| Compound ID |
Compound Name |
Compound Formula |
|
CP0525758
|
5-cyano-N-(4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C24H31N5O3
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0528036
|
N-[4-(4-acetylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl]-4-cyano-1H-pyrrole-2-carboxamide
Show/Hide
|
C24H30N6O2
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0528074
|
5-cyano-furan-2-carboxylic acid [4-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-2-piperidin-1-yl-phenyl]-amide
Show/Hide
|
C21H24N4O4S
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0161333
|
4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl]-1H-pyrrole-2-carboxamide
Show/Hide
|
C23H30N6O
|
1
|
| 1 |
IC50 = 0.78 nM
|
|
|
|
CP0120760
|
5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C22H27N5O2
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0459818
|
5-cyano-N-(2-(4-methylpiperidin-1-yl)-4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C23H29N5O4S
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0344654
|
5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C23H29N5O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0528075
|
4-cyano-N-(2-(4-methylpiperidin-1-yl)-4-(piperazin-1-yl)phenyl)-1H-pyrrole-2-carboxamide
Show/Hide
|
C22H28N6O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0551168
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[1-(1,3-thiazol-2-yl)ethyl]urea
Show/Hide
|
C22H22N6O2S
|
1
|
| 1 |
IC50 = 1.41 nM
|
|
|
|
CP0161570
|
4-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)-1H-pyrrole-2-carboxamide
Show/Hide
|
C22H28N6O
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0502017
|
5-cyano-N-(4-imidazol-1-yl-2-piperidin-1-ylphenyl)furan-2-carboxamide
Show/Hide
|
C20H19N5O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0372095
|
5-cyano-N-(2-(3-fluoropiperidin-1-yl)-4-(4-methylpiperazin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C22H26FN5O2
|
1
|
| 1 |
IC50 = 6.3 nM
|
|
|
|
CP0558728
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[(4-fluorophenyl)methyl]urea
Show/Hide
|
C24H22FN5O2
|
1
|
| 1 |
IC50 = 8.3 nM
|
|
|
|
CP0457796
|
5-cyano-N-(6-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)pyridin-3-yl)furan-2-carboxamide
Show/Hide
|
C22H28N6O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0485128
|
1-(3-chlorophenyl)-3-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]urea
Show/Hide
|
C23H20ClN5O2
|
1
|
| 1 |
IC50 = 10.5 nM
|
|
|
|
CP0502018
|
5-cyano-N-(2-(4-methylpiperidin-1-yl)-4-morpholinophenyl)furan-2-carboxamide
Show/Hide
|
C22H26N4O3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0485122
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[(6-methylpyridin-3-yl)methyl]urea
Show/Hide
|
C24H24N6O2
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0551134
|
1-(3-chloro-4-methoxyphenyl)-3-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]urea
Show/Hide
|
C24H22ClN5O3
|
1
|
| 1 |
IC50 = 11.1 nM
|
|
|
|
CP0551170
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-(3-methoxyphenyl)urea
Show/Hide
|
C24H23N5O3
|
1
|
| 1 |
IC50 = 11.6 nM
|
|
|
|
CP0494136
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[(6-methoxypyridin-3-yl)methyl]urea
Show/Hide
|
C24H24N6O3
|
1
|
| 1 |
IC50 = 12.7 nM
|
|
|
|
CP0548388
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[(4-methoxyphenyl)methyl]urea
Show/Hide
|
C25H25N5O3
|
1
|
| 1 |
IC50 = 12.9 nM
|
|
|
|
CP0133124
|
5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine
Show/Hide
|
C20H15ClF3N5
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
IC50 = 35 nM
|
|
|
|
CP0494134
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-(4-methoxyphenyl)urea
Show/Hide
|
C24H23N5O3
|
1
|
| 1 |
IC50 = 14.1 nM
|
|
|
|
CP0253957
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[[6-(trifluoromethyl)pyridin-3-yl]methyl]urea
Show/Hide
|
C24H21F3N6O2
|
1
|
| 1 |
IC50 = 14.4 nM
|
|
|
|
CP0548387
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-(2-phenylethyl)urea
Show/Hide
|
C25H25N5O2
|
1
|
| 1 |
IC50 = 15.4 nM
|
|
|
|
CP0565351
|
1-(2-chlorophenyl)-3-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]urea
Show/Hide
|
C23H20ClN5O2
|
1
|
| 1 |
IC50 = 15.4 nM
|
|
|
|
CP0549769
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[(4-sulfamoylphenyl)methyl]urea
Show/Hide
|
C24H24N6O4S
|
1
|
| 1 |
IC50 = 16.3 nM
|
|
|
|
CP0558776
|
1-benzyl-3-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]urea
Show/Hide
|
C24H23N5O2
|
1
|
| 1 |
IC50 = 16.3 nM
|
|
|
|
CP0467743
|
5-cyano-N-(2,4-di(piperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C22H26N4O2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0494140
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[(2,3,4,5,6-pentafluorophenyl)methyl]urea
Show/Hide
|
C24H18F5N5O2
|
1
|
| 1 |
IC50 = 18.6 nM
|
|
|
|
CP0548485
|
1-(3-chlorophenyl)-3-[5-[2-[[7-[3-(dimethylamino)propoxy]quinazolin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
Show/Hide
|
C25H28ClN7O2S
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0372097
|
5-cyano-N-(4-ethoxy-2-(piperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C19H21N3O3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0551192
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-phenylurea
Show/Hide
|
C23H21N5O2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0086098
|
5-cyano-N-[5-(hydroxymethyl)-2-(4-methylpiperidin-1-yl)phenyl]furan-2-carboxamide
Show/Hide
|
C19H21N3O3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0551169
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-(1,3-thiazol-2-ylmethyl)urea
Show/Hide
|
C21H20N6O2S
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0525757
|
5-cyano-N-(4-(N-methylmethan-2-ylsulfonamido)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C19H22N4O4S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0015521
|
5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine
Show/Hide
|
C20H22N4O3
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0041597
|
1-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-methoxyphenyl]-3-[1-(1,3-thiazol-2-yl)ethyl]urea
Show/Hide
|
C24H24N4O5S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0219113
|
1-(4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-phenylurea
Show/Hide
|
C23H20N4O4
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0494137
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-(2-methoxyphenyl)urea
Show/Hide
|
C24H23N5O3
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0485120
|
1-(5-chloro-2-methoxyphenyl)-3-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]urea
Show/Hide
|
C24H22ClN5O3
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0494139
|
1-[4-[6-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-phenylurea
Show/Hide
|
C23H21N5O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0485124
|
1-[4-[7-(methylamino)quinazolin-4-yl]oxyphenyl]-3-phenylurea
Show/Hide
|
C22H19N5O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0485121
|
1-[(4-cyanophenyl)methyl]-3-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]urea
Show/Hide
|
C25H22N6O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0372096
|
5-cyano-N-(4-(3-(ethyl(methyl)amino)propyl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C23H30N4O2
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0485119
|
1-[4-(7-aminoquinazolin-4-yl)oxyphenyl]-3-phenylurea
Show/Hide
|
C21H17N5O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0525756
|
5-cyano-N-(4-fluoro-2-(piperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C17H16FN3O2
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0485127
|
1-phenyl-3-[4-(7-pyrrolidin-1-ylquinazolin-4-yl)oxyphenyl]urea
Show/Hide
|
C25H23N5O2
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0372098
|
5-cyano-N-(4-(4-methyl-1H-pyrazol-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C21H21N5O2
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0485129
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[4-(trifluoromethyl)phenyl]urea
Show/Hide
|
C24H20F3N5O2
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0494138
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
Show/Hide
|
C24H20F3N5O2
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0457795
|
5-cyano-N-(4-(methylsulfonamido)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C18H20N4O4S
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0494132
|
1-[4-(7-methoxyquinazolin-4-yl)oxyphenyl]-3-phenylurea
Show/Hide
|
C22H18N4O3
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0494135
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-(pyridin-3-ylmethyl)urea
Show/Hide
|
C23H22N6O2
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0372093
|
5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-morpholinophenyl)furan-2-carboxamide
Show/Hide
|
C21H25N5O3
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0467742
|
N-[4-[(5-cyanofuran-2-carbonyl)amino]-3-piperidin-1-ylphenyl]-N,4-dimethylpiperazine-1-carboxamide
Show/Hide
|
C24H30N6O3
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0551191
|
1-[(3,4-dimethoxyphenyl)methyl]-3-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]urea
Show/Hide
|
C26H27N5O4
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0565352
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[[4-(trifluoromethyl)phenyl]methyl]urea
Show/Hide
|
C25H22F3N5O2
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0494141
|
1-(3-chlorophenyl)-3-[5-[2-[(7-methoxyquinazolin-4-yl)amino]ethyl]-1,3-thiazol-2-yl]urea
Show/Hide
|
C21H19ClN6O2S
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0485117
|
1-[4-[(7-methoxyquinazolin-4-yl)amino]phenyl]-3-phenylurea
Show/Hide
|
C22H19N5O2
|
1
|
| 1 |
IC50 = 124 nM
|
|
|
|
CP0557939
|
1-(4-chlorophenyl)-3-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]urea
Show/Hide
|
C23H20ClN5O2
|
1
|
| 1 |
IC50 = 164 nM
|
|
|
|
CP0485126
|
1-[4-[7-(dimethylamino)quinazolin-4-yl]oxyphenyl]-3-[(1-methylpyrazol-3-yl)methyl]urea
Show/Hide
|
C22H23N7O2
|
1
|
| 1 |
IC50 = 204 nM
|
|
|
|
CP0558751
|
1-[4-[[7-(dimethylamino)quinazolin-4-yl]amino]phenyl]-3-phenylurea
Show/Hide
|
C23H22N6O
|
1
|
| 1 |
IC50 = 243 nM
|
|
|
|
CP0192173
|
N-(2-piperidin-1-ylphenyl)-1,2-oxazole-5-carboxamide
Show/Hide
|
C15H17N3O2
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0372092
|
5-cyano-N-(5-(4-methylpiperazin-1-yl)-3-(4-methylpiperidin-1-yl)pyridin-2-yl)furan-2-carboxamide
Show/Hide
|
C22H28N6O2
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
|
CP0485118
|
1-[4-(7-fluoroquinazolin-4-yl)oxyphenyl]-3-phenylurea
Show/Hide
|
C21H15FN4O2
|
1
|
| 1 |
IC50 = 753 nM
|
|
|
|
CP0485116
|
1-(3-chlorophenyl)-3-[5-[2-[(7-fluoroquinazolin-4-yl)amino]ethyl]-1,3-thiazol-2-yl]urea
Show/Hide
|
C20H16ClFN6OS
|
1
|
| 1 |
IC50 > 10 nM
|
|
|
|
CP0494133
|
1-phenyl-3-[4-(6-pyrrolidin-1-ylquinazolin-4-yl)oxyphenyl]urea
Show/Hide
|
C25H23N5O2
|
1
|
| 1 |
IC50 > 10 nM
|
|
|
|
CP0372094
|
5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(2-oxopiperidin-1-yl)phenyl)furan-2-carboxamide
Show/Hide
|
C22H25N5O3
|
1
|
| 1 |
IC50 > 60 nM
|
|
|
|
CP0382724
|
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
Show/Hide
|
C49H54BF2N7O7
|
1
|
| 1 |
Kd = 279 nM
|
|
|
|
CP0382649
|
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
Show/Hide
|
C50H56BF2N7O7
|
1
|
| 1 |
Kd = 324 nM
|
|
|
