| Compound ID |
Compound Name |
Compound Formula |
|
CP0274741
|
2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-5-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-ylamino)ethanol
Show/Hide
|
C28H25ClN6O2
|
1
|
| 1 |
EC50 = 190 nM
|
|
|
|
CP0240340
|
2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-5-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-yloxy)ethanol
Show/Hide
|
C28H24ClN5O3
|
1
|
| 1 |
EC50 = 440 nM
|
|
|
|
CP0075443
|
6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C27H28ClN3O
|
1
|
| 1 |
EC50 = 2100 nM
|
|
|
|
CP0315887
|
6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-5-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C26H20ClN5O
|
1
|
| 1 |
EC50 = 2200 nM
|
|
|
|
CP0294456
|
2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-ylamino)ethanol
Show/Hide
|
C29H33ClN4O2
|
1
|
| 1 |
EC50 = 3200 nM
|
|
|
|
CP0128706
|
6-((2-(2-chlorophenyl)-5-(4-(pyridin-4-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C27H21ClN4O
|
1
|
| 1 |
EC50 = 4800 nM
|
|
|
|
CP0316186
|
4-[1-[(6-aminopyridin-2-yl)methyl]-5-phenylpyrrol-2-yl]-N-prop-2-enylbenzamide
Show/Hide
|
C26H24N4O
|
1
|
| 1 |
EC50 = 4800 nM
|
|
|
|
CP0228587
|
4-(4-(1-((6-aminopyridin-2-yl)methyl)-5-(2-chlorophenyl)-1H-pyrrol-2-yl)phenoxy)butanenitrile
Show/Hide
|
C26H23ClN4O
|
1
|
| 1 |
EC50 = 5200 nM
|
|
|
|
CP0294457
|
N-[4-[1-[(6-aminopyridin-2-yl)methyl]-5-(2-chlorophenyl)pyrrol-2-yl]phenyl]pyrimidin-5-amine
Show/Hide
|
C26H21ClN6
|
1
|
| 1 |
EC50 = 8600 nM
|
|
|
|
CP0330890
|
6-((2-(2-chlorophenyl)-5-(4-phenoxyphenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C28H22ClN3O
|
1
|
| 1 |
EC50 = 9200 nM
|
|
|
|
CP0293106
|
6-((2-(2-chlorophenyl)-5-(4-(thiophen-2-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C26H20ClN3OS
|
1
|
| 1 |
EC50 = 11800 nM
|
|
|
|
CP0228588
|
6-((2-(2-chlorophenyl)-5-(4-(pyrazin-2-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C26H20ClN5O
|
1
|
| 1 |
EC50 = 13300 nM
|
|
|
|
CP0046914
|
2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-yloxy)ethanol
Show/Hide
|
C29H32ClN3O3
|
1
|
| 1 |
EC50 = 13600 nM
|
|
|
|
CP0075448
|
6-((2,5-diphenyl-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C22H19N3
|
1
|
| 1 |
EC50 = 15400 nM
|
|
|
|
CP0150366
|
6-((2-(2-chlorophenyl)-5-(4-methoxyphenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C23H20ClN3O
|
1
|
| 1 |
EC50 = 16000 nM
|
|
|
|
CP0363240
|
US10035794, Example 34
Show/Hide
|
C19H15ClF7N5O2
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
|
CP0551555
|
US10035794, Example 24
Show/Hide
|
C19H15ClF4N6O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0578738
|
US10035794, Example 11
Show/Hide
|
C20H18F4N6O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0097530
|
N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Show/Hide
|
C21H19F4N5O2
|
3
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
| 3 |
IC50 = 98 nM
|
|
|
|
CP0573822
|
US8846658, 60
Show/Hide
|
C17H16BrFN4O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0546281
|
N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-3-chloro-5-cyanopyridine-2-carboxamide
Show/Hide
|
C20H16ClF4N5O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0575026
|
3-amino-N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Show/Hide
|
C20H18F4N6O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0571971
|
N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]phenyl]-5-bromopyridine-2-carboxamide
Show/Hide
|
C17H17BrN4OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0576684
|
US10035794, Example 27
Show/Hide
|
C19H17F4N7O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0576602
|
US8846658, 71
Show/Hide
|
C18H16BrF4N5O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0562128
|
N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Show/Hide
|
C21H20F6N4O3
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0412094
|
US9163011, 1
Show/Hide
|
C18H15F3N6O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0483000
|
US9163011, 3
Show/Hide
|
C19H16ClF3N6O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0425572
|
US9163011, 2
Show/Hide
|
C17H12ClF3N6O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0546280
|
US8846658, 73
Show/Hide
|
C20H17F4N5O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0576605
|
N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-3-chloro-5-(difluoromethoxy)pyridine-2-carboxamide
Show/Hide
|
C20H17ClF6N4O3
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0579981
|
US10035794, Example 31
Show/Hide
|
C18H15Cl2F4N5O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0539980
|
US9163011, 9
Show/Hide
|
C16H12Cl2F3N5O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0423339
|
US9163011, 30
Show/Hide
|
C15H12ClF5N6O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0539982
|
US9163011, 35
Show/Hide
|
C17H13F3N6O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0327522
|
US8846658, 3
Show/Hide
|
C17H17BrN4O2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0576512
|
N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxy-3-methylpyridine-2-carboxamide
Show/Hide
|
C21H22F4N4O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0572355
|
US9163011, 32
Show/Hide
|
C19H15ClF3N5O3
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0568763
|
N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-3,5-dichloropyridine-2-carboxamide
Show/Hide
|
C19H16Cl2F4N4O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0572962
|
US8846658, 68
Show/Hide
|
C19H17BrF4N4O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0575199
|
3-amino-N-[6-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-5-fluoropyridin-2-yl]-5-(2-methoxyethoxy)pyrazine-2-carboxamide
Show/Hide
|
C20H23F4N7O4
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0571331
|
US10035794, Example 30
Show/Hide
|
C19H16ClF6N5O3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0576604
|
US8846658, 70
Show/Hide
|
C19H16F4N6O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0571908
|
US10035794, Example 44
Show/Hide
|
C18H16F7N7O2
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0560025
|
US9163011, 7
Show/Hide
|
C17H12ClF6N5O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0443085
|
US9163011, 15
Show/Hide
|
C16H15F4N7O3
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0546848
|
3-amino-N-[6-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-5-fluoropyridin-2-yl]-5-(trifluoromethyl)pyridine-2-carboxamide
Show/Hide
|
C19H17F7N6O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0359953
|
US8846658, 66
Show/Hide
|
C19H18BrF3N4O2
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0556156
|
US9163011, 19
Show/Hide
|
C16H14ClF3N6O2
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0515470
|
US9163011, 4
Show/Hide
|
C20H19F3N6O3
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0516264
|
US9163011, 26
Show/Hide
|
C17H14ClF4N5O3
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0516265
|
US9163011, 36
Show/Hide
|
C18H15ClF5N5O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0550223
|
US9163011, 22
Show/Hide
|
C16H14F5N7O2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0539981
|
US9163011, 17
Show/Hide
|
C19H17F3N6O3
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0478263
|
US9163011, 33
Show/Hide
|
C17H15F5N6O2
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0564860
|
US9163011, 29
Show/Hide
|
C18H20F3N7O3
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0560026
|
US9163011, 21
Show/Hide
|
C20H17ClF3N5O3
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0443084
|
US9163011, 13
Show/Hide
|
C18H18F3N5O3
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0525173
|
US9163011, 20
Show/Hide
|
C16H13ClF3N5O2
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0556155
|
US9163011, 18
Show/Hide
|
C16H14F4N6O2
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0579499
|
US10035794, Example 16
Show/Hide
|
C20H18F4N6O2
|
1
|
| 1 |
IC50 = 98 nM
|
|
|
|
CP0570523
|
N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyrazine-2-carboxamide
Show/Hide
|
C20H18F4N6O2
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
|
CP0546044
|
US9163011, 8
Show/Hide
|
C16H13F6N7O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0523902
|
US9163011, 31
Show/Hide
|
C15H14F3N7O2
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0570742
|
US9163011, 24
Show/Hide
|
C18H15ClF5N5O3
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0579982
|
3-amino-N-[6-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-5-fluoropyridin-2-yl]-5-(2-fluoroethoxy)pyrazine-2-carboxamide
Show/Hide
|
C19H20F5N7O3
|
1
|
| 1 |
IC50 = 263 nM
|
|
|
|
CP0571332
|
US10035794, Example 26
Show/Hide
|
C19H18F7N7O3
|
1
|
| 1 |
IC50 = 284 nM
|
|
|
|
CP0469975
|
US9163011, 37
Show/Hide
|
C17H16F5N7O2
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0516262
|
US9163011, 12
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|
C18H19F4N7O3
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0516261
|
US9163011, 6
Show/Hide
|
C19H16ClF6N5O3
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0566249
|
US9163011, 11
Show/Hide
|
C17H16F5N7O3
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0572354
|
US9163011, 27
Show/Hide
|
C18H17ClF3N5O3
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0516263
|
US9163011, 25
Show/Hide
|
C17H17F4N7O3
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0478262
|
US9163011, 14
Show/Hide
|
C20H19F3N6O3
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0483001
|
US9163011, 10
Show/Hide
|
C17H15F6N7O3
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0521286
|
US9163011, 28
Show/Hide
|
C17H18F3N7O3
|
1
|
| 1 |
IC50 = 840 nM
|
|
|
|
CP0546849
|
N-[3-[(3R,6S)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]phenyl]-5-bromopyridine-2-carboxamide
Show/Hide
|
C19H18BrF3N4O2
|
1
|
| 1 |
IC50 = 1160 nM
|
|
|
|
CP0522210
|
US9163011, 23
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|
C17H17ClF3N7O3
|
1
|
| 1 |
IC50 = 2900 nM
|
|
|
|
CP0519885
|
US9163011, 34
Show/Hide
|
C17H15ClF5N7O2
|
1
|
| 1 |
IC50 = 6500 nM
|
|
|
|
CP0425573
|
US9163011, 5
Show/Hide
|
C20H19F3N6O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
