Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione
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 PubChem ID
CID: 110635
SID: 14756405
Canonical SMILES
CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
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Compound Formula C22H19N3O4
Compound Structure
Protein Name
 Protein Info 
cGMP-specific 3',5'-cyclic phosphodiesterase
Protein Classification
Enzyme
>
Phosphodiesterase
>
Phosphodiesterase 5
>
Phosphodiesterase 5A
Uniprot ID
O76074
Gene Name
PDE5A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 5810 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 2.35 nM
   TI
   LI
   LO
   TS
2
IC50 = 4.67 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.2 nM
2 IC50 = 3 nM
3 IC50 = 3.162 nM
4 IC50 = 4 nM
5 IC50 = 5 nM
6 IC50 = 5.012 nM
7 IC50 = 6.7 nM
8 IC50 = 9.4 nM
9 Ki = 5.2 nM
10 Ki = 10 nM