Brief Information of the Cell Line and Protein
Cell Line ID: CL000013 , Sf9
Synonyms
SF9
sf9
SF-9
Sf-9
sf-9
Sf 9
Spodoptera frugiperda clone 9
Sf clone 9
IPLB-Sf-9AE
IPLB-SF-9AE
IPLB-SF-9
IPLB-Sf-9
IPLB-Sf9
Category Spontaneously immortalized cell line
Organism
Spodoptera frugiperda (Fall armyworm)
Cellosaurus ID
CVCL_0549
Protein ID: PT01176 , cGMP-specific 3',5'-cyclic phosphodiesterase
Gene Name PDE5A
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID O76074
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000013  Protein ID: PT01176
 
Compound ID Compound Name Compound Formula
CP0391810
(3S)-3-(5-ethylfuran-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C26H21N5O2
 1
1
IC50 = 0.39 nM
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CP0385171
3-[1-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperidin-4-yl]-N-hydroxypropanamide
   Show/Hide
C25H34N6O6S
 1
1
IC50 = 0.5 nM
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CP0411277
(3S)-3-(5-ethylthiophen-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C26H21N5OS
 1
1
IC50 = 0.52 nM
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CP0175962
3-(5-ethylfuran-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C26H21N5O2
 1
1
IC50 = 0.54 nM
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CP0554231
(2S)-1-acetyl-N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]pyrrolidine-2-carboxamide
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C24H32N4O4
 1
1
IC50 = 0.54 nM
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CP0001244
2-[4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylamino]piperidin-1-yl]-N-hydroxypyrimidine-5-carboxamide
   Show/Hide
C27H33N9O6S
 1
1
IC50 = 0.6 nM
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CP0117113
3-(5-ethylthiophen-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C26H21N5OS
 1
1
IC50 = 0.6 nM
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CP0411255
3-(5-ethylthiophen-2-yl)-2-(5-pyridin-3-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C26H21N5OS
 1
1
IC50 = 0.6 nM
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CP0384486
N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]-2-(4-methylpiperazin-1-yl)acetamide
   Show/Hide
C24H35N5O3
 1
1
IC50 = 0.62 nM
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CP0481859
3-(5-ethylthiophen-2-yl)-2-(5-pyridin-4-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C26H21N5OS
 1
1
IC50 = 0.67 nM
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CP0573024
N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]-1-methylpiperidine-4-carboxamide
   Show/Hide
C24H34N4O3
 1
1
IC50 = 0.79 nM
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CP0521666
3-(5-ethylthiophen-2-yl)-2-[5-(2-fluoropyridin-3-yl)pyrimidin-2-yl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C26H20FN5OS
 1
1
IC50 = 0.82 nM
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CP0565241
N'-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]oxamide
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C19H24N4O4
 1
1
IC50 = 0.83 nM
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CP0565240
4-acetamido-N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]butanamide
   Show/Hide
C23H32N4O4
 1
1
IC50 = 0.92 nM
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CP0383136
(3R)-3-(5-ethylfuran-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C26H21N5O2
 1
1
IC50 = 0.97 nM
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CP0455981
(E)-3-[4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylamino]phenyl]-N-hydroxyprop-2-enamide
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C26H28N6O6S
 1
1
IC50 = 1 nM
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CP0427674
4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxybenzamide
   Show/Hide
C24H25N5O4
 1
1
IC50 = 1 nM
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CP0365459
[4-[5-tert-butyl-3-(3,5-difluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C26H32F2N4O2
 1
1
IC50 = 1 nM
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CP0550150
3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-N-(2-hydroxyethyl)-N-(2-morpholin-4-ylethyl)-4-propoxybenzenesulfonamide
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C25H38N4O6S
 1
1
IC50 = 1.01 nM
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CP0577103
3-(5-ethylthiophen-2-yl)-2-(5-pyridin-2-ylpyridin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C27H22N4OS
 1
1
IC50 = 1.2 nM
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CP0562310
N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]propanamide
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C20H27N3O3
 1
1
IC50 = 1.21 nM
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CP0574705
N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]methanesulfonamide
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C18H25N3O4S
 1
1
IC50 = 1.23 nM
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CP0547128
2-[5-(3,4-dimethoxyphenyl)pyrimidin-2-yl]-3-(5-ethylthiophen-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C29H26N4O3S
 1
1
IC50 = 1.25 nM
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CP0554124
N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]-2-piperidin-1-ylacetamide
   Show/Hide
C24H34N4O3
 1
1
IC50 = 1.46 nM
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CP0116540
4-ethoxy-N-(6-hydroxyhexyl)-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
   Show/Hide
C23H33N5O5S
 1
1
IC50 = 1.5 nM
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CP0550152
N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]-2-(4-methylpiperazin-1-yl)-2-oxoacetamide
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C24H33N5O4
 1
1
IC50 = 1.55 nM
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CP0487967
4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-(2-morpholin-4-ylethyl)benzenesulfonamide
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C23H32N6O5S
 1
1
IC50 = 1.6 nM
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CP0086283
4,5-diethyl-2-[5-(4-methylpiperazin-1-yl)sulfonyl-2-propoxyphenyl]-1H-pyrimidin-6-one
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C22H32N4O4S
 1
1
IC50 = 1.6 nM
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CP0574704
[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]urea
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C18H24N4O3
 1
1
IC50 = 1.61 nM
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CP0550151
3-[[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]sulfonylamino]propanoic acid
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C20H27N3O6S
 1
1
IC50 = 1.69 nM
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CP0544248
4-ethoxy-N-(5-hydroxypentyl)-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
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C22H31N5O5S
 1
1
IC50 = 1.7 nM
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CP0492207
N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]pyrrolidine-1-carboxamide
   Show/Hide
C22H30N4O3
 1
1
IC50 = 1.86 nM
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CP0387032
4-ethoxy-N-(4-hydroxybutyl)-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
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C21H29N5O5S
 1
1
IC50 = 1.9 nM
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CP0395676
(E)-3-[4-[[4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperazin-1-yl]methyl]phenyl]-N-hydroxyprop-2-enamide
   Show/Hide
C31H37N7O6S
 1
1
IC50 = 2 nM
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CP0470875
4-[4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperazin-1-yl]-N-hydroxybutanamide
   Show/Hide
C25H35N7O6S
 1
1
IC50 = 2 nM
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CP0411311
4-[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-2-yl)phenyl]-N-hydroxybenzamide
   Show/Hide
C24H25N5O4
 1
1
IC50 = 2 nM
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CP0427293
4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)anilino]-N-hydroxybenzamide
   Show/Hide
C24H26N6O4
 1
1
IC50 = 2 nM
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CP0572696
(2S)-1-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]sulfonylpyrrolidine-2-carboxylic acid
   Show/Hide
C22H29N3O6S
 1
1
IC50 = 2.02 nM
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CP0000847
(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione
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C22H19N3O4
 2
1
IC50 = 2.35 nM
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2
IC50 = 4.67 nM
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CP0457227
3-(5-ethylthiophen-2-yl)-2-pyrimidin-2-yl-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C21H18N4OS
 1
1
IC50 = 2.5 nM
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CP0432323
4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-(3-morpholin-4-ylpropyl)benzenesulfonamide
   Show/Hide
C24H34N6O5S
 1
1
IC50 = 2.6 nM
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CP0402412
3-(5-ethylthiophen-2-yl)-2-pyridin-2-yl-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
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C22H19N3OS
 1
1
IC50 = 2.85 nM
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CP0257911
(10S,15S)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O3
 1
1
IC50 = 2.92 nM
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CP0002022
2-[4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperazin-1-yl]-N-hydroxypyrimidine-5-carboxamide
   Show/Hide
C26H31N9O6S
 1
1
IC50 = 3 nM
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CP0470869
3-[4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperazin-1-yl]-N-hydroxypropanamide
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C24H33N7O6S
 1
1
IC50 = 3 nM
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CP0012955
5-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxyfuran-2-carboxamide
   Show/Hide
C23H25N5O5
 1
1
IC50 = 3 nM
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CP0201347
5-[[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-2-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamide
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C23H25N5O4S
 1
1
IC50 = 3 nM
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CP0456041
5-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzoyl]-N-hydroxythiophene-2-carboxamide
   Show/Hide
C23H23N5O5S
 1
1
IC50 = 3 nM
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CP0010658
5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
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C22H30N6O4S
 5
1
IC50 = 3 nM
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2
IC50 = 3.65 nM
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3
IC50 = 4 nM
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4
IC50 = 4.31 nM
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5
IC50 = 5.6 nM
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CP0383137
3-(5-ethylfuran-2-yl)-2-pyrimidin-2-yl-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C21H18N4O2
 1
1
IC50 = 3.14 nM
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CP0564229
2-(5-bromopyrimidin-2-yl)-3-(5-ethylthiophen-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
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C21H17BrN4OS
 1
1
IC50 = 3.28 nM
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CP0451865
4-ethoxy-N-[(3-fluoro-4-methoxyphenyl)methyl]-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
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C25H28FN5O5S
 1
1
IC50 = 3.3 nM
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CP0432322
4-ethoxy-N-(3-hydroxypropyl)-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
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C20H27N5O5S
 1
1
IC50 = 3.4 nM
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CP0268684
(2S,8R)-2-(5-ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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C21H21N3O2S
 1
1
IC50 = 3.87 nM
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CP0413523
4-ethoxy-N-heptyl-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
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C24H35N5O4S
 1
1
IC50 = 3.9 nM
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CP0385176
6-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxypyridine-3-carboxamide
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C22H22N6O4
 1
1
IC50 = 4 nM
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CP0446576
5-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxypyridine-2-carboxamide
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C22H22N6O4
 1
1
IC50 = 4 nM
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CP0419693
[4-[5-tert-butyl-3-(2,3-difluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
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C26H32F2N4O2
 1
1
IC50 = 4 nM
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CP0001245
2-[4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)anilino]piperidin-1-yl]-N-hydroxypyrimidine-5-carboxamide
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C27H33N9O4
 1
1
IC50 = 5 nM
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CP0385170
5-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxyfuran-2-carboxamide
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C21H21N5O5
 1
1
IC50 = 5 nM
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CP0385173
4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-hydroxybenzamide
   Show/Hide
C17H19N5O4
 1
1
IC50 = 5 nM
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CP0157969
(10S,15S)-13-ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C21H21N3O2S
 1
1
IC50 = 5.24 nM
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CP0417057
2-(5-amino-2-propoxyphenyl)-4,5-diethyl-1H-pyrimidin-6-one
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C17H23N3O2
 1
1
IC50 = 5.33 nM
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CP0478556
3-(5-ethylthiophen-2-yl)-2-[5-(4-methoxyphenyl)pyrimidin-2-yl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
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C28H24N4O2S
 1
1
IC50 = 6.45 nM
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CP0010249
2-[4-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]piperidin-1-yl]-N-hydroxypyrimidine-5-carboxamide
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C27H32N8O4
 1
1
IC50 = 7 nM
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   TS
CP0395674
2-[4-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]piperazin-1-yl]-N-hydroxypyrimidine-5-carboxamide
   Show/Hide
C26H31N9O4
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0410225
5-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxythiophene-2-carboxamide
   Show/Hide
C22H23N5O4S
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0164472
(10S,15R)-13-ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C21H21N3O2S
 1
1
IC50 = 7.02 nM
   TI
   LI
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   TS
CP0109248
(2S,8R)-2-(5-bromothiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
   Show/Hide
C19H16BrN3O2S
 1
1
IC50 = 7.2 nM
   TI
   LI
   LO
   TS
CP0168902
(10S,15R)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C21H21N3O3
 1
1
IC50 = 8.44 nM
   TI
   LI
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   TS
CP0109250
(2S,8R)-6-methyl-2-(5-methylthiophen-2-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
   Show/Hide
C20H19N3O2S
 1
1
IC50 = 8.68 nM
   TI
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   LO
   TS
CP0014421
2-[4-[4-ethoxy-N-methyl-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)anilino]piperidin-1-yl]-N-hydroxypyrimidine-5-carboxamide
   Show/Hide
C28H35N9O4
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0385143
2-[4-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenoxy]piperidin-1-yl]-N-hydroxypyrimidine-5-carboxamide
   Show/Hide
C26H30N8O5
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0396658
2-[4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]phenyl]-N-hydroxyacetamide
   Show/Hide
C25H27N5O4
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0489847
4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-hydroxymethyl]-N-hydroxybenzamide
   Show/Hide
C25H27N5O5
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0157968
(10S,15S)-13-ethyl-10-(5-methylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C20H19N3O3
 1
1
IC50 = 10.5 nM
   TI
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   LO
   TS
CP0463887
4-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenoxy]-N-hydroxycyclohexane-1-carboxamide
   Show/Hide
C23H29N5O5
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0012519
5-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamide
   Show/Hide
C23H25N5O4S
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0494592
4-ethoxy-N-hexyl-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
   Show/Hide
C23H33N5O4S
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0458109
8-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxy-8-azaspiro[4.5]decane-3-carboxamide
   Show/Hide
C27H36N6O4
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0144390
(2S,8R)-2-(5-ethylfuran-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
   Show/Hide
C21H21N3O3
 1
1
IC50 = 12.7 nM
   TI
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   LO
   TS
CP0494593
4-ethoxy-N-[2-(1H-indol-3-yl)ethyl]-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
   Show/Hide
C27H30N6O4S
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0003596
3-[4-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]phenyl]-N-hydroxypropanamide
   Show/Hide
C26H29N5O4
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0458111
4-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclohexane-1-carboxamide
   Show/Hide
C24H31N5O4
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0410227
4-[[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-2-yl)phenyl]methyl]-N-hydroxybenzamide
   Show/Hide
C25H27N5O4
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0478310
N-[3-(dimethylamino)propyl]-4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
   Show/Hide
C22H32N6O4S
 1
1
IC50 = 14 nM
   TI
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   LO
   TS
CP0526726
2-[4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]cyclohex-3-en-1-yl]-N-hydroxyacetamide
   Show/Hide
C25H31N5O4
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0003091
2-[4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]phenyl]-N-hydroxyacetamide
   Show/Hide
C26H29N5O4
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0522209
4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-(2-piperidin-1-ylethyl)benzenesulfonamide
   Show/Hide
C24H34N6O4S
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0385177
2-[4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)anilino]methyl]piperidin-1-yl]-N-hydroxypyrimidine-5-carboxamide
   Show/Hide
C28H35N9O4
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0395683
3-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxycyclobutane-1-carboxamide
   Show/Hide
C21H25N5O4
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0525405
2-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxyacetamide
   Show/Hide
C18H21N5O4
 1
1
IC50 = 19 nM
   TI
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   LO
   TS
CP0392491
(2R,8S)-2-(5-ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
   Show/Hide
C21H21N3O2S
 1
1
IC50 = 19.9 nM
   TI
   LI
   LO
   TS
CP0458110
4-[4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)anilino]piperidin-1-yl]-N-hydroxybenzamide
   Show/Hide
C29H35N7O4
 1
1
IC50 = 20 nM
   TI
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   LO
   TS
CP0463889
2-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxycyclopropane-1-carboxamide
   Show/Hide
C20H23N5O4
 1
1
IC50 = 20 nM
   TI
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   LO
   TS
CP0410220
4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-methoxymethyl]-N-hydroxybenzamide
   Show/Hide
C26H29N5O5
 1
1
IC50 = 20 nM
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CP0444322
[4-[5-tert-butyl-3-(3-fluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C26H33FN4O2
 1
1
IC50 = 20 nM
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CP0444327
[4-[3-(4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C29H32N4O2
 1
1
IC50 = 21 nM
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CP0440103
(10S,15S)-13-ethyl-10-(3-methylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C20H19N3O2S
 1
1
IC50 = 21.4 nM
   TI
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   LO
   TS
CP0419618
4-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclohexane-1-carboxamide
   Show/Hide
C24H31N5O4
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0458112
4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)anilino]-N-hydroxycyclohexane-1-carboxamide
   Show/Hide
C24H32N6O4
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0419590
4-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenoxy]-N-hydroxybenzamide
   Show/Hide
C23H23N5O5
 1
1
IC50 = 23 nM
   TI
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CP0470868
3-[1-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]piperidin-4-yl]-N-hydroxypropanamide
   Show/Hide
C25H34N6O4
 1
1
IC50 = 24 nM
   TI
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   TS
CP0411276
(3R)-3-(5-ethylthiophen-2-yl)-2-(5-pyridin-2-ylpyrimidin-2-yl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
   Show/Hide
C26H21N5OS
 1
1
IC50 = 26.9 nM
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   TS
CP0413950
4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxycyclohex-3-ene-1-carboxamide
   Show/Hide
C24H29N5O4
 1
1
IC50 = 27 nM
   TI
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   TS
CP0392075
(10R,15R)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C21H21N3O3
 1
1
IC50 = 27.6 nM
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CP0552628
[4-[3-(4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-morpholin-4-ylmethanone
   Show/Hide
C28H29N3O3
 1
1
IC50 = 29 nM
   TI
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   TS
CP0392073
(10S,15S)-13-butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C23H25N3O2S
 1
1
IC50 = 30.3 nM
   TI
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   TS
CP0409165
4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-2-fluoro-N-hydroxybenzamide
   Show/Hide
C25H26FN5O4
 1
1
IC50 = 31 nM
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   TS
CP0413612
N-[2-(diethylamino)ethyl]-4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
   Show/Hide
C23H34N6O4S
 1
1
IC50 = 32 nM
   TI
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CP0007842
CHEMBL3955253
   Show/Hide
C22H27N5O4
 1
1
IC50 = 34 nM
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CP0413948
1-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxypiperidine-4-carboxamide
   Show/Hide
C23H30N6O4
 1
1
IC50 = 36 nM
   TI
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   LO
   TS
CP0432292
(10S,15R)-13-butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C23H25N3O2S
 1
1
IC50 = 36.4 nM
   TI
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   TS
CP0438008
(2S,8R)-6-methyl-2-(5-methylfuran-2-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
   Show/Hide
C20H19N3O3
 1
1
IC50 = 36.9 nM
   TI
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   TS
CP0419620
2-[4-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]cyclohexyl]-N-hydroxyacetamide
   Show/Hide
C25H33N5O4
 1
1
IC50 = 38 nM
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   LO
   TS
CP0458113
2-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclopropane-1-carboxamide
   Show/Hide
C21H25N5O4
 1
1
IC50 = 39 nM
   TI
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   LO
   TS
CP0392076
2-[5-(3,4-dimethoxyphenyl)pyrimidin-2-yl]-1-(5-ethylthiophen-2-yl)-3,9-dihydro-1H-pyrido[3,4-b]indol-4-one
   Show/Hide
C29H26N4O3S
 1
1
IC50 = 39.7 nM
   TI
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   LO
   TS
CP0385172
2-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxy-2-azaspiro[5.5]undecane-9-carboxamide
   Show/Hide
C28H38N6O4
 1
1
IC50 = 40 nM
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   TS
CP0176508
[4-[3-(3-fluoro-4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C29H31FN4O2
 1
1
IC50 = 40 nM
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   LO
   TS
CP0458108
3-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)anilino]-N-hydroxypropanamide
   Show/Hide
C20H26N6O4
 1
1
IC50 = 44 nM
   TI
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   LO
   TS
CP0014935
3-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclobutane-1-carboxamide
   Show/Hide
C22H27N5O4
 1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CP0385174
3-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxypropanamide
   Show/Hide
C19H23N5O4
 1
1
IC50 = 46 nM
   TI
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   LO
   TS
CP0411310
4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxy-3-methoxybenzamide
   Show/Hide
C26H29N5O5
 1
1
IC50 = 47 nM
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   TS
CP0003090
4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxybenzamide
   Show/Hide
C25H27N5O4
 1
1
IC50 = 48 nM
   TI
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   LO
   TS
CP0536709
(2S,8R)-6-methyl-2-(3-methylthiophen-2-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
   Show/Hide
C20H19N3O2S
 1
1
IC50 = 50.2 nM
   TI
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   LO
   TS
CP0438006
2-[5-(3,4-dimethoxyphenyl)pyrimidin-2-yl]-1-(5-ethylfuran-2-yl)-3,9-dihydro-1H-pyrido[3,4-b]indol-4-one
   Show/Hide
C29H26N4O4
 1
1
IC50 = 52.5 nM
   TI
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   TS
CP0456039
4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxycyclohexane-1-carboxamide
   Show/Hide
C24H31N5O4
 1
1
IC50 = 53 nM
   TI
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   LO
   TS
CP0552851
(2R,8S)-2-(5-ethylfuran-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
   Show/Hide
C21H21N3O3
 1
1
IC50 = 56.4 nM
   TI
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   LO
   TS
CP0385169
6-[4-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]piperidin-1-yl]-N-hydroxypyridine-3-carboxamide
   Show/Hide
C28H33N7O4
 1
1
IC50 = 57 nM
   TI
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   LO
   TS
CP0385179
3-[4-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]piperidin-1-yl]-N-hydroxypropanamide
   Show/Hide
C25H34N6O4
 1
1
IC50 = 57 nM
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   LO
   TS
CP0007669
3-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclobutane-1-carboxamide
   Show/Hide
C22H27N5O4
 1
1
IC50 = 60 nM
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   TS
CP0570813
4-[5-tert-butyl-3-(2,3-difluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C21H22F2N2O3
 1
1
IC50 = 60 nM
   TI
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CP0518130
(2S,8S)-2-(5-ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
   Show/Hide
C21H21N3O2S
 1
1
IC50 = 61 nM
   TI
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CP0385168
2-[1-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]piperidin-4-yl]-N-hydroxyacetamide
   Show/Hide
C24H32N6O4
 1
1
IC50 = 65 nM
   TI
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CP0395675
2-[4-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]cyclohexyl]-N-hydroxyacetamide
   Show/Hide
C24H31N5O4
 1
1
IC50 = 70 nM
   TI
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CP0385178
2-[2-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-N-hydroxypyrimidine-5-carboxamide
   Show/Hide
C30H37N9O4
 1
1
IC50 = 74 nM
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CP0567915
[4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C28H30N4O2
 1
1
IC50 = 78 nM
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CP0410221
4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenoxy]methyl]-N-hydroxybenzamide
   Show/Hide
C25H27N5O5
 1
1
IC50 = 79 nM
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CP0392070
(2S,8R)-2-(3-bromothiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
   Show/Hide
C19H16BrN3O2S
 1
1
IC50 = 80.2 nM
   TI
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CP0421420
(10R,15S)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C21H21N3O3
 1
1
IC50 = 81.2 nM
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CP0491958
4-[5-tert-butyl-3-(3,5-difluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C21H22F2N2O3
 1
1
IC50 = 90 nM
   TI
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CP0571576
[4-[5-tert-butyl-3-(4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C26H34N4O2
 1
1
IC50 = 90 nM
   TI
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CP0476757
(2R,8R)-6-methyl-2-(3-methylthiophen-2-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
   Show/Hide
C20H19N3O2S
 1
1
IC50 = 97.5 nM
   TI
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CP0385175
4-[4-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]piperidin-1-yl]-N-hydroxybenzamide
   Show/Hide
C29H34N6O4
 1
1
IC50 = 121 nM
   TI
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CP0470874
(E)-3-[4-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]phenyl]-N-hydroxyprop-2-enamide
   Show/Hide
C26H27N5O4
 1
1
IC50 = 122 nM
   TI
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   TS
CP0419287
[4-[5-tert-butyl-3-(4-ethoxy-3,5-difluorophenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C27H34F2N4O2
 1
1
IC50 = 130 nM
   TI
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CP0570812
4-[3-(3-fluoro-4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C24H21FN2O3
 1
1
IC50 = 130 nM
   TI
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   TS
CP0477735
4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxy-2-methoxybenzamide
   Show/Hide
C26H29N5O5
 1
1
IC50 = 144 nM
   TI
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CP0489846
4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxycyclohexane-1-carboxamide
   Show/Hide
C24H31N5O4
 1
1
IC50 = 146 nM
   TI
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CP0411308
4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-3-fluoro-N-hydroxybenzamide
   Show/Hide
C25H26FN5O4
 1
1
IC50 = 149 nM
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CP0476758
(10R,15R)-13-ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C21H21N3O2S
 1
1
IC50 = 155 nM
   TI
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CP0385180
3-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxycyclopentane-1-carboxamide
   Show/Hide
C23H29N5O4
 1
1
IC50 = 165 nM
   TI
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CP0518019
2-[5-(3,4-dimethoxyphenyl)pyrimidin-2-yl]-1-(5-ethylfuran-2-yl)-1,3,4,9-tetrahydropyrido[3,4-b]indole
   Show/Hide
C29H28N4O3
 1
1
IC50 = 177 nM
   TI
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   TS
CP0489845
4-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]-N-hydroxycyclohexane-1-carboxamide
   Show/Hide
C24H31N5O4
 1
1
IC50 = 190 nM
   TI
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CP0539174
[4-[5-tert-butyl-3-(3-chloro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C26H33ClN4O2
 1
1
IC50 = 190 nM
   TI
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   TS
CP0570814
4-[5-tert-butyl-3-(4-ethoxy-3,5-difluorophenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C22H24F2N2O3
 1
1
IC50 = 200 nM
   TI
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   TS
CP0477630
1-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxypiperidine-4-carboxamide
   Show/Hide
C23H30N6O4
 1
1
IC50 = 207 nM
   TI
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   TS
CP0455748
N-ethyl-1-(5-ethylthiophen-2-yl)-9H-pyrido[3,4-b]indole-3-carboxamide
   Show/Hide
C20H19N3OS
 1
1
IC50 = 227 nM
   TI
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CP0392071
4-[(E)-3-[1-(5-ethylthiophen-2-yl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-3-oxoprop-1-enyl]benzoic acid
   Show/Hide
C27H24N2O3S
 1
1
IC50 = 235 nM
   TI
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   TS
CP0552627
[4-[5-tert-butyl-3-(2,5-difluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C26H32F2N4O2
 1
1
IC50 = 260 nM
   TI
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CP0552625
N-butyl-4-[3-(4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]benzamide
   Show/Hide
C28H31N3O2
 1
1
IC50 = 280 nM
   TI
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CP0385181
1-[[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxyazetidine-3-carboxamide
   Show/Hide
C21H26N6O4
 1
1
IC50 = 303 nM
   TI
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CP0570811
4-[5-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C23H20N2O4
 1
1
IC50 = 330 nM
   TI
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CP0419692
N-(2-hydroxyethyl)-4-[3-(4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]benzamide
   Show/Hide
C26H27N3O3
 1
1
IC50 = 340 nM
   TI
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   TS
CP0392486
(10R,15S)-13-ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
   Show/Hide
C21H21N3O2S
 1
1
IC50 = 383 nM
   TI
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CP0546442
N-butyl-4-[5-tert-butyl-3-(3-fluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzamide
   Show/Hide
C25H32FN3O2
 1
1
IC50 = 410 nM
   TI
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CP0570350
N-butyl-4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzamide
   Show/Hide
C27H29N3O2
 1
1
IC50 = 410 nM
   TI
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CP0551208
4-[3-(4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C24H22N2O3
 1
1
IC50 = 500 nM
   TI
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CP0569811
4-[5-tert-butyl-3-(3-fluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C21H23FN2O3
 1
1
IC50 = 590 nM
   TI
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CP0534061
N-ethyl-4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzamide
   Show/Hide
C25H25N3O2
 1
1
IC50 = 600 nM
   TI
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CP0491956
4-[5-tert-butyl-3-(3-chloro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C21H23ClN2O3
 1
1
IC50 = 900 nM
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CP0570349
4-[3-(4-methoxyphenyl)-3a,4-dihydro-3H-chromeno[4,3-c]pyrazol-2-yl]benzoic acid
   Show/Hide
C24H20N2O4
 1
1
IC50 = 1160 nM
   TI
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CP0552213
4-[3-(3-fluoro-4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C23H19FN2O3
 1
1
IC50 = 1190 nM
   TI
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CP0218821
4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C23H20N2O3
 1
1
IC50 = 1200 nM
   TI
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CP0444346
N-butyl-4-[5-tert-butyl-3-(4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzamide
   Show/Hide
C25H33N3O2
 1
1
IC50 = 1200 nM
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CP0576131
[4-[5-tert-butyl-3-(4-fluoro-3-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone
   Show/Hide
C26H33FN4O2
 1
1
IC50 = 1290 nM
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CP0570815
4-[3-(4-methoxyphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl]benzoic acid
   Show/Hide
C24H20N2O3
 1
1
IC50 = 1440 nM
   TI
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CP0570347
4-[3-(4-methoxyphenyl)-5-(3-methylphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C24H22N2O3
 1
1
IC50 = 1560 nM
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CP0053897
US9388139, 9
   Show/Hide
C24H22N2O4
 1
1
IC50 = 1800 nM
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CP0340455
US9388139, 1
   Show/Hide
C21H24N2O3
 1
1
IC50 = 2000 nM
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CP0491954
4-[5-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C23H20N2O4
 1
1
IC50 = 2500 nM
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CP0177639
US9388139, 27
   Show/Hide
C23H19FN2O3
 1
1
IC50 = 3100 nM
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CP0250532
US9388139, 8
   Show/Hide
C24H22N2O4
 1
1
IC50 = 3200 nM
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CP0244231
US9388139, 10
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C25H24N2O5
 1
1
IC50 = 6900 nM
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CP0053899
US9388139, 23
   Show/Hide
C21H24N2O2
 1
1
IC50 = 8400 nM
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CP0414199
4-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
   Show/Hide
C21H20ClN5O
 1
1
IC50 > 10000 nM
   TI
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   TS
CP0090153
4-[[1-(5-butoxypyridin-3-yl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
   Show/Hide
C24H28N6O2
 1
1
IC50 > 10000 nM
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CP0147040
US11419874, Example 28
   Show/Hide
C15H10ClN5
 1
1
IC50 > 10000 nM
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CP0552499
4-[5-tert-butyl-3-(2,5-difluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C21H22F2N2O3
 1
1
IC50 = 10000 nM
   TI
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   TS
CP0570019
4-[5-tert-butyl-3-[4-(trifluoromethoxy)phenyl]-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C21H21F3N2O3
 1
1
IC50 = 10000 nM
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   TS
CP0570348
4-[5-tert-butyl-3-(4-fluoro-3-methoxyphenyl)-3,4-dihydropyrazol-2-yl]benzoic acid
   Show/Hide
C21H23FN2O3
 1
1
IC50 = 10080 nM
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CP0013428
N-[(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide
   Show/Hide
C19H18F4N4O5
 1
1
IC50 > 30000 nM
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CP0011191
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide
   Show/Hide
C17H14F3N3O2S
 1
1
IC50 = 37000 nM
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