4-(4-Chlorobenzyl)-1-(1H-pyrazolo[3,4-b]pyridin-4-yl)-piperidin-4-ylamine

4-Amino-N-(4-chloro-2-fluorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

6-(4-Amino-4-(4-tert-butylbenzyl)piperidin-1-yl)-7H-purin-8(9H)-one

4-((4-Chlorobenzyloxy)methyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine

4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-

N-[6-[6-chloro-5-[(2-chlorophenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[(4-methoxyphenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[5-(benzenesulfonamido)-6-chloropyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[(4-fluorophenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

4-(4-tert-Butylbenzyl)-1-(1H-pyrazolo[3,4-b]pyridin-4-yl)piperidin-4-amine

N-[6-[5-[(4-tert-butylphenyl)sulfonylamino]-6-chloropyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

4-Amino-N-(4-chlorobenzyl)-1-(1H-pyrrolo[2,3-b]pyridin-4-yl)piperidine-4-carboxamide

N-[6-[6-chloro-5-[[2-(trifluoromethyl)phenyl]sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[(4-chlorophenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[(2-fluorophenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[[3-(trifluoromethyl)phenyl]sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[(3-chlorophenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[(3-fluorophenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[5-[(3-tert-butylphenyl)sulfonylamino]-6-chloropyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[(4-fluorophenyl)sulfonylamino]pyridin-3-yl]imidazo[1,2-b]pyridazin-2-yl]acetamide

N-[6-[5-[(4-methoxyphenyl)sulfonylamino]-6-methylpyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[[4-(trifluoromethyl)phenyl]sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

2-methyl-2-[4-[3-methyl-2-oxo-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile

N-[6-[2-[(4-methoxyphenyl)sulfonylamino]pyridin-4-yl]-1,3-benzothiazol-2-yl]acetamide

N-[5-(2-amino-1,3-benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide

2-[4-[2-methyl-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile

4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine

4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

N-(2-chloro-5-imidazo[1,2-b]pyridazin-6-ylpyridin-3-yl)-4-fluorobenzenesulfonamide

5-chloro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-dihydrospiro[indole-3,4'-piperidine]

1-{5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-dihydrospiro[indole-3,4'-piperidine]

5-fluoro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-dihydrospiro[indole-3,4'-piperidine]

2-[4-[2-methyl-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]acetonitrile

2-[4-[8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]acetonitrile

1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-dihydrospiro[indole-3,4'-piperidine]

N-[5-(2-amino-1,3-benzoxazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide

N-[6-[5-[(4-methoxyphenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[(4-fluorophenyl)sulfonylamino]pyridin-3-yl]imidazo[1,2-a]pyridin-2-yl]acetamide

1-{5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-dihydrospiro[indole-3,4'-piperidine]

1'-methyl-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-dihydrospiro[indole-3,4'-piperidine]

2-[4-[2-ethyl-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]acetonitrile

2-[4-[8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile

(S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine

(S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-2,4-difluorobenzamide

(S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)thiazol-5-yl)indolin-2-one

N-[6-[2-[ethyl-(4-methoxyphenyl)sulfonylamino]pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide

(S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-2,4-difluorobenzamide

(S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-2,4-difluorobenzamide

N-[6-[2-[methyl-(4-methylphenyl)sulfonylamino]pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-chloro-5-[(4-fluorophenyl)sulfonylamino]pyridin-3-yl]-1H-benzimidazol-2-yl]acetamide

N-[6-[2-[(4-methoxyphenyl)sulfonyl-methylamino]pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide

(S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-4-chlorobenzamide

(S)-N-((3-amino-1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-4-fluorobenzamide

N-[5-(2-aminoimidazo[1,2-b]pyridazin-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide

(S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine

(S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)thiazol-5-yl)benzo[d]oxazol-2(3H)-one

N-(2-chloro-5-imidazo[1,2-a]pyridin-6-ylpyridin-3-yl)-4-fluorobenzenesulfonamide

(S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)thiazol-5-yl)-1-methyl-1H-benzo[d]imidazol-2(3H)-one

(S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-4-fluorobenzamide

N-[6-[2-[(2-fluorophenyl)sulfonyl-methylamino]pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide

(S)-N1-(5-(1H-indazol-5-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine

N-[6-[6-[(4-methoxyphenyl)sulfonylamino]pyrazin-2-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[6-cyano-5-[(4-methoxyphenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide

N-[5-(1,3-benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide

(S)-N1-(5-(3-aminoisoquinolin-6-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine

(S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)thiazol-5-yl)benzo[d]thiazol-2(3H)-one

(S)-N-((3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-4-chlorobenzamide

N-[6-[6-chloro-5-[(4-fluorophenyl)sulfonylamino]pyridin-3-yl]-1,3-benzoxazol-2-yl]acetamide

N-[6-[3-[(4-methoxyphenyl)sulfonylamino]phenyl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[2-[(4-methylphenyl)sulfonylamino]pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide

(S)-N1-(5-(quinazolin-7-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine

(S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-4-fluorobenzamide

(S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-2,4-difluorobenzamide

(S)-N-((3-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-4-chlorobenzamide

N-[6-[2-[(4-methoxyphenyl)sulfonylamino]pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[2-(2-phenylpropan-2-ylamino)pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide

(R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-amine

N-[6-[2-[(2-fluorophenyl)sulfonylamino]pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide

(S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-4-fluorobenzamide

(S)-5-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)thiazol-5-yl)isoindolin-1-one

(S)-N-((3-amino-1-(5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)methyl)-4-chlorobenzamide

N-[5-(1,2-benzothiazol-5-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide

N-[5-(2-amino-3H-benzimidazol-5-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide

N-[5-(2-aminoimidazo[1,2-a]pyridin-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide

N-[5-(1,3-benzoxazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide

N-[5-(3H-benzimidazol-5-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide

N-[2-chloro-5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide

4-Amino-N-(4-chlorobenzyl)-1-(8-oxo-8,9-dihydro-7H-purin-6-yl)-piperidine-4-carboxamide

N-[6-[2-[(3-fluorophenyl)sulfonylamino]pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[2-[(4-fluorophenyl)sulfonylamino]pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide

N-[6-[2-(benzylamino)pyrimidin-4-yl]-1,3-benzothiazol-2-yl]acetamide