chloro-5-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]tetrazol-2-yl]acetic acid
Show/Hide
|
C16H15ClFN7O2S
|
1
|
| 1 |
IC50 = 4200 nM
|
|
|
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CP0293796
|
5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2,4-triazin-6-yl]pyridine-3-carboxylic acid
Show/Hide
|
C20H17BrFN5O3
|
1
|
| 1 |
IC50 = 4466 nM
|
|
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CP0508210
|
N-[2-[2-[(3-chlorophenyl)methylamino]-6-(4-methoxyphenyl)-7-oxopteridin-8-yl]ethyl]acetamide
Show/Hide
|
C24H23ClN6O3
|
1
|
| 1 |
IC50 = 4600 nM
|
|
|
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CP0354487
|
5-[6-[4-(2-iodophenoxy)piperidin-1-yl]pyridazin-3-yl]pyridine-3-carboxylic acid
Show/Hide
|
C21H19IN4O3
|
1
|
| 1 |
IC50 = 5080 nM
|
|
|
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CP0493842
|
6-[4-[2-chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl]piperazin-1-yl]-N-(2-cyclopropylethyl)pyridazine-3-carboxamide
Show/Hide
|
C20H21ClF3N7O2
|
1
|
| 1 |
IC50 = 5870 nM
|
|
|
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CP0090844
|
5-[6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl]pyridine-3-carboxylic acid
Show/Hide
|
C21H18BrFN4O3
|
1
|
| 1 |
IC50 = 6030 nM
|
|
|
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CP0507645
|
N-hexyl-5-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyrimidine-2-carboxamide
Show/Hide
|
C23H28F3N5O2
|
1
|
| 1 |
IC50 = 6400 nM
|
|
|
|
CP0529088
|
2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)thiazole-4-carboxamide
Show/Hide
|
C16H16F3N3O2S
|
1
|
| 1 |
IC50 = 6523 nM
|
|
|
|
CP0235778
|
5-[5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrazin-2-yl]pyridine-3-carboxylic acid
Show/Hide
|
C21H18BrFN4O3
|
1
|
| 1 |
IC50 = 6715 nM
|
|
|
|
CP0200792
|
2-[5-[3-[3-(2-bromo-5-fluorophenoxy)propoxy]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid
Show/Hide
|
C15H13BrFN5O5
|
1
|
| 1 |
IC50 = 7740 nM
|
|
|
|
CP0094063
|
5-[6-[4-(2-bromo-4,5-difluorophenoxy)piperidin-1-yl]pyridazin-3-yl]pyridine-3-carboxylic acid
Show/Hide
|
C21H17BrF2N4O3
|
1
|
| 1 |
IC50 = 8264 nM
|
|
|
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CP0496295
|
2-[5-[2-[(1S,4S)-5-(2-chloro-5-fluorophenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3-thiazol-5-yl]tetrazol-2-yl]acetic acid
Show/Hide
|
C17H15ClFN7O2S
|
1
|
| 1 |
IC50 = 9140 nM
|
|
|
|
CP0094065
|
5-[2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl]pyridine-3-carboxylic acid
Show/Hide
|
C21H18BrFN4O3
|
1
|
| 1 |
IC50 = 9422 nM
|
|
|
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CP0096178
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2-[5-[3-[2-(2-chloro-5-fluorophenyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid
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C18H17ClFN7O3
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1
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| 1 |
IC50 = 9900 nM
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CP0159133
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N-benzyl-2-(1-benzyltriazol-4-yl)-4-methyl-1,3-thiazole-5-carboxamide
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C21H19N5OS
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1
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| 1 |
IC50 = 9983 nM
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CP0401993
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2-[5-[5-[2-(2-chloro-5-fluorophenyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-1,3,4-thiadiazol-2-yl]tetrazol-2-yl]acetic acid
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C17H16ClFN8O2S
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1
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| 1 |
IC50 > 10000 nM
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CP0354486
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5-[6-[4-(2-chlorophenoxy)piperidin-1-yl]pyridazin-3-yl]pyridine-3-carboxylic acid
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C21H19ClN4O3
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1
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| 1 |
IC50 > 10000 nM
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CP0189186
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2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3-benzothiazole
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C18H16BrFN2OS
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1
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| 1 |
IC50 = 10639 nM
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CP0461025
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2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-5-(2H-tetrazol-5-yl)-1,3,4-thiadiazole
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C14H13BrFN7OS
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1
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| 1 |
IC50 = 12588 nM
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CP0382651
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2-[5-[2-[2-(2-chloro-5-fluorophenyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-1,3-thiazol-5-yl]tetrazol-2-yl]acetic acid
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C18H17ClFN7O2S
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1
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| 1 |
IC50 = 15400 nM
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CP0315667
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5-[6-[4-(2-bromophenoxy)piperidin-1-yl]pyridazin-3-yl]pyridine-3-carboxylic acid
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C21H19BrN4O3
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1
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| 1 |
IC50 = 18259 nM
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CP0094061
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5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]pyridine-3-carboxylic acid
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C22H19F3N4O3
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1
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| 1 |
IC50 > 20000 nM
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CP0437986
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2-[5-[2-[3-(2-bromo-5-fluorophenoxy)propoxy]-4-methyl-1,3-thiazol-5-yl]tetrazol-2-yl]acetic acid
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C16H15BrFN5O4S
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1
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| 1 |
IC50 = 20500 nM
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CP0451070
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3-[2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-7-oxo-6H-[1,3]thiazolo[4,5-d]pyrimidin-5-yl]propanoic acid
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C19H18BrFN4O4S
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1
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| 1 |
IC50 = 24345 nM
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CP0456272
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2-[5-[3-[2-(2-bromo-5-fluorophenoxy)ethoxy]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid
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C14H11BrFN5O5
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1
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| 1 |
IC50 > 40000 nM
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CP0499542
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2-[5-[3-[4-(2-bromo-5-fluorophenoxy)butoxy]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid
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C16H15BrFN5O5
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1
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| 1 |
IC50 > 40000 nM
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CP0381185
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2-(2H-tetrazol-5-yl)-5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-thiadiazole
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C15H14F3N7OS
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1
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| 1 |
IC50 > 50000 nM
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CP0372824
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2-[5-[2-[6-(2-chloro-5-fluorophenyl)-2,6-diazaspiro[3.3]heptan-2-yl]-1,3-thiazol-5-yl]tetrazol-2-yl]acetic acid
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C17H15ClFN7O2S
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1
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| 1 |
IC50 = 50900 nM
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CP0437985
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2-[5-[5-[3-(2-bromo-5-fluorophenoxy)propoxy]-1,3,4-thiadiazol-2-yl]tetrazol-2-yl]acetic acid
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C14H12BrFN6O4S
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1
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| 1 |
IC50 > 60000 nM
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CP0382652
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2-[5-[2-[7-(2-chloro-5-fluorophenyl)-2,7-diazaspiro[3.5]nonan-2-yl]-1,3-thiazol-5-yl]tetrazol-2-yl]acetic acid
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C19H19ClFN7O2S
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1
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| 1 |
IC50 > 100000 nM
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CP0403698
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2-[5-[2-[2-(2-chloro-5-fluorophenyl)-2,7-diazaspiro[3.5]nonan-7-yl]-1,3-thiazol-5-yl]tetrazol-2-yl]acetic acid
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C19H19ClFN7O2S
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1
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| 1 |
IC50 > 100000 nM
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CP0391864
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2-[5-[3-[2-[(2-bromo-5-fluorophenyl)methoxy]ethoxy]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid
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C15H13BrFN5O5
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1
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| 1 |
IC50 > 100000 nM
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CP0431171
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2-hydroxy-N-[4-oxo-3-[(3-phenylphenyl)methyl]quinazolin-6-yl]acetamide
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C23H19N3O3
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1
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| 1 |
IC50 > 1000 nM
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CP0514671
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2-(3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-ylamino)-2-oxoacetic acid
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C17H11Cl2N3O4
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1
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| 1 |
IC50 > 1000 nM
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CP0447929
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1-(2-(3-methyl-2-oxo-7-(3-(trifluoromethyl)benzylamino)quinoxalin-1(2H)-yl)ethyl)urea
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C20H20F3N5O2
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1
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| 1 |
IC50 > 1000 nM
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CP0175010
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2-(4-hydroxy-2-oxopyridin-1-yl)-4-methyl-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamide
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C16H14N4O3S
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1
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| 1 |
IC50 > 1000 nM
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CP0473791
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N-[2-[2-[(3,4-dichlorophenyl)methylamino]-6-(4-methoxyphenyl)-7-oxopteridin-8-yl]ethyl]benzamide
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C29H24Cl2N6O3
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1
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| 1 |
IC50 > 3000 nM
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