Brief Information of the Cell Line and Protein
Cell Line ID: CL000305 , RERF-LC-A1
Synonyms
RERF-LC-AI
RERF-LCAI
RERFLCAI
AOI
Radiation Effects Research Foundation-Lung Cancer-AI
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_4402
Protein ID: PT01348 , Dual specificity protein kinase TTK
Gene Name TTK
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P33981
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000305  Protein ID: PT01348
 
Compound ID Compound Name Compound Formula
CP0171137
N-cyclopropyl-4-[6-(2-hydroxyphenoxy)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide
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C28H29N5O4
 1
1
IC50 = 0.3 nM
   TI
   LI
   LO
   TS
CP0302610
N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-[(1,1,1-trifluoro-2-methylpropan-2-yl)amino]imidazo[1,2-b]pyridazin-3-yl]benzamide
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C26H31F3N6O2
 1
1
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0351982
4-[6-(2-amino-4-cyanophenyl)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide
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C29H29N7O2
 1
1
IC50 = 1.3 nM
   TI
   LI
   LO
   TS
CP0257237
4-[6-(tert-butylamino)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide
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C26H34N6O2
 1
1
IC50 = 3.2 nM
   TI
   LI
   LO
   TS
CP0516727
N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-phenoxyimidazo[1,2-b]pyridazin-3-yl]benzamide
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C28H29N5O3
 1
1
IC50 = 3.6 nM
   TI
   LI
   LO
   TS
CP0302606
N-cyclopropyl-4-[6-(2-fluorophenoxy)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide
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C28H28FN5O3
 1
1
IC50 = 3.7 nM
   TI
   LI
   LO
   TS
CP0560923
4-[6-(cyclopentylamino)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide
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C27H34N6O2
 1
1
IC50 = 4.2 nM
   TI
   LI
   LO
   TS
CP0556288
4-[6-(cyclohexylamino)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide
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C28H36N6O2
 1
1
IC50 = 5.6 nM
   TI
   LI
   LO
   TS
CP0441691
N-cyclopropyl-4-[6-(4-fluorophenoxy)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide
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C28H28FN5O3
 1
1
IC50 = 7.8 nM
   TI
   LI
   LO
   TS
CP0171139
N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-(propan-2-ylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide
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C25H32N6O2
 1
1
IC50 = 8.4 nM
   TI
   LI
   LO
   TS
CP0257236
4-[6-(4-cyanophenyl)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide
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C29H28N6O2
 1
1
IC50 = 9.6 nM
   TI
   LI
   LO
   TS
CP0366329
4-[6-(4-cyanophenyl)-8-(oxan-4-ylmethylamino)imidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide
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C29H28N6O2
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0192284
4-[6-anilino-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide
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C28H30N6O2
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0539578
4-[6-cyclohexyloxy-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamide
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C28H35N5O3
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0257235
N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]benzamide
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C28H29N5O2
 1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CP0321819
N-cyclopropyl-4-[8-(oxan-4-ylmethylamino)imidazo[1,2-a]pyrazin-3-yl]benzamide
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C22H25N5O2
 1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS