Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine
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 PubChem ID
CID: 25151352
SID: 57245138
Canonical SMILES
FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1
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Compound Formula C20H15ClF3N5
Compound Structure
Protein Name
 Protein Info 
Macrophage colony-stimulating factor 1 receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P07333
Gene Name
CSF1R
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
2
IC50 = 35 nM
   TI
   LI
   LO
   TS
CL000040 THP-1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.7 nM
2 IC50 = 12 nM
3 IC50 = 13 nM
4 IC50 = 20 nM