General Information of the Compound
Compound ID
CP0278617
Compound Name
2-[5-[6-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl]pyridin-3-yl]acetic acid
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Structure
Formula
C22H20BrFN4O3
Molecular Weight
487.329
Canonical SMILES
OC(=O)Cc1cncc(c1)-c1ccc(nn1)N1CCC(CC1)Oc1cc(F)ccc1Br
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InChI
InChI=1S/C22H20BrFN4O3/c23-18-2-1-16(24)11-20(18)31-17-5-7-28(8-6-17)21-4-3-19(26-27-21)15-9-14(10-22(29)30)12-25-13-15/h1-4,9,11-13,17H,5-8,10H2,(H,29,30)
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InChIKey
QRBORTBSPFTFBT-UHFFFAOYSA-N
Physicochemical Property
logP
4.1151
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
88.44
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25065739
SID: 56402606
ChEMBL ID
CHEMBL1950402
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01587, Stearoyl-CoA desaturase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
IC50 = 780 nM
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