Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
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 PubChem ID
CID: 135398744
SID: 14883184
Canonical SMILES
CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
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Compound Formula C22H30N6O4S
Compound Structure
Protein Name
 Protein Info 
cGMP-specific 3',5'-cyclic phosphodiesterase
Protein Classification
Enzyme
>
Phosphodiesterase
>
Phosphodiesterase 5
>
Phosphodiesterase 5A
Uniprot ID
O76074
Gene Name
PDE5A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
IC50 = 75 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  5
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
2
IC50 = 3.65 nM
   TI
   LI
   LO
   TS
3
IC50 = 4 nM
   TI
   LI
   LO
   TS
4
IC50 = 4.31 nM
   TI
   LI
   LO
   TS
5
IC50 = 5.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.4 nM
2 IC50 = 1.6 nM
3 IC50 = 2.2 nM
4 IC50 = 3 nM
5 IC50 = 3.5 nM
6 IC50 = 3.9 nM
7 IC50 = 3.981 nM
8 IC50 = 5.22 nM
9 IC50 = 5.6 nM
10 IC50 = 6.6 nM
11 IC50 = 8.5 nM
12 IC50 = 20 nM
13 IC50 = 12590 nM
14 Ki = 1.6 nM
15 Ki = 1.87 nM
16 Ki = 1.91 nM
17 Ki = 10 nM