| Compound ID |
Compound Name |
Compound Formula |
|
CP0158682
|
US8664236, A16
Show/Hide
|
C23H21ClN8O
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0074211
|
US8664236, A30
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|
C24H21N9
|
1
|
| 1 |
IC50 = 7.1 nM
|
|
|
|
CP0035637
|
1,1-Dimethylethyl{(3R,5R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}methylcarbamate
Show/Hide
|
C24H34N8O2
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 19 nM
|
|
|
|
CP0082116
|
Indolinone based compound, 7g
Show/Hide
|
C21H18N4O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0167512
|
Indolinone based compound, 7f
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|
C20H16N4O3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0438243
|
US8664236, A42
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|
C24H20FN7
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0281194
|
N-[(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-5-methylpiperidin-3-yl]-N,3,3-trimethylbutanamide
Show/Hide
|
C24H34N8O
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
IC50 = 116 nM
|
|
|
|
CP0314834
|
US8664236, A26
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|
C23H21FN8O
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0290173
|
(2S,5R)-4-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-5-methyl-2-morpholinecarboxamide
Show/Hide
|
C24H32N8O2
|
2
|
| 1 |
IC50 = 24 nM
|
|
|
| 2 |
IC50 = 30 nM
|
|
|
|
CP0438242
|
US8664236, A29
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|
C24H23ClN8O
|
1
|
| 1 |
IC50 = 25.5 nM
|
|
|
|
CP0174340
|
US8664236, A10
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|
C22H19ClN8
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0074210
|
US8664236, A9
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|
C22H19FN8
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0172227
|
US8664236, A25
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|
C23H20F2N8O
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0164512
|
(2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-5-ethyl-N-phenyl-2-morpholinecarboxamide
Show/Hide
|
C25H28N8O2
|
2
|
| 1 |
IC50 = 57 nM
|
|
|
| 2 |
IC50 = 88 nM
|
|
|
|
CP0207434
|
1,1-Dimethylethyl{(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate
Show/Hide
|
C22H30N8O2
|
2
|
| 1 |
IC50 = 74 nM
|
|
|
| 2 |
IC50 = 151 nM
|
|
|
|
CP0035635
|
(2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-5-ethyl-2-morpholinecarboxamide
Show/Hide
|
C25H34N8O2
|
2
|
| 1 |
IC50 = 85 nM
|
|
|
| 2 |
IC50 = 102 nM
|
|
|
|
CP0039182
|
BX-517
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|
C15H14N4O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0157673
|
3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)-N-[2-(dimethylamino)ethyl]benzamide
Show/Hide
|
C25H26N6O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0293292
|
Indolinone based compound, 7b
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|
C19H15N5O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0331584
|
US8664236, A3
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|
C24H21N7
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0170186
|
(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide
Show/Hide
|
C25H34N8O
|
2
|
| 1 |
IC50 = 113 nM
|
|
|
| 2 |
IC50 = 293 nM
|
|
|
|
CP0246240
|
US8664236, A13
Show/Hide
|
C23H21ClN8
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0074208
|
US8664236, A2
Show/Hide
|
C24H23N7
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0035650
|
(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide
Show/Hide
|
C25H28N8O
|
2
|
| 1 |
IC50 = 165 nM
|
|
|
| 2 |
IC50 = 655 nM
|
|
|
|
CP0074209
|
US8664236, A8
Show/Hide
|
C22H19ClN8
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0136907
|
US8664236, A4
Show/Hide
|
C23H22N8O
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0035658
|
(2S,5R)-4-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide
Show/Hide
|
C23H24N8O2
|
3
|
| 1 |
IC50 = 264 nM
|
|
|
| 2 |
IC50 = 594 nM
|
|
|
| 3 |
IC50 > 29300 nM
|
|
|
|
CP0220217
|
US8664236, A1
Show/Hide
|
C22H19FN8
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0217037
|
(3S,6R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide
Show/Hide
|
C24H32N8O
|
2
|
| 1 |
IC50 = 316 nM
|
|
|
| 2 |
IC50 = 472 nM
|
|
|
|
CP0222470
|
(3S,6R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide
Show/Hide
|
C24H26N8O
|
3
|
| 1 |
IC50 = 327 nM
|
|
|
| 2 |
IC50 = 333 nM
|
|
|
| 3 |
IC50 > 29300 nM
|
|
|
|
CP0158683
|
US8664236, A19
Show/Hide
|
C24H23ClN8
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0325023
|
US8664236, A43
Show/Hide
|
C26H27N9O
|
1
|
| 1 |
IC50 = 430 nM
|
|
|
|
CP0342881
|
US9238651, A24
Show/Hide
|
C25H23ClN8O
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0906206
|
US9238651, A55
Show/Hide
|
C25H25N7O
|
1
|
| 1 |
IC50 = 492 nM
|
|
|
|
CP0216812
|
US8664236, A21
Show/Hide
|
C25H26N8O2
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0158681
|
US8664236, A14
Show/Hide
|
C24H24N8
|
1
|
| 1 |
IC50 = 530 nM
|
|
|
|
CP0361572
|
US8664236, A6
Show/Hide
|
C26H25N7
|
1
|
| 1 |
IC50 = 625 nM
|
|
|
|
CP0272839
|
US8664236, A30a
Show/Hide
|
C22H18FN7
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0174341
|
US8664236, A12
Show/Hide
|
C23H22N8
|
1
|
| 1 |
IC50 = 690 nM
|
|
|
|
CP0268213
|
US8664236, A11
Show/Hide
|
C22H20N8
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
|
CP0062066
|
Indolinone based compound, 21
Show/Hide
|
C18H19N5O4
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0062068
|
Indolinone based compound, 16
Show/Hide
|
C22H20N6O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0082113
|
Indolinone based compound, 7k
Show/Hide
|
C22H19N5O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0157669
|
Indolinone based compound, 22
Show/Hide
|
C24H30N6O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0215668
|
Indolinone based compound, 14
Show/Hide
|
C18H19N5O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0341514
|
5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-N-[2-(piperidin-1-yl)ethyl]-1H-pyrrole-3-carboxamide
Show/Hide
|
C22H26N6O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0344382
|
3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)-N-[2-(piperidin-1-yl)ethyl]benzamide
Show/Hide
|
C28H30N6O3
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0562367
|
US8664236, A7
Show/Hide
|
C26H24ClN7
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0313350
|
US8664236, A15
Show/Hide
|
C25H25ClN8O
|
1
|
| 1 |
IC50 = 2100 nM
|
|
|
|
CP0031346
|
4-butyl-6-[5-(1-piperidin-4-ylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Show/Hide
|
C23H28N8
|
1
|
| 1 |
IC50 = 2300 nM
|
|
|
|
CP0039185
|
BX-201
Show/Hide
|
C14H12N4O2
|
1
|
| 1 |
IC50 = 3000 nM
|
|
|
|
CP0074981
|
4-ethyl-6-[5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Show/Hide
|
C16H15N7
|
1
|
| 1 |
IC50 = 5400 nM
|
|
|
|
CP0062687
|
US8664236, A5
Show/Hide
|
C25H26N8O3
|
1
|
| 1 |
IC50 = 6800 nM
|
|
|
|
CP0577898
|
US8664236, A31
Show/Hide
|
C24H25N9
|
1
|
| 1 |
IC50 = 6800 nM
|
|
|
|
CP0133052
|
4-ethyl-6-[5-[1-(2-methylpropyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Show/Hide
|
C20H23N7
|
1
|
| 1 |
IC50 = 9600 nM
|
|
|
|
CP0563778
|
US8664236, A28
Show/Hide
|
C27H28FN9O
|
1
|
| 1 |
IC50 = 9700 nM
|
|
|
|
CP0360224
|
3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)benzoic acid
Show/Hide
|
C21H16N4O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0370386
|
3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrol-3-yl)propanoic acid
Show/Hide
|
C19H20N4O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0360225
|
5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrole-3-carboxylic acid
Show/Hide
|
C15H12N4O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0004541
|
MERIOLIN 1
Show/Hide
|
C11H9N5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0023612
|
4-butyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
Show/Hide
|
C15H17N5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0119426
|
US8664236, A23
Show/Hide
|
C24H21ClN8O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0158684
|
US8664236, A20
Show/Hide
|
C19H18N10S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0244029
|
US8664236, A17
Show/Hide
|
C23H19FN8
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0300378
|
US8664236, A22
Show/Hide
|
C25H23N9O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0314833
|
US8664236, A18
Show/Hide
|
C25H23FN8
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0318508
|
US8664236, A27
Show/Hide
|
C23H20N8O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0191538
|
4-ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Show/Hide
|
C17H17N7
|
1
|
| 1 |
IC50 = 11000 nM
|
|
|
|
CP0023790
|
4-ethyl-6-[5-(1-piperidin-4-ylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Show/Hide
|
C21H24N8
|
1
|
| 1 |
IC50 = 13000 nM
|
|
|
|
CP0197716
|
4-[5-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-6-ethylpyrimidin-2-amine
Show/Hide
|
C20H24N8
|
1
|
| 1 |
IC50 = 14000 nM
|
|
|
|
CP0132928
|
4-[5-(6-aminopyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-6-ethylpyrimidin-2-amine
Show/Hide
|
C18H17N7
|
1
|
| 1 |
IC50 = 21000 nM
|
|
|
|
CP0313374
|
US8664236, A35
Show/Hide
|
C24H23N9O
|
1
|
| 1 |
IC50 = 23000 nM
|
|
|
|
CP0112814
|
4-ethyl-6-[5-(1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Show/Hide
|
C16H15N7
|
1
|
| 1 |
IC50 = 26000 nM
|
|
|
|
CP0191537
|
4-ethyl-6-[5-(furan-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Show/Hide
|
C17H15N5O
|
1
|
| 1 |
IC50 = 28000 nM
|
|
|
|
CP0273443
|
(3R,6S)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl)-6-methyl-N-phenylpiperidine-3-carboxamide
Show/Hide
|
C24H26N8O
|
1
|
| 1 |
IC50 > 29300 nM
|
|
|
|
CP0112815
|
4-ethyl-6-[5-(1,3,5-trimethylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Show/Hide
|
C19H21N7
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0132920
|
3-(6-ethylpyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C13H12N4
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0132921
|
4-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-6-ethylpyrimidin-2-amine
Show/Hide
|
C13H12BrN5
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0132922
|
4-ethyl-6-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
Show/Hide
|
C18H16N6
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0132924
|
4-ethyl-6-[5-(2-methylpyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Show/Hide
|
C17H17N7
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0191454
|
4-(4-aminobutyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
Show/Hide
|
C15H18N6
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0191535
|
4-ethyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
Show/Hide
|
C13H13N5
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0240521
|
4-(3-aminopropyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
Show/Hide
|
C14H16N6
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0283467
|
4-propyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
Show/Hide
|
C14H15N5
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0356163
|
4-ethyl-6-(5-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
Show/Hide
|
C18H16N6
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0534254
|
4-ethyl-6-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
Show/Hide
|
C19H17N5
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0544740
|
4-pentyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
Show/Hide
|
C16H19N5
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0346927
|
3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)benzamide
Show/Hide
|
C21H17N5O3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
