Protein Information

General Information of the Protein

Protein ID	PT01348
Protein Name	Dual specificity protein kinase TTK
Secondarily Protein Name	Phosphotyrosine picked threonine-protein kinase
Gene Name	TTK
Secondarily Gene Name	MPS1 MPS1L1
Sequence	MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Kinase > Protein Kinase > Other protein kinase group > Other protein kinase TTK family
Function	Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099). Show/Hide
Uniprot ID	Primary ID: P33981 Secondarily ID: A8K8U5 B2RDW2 E1P543 Q15272 Q5TCS0 Q9BW51 Q9NTM0 Show/Hide
Ensembl ID	ENSG00000112742
HGNC ID	HGNC:12401

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000067 , HCT 116

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0391331 Compound Info	US10479788, Example 175 Show/Hide	C22H26N8O	1
1	IC50 = 3.5 nM Bioactivity Info	TI LI LO TS
CP0471512 Compound Info	US10399974, Example 54 Show/Hide	C25H32N8O	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0473781 Compound Info	US9409907, 179 Show/Hide	C23H28N8O	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0529342 Compound Info	N2-(4-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)-2-ethoxyphenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine Show/Hide	C25H32N8O	1
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0529341 Compound Info	N-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-8-(7-oxa-2-azaspiro[3.5]nonan-2-yl)pyrido[3,4-d]pyrimidin-2-amine Show/Hide	C26H30N8O2	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0578491 Compound Info	8-(3,3-dimethylazetidin-1-yl)-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidin-2-amine Show/Hide	C24H28N8O	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0030809 Compound Info	tert-butyl 6-[2-chloro-4-(3-methylimidazol-4-yl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C26H26ClN7O2	1
1	IC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0484333 Compound Info	US11046688, Example 50 Show/Hide	C24H29N7O	1
1	IC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0033865 Compound Info	US10479788, Example 77 Show/Hide	C24H29N7O	1
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0139457 Compound Info	US10479788, Example 182 Show/Hide	C24H30N8O	1
1	IC50 = 63 nM Bioactivity Info	TI LI LO TS
CP0322505 Compound Info	US11046688, Example 49 Show/Hide	C24H29N7O	1
1	IC50 = 95 nM Bioactivity Info	TI LI LO TS
CP0405043 Compound Info	1-(2-((2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)amino)-6-methylpyrido[3,4-d]pyrimidin-8-yl)-3-methylazetidine-3-carbonitrile Show/Hide	C24H25N9O	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0416442 Compound Info	US10479788, Example 68 Show/Hide	C23H27N7O	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0020307 Compound Info	tert-butyl 6-[2-chloro-4-(1-methylpyrazol-4-yl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C26H26ClN7O2	1
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0027579 Compound Info	N-(2,6-diethylphenyl)-1-methyl-8-[4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide Show/Hide	C35H39F3N8O3	1
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0093675 Compound Info	US10479788, Example 177 Show/Hide	C25H31N7O	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0409723 Compound Info	US10479788, Example 76 Show/Hide	C24H29N7O	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0024475 Compound Info	tert-butyl 6-(2-chloro-4-pyrimidin-5-ylanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C26H24ClN7O2	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0329773 Compound Info	US10479788, Example 55 Show/Hide	C24H27N7O	1
1	IC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0023726 Compound Info	tert-butyl 6-[4-(azetidine-1-carbonyl)-2-chloroanilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C26H27ClN6O3	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0322590 Compound Info	US11046688, Example 48 Show/Hide	C24H29N7O	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0391330 Compound Info	2-N-[4-[5-[2-(dimethylamino)ethyl]-4-methyl-1,2,4-triazol-3-yl]-2-ethoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamine Show/Hide	C28H39N9O	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0405044 Compound Info	2-N-[4-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)-2-methoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamine Show/Hide	C25H30N8O	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0473799 Compound Info	2-N-[4-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)-2-ethoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamine Show/Hide	C26H32N8O	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0030810 Compound Info	tert-butyl 6-[2-chloro-4-(1,3-oxazol-5-yl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C25H23ClN6O3	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0484332 Compound Info	US10399974, Example 56 Show/Hide	C23H26N8O	1
1	IC50 = 370 nM Bioactivity Info	TI LI LO TS
CP0380193 Compound Info	US10479788, Example 58 Show/Hide	C22H23N7O	1
1	IC50 = 430 nM Bioactivity Info	TI LI LO TS
CP0464249 Compound Info	US10479788, Example 34 Show/Hide	C24H20N6O	1
1	IC50 = 480 nM Bioactivity Info	TI LI LO TS
CP0023705 Compound Info	4-[[4-amino-6-(tert-butylamino)-5-cyanopyridin-2-yl]amino]benzamide Show/Hide	C17H20N6O	1
1	IC50 = 560 nM Bioactivity Info	TI LI LO TS
CP0023842 Compound Info	tert-butyl 6-[2-chloro-4-(dimethylcarbamoyl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C25H27ClN6O3	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0380192 Compound Info	US11046688, Example 32 Show/Hide	C22H20N8O	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0016088 Compound Info	tert-butyl 6-(2-chloro-4-pyrazin-2-ylanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C26H24ClN7O2	1
1	IC50 = 620 nM Bioactivity Info	TI LI LO TS
CP0322506 Compound Info	US10479788, Example 65 Show/Hide	C22H25N7O	1
1	IC50 = 650 nM Bioactivity Info	TI LI LO TS
CP0022007 Compound Info	tert-butyl 6-(2-chloro-4-pyridin-3-ylanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C27H25ClN6O2	1
1	IC50 = 710 nM Bioactivity Info	TI LI LO TS
CP0024754 Compound Info	tert-butyl 6-[2-chloro-4-(4-methoxypiperidine-1-carbonyl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C29H33ClN6O4	1
1	IC50 = 720 nM Bioactivity Info	TI LI LO TS
CP0032521 Compound Info	9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one Show/Hide	C24H32N6O3	1
1	IC50 = 720 nM Bioactivity Info	TI LI LO TS
CP0022008 Compound Info	tert-butyl 6-[2-chloro-4-(dimethylsulfamoyl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C24H27ClN6O4S	1
1	IC50 = 840 nM Bioactivity Info	TI LI LO TS
CP0029562 Compound Info	tert-butyl 6-[2-chloro-4-(1,1-dioxo-1,4-thiazinane-4-carbonyl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C27H29ClN6O5S	1
1	IC50 = 860 nM Bioactivity Info	TI LI LO TS
CP0030351 Compound Info	tert-butyl 6-[2-chloro-4-[4-(dimethylamino)piperidine-1-carbonyl]anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C30H36ClN7O3	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0455282 Compound Info	US10479788, Example 37 Show/Hide	C22H23N7O	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0020468 Compound Info	tert-butyl 6-[2-chloro-4-(1-methylpyrazol-3-yl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C26H26ClN7O2	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0510841 Compound Info	US11046688, Example 95 Show/Hide	C22H20N8	1
1	IC50 = 2540 nM Bioactivity Info	TI LI LO TS
CP0409721 Compound Info	US11046688, Example 96 Show/Hide	C23H22N8O	1
1	IC50 = 2640 nM Bioactivity Info	TI LI LO TS
CP0218744 Compound Info	US11046688, Example 30 Show/Hide	C21H20N4O2	1
1	IC50 = 2770 nM Bioactivity Info	TI LI LO TS
CP0020250 Compound Info	tert-butyl 6-(2-chloroanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C22H22ClN5O2	1
1	IC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0431816 Compound Info	US10399974, Example 42 Show/Hide	C24H28N8O	1
1	IC50 = 3800 nM Bioactivity Info	TI LI LO TS
CP0029560 Compound Info	3-chloro-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzamide Show/Hide	C20H19ClN6O	1
1	IC50 = 4100 nM Bioactivity Info	TI LI LO TS
CP0380191 Compound Info	N-(2,4-dimethoxyphenyl)-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amine Show/Hide	C19H18N6O2	1
1	IC50 = 4840 nM Bioactivity Info	TI LI LO TS
CP0023441 Compound Info	tert-butyl 6-[2-chloro-4-(dimethylcarbamoyl)anilino]-2-(1,3-oxazol-5-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Show/Hide	C24H24ClN5O4	1
1	IC50 = 5600 nM Bioactivity Info	TI LI LO TS
CP0020306 Compound Info	N-[2-chloro-4-(1-methylpyrazol-4-yl)phenyl]-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine Show/Hide	C21H18ClN7	1
1	IC50 = 6900 nM Bioactivity Info	TI LI LO TS
CP0509105 Compound Info	US10479788, Example 35 Show/Hide	C21H20N6O	1
1	IC50 = 7810 nM Bioactivity Info	TI LI LO TS
CP0452275 Compound Info	N-(4-methoxyphenyl)-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amine Show/Hide	C18H16N6O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000305 , RERF-LC-A1

Cell Line Info

Cell Line ID: CL000897 , RERF-LC-AI Tet-off

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0204277 Compound Info	(2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]-amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]propanamide Show/Hide	C29H26FN5O4S	1
1	IC50 = 0.34 nM
CP0437416 Compound Info	US9512130, 2 Show/Hide	C27H24F5N5O3	2
1	IC50 = 0.63 nM
2	IC50 < 1 nM
CP0344042 Compound Info	JGS79C Show/Hide	C33H39N7O2	2
1	IC50 = 0.9 nM
2	IC50 < 1 nM
CP0157630 Compound Info	CHEMBL4469414 Show/Hide	C28H30N6O3	1
1	IC50 = 1.2 nM
CP0257234 Compound Info	N-cyclopropyl-4-[8-(2-methylpropylamino)imidazo[1,2-a]pyrazin-3-yl]benzamide Show/Hide	C20H23N5O	3
1	IC50 = 1.4 nM
2	IC50 = 14 nM
3	IC50 = 55 nM
CP0391331 Compound Info	US10479788, Example 175 Show/Hide	C22H26N8O	1
1	IC50 = 2 nM
CP0473781 Compound Info	US9409907, 179 Show/Hide	C23H28N8O	1
1	IC50 = 2 nM
CP0351982 Compound Info	4-[6-(2-amino-4-cyanophenyl)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide Show/Hide	C29H29N7O2	1
1	IC50 = 2.5 nM
CP0171137 Compound Info	N-cyclopropyl-4-[6-(2-hydroxyphenoxy)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide Show/Hide	C28H29N5O4	1
1	IC50 = 2.6 nM
CP0302610 Compound Info	N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-[(1,1,1-trifluoro-2-methylpropan-2-yl)amino]imidazo[1,2-b]pyridazin-3-yl]benzamide Show/Hide	C26H31F3N6O2	1
1	IC50 = 2.8 nM
CP0031875 Compound Info	2-pyrrolidin-1-yl-N-[3-(3-sulfamoylphenyl)-1H-indazol-5-yl]-2-thiophen-3-ylacetamide Show/Hide	C23H23N5O3S2	1
1	IC50 = 2.9 nM
CP0139457 Compound Info	US10479788, Example 182 Show/Hide	C24H30N8O	1
1	IC50 = 3 nM
CP0262091 Compound Info	2-(2,6-diethylphenyl)-7-[2-[2-methoxy-4-[4-(6-methyl-2,6-diazaspiro[3.3]heptane-2-carbonyl)piperidin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1-one Show/Hide	C42H49N9O3	1
1	IC50 = 3 nM
CP0066304 Compound Info	3-[5-ethoxy-6-(1-methylpyrazol-4-yl)-1H-indazol-3-yl]benzenesulfonamide Show/Hide	C19H19N5O3S	1
1	IC50 = 3.06 nM
CP0139843 Compound Info	2-(dimethylamino)-2-(2-ethylphenyl)-N-[3-(3-sulfamoylphenyl)-1H-indazol-5-yl]acetamide Show/Hide	C25H27N5O3S	1
1	IC50 = 3.6 nM
CP0153937 Compound Info	5-[5-ethoxy-6-(1-methylpyrazol-4-yl)-1H-indazol-3-yl]-2-methylbenzenesulfonamide Show/Hide	C20H21N5O3S	1
1	IC50 = 3.67 nM
CP0257236 Compound Info	4-[6-(4-cyanophenyl)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide Show/Hide	C29H28N6O2	1
1	IC50 = 4.2 nM
CP0033865 Compound Info	US10479788, Example 77 Show/Hide	C24H29N7O	3
1	IC50 = 5 nM
2	IC50 = 11.2 nM
3	IC50 = 20 nM
CP0093675 Compound Info	US10479788, Example 177 Show/Hide	C25H31N7O	1
1	IC50 = 5 nM
CP0322505 Compound Info	US11046688, Example 49 Show/Hide	C24H29N7O	1
1	IC50 = 5 nM
CP0322590 Compound Info	US11046688, Example 48 Show/Hide	C24H29N7O	1
1	IC50 = 5 nM
CP0478189 Compound Info	4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2- ylamino)-3-methoxy-N- methylbenzamide Show/Hide	C28H28N6O4	1
1	IC50 = 5 nM
CP0560923 Compound Info	4-[6-(cyclopentylamino)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide Show/Hide	C27H34N6O2	1
1	IC50 = 5.3 nM
CP0535312 Compound Info	US9388140, 8 Show/Hide	C27H28N4O	1
1	IC50 = 5.3 nM
CP0171139 Compound Info	N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-(propan-2-ylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide Show/Hide	C25H32N6O2	1
1	IC50 = 5.5 nM
CP0441691 Compound Info	N-cyclopropyl-4-[6-(4-fluorophenoxy)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide Show/Hide	C28H28FN5O3	1
1	IC50 = 5.6 nM
CP0380193 Compound Info	US10479788, Example 58 Show/Hide	C22H23N7O	1
1	IC50 = 6 nM
CP0257237 Compound Info	4-[6-(tert-butylamino)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide Show/Hide	C26H34N6O2	1
1	IC50 = 6.2 nM
CP0023705 Compound Info	4-[[4-amino-6-(tert-butylamino)-5-cyanopyridin-2-yl]amino]benzamide Show/Hide	C17H20N6O	1
1	IC50 = 6.4 nM
CP0302606 Compound Info	N-cyclopropyl-4-[6-(2-fluorophenoxy)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide Show/Hide	C28H28FN5O3	1
1	IC50 = 6.6 nM
CP0366329 Compound Info	4-[6-(4-cyanophenyl)-8-(oxan-4-ylmethylamino)imidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide Show/Hide	C29H28N6O2	1
1	IC50 = 6.6 nM
CP0556288 Compound Info	4-[6-(cyclohexylamino)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide Show/Hide	C28H36N6O2	1
1	IC50 = 6.6 nM
CP0516727 Compound Info	N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-phenoxyimidazo[1,2-b]pyridazin-3-yl]benzamide Show/Hide	C28H29N5O3	1
1	IC50 = 6.8 nM
CP0484333 Compound Info	US11046688, Example 50 Show/Hide	C24H29N7O	1
1	IC50 = 7 nM
CP0539578 Compound Info	4-[6-cyclohexyloxy-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide Show/Hide	C28H35N5O3	1
1	IC50 = 7.5 nM
CP0153938 Compound Info	3-[5-cyclohexyloxy-6-(1-methylpyrazol-4-yl)-1H-indazol-3-yl]benzenesulfonamide Show/Hide	C23H25N5O3S	1
1	IC50 = 7.93 nM
CP0027579 Compound Info	N-(2,6-diethylphenyl)-1-methyl-8-[4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide Show/Hide	C35H39F3N8O3	2
1	IC50 = 8 nM
2	IC50 = 182 nM
CP0322506 Compound Info	US10479788, Example 65 Show/Hide	C22H25N7O	1
1	IC50 = 8 nM
CP0380192 Compound Info	US11046688, Example 32 Show/Hide	C22H20N8O	1
1	IC50 = 8 nM
CP0409721 Compound Info	US11046688, Example 96 Show/Hide	C23H22N8O	1
1	IC50 = 8 nM
CP0416442 Compound Info	US10479788, Example 68 Show/Hide	C23H27N7O	1
1	IC50 = 8 nM
CP0455282 Compound Info	US10479788, Example 37 Show/Hide	C22H23N7O	1
1	IC50 = 8 nM
CP0257235 Compound Info	N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]benzamide Show/Hide	C28H29N5O2	1
1	IC50 = 8.5 nM
CP0329773 Compound Info	US10479788, Example 55 Show/Hide	C24H27N7O	1
1	IC50 = 9 nM
CP0409723 Compound Info	US10479788, Example 76 Show/Hide	C24H29N7O	1
1	IC50 = 9 nM
CP0574217 Compound Info	N-(2,6-diethylphenyl)-2-[4-(4-methylpiperazin-1-yl)-2-(propanoylamino)anilino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide Show/Hide	C35H42N8O2	1
1	IC50 = 9.06 nM
CP0166315 Compound Info	3-[5-ethoxy-6-(1H-pyrazol-4-yl)-1H-indazol-3-yl]benzenesulfonamide Show/Hide	C18H17N5O3S	1
1	IC50 = 9.76 nM
CP0032521 Compound Info	9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one Show/Hide	C24H32N6O3	2
1	IC50 = 9.79 nM
2	IC50 = 35 nM
CP0043316 Compound Info	3-[5-(cyclohexylamino)-6-(1-methylpyrazol-4-yl)-1H-indazol-3-yl]benzenesulfonamide Show/Hide	C23H26N6O2S	2
1	IC50 = 10 nM
2	IC50 = 10.4 nM
CP0043317 Compound Info	N-[3-[5-(cyclohexylamino)-6-(1-methylpyrazol-4-yl)-1H-indazol-3-yl]phenyl]acetamide Show/Hide	C25H28N6O	1
1	IC50 = 12 nM
CP0192284 Compound Info	4-[6-anilino-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide Show/Hide	C28H30N6O2	1
1	IC50 = 13 nM
CP0357567 Compound Info	N-(2,6-diethylphenyl)-2-[4-(4-methylpiperazin-1-yl)-2-(prop-2-enoylamino)anilino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide Show/Hide	C35H40N8O2	7
1	IC50 = 13 nM
2	IC50 = 13.8 nM
3	IC50 = 20 nM
4	IC50 = 28.1 nM
5	IC50 = 40.2 nM
6	Ki = 0.83 nM
7	Ki = 14.2 nM
CP0464249 Compound Info	US10479788, Example 34 Show/Hide	C24H20N6O	1
1	IC50 = 14 nM
CP0085315 Compound Info	3-(6-cyano-5-ethoxy-1H-indazol-3-yl)benzenesulfonamide Show/Hide	C16H14N4O3S	1
1	IC50 = 17 nM
CP0510841 Compound Info	US11046688, Example 95 Show/Hide	C22H20N8	1
1	IC50 = 21 nM
CP0326593 Compound Info	US9388140, 1 Show/Hide	C21H24N4O	1
1	IC50 = 24.4 nM
CP0095170 Compound Info	3-(5-ethoxy-1H-indazol-3-yl)benzenesulfonamide Show/Hide	C15H15N3O3S	1
1	IC50 = 28 nM
CP0043325 Compound Info	N-[3-(6-cyano-5-ethoxy-1H-indazol-3-yl)phenyl]acetamide Show/Hide	C18H16N4O2	1
1	IC50 = 32 nM
CP0321819 Compound Info	N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)imidazo[1,2-a]pyrazin-3-yl]benzamide Show/Hide	C22H25N5O2	1
1	IC50 = 35 nM
CP0322591 Compound Info	US11046688, Example 97 Show/Hide	C24H24N8O	1
1	IC50 = 49 nM
CP0473508 Compound Info	US10479788, Example 70 Show/Hide	C25H29N7O	1
1	IC50 = 61 nM
CP0409722 Compound Info	US10479788, Example 38 Show/Hide	C22H25N7O	1
1	IC50 = 69 nM
CP0218744 Compound Info	US11046688, Example 30 Show/Hide	C21H20N4O2	1
1	IC50 = 74 nM
CP0509105 Compound Info	US10479788, Example 35 Show/Hide	C21H20N6O	1
1	IC50 = 96 nM
CP0510840 Compound Info	US11046688, Example 53 Show/Hide	C22H22N6O2	1
1	IC50 = 98 nM
CP0266351 Compound Info	3-[5-ethoxy-6-[1-(2-methylpropyl)pyrazol-4-yl]-1H-indazol-3-yl]benzenesulfonamide Show/Hide	C22H25N5O3S	1
1	IC50 = 119 nM
CP0558078 Compound Info	US11046688, Example 98 Show/Hide	C24H24N8O2	1
1	IC50 = 146 nM
CP0153939 Compound Info	3-(5-ethoxy-6-phenyl-1H-indazol-3-yl)benzenesulfonamide Show/Hide	C21H19N3O3S	1
1	IC50 = 173 nM
CP0329775 Compound Info	US11046688, Example 90 Show/Hide	C24H26N6OS	1
1	IC50 = 234 nM
CP0380190 Compound Info	US11046688, Example 28 Show/Hide	C20H18N4O	1
1	IC50 = 666 nM
CP0574196 Compound Info	US11046688, Example 27 Show/Hide	C20H16N2O2	1
1	IC50 = 3657 nM
CP0634648 Compound Info	N-((R)-Cyclopropyl(pyridin-2-yl)methyl)-3-(4-((endo)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5-carboxamide Show/Hide	C30H31N5O2	1
1	Ki = 0.7 nM

Clinical Information about the Protein

Target 1 ( Dual specificity protein kinase TTK (MPS1) )

Target Type	Clinical trial Target
Disease	1 Target-related Disease				1
1	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	BAY1161909	Drug Info	Phase 1	Solid tumour/cancer
2	BOS172722	Drug Info	Phase 1	Solid tumour/cancer

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han