General Information of the Compound
Compound ID
CP0462823
Compound Name
N-(2-hydroxy-2-pyridin-3-ylethyl)-6-(5-methylspiro[3,4-dihydro-1,5-benzoxazepine-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide
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Structure
Formula
C26H30N6O3
Molecular Weight
474.565
Canonical SMILES
CN1CCC2(CCN(CC2)c2ccc(nn2)C(=O)NCC(O)c2cccnc2)Oc2ccccc12
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InChI
InChI=1S/C26H30N6O3/c1-31-14-10-26(35-23-7-3-2-6-21(23)31)11-15-32(16-12-26)24-9-8-20(29-30-24)25(34)28-18-22(33)19-5-4-13-27-17-19/h2-9,13,17,22,33H,10-12,14-16,18H2,1H3,(H,28,34)
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InChIKey
PFEGOQVRJUBECN-UHFFFAOYSA-N
Physicochemical Property
logP
2.5929
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
103.71
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53231167
SID: 124339951
ChEMBL ID
CHEMBL1774093
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01587, Stearoyl-CoA desaturase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000050 HEK293-A Homo sapiens (Human)  1
1
IC50 = 700 nM
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