| Compound ID |
Compound Name |
Compound Formula |
|
CP0303266
|
1'-(6-(5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl)pyridazin-3-yl)-5-(trifluoromethyl)spiro[chroman-2,4'-piperidine]
Show/Hide
|
C26H23F3N6O2
|
2
|
| 1 |
IC50 = 0.06 nM
|
|
|
| 2 |
IC50 = 0.8 nM
|
|
|
|
CP0374076
|
N-(2-hydroxy-2-phenylethyl)-6-spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-ylpyridazine-3-carboxamide
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|
C26H28N4O3
|
2
|
| 1 |
IC50 = 0.068 nM
|
|
|
| 2 |
IC50 = 2.7 nM
|
|
|
|
CP0374077
|
N-(2-hydroxy-2-pyridin-3-ylethyl)-6-[5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl]pyridazine-3-carboxamide
Show/Hide
|
C26H26F3N5O3
|
2
|
| 1 |
IC50 = 0.45 nM
|
|
|
| 2 |
IC50 = 3 nM
|
|
|
|
CP0459060
|
N-(2-hydroxy-2-phenylethyl)-6-(4-hydroxyspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
Show/Hide
|
C26H28N4O4
|
2
|
| 1 |
IC50 = 0.48 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0526840
|
N-(2-hydroxy-2-phenylethyl)-6-(3-hydroxyspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
Show/Hide
|
C26H28N4O4
|
2
|
| 1 |
IC50 = 0.56 nM
|
|
|
| 2 |
IC50 = 49 nM
|
|
|
|
CP0374078
|
N-(2-hydroxy-2-phenylethyl)-6-(4-oxospiro[3H-chromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
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|
C26H26N4O4
|
2
|
| 1 |
IC50 = 0.69 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0072921
|
5-Fluoro-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine]
Show/Hide
|
C25H23FN6O2
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0526936
|
5-Methyl-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine]
Show/Hide
|
C26H26N6O2
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0383052
|
6-(5-chlorospiro[chroman-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-(pyridin-3-yl)ethyl)pyridazine-3-carboxamide
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|
C25H26ClN5O3
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 2 nM
|
|
|
|
CP0402283
|
1'-(6-(3-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-yl)pyridazin-3-yl)-5-(trifluoromethyl)spiro[chroman-2,4'-piperidine]
Show/Hide
|
C26H24F3N7O
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
|
CP0504607
|
N-(2-hydroxy-2-pyridin-3-ylethyl)-6-(5-methylspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
Show/Hide
|
C26H29N5O3
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
|
CP0499049
|
5-Chloro-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine]
Show/Hide
|
C25H23ClN6O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0508307
|
5,8-Difluoro-1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine]
Show/Hide
|
C25H22F2N6O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0383053
|
6-(5,8-difluorospiro[chroman-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-(pyridin-3-yl)ethyl)pyridazine-3-carboxamide
Show/Hide
|
C25H25F2N5O3
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
|
CP0507784
|
1'-{6-[5-(Pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine]
Show/Hide
|
C25H24N6O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0374080
|
6-(5-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-(pyridin-3-yl)ethyl)pyridazine-3-carboxamide
Show/Hide
|
C25H26FN5O3
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
|
CP0317752
|
N-(2-hydroxy-2-phenylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C26H28N4O3
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 51 nM
|
|
|
|
CP0499050
|
1'-{6-[5-(Pyridin-4-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine]
Show/Hide
|
C25H24N6O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0455261
|
N-[5-[[4-fluoro-3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
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|
C21H18F4N2O4S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0418157
|
N-[5-[(3-chlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
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|
C20H19ClN2O4S
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0523673
|
1'-{6-[5-(Pyridin-2-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine]
Show/Hide
|
C25H24N6O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0471589
|
1-(pyridin-3-ylmethyl)-3-(6-(5-(trifluoromethyl)spiro[chroman-2,4'-piperidine]-1'-yl)pyridazin-3-yl)urea
Show/Hide
|
C25H25F3N6O2
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 106 nM
|
|
|
|
CP0494463
|
6-[5-(Cyclopropylmethyl)-4,5-dihydro-1'H,3H-spiro[1,5-benzoxazepine-2,4'-piperidin]-1'-yl]-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamide
Show/Hide
|
C29H34N6O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0518898
|
N-[2-(3-fluorophenyl)-2-hydroxyethyl]-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C26H27FN4O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0462655
|
N-[5-[(3,4-dichlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Show/Hide
|
C20H18Cl2N2O4S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0472116
|
N-[5-[(3,5-dichlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Show/Hide
|
C20H18Cl2N2O4S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0345112
|
N-(2-hydroxy-2-phenylethyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C26H25F3N4O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0504609
|
1'-(6-(5-(2-(pyridin-3-yl)ethyl)-1,3,4-oxadiazol-2-yl)pyridazin-3-yl)-5-(trifluoromethyl)spiro[chroman-2,4'-piperidine]
Show/Hide
|
C27H25F3N6O2
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
IC50 = 35 nM
|
|
|
|
CP0472117
|
N-[5-[(3-chloro-4-fluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Show/Hide
|
C20H18ClFN2O4S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0452912
|
6-(5-fluoro-4-hydroxyspiro[chroman-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide
Show/Hide
|
C26H27FN4O4
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 157 nM
|
|
|
|
CP0374074
|
N-(2-hydroxy-2-phenylethyl)-6-(4-oxospiro[1,2-dihydronaphthalene-3,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
Show/Hide
|
C27H28N4O3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0498680
|
N-(2-hydroxy-2-thiophen-3-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C24H26N4O3S
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0452725
|
N-[2-(4-fluorophenyl)-2-hydroxyethyl]-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C26H27FN4O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0534050
|
N-(2-hydroxy-2-thiophen-2-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C24H26N4O3S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0070642
|
N-[5-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Show/Hide
|
C22H18F6N2O4S
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0459061
|
6-(8-fluoro-4-hydroxyspiro[chroman-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide
Show/Hide
|
C26H27FN4O4
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0505035
|
N-[5-[(3-fluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Show/Hide
|
C20H19FN2O4S
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0505036
|
N-[5-[(3,4-difluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Show/Hide
|
C20H18F2N2O4S
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0469537
|
1'-(6-(1-methyl-3-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-yl)pyridazin-3-yl)-5-(trifluoromethyl)spiro[chroman-2,4'-piperidine]
Show/Hide
|
C27H26F3N7O
|
2
|
| 1 |
IC50 = 38 nM
|
|
|
| 2 |
IC50 = 65 nM
|
|
|
|
CP0524471
|
N-(2-hydroxy-2-pyridin-3-ylethyl)-6-(5-propan-2-ylspiro[3,4-dihydro-1,5-benzoxazepine-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
Show/Hide
|
C28H34N6O3
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0341925
|
N-(2-hydroxy-2-pyridin-3-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C25H27N5O3
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0505996
|
3-(2-hydroxyethoxy)-4-methoxy-N-(5-(3-(trifluoromethoxy)benzyl)thiazol-2-yl)benzamide
Show/Hide
|
C21H19F3N2O5S
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0518897
|
N-[2-(2-fluorophenyl)-2-hydroxyethyl]-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C26H27FN4O3
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0383054
|
N-(2-hydroxy-2-phenylethyl)-6-(4-methoxyspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
Show/Hide
|
C27H30N4O4
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0504612
|
N-(2-hydroxy-2-phenylethyl)-6-spiro[chromene-2,4'-piperidine]-1'-ylpyridazine-3-carboxamide
Show/Hide
|
C26H26N4O3
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0268764
|
(R)-N-(2-hydroxy-2-phenylethyl)-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamide
Show/Hide
|
C25H24F3N5O3
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0527078
|
N-(2-hydroxy-2-phenylethyl)-6-spiro[1,4-dihydroisochromene-3,4'-piperidine]-1'-ylpyridazine-3-carboxamide
Show/Hide
|
C26H28N4O3
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0372690
|
6-(3,4-Dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-N-(2-pyridin-3-ylethyl)pyridazine-3-carboxamide
Show/Hide
|
C24H25N5O2
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0355772
|
6-(4-(4-fluorobenzoyl)piperidin-1-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide
Show/Hide
|
C25H25FN4O3
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0281223
|
(S)-N-(2-hydroxy-2-phenylethyl)-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamide
Show/Hide
|
C25H24F3N5O3
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0566041
|
6-(5-Ethyl-4,5-dihydro-1'H,3H-spiro[1,5-benzoxazepine-2,4'-piperidin]-1'-yl)-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamide
Show/Hide
|
C27H32N6O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0096186
|
N-(2-hydroxy-2-phenylethyl)-6-[4-[2-(trifluoromethoxy)benzoyl]piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C26H25F3N4O4
|
1
|
| 1 |
IC50 = 103 nM
|
|
|
|
CP0192117
|
6-(4-benzoylpiperidin-1-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide
Show/Hide
|
C25H26N4O3
|
1
|
| 1 |
IC50 = 108 nM
|
|
|
|
CP0455260
|
N-[5-[(3,5-difluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Show/Hide
|
C20H18F2N2O4S
|
1
|
| 1 |
IC50 = 116 nM
|
|
|
|
CP0534049
|
N-(2-hydroxy-2-pyridin-4-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C25H27N5O3
|
1
|
| 1 |
IC50 = 144 nM
|
|
|
|
CP0527079
|
6-(7-fluoro-4-hydroxyspiro[chroman-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide
Show/Hide
|
C26H27FN4O4
|
1
|
| 1 |
IC50 = 156 nM
|
|
|
|
CP0459055
|
N-(2-hydroxy-2-phenylethyl)-6-(1-oxospiro[4H-isochromene-3,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
Show/Hide
|
C26H26N4O4
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0373565
|
N-(2-hydroxy-2-pyridin-2-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C25H27N5O3
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0508049
|
N-[5-[(2,5-dichlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Show/Hide
|
C20H18Cl2N2O4S
|
1
|
| 1 |
IC50 = 429 nM
|
|
|
|
CP0476760
|
6-[5-(2-Hydroxyethyl)-4,5-dihydro-1'H,3H-spiro[1,5-benzoxazepine-2,4'-piperidin]-1'-yl]-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamide
Show/Hide
|
C27H32N6O4
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0508106
|
N-[5-[(3-fluoro-4-methylphenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Show/Hide
|
C21H21FN2O4S
|
1
|
| 1 |
IC50 = 639 nM
|
|
|
|
CP0462823
|
N-(2-hydroxy-2-pyridin-3-ylethyl)-6-(5-methylspiro[3,4-dihydro-1,5-benzoxazepine-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
Show/Hide
|
C26H30N6O3
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0355771
|
N-(2-hydroxy-2-phenylethyl)-6-[4-(2-methoxybenzoyl)piperidin-1-yl]pyridazine-3-carboxamide
Show/Hide
|
C26H28N4O4
|
1
|
| 1 |
IC50 = 1048 nM
|
|
|
|
CP0417922
|
1'-(6-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)pyridazin-3-yl)-5-(trifluoromethyl)spiro[chroman-2,4'-piperidine]
Show/Hide
|
C25H21F3N6O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0439036
|
N-(2-hydroxy-2-phenylethyl)-6-(3-oxospiro[1-benzofuran-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
Show/Hide
|
C25H24N4O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
